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PubMed code 12361403

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50119634
PNG
(2-(5,6-Dichloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]...)
Show SMILES Clc1cc(cnc1Cl)[C@H]1CC2CCC1N2
Show InChI InChI=1S/C11H12Cl2N2/c12-9-3-6(5-14-11(9)13)8-4-7-1-2-10(8)15-7/h3,5,7-8,10,15H,1-2,4H2/t7?,8-,10?/m1/s1
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PubMed
1.12n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- iodo-MLA binding at the Nicotinic acetylcholine receptor alpha-7 (nAChR) in male rat cerebral cortex


J Med Chem 45: 4755-61 (2002)


Article DOI: 10.1021/jm0202268
BindingDB Entry DOI: 10.7270/Q2S18362
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50119640
PNG
(2-(6-Chloro-5-fluoro-pyridin-3-yl)-7-aza-bicyclo[2...)
Show SMILES Fc1cc(cnc1Cl)[C@H]1CC2CCC1N2
Show InChI InChI=1S/C11H12ClFN2/c12-11-9(13)3-6(5-14-11)8-4-7-1-2-10(8)15-7/h3,5,7-8,10,15H,1-2,4H2/t7?,8-,10?/m1/s1
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PubMed
3.43n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- iodo-MLA binding at the Nicotinic acetylcholine receptor alpha-7 (nAChR) in male rat cerebral cortex


J Med Chem 45: 4755-61 (2002)


Article DOI: 10.1021/jm0202268
BindingDB Entry DOI: 10.7270/Q2S18362
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50119642
PNG
(5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-2-chloro-pyridin...)
Show SMILES Nc1cc(cnc1Cl)[C@H]1CC2CCC1N2
Show InChI InChI=1S/C11H14ClN3/c12-11-9(13)3-6(5-14-11)8-4-7-1-2-10(8)15-7/h3,5,7-8,10,15H,1-2,4,13H2/t7?,8-,10?/m1/s1
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13.9n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- iodo-MLA binding at the Nicotinic acetylcholine receptor alpha-7 (nAChR) in male rat cerebral cortex


J Med Chem 45: 4755-61 (2002)


Article DOI: 10.1021/jm0202268
BindingDB Entry DOI: 10.7270/Q2S18362
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50119633
PNG
(5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-3-iodo-pyridin-2...)
Show SMILES Nc1ncc(cc1I)[C@H]1CC2CCC1N2
Show InChI InChI=1S/C11H14IN3/c12-9-3-6(5-14-11(9)13)8-4-7-1-2-10(8)15-7/h3,5,7-8,10,15H,1-2,4H2,(H2,13,14)/t7?,8-,10?/m1/s1
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34.1n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- iodo-MLA binding at the Nicotinic acetylcholine receptor alpha-7 (nAChR) in male rat cerebral cortex


J Med Chem 45: 4755-61 (2002)


Article DOI: 10.1021/jm0202268
BindingDB Entry DOI: 10.7270/Q2S18362
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50049757
PNG
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Show SMILES Clc1ccc(cn1)C1CC2CCC1N2
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2
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Article
PubMed
198n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- iodo-MLA binding at the Nicotinic acetylcholine receptor alpha-7 (nAChR) in male rat cerebral cortex


J Med Chem 45: 4755-61 (2002)


Article DOI: 10.1021/jm0202268
BindingDB Entry DOI: 10.7270/Q2S18362
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50119631
PNG
(5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-2-ol | C...)
Show SMILES O=c1ccc(c[nH]1)[C@H]1CC2CCC1N2
Show InChI InChI=1S/C11H14N2O/c14-11-4-1-7(6-12-11)9-5-8-2-3-10(9)13-8/h1,4,6,8-10,13H,2-3,5H2,(H,12,14)/t8?,9-,10?/m1/s1
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675n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- iodo-MLA binding at the Nicotinic acetylcholine receptor alpha-7 (nAChR) in male rat cerebral cortex


J Med Chem 45: 4755-61 (2002)


Article DOI: 10.1021/jm0202268
BindingDB Entry DOI: 10.7270/Q2S18362
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%