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PubMed code 11412980

Compile data set for download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(homo sapiens (human))
BDBM50100934
PNG
(CHEMBL40151 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazo...)
Show SMILES CCOc1ccc(cc1)-c1ccc(OCC(CN2C(=O)NC(C)(C)C2=O)N(O)C=O)cc1
Show InChI InChI=1S/C23H27N3O6/c1-4-31-19-9-5-16(6-10-19)17-7-11-20(12-8-17)32-14-18(26(30)15-27)13-25-21(28)23(2,3)24-22(25)29/h5-12,15,18,30H,4,13-14H2,1-3H3,(H,24,29)
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n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100927
PNG
((S)-N-(1-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)...)
Show SMILES CC1(C)NC(=O)N(C[C@@H](COc2ccc(cc2)-c2ccc(OC(F)(F)F)cc2)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O6/c1-21(2)19(30)27(20(31)26-21)11-16(28(32)13-29)12-33-17-7-3-14(4-8-17)15-5-9-18(10-6-15)34-22(23,24)25/h3-10,13,16,32H,11-12H2,1-2H3,(H,26,31)/t16-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100924
PNG
(CHEMBL41408 | N-Hydroxy-N-[1-(4'-methoxy-biphenyl-...)
Show SMILES COc1ccc(cc1)-c1ccc(OCC(CN2C(=O)N(C)C(C)(C)C2=O)N(O)C=O)cc1
Show InChI InChI=1S/C23H27N3O6/c1-23(2)21(28)25(22(29)24(23)3)13-18(26(30)15-27)14-32-20-11-7-17(8-12-20)16-5-9-19(31-4)10-6-16/h5-12,15,18,30H,13-14H2,1-4H3
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n/an/a 4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100932
PNG
(CHEMBL416421 | N-{2-(4,4-Dimethyl-2,5-dioxo-imidaz...)
Show SMILES COCCOc1ccc(cc1)-c1ccc(OCC(CN2C(=O)NC(C)(C)C2=O)N(O)C=O)cc1
Show InChI InChI=1S/C24H29N3O7/c1-24(2)22(29)26(23(30)25-24)14-19(27(31)16-28)15-34-21-10-6-18(7-11-21)17-4-8-20(9-5-17)33-13-12-32-3/h4-11,16,19,31H,12-15H2,1-3H3,(H,25,30)
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n/an/a 4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100925
PNG
(CHEMBL38868 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazo...)
Show SMILES CCCOc1ccc(cc1)-c1ccc(OCC(CN2C(=O)NC(C)(C)C2=O)N(O)C=O)cc1
Show InChI InChI=1S/C24H29N3O6/c1-4-13-32-20-9-5-17(6-10-20)18-7-11-21(12-8-18)33-15-19(27(31)16-28)14-26-22(29)24(2,3)25-23(26)30/h5-12,16,19,31H,4,13-15H2,1-3H3,(H,25,30)
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n/an/a 4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100922
PNG
(CHEMBL43411 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazo...)
Show SMILES CC1(C)NC(=O)N(CC(COc2ccc(cc2)-c2ccc(OC(F)(F)F)cc2)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O6/c1-21(2)19(30)27(20(31)26-21)11-16(28(32)13-29)12-33-17-7-3-14(4-8-17)15-5-9-18(10-6-15)34-22(23,24)25/h3-10,13,16,32H,11-12H2,1-2H3,(H,26,31)
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n/an/a 6n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100918
PNG
(CHEMBL41102 | N-[1-(4'-Cyano-biphenyl-4-yloxymethy...)
Show SMILES CC1(C)NC(=O)N(CC(COc2ccc(cc2)-c2ccc(cc2)C#N)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22N4O5/c1-22(2)20(28)25(21(29)24-22)12-18(26(30)14-27)13-31-19-9-7-17(8-10-19)16-5-3-15(11-23)4-6-16/h3-10,14,18,30H,12-13H2,1-2H3,(H,24,29)
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n/an/a 8n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100938
PNG
(CHEMBL42970 | N-[1-(4'-Butyl-biphenyl-4-yloxymethy...)
Show SMILES CCCCc1ccc(cc1)-c1ccc(OCC(CN2C(=O)NC(C)(C)C2=O)N(O)C=O)cc1
Show InChI InChI=1S/C25H31N3O5/c1-4-5-6-18-7-9-19(10-8-18)20-11-13-22(14-12-20)33-16-21(28(32)17-29)15-27-23(30)25(2,3)26-24(27)31/h7-14,17,21,32H,4-6,15-16H2,1-3H3,(H,26,31)
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n/an/a 16n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100930
PNG
(CHEMBL39566 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazo...)
Show SMILES CC1(C)NC(=O)N(CC(COc2ccc(cc2)-c2ccc(cc2)C(F)(F)F)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O5/c1-21(2)19(30)27(20(31)26-21)11-17(28(32)13-29)12-33-18-9-5-15(6-10-18)14-3-7-16(8-4-14)22(23,24)25/h3-10,13,17,32H,11-12H2,1-2H3,(H,26,31)
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n/an/a 20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100931
PNG
(CHEMBL41324 | N-Hydroxy-N-[1-(4'-methyl-biphenyl-4...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2ccc(C)cc2)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C23H27N3O5/c1-16-5-7-17(8-6-16)18-9-11-20(12-10-18)31-14-19(26(30)15-27)13-25-21(28)23(2,3)24(4)22(25)29/h5-12,15,19,30H,13-14H2,1-4H3
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n/an/a 20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100929
PNG
(CHEMBL39601 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazo...)
Show SMILES CCCCCOc1ccc(cc1)-c1ccc(OCC(CN2C(=O)NC(C)(C)C2=O)N(O)C=O)cc1
Show InChI InChI=1S/C26H33N3O6/c1-4-5-6-15-34-22-11-7-19(8-12-22)20-9-13-23(14-10-20)35-17-21(29(33)18-30)16-28-24(31)26(2,3)27-25(28)32/h7-14,18,21,33H,4-6,15-17H2,1-3H3,(H,27,32)
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n/an/a 26n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM50100927
PNG
((S)-N-(1-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)...)
Show SMILES CC1(C)NC(=O)N(C[C@@H](COc2ccc(cc2)-c2ccc(OC(F)(F)F)cc2)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O6/c1-21(2)19(30)27(20(31)26-21)11-16(28(32)13-29)12-33-17-7-3-14(4-8-17)15-5-9-18(10-6-15)34-22(23,24)25/h3-10,13,16,32H,11-12H2,1-2H3,(H,26,31)/t16-/m0/s1
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n/an/a 42n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloproteinase-3


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100926
PNG
(CHEMBL285296 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidaz...)
Show SMILES CC1(C)NC(=O)N(CC(COc2ccc(cc2)-c2ccc(cc2)S(C)(=O)=O)N(O)C=O)C1=O
Show InChI InChI=1S/C22H25N3O7S/c1-22(2)20(27)24(21(28)23-22)12-17(25(29)14-26)13-32-18-8-4-15(5-9-18)16-6-10-19(11-7-16)33(3,30)31/h4-11,14,17,29H,12-13H2,1-3H3,(H,23,28)
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n/an/a 48n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100902
PNG
(CHEMBL288067 | N-[1-(4'-Cyano-biphenyl-4-yloxymeth...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2ccc(cc2)C#N)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C23H24N4O5/c1-23(2)21(29)26(22(30)25(23)3)13-19(27(31)15-28)14-32-20-10-8-18(9-11-20)17-6-4-16(12-24)5-7-17/h4-11,15,19,31H,13-14H2,1-3H3
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n/an/a 58n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100936
PNG
(CHEMBL38299 | N-Hydroxy-N-[2-(3,4,4-trimethyl-2,5-...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2ccc(C=C)cc2)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C24H27N3O5/c1-5-17-6-8-18(9-7-17)19-10-12-21(13-11-19)32-15-20(27(31)16-28)14-26-22(29)24(2,3)25(4)23(26)30/h5-13,16,20,31H,1,14-15H2,2-4H3
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n/an/a 61n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100921
PNG
(CHEMBL40613 | N-[1-(4-Furan-2-yl-phenoxymethyl)-2-...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2ccco2)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C20H23N3O6/c1-20(2)18(25)22(19(26)21(20)3)11-15(23(27)13-24)12-29-16-8-6-14(7-9-16)17-5-4-10-28-17/h4-10,13,15,27H,11-12H2,1-3H3
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n/an/a 85n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100920
PNG
(CHEMBL288385 | N-[1-(Biphenyl-4-yloxymethyl)-2-(3,...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2ccccc2)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C22H25N3O5/c1-22(2)20(27)24(21(28)23(22)3)13-18(25(29)15-26)14-30-19-11-9-17(10-12-19)16-7-5-4-6-8-16/h4-12,15,18,29H,13-14H2,1-3H3
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n/an/a 89n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50100927
PNG
((S)-N-(1-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)...)
Show SMILES CC1(C)NC(=O)N(C[C@@H](COc2ccc(cc2)-c2ccc(OC(F)(F)F)cc2)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O6/c1-21(2)19(30)27(20(31)26-21)11-16(28(32)13-29)12-33-17-7-3-14(4-8-17)15-5-9-18(10-6-15)34-22(23,24)25/h3-10,13,16,32H,11-12H2,1-2H3,(H,26,31)/t16-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-9


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100935
PNG
(CHEMBL40335 | N-Hydroxy-N-[1-(4-thiophen-2-yl-phen...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2cccs2)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C20H23N3O5S/c1-20(2)18(25)22(19(26)21(20)3)11-15(23(27)13-24)12-28-16-8-6-14(7-9-16)17-5-4-10-29-17/h4-10,13,15,27H,11-12H2,1-3H3
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n/an/a 130n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100923
PNG
(CHEMBL41943 | N-[(R)-2-(4,4-Dimethyl-2,5-dioxo-imi...)
Show SMILES CC1(C)NC(=O)N(C[C@H](COc2ccc(cc2)-c2ccc(OC(F)(F)F)cc2)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O6/c1-21(2)19(30)27(20(31)26-21)11-16(28(32)13-29)12-33-17-7-3-14(4-8-17)15-5-9-18(10-6-15)34-22(23,24)25/h3-10,13,16,32H,11-12H2,1-2H3,(H,26,31)/t16-/m1/s1
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n/an/a 180n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100924
PNG
(CHEMBL41408 | N-Hydroxy-N-[1-(4'-methoxy-biphenyl-...)
Show SMILES COc1ccc(cc1)-c1ccc(OCC(CN2C(=O)N(C)C(C)(C)C2=O)N(O)C=O)cc1
Show InChI InChI=1S/C23H27N3O6/c1-23(2)21(28)25(22(29)24(23)3)13-18(26(30)15-27)14-32-20-11-7-17(8-12-20)16-5-9-19(31-4)10-6-16/h5-12,15,18,30H,13-14H2,1-4H3
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n/an/a 440n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100930
PNG
(CHEMBL39566 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazo...)
Show SMILES CC1(C)NC(=O)N(CC(COc2ccc(cc2)-c2ccc(cc2)C(F)(F)F)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O5/c1-21(2)19(30)27(20(31)26-21)11-17(28(32)13-29)12-33-18-9-5-15(6-10-18)14-3-7-16(8-4-14)22(23,24)25/h3-10,13,17,32H,11-12H2,1-2H3,(H,26,31)
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n/an/a 840n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100934
PNG
(CHEMBL40151 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazo...)
Show SMILES CCOc1ccc(cc1)-c1ccc(OCC(CN2C(=O)NC(C)(C)C2=O)N(O)C=O)cc1
Show InChI InChI=1S/C23H27N3O6/c1-4-31-19-9-5-16(6-10-19)17-7-11-20(12-8-17)32-14-18(26(30)15-27)13-25-21(28)23(2,3)24-22(25)29/h5-12,15,18,30H,4,13-14H2,1-3H3,(H,24,29)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100920
PNG
(CHEMBL288385 | N-[1-(Biphenyl-4-yloxymethyl)-2-(3,...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2ccccc2)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C22H25N3O5/c1-22(2)20(27)24(21(28)23(22)3)13-18(25(29)15-26)14-30-19-11-9-17(10-12-19)16-7-5-4-6-8-16/h4-12,15,18,29H,13-14H2,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50100923
PNG
(CHEMBL41943 | N-[(R)-2-(4,4-Dimethyl-2,5-dioxo-imi...)
Show SMILES CC1(C)NC(=O)N(C[C@H](COc2ccc(cc2)-c2ccc(OC(F)(F)F)cc2)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O6/c1-21(2)19(30)27(20(31)26-21)11-16(28(32)13-29)12-33-17-7-3-14(4-8-17)15-5-9-18(10-6-15)34-22(23,24)25/h3-10,13,16,32H,11-12H2,1-2H3,(H,26,31)/t16-/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-9


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100928
PNG
(CHEMBL39921 | N-[1-(3'-Cyano-biphenyl-4-yloxymethy...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2cccc(c2)C#N)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C23H24N4O5/c1-23(2)21(29)26(22(30)25(23)3)13-19(27(31)15-28)14-32-20-9-7-17(8-10-20)18-6-4-5-16(11-18)12-24/h4-11,15,19,31H,13-14H2,1-3H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100921
PNG
(CHEMBL40613 | N-[1-(4-Furan-2-yl-phenoxymethyl)-2-...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2ccco2)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C20H23N3O6/c1-20(2)18(25)22(19(26)21(20)3)11-15(23(27)13-24)12-29-16-8-6-14(7-9-16)17-5-4-10-28-17/h4-10,13,15,27H,11-12H2,1-3H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100931
PNG
(CHEMBL41324 | N-Hydroxy-N-[1-(4'-methyl-biphenyl-4...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2ccc(C)cc2)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C23H27N3O5/c1-16-5-7-17(8-6-16)18-9-11-20(12-10-18)31-14-19(26(30)15-27)13-25-21(28)23(2,3)24(4)22(25)29/h5-12,15,19,30H,13-14H2,1-4H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100918
PNG
(CHEMBL41102 | N-[1-(4'-Cyano-biphenyl-4-yloxymethy...)
Show SMILES CC1(C)NC(=O)N(CC(COc2ccc(cc2)-c2ccc(cc2)C#N)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22N4O5/c1-22(2)20(28)25(21(29)24-22)12-18(26(30)14-27)13-31-19-9-7-17(8-10-19)16-5-3-15(11-23)4-6-16/h3-10,14,18,30H,12-13H2,1-2H3,(H,24,29)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100902
PNG
(CHEMBL288067 | N-[1-(4'-Cyano-biphenyl-4-yloxymeth...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2ccc(cc2)C#N)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C23H24N4O5/c1-23(2)21(29)26(22(30)25(23)3)13-19(27(31)15-28)14-32-20-10-8-18(9-11-20)17-6-4-16(12-24)5-7-17/h4-11,15,19,31H,13-14H2,1-3H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM50100923
PNG
(CHEMBL41943 | N-[(R)-2-(4,4-Dimethyl-2,5-dioxo-imi...)
Show SMILES CC1(C)NC(=O)N(C[C@H](COc2ccc(cc2)-c2ccc(OC(F)(F)F)cc2)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O6/c1-21(2)19(30)27(20(31)26-21)11-16(28(32)13-29)12-33-17-7-3-14(4-8-17)15-5-9-18(10-6-15)34-22(23,24)25/h3-10,13,16,32H,11-12H2,1-2H3,(H,26,31)/t16-/m1/s1
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n/an/a 3.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloproteinase-3


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100935
PNG
(CHEMBL40335 | N-Hydroxy-N-[1-(4-thiophen-2-yl-phen...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2cccs2)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C20H23N3O5S/c1-20(2)18(25)22(19(26)21(20)3)11-15(23(27)13-24)12-28-16-8-6-14(7-9-16)17-5-4-10-29-17/h4-10,13,15,27H,11-12H2,1-3H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100927
PNG
((S)-N-(1-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)...)
Show SMILES CC1(C)NC(=O)N(C[C@@H](COc2ccc(cc2)-c2ccc(OC(F)(F)F)cc2)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O6/c1-21(2)19(30)27(20(31)26-21)11-16(28(32)13-29)12-33-17-7-3-14(4-8-17)15-5-9-18(10-6-15)34-22(23,24)25/h3-10,13,16,32H,11-12H2,1-2H3,(H,26,31)/t16-/m0/s1
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n/an/a 4.60E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100926
PNG
(CHEMBL285296 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidaz...)
Show SMILES CC1(C)NC(=O)N(CC(COc2ccc(cc2)-c2ccc(cc2)S(C)(=O)=O)N(O)C=O)C1=O
Show InChI InChI=1S/C22H25N3O7S/c1-22(2)20(27)24(21(28)23-22)12-17(25(29)14-26)13-32-18-8-4-15(5-9-18)16-6-10-19(11-7-16)33(3,30)31/h4-11,14,17,29H,12-13H2,1-3H3,(H,23,28)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100922
PNG
(CHEMBL43411 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazo...)
Show SMILES CC1(C)NC(=O)N(CC(COc2ccc(cc2)-c2ccc(OC(F)(F)F)cc2)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O6/c1-21(2)19(30)27(20(31)26-21)11-16(28(32)13-29)12-33-17-7-3-14(4-8-17)15-5-9-18(10-6-15)34-22(23,24)25/h3-10,13,16,32H,11-12H2,1-2H3,(H,26,31)
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n/an/a 8.60E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100923
PNG
(CHEMBL41943 | N-[(R)-2-(4,4-Dimethyl-2,5-dioxo-imi...)
Show SMILES CC1(C)NC(=O)N(C[C@H](COc2ccc(cc2)-c2ccc(OC(F)(F)F)cc2)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O6/c1-21(2)19(30)27(20(31)26-21)11-16(28(32)13-29)12-33-17-7-3-14(4-8-17)15-5-9-18(10-6-15)34-22(23,24)25/h3-10,13,16,32H,11-12H2,1-2H3,(H,26,31)/t16-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100933
PNG
(CHEMBL41150 | N-Hydroxy-N-[1-(4-pyridin-3-yl-pheno...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2cccnc2)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C21H24N4O5/c1-21(2)19(27)24(20(28)23(21)3)12-17(25(29)14-26)13-30-18-8-6-15(7-9-18)16-5-4-10-22-11-16/h4-11,14,17,29H,12-13H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100938
PNG
(CHEMBL42970 | N-[1-(4'-Butyl-biphenyl-4-yloxymethy...)
Show SMILES CCCCc1ccc(cc1)-c1ccc(OCC(CN2C(=O)NC(C)(C)C2=O)N(O)C=O)cc1
Show InChI InChI=1S/C25H31N3O5/c1-4-5-6-18-7-9-19(10-8-18)20-11-13-22(14-12-20)33-16-21(28(32)17-29)15-27-23(30)25(2,3)26-24(27)31/h7-14,17,21,32H,4-6,15-16H2,1-3H3,(H,26,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50100927
PNG
((S)-N-(1-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)...)
Show SMILES CC1(C)NC(=O)N(C[C@@H](COc2ccc(cc2)-c2ccc(OC(F)(F)F)cc2)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O6/c1-21(2)19(30)27(20(31)26-21)11-16(28(32)13-29)12-33-17-7-3-14(4-8-17)15-5-9-18(10-6-15)34-22(23,24)25/h3-10,13,16,32H,11-12H2,1-2H3,(H,26,31)/t16-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloproteinase-7


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100937
PNG
(CHEMBL418437 | N-[1-(4'-Cyano-biphenyl-3-yloxymeth...)
Show SMILES CN1C(=O)N(CC(COc2cccc(c2)-c2ccc(cc2)C#N)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C23H24N4O5/c1-23(2)21(29)26(22(30)25(23)3)13-19(27(31)15-28)14-32-20-6-4-5-18(11-20)17-9-7-16(12-24)8-10-17/h4-11,15,19,31H,13-14H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50100923
PNG
(CHEMBL41943 | N-[(R)-2-(4,4-Dimethyl-2,5-dioxo-imi...)
Show SMILES CC1(C)NC(=O)N(C[C@H](COc2ccc(cc2)-c2ccc(OC(F)(F)F)cc2)N(O)C=O)C1=O
Show InChI InChI=1S/C22H22F3N3O6/c1-21(2)19(30)27(20(31)26-21)11-16(28(32)13-29)12-33-17-7-3-14(4-8-17)15-5-9-18(10-6-15)34-22(23,24)25/h3-10,13,16,32H,11-12H2,1-2H3,(H,26,31)/t16-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloproteinase-7


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100937
PNG
(CHEMBL418437 | N-[1-(4'-Cyano-biphenyl-3-yloxymeth...)
Show SMILES CN1C(=O)N(CC(COc2cccc(c2)-c2ccc(cc2)C#N)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C23H24N4O5/c1-23(2)21(29)26(22(30)25(23)3)13-19(27(31)15-28)14-32-20-6-4-5-18(11-20)17-9-7-16(12-24)8-10-17/h4-11,15,19,31H,13-14H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100932
PNG
(CHEMBL416421 | N-{2-(4,4-Dimethyl-2,5-dioxo-imidaz...)
Show SMILES COCCOc1ccc(cc1)-c1ccc(OCC(CN2C(=O)NC(C)(C)C2=O)N(O)C=O)cc1
Show InChI InChI=1S/C24H29N3O7/c1-24(2)22(29)26(23(30)25-24)14-19(27(31)16-28)15-34-21-10-6-18(7-11-21)17-4-8-20(9-5-17)33-13-12-32-3/h4-11,16,19,31H,12-15H2,1-3H3,(H,25,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100925
PNG
(CHEMBL38868 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazo...)
Show SMILES CCCOc1ccc(cc1)-c1ccc(OCC(CN2C(=O)NC(C)(C)C2=O)N(O)C=O)cc1
Show InChI InChI=1S/C24H29N3O6/c1-4-13-32-20-9-5-17(6-10-20)18-7-11-21(12-8-18)33-15-19(27(31)16-28)14-26-22(29)24(2,3)25-23(26)30/h5-12,16,19,31H,4,13-15H2,1-3H3,(H,25,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50100933
PNG
(CHEMBL41150 | N-Hydroxy-N-[1-(4-pyridin-3-yl-pheno...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2cccnc2)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C21H24N4O5/c1-21(2)19(27)24(20(28)23(21)3)12-17(25(29)14-26)13-30-18-8-6-15(7-9-18)16-5-4-10-22-11-16/h4-11,14,17,29H,12-13H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-2.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100928
PNG
(CHEMBL39921 | N-[1-(3'-Cyano-biphenyl-4-yloxymethy...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2cccc(c2)C#N)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C23H24N4O5/c1-23(2)21(29)26(22(30)25(23)3)13-19(27(31)15-28)14-32-20-9-7-17(8-10-20)18-6-4-5-16(11-18)12-24/h4-11,15,19,31H,13-14H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100929
PNG
(CHEMBL39601 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazo...)
Show SMILES CCCCCOc1ccc(cc1)-c1ccc(OCC(CN2C(=O)NC(C)(C)C2=O)N(O)C=O)cc1
Show InChI InChI=1S/C26H33N3O6/c1-4-5-6-15-34-22-11-7-19(8-12-22)20-9-13-23(14-10-20)35-17-21(29(33)18-30)16-28-24(31)26(2,3)27-25(28)32/h7-14,18,21,33H,4-6,15-17H2,1-3H3,(H,27,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50100936
PNG
(CHEMBL38299 | N-Hydroxy-N-[2-(3,4,4-trimethyl-2,5-...)
Show SMILES CN1C(=O)N(CC(COc2ccc(cc2)-c2ccc(C=C)cc2)N(O)C=O)C(=O)C1(C)C
Show InChI InChI=1S/C24H27N3O5/c1-5-17-6-8-18(9-7-17)19-10-12-21(13-11-19)32-15-20(27(31)16-28)14-26-22(29)24(2,3)25(4)23(26)30/h5-13,16,20,31H,1,14-15H2,2-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of human Matrix metalloproteinase-1.


Bioorg Med Chem Lett 11: 1557-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00032-4
BindingDB Entry DOI: 10.7270/Q2CZ36DP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%