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PubMed code 11412983

Compile data set for download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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Article
PubMed
n/an/an/an/a 8.00E+3n/an/an/an/a



Universit£ Ren£ Descartes

Curated by ChEMBL


Assay Description
Agonist activity in rat at Metabotropic glutamate receptor 8 expressed in HEK293 cells


Bioorg Med Chem Lett 11: 1569-72 (2001)


Article DOI: 10.1016/s0960-894x(01)00158-5
BindingDB Entry DOI: 10.7270/Q2M61KRJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50100941
PNG
((2S,4R)-2-ammonio-4-carboxy-4-hydroxybutanoate)
Show SMILES [NH3+][C@@H](C[C@@H](O)C(O)=O)C([O-])=O
Show InChI InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1
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Article
PubMed
n/an/an/an/a 3.73E+5n/an/an/an/a



Universit£ Ren£ Descartes

Curated by ChEMBL


Assay Description
Agonist activity in rat at mGlu1a receptor expressed in HEK293 cells


Bioorg Med Chem Lett 11: 1569-72 (2001)


Article DOI: 10.1016/s0960-894x(01)00158-5
BindingDB Entry DOI: 10.7270/Q2M61KRJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50100942
PNG
((2S,4S)-2-ammonio-4-carboxy-4-hydroxybutanoate)
Show SMILES [NH3+][C@@H](C[C@H](O)C(O)=O)C([O-])=O
Show InChI InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3-/m0/s1
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Article
PubMed
n/an/an/an/a 5.30E+4n/an/an/an/a



Universit£ Ren£ Descartes

Curated by ChEMBL


Assay Description
Agonist activity in rat at mGlu8a receptor expressed in HEK293 cells


Bioorg Med Chem Lett 11: 1569-72 (2001)


Article DOI: 10.1016/s0960-894x(01)00158-5
BindingDB Entry DOI: 10.7270/Q2M61KRJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM50100942
PNG
((2S,4S)-2-ammonio-4-carboxy-4-hydroxybutanoate)
Show SMILES [NH3+][C@@H](C[C@H](O)C(O)=O)C([O-])=O
Show InChI InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3-/m0/s1
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PC cid
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Article
PubMed
n/an/an/an/a 1.37E+5n/an/an/an/a



Universit£ Ren£ Descartes

Curated by ChEMBL


Assay Description
Agonist activity in rat at mGlu2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 11: 1569-72 (2001)


Article DOI: 10.1016/s0960-894x(01)00158-5
BindingDB Entry DOI: 10.7270/Q2M61KRJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50100941
PNG
((2S,4R)-2-ammonio-4-carboxy-4-hydroxybutanoate)
Show SMILES [NH3+][C@@H](C[C@@H](O)C(O)=O)C([O-])=O
Show InChI InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1
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PC cid
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Article
PubMed
n/an/an/an/a 6.90E+4n/an/an/an/a



Universit£ Ren£ Descartes

Curated by ChEMBL


Assay Description
Agonist activity in rat at mGlu8a receptor expressed in HEK293 cells


Bioorg Med Chem Lett 11: 1569-72 (2001)


Article DOI: 10.1016/s0960-894x(01)00158-5
BindingDB Entry DOI: 10.7270/Q2M61KRJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50100942
PNG
((2S,4S)-2-ammonio-4-carboxy-4-hydroxybutanoate)
Show SMILES [NH3+][C@@H](C[C@H](O)C(O)=O)C([O-])=O
Show InChI InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3-/m0/s1
UniProtKB/SwissProt

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PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a 1.10E+4n/an/an/an/a



Universit£ Ren£ Descartes

Curated by ChEMBL


Assay Description
Agonist activity in rat at mGlu1a receptor expressed in HEK293 cells


Bioorg Med Chem Lett 11: 1569-72 (2001)


Article DOI: 10.1016/s0960-894x(01)00158-5
BindingDB Entry DOI: 10.7270/Q2M61KRJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
UniProtKB/SwissProt

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KEGG
MMDB
PC cid
PC sid
PDB
UniChem

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Article
PubMed
n/an/an/an/a 3.00E+3n/an/an/an/a



Universit£ Ren£ Descartes

Curated by ChEMBL


Assay Description
Agonist activity in rat at Metabotropic glutamate receptor 1 expressed in HEK293 cells


Bioorg Med Chem Lett 11: 1569-72 (2001)


Article DOI: 10.1016/s0960-894x(01)00158-5
BindingDB Entry DOI: 10.7270/Q2M61KRJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
UniProtKB/SwissProt

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KEGG
MMDB
PC cid
PC sid
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UniChem

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Article
PubMed
n/an/an/an/a 1.60E+4n/an/an/an/a



Universit£ Ren£ Descartes

Curated by ChEMBL


Assay Description
Agonist activity in rat at Metabotropic glutamate receptor 2 expressed in HEK293 cells


Bioorg Med Chem Lett 11: 1569-72 (2001)


Article DOI: 10.1016/s0960-894x(01)00158-5
BindingDB Entry DOI: 10.7270/Q2M61KRJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM50100941
PNG
((2S,4R)-2-ammonio-4-carboxy-4-hydroxybutanoate)
Show SMILES [NH3+][C@@H](C[C@@H](O)C(O)=O)C([O-])=O
Show InChI InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1
UniProtKB/SwissProt

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PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a 1.61E+5n/an/an/an/a



Universit£ Ren£ Descartes

Curated by ChEMBL


Assay Description
Agonist activity in rat at mGlu2 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 11: 1569-72 (2001)


Article DOI: 10.1016/s0960-894x(01)00158-5
BindingDB Entry DOI: 10.7270/Q2M61KRJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%