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PubMed code 12408713

Compile data set for download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine A1 receptor


(BOVINE)
BDBM50120763
PNG
(CHEMBL358076 | Cyclopentanecarboxylic acid (7-ethy...)
Show SMILES CCc1cn2c(NC(=O)C3CCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H21N5O/c1-2-15-12-24-18(20-15)21-16(13-8-4-3-5-9-13)22-19(24)23-17(25)14-10-6-7-11-14/h3-5,8-9,12,14H,2,6-7,10-11H2,1H3,(H,20,21,22,23,25)
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3.30n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120761
PNG
(CHEMBL355898 | Cyclopentanecarboxylic acid (7-meth...)
Show SMILES Cc1cn2c(NC(=O)C3CCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C18H19N5O/c1-12-11-23-17(19-12)20-15(13-7-3-2-4-8-13)21-18(23)22-16(24)14-9-5-6-10-14/h2-4,7-8,11,14H,5-6,9-10H2,1H3,(H,19,20,21,22,24)
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4.40n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120767
PNG
(CHEMBL148464 | Cyclopentanecarboxylic acid (7-isop...)
Show SMILES CC(C)c1cn2c(NC(=O)C3CCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C20H23N5O/c1-13(2)16-12-25-19(21-16)22-17(14-8-4-3-5-9-14)23-20(25)24-18(26)15-10-6-7-11-15/h3-5,8-9,12-13,15H,6-7,10-11H2,1-2H3,(H,21,22,23,24,26)
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5.80n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120759
PNG
(CHEMBL146479 | N-(7-Methyl-2-phenyl-imidazo[1,2-a]...)
Show SMILES Cc1cn2c(NC(=O)c3ccccc3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H15N5O/c1-13-12-24-18(20-13)21-16(14-8-4-2-5-9-14)22-19(24)23-17(25)15-10-6-3-7-11-15/h2-12H,1H3,(H,20,21,22,23,25)
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11.8n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120765
PNG
(1-(7-Methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-...)
Show SMILES CC(=O)CNc1nc(nc2nc(C)cn12)-c1ccccc1
Show InChI InChI=1S/C15H15N5O/c1-10-9-20-14(16-8-11(2)21)18-13(19-15(20)17-10)12-6-4-3-5-7-12/h3-7,9H,8H2,1-2H3,(H,16,17,18,19)
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12n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120764
PNG
(CHEMBL149732 | Cyclopentanecarboxylic acid (2,7-di...)
Show SMILES O=C(Nc1nc(nc2nc(cn12)-c1ccccc1)-c1ccccc1)C1CCCC1
Show InChI InChI=1S/C23H21N5O/c29-21(18-13-7-8-14-18)27-23-26-20(17-11-5-2-6-12-17)25-22-24-19(15-28(22)23)16-9-3-1-4-10-16/h1-6,9-12,15,18H,7-8,13-14H2,(H,24,25,26,27,29)
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17n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120767
PNG
(CHEMBL148464 | Cyclopentanecarboxylic acid (7-isop...)
Show SMILES CC(C)c1cn2c(NC(=O)C3CCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C20H23N5O/c1-13(2)16-12-25-19(21-16)22-17(14-8-4-3-5-9-14)23-20(25)24-18(26)15-10-6-7-11-15/h3-5,8-9,12-13,15H,6-7,10-11H2,1-2H3,(H,21,22,23,24,26)
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17.4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120763
PNG
(CHEMBL358076 | Cyclopentanecarboxylic acid (7-ethy...)
Show SMILES CCc1cn2c(NC(=O)C3CCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H21N5O/c1-2-15-12-24-18(20-15)21-16(13-8-4-3-5-9-13)22-19(24)23-17(25)14-10-6-7-11-14/h3-5,8-9,12,14H,2,6-7,10-11H2,1H3,(H,20,21,22,23,25)
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20.2n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120766
PNG
(CHEMBL147582 | N-(2,7-Diphenyl-imidazo[1,2-a][1,3,...)
Show SMILES CC(=O)Nc1nc(nc2nc(cn12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C19H15N5O/c1-13(25)20-18-22-17(15-10-6-3-7-11-15)23-19-21-16(12-24(18)19)14-8-4-2-5-9-14/h2-12H,1H3,(H,20,21,22,23,25)
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23n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120759
PNG
(CHEMBL146479 | N-(7-Methyl-2-phenyl-imidazo[1,2-a]...)
Show SMILES Cc1cn2c(NC(=O)c3ccccc3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H15N5O/c1-13-12-24-18(20-13)21-16(14-8-4-2-5-9-14)22-19(24)23-17(25)15-10-6-3-7-11-15/h2-12H,1H3,(H,20,21,22,23,25)
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27.2n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120766
PNG
(CHEMBL147582 | N-(2,7-Diphenyl-imidazo[1,2-a][1,3,...)
Show SMILES CC(=O)Nc1nc(nc2nc(cn12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C19H15N5O/c1-13(25)20-18-22-17(15-10-6-3-7-11-15)23-19-21-16(12-24(18)19)14-8-4-2-5-9-14/h2-12H,1H3,(H,20,21,22,23,25)
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40n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120758
PNG
(CHEMBL148074 | Cyclopentyl-(7-methyl-2-phenyl-imid...)
Show SMILES Cc1cn2c(NC3CCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C17H19N5/c1-12-11-22-16(18-12)20-15(13-7-3-2-4-8-13)21-17(22)19-14-9-5-6-10-14/h2-4,7-8,11,14H,5-6,9-10H2,1H3,(H,18,19,20,21)
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41n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120760
PNG
(CHEMBL343256 | Cyclohexanecarboxylic acid (7-methy...)
Show SMILES Cc1cn2c(NC(=O)C3CCCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H21N5O/c1-13-12-24-18(20-13)21-16(14-8-4-2-5-9-14)22-19(24)23-17(25)15-10-6-3-7-11-15/h2,4-5,8-9,12,15H,3,6-7,10-11H2,1H3,(H,20,21,22,23,25)
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116n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120760
PNG
(CHEMBL343256 | Cyclohexanecarboxylic acid (7-methy...)
Show SMILES Cc1cn2c(NC(=O)C3CCCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H21N5O/c1-13-12-24-18(20-13)21-16(14-8-4-2-5-9-14)22-19(24)23-17(25)15-10-6-3-7-11-15/h2,4-5,8-9,12,15H,3,6-7,10-11H2,1H3,(H,20,21,22,23,25)
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202n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120753
PNG
(CHEMBL421782 | N-(7-Methyl-2-phenyl-imidazo[1,2-a]...)
Show SMILES CC(=O)Nc1nc(nc2nc(C)cn12)-c1ccccc1
Show InChI InChI=1S/C14H13N5O/c1-9-8-19-13(15-9)17-12(11-6-4-3-5-7-11)18-14(19)16-10(2)20/h3-8H,1-2H3,(H,15,16,17,18,20)
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231n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120754
PNG
(CHEMBL147913 | Cyclohexylmethyl-(7-methyl-2-phenyl...)
Show SMILES Cc1cn2c(NCC3CCCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H23N5/c1-14-13-24-18(20-12-15-8-4-2-5-9-15)22-17(23-19(24)21-14)16-10-6-3-7-11-16/h3,6-7,10-11,13,15H,2,4-5,8-9,12H2,1H3,(H,20,21,22,23)
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231n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120757
PNG
(7-Methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-4-y...)
Show SMILES Cc1cn2c(N)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C12H11N5/c1-8-7-17-11(13)15-10(16-12(17)14-8)9-5-3-2-4-6-9/h2-7H,1H3,(H2,13,14,15,16)
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332n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120761
PNG
(CHEMBL355898 | Cyclopentanecarboxylic acid (7-meth...)
Show SMILES Cc1cn2c(NC(=O)C3CCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C18H19N5O/c1-12-11-23-17(19-12)20-15(13-7-3-2-4-8-13)21-18(23)22-16(24)14-9-5-6-10-14/h2-4,7-8,11,14H,5-6,9-10H2,1H3,(H,19,20,21,22,24)
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410n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120770
PNG
(Adamantan-1-yl-(7-methyl-2-phenyl-imidazo[1,2-a][1...)
Show SMILES Cc1cn2c(NC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C22H25N5/c1-14-13-27-20(23-14)24-19(18-5-3-2-4-6-18)25-21(27)26-22-10-15-7-16(11-22)9-17(8-15)12-22/h2-6,13,15-17H,7-12H2,1H3,(H,23,24,25,26)/t15-,16+,17-,22?
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511n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120770
PNG
(Adamantan-1-yl-(7-methyl-2-phenyl-imidazo[1,2-a][1...)
Show SMILES Cc1cn2c(NC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C22H25N5/c1-14-13-27-20(23-14)24-19(18-5-3-2-4-6-18)25-21(27)26-22-10-15-7-16(11-22)9-17(8-15)12-22/h2-6,13,15-17H,7-12H2,1H3,(H,23,24,25,26)/t15-,16+,17-,22?
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526n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120757
PNG
(7-Methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-4-y...)
Show SMILES Cc1cn2c(N)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C12H11N5/c1-8-7-17-11(13)15-10(16-12(17)14-8)9-5-3-2-4-6-9/h2-7H,1H3,(H2,13,14,15,16)
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682n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120753
PNG
(CHEMBL421782 | N-(7-Methyl-2-phenyl-imidazo[1,2-a]...)
Show SMILES CC(=O)Nc1nc(nc2nc(C)cn12)-c1ccccc1
Show InChI InChI=1S/C14H13N5O/c1-9-8-19-13(15-9)17-12(11-6-4-3-5-7-11)18-14(19)16-10(2)20/h3-8H,1-2H3,(H,15,16,17,18,20)
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855n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120764
PNG
(CHEMBL149732 | Cyclopentanecarboxylic acid (2,7-di...)
Show SMILES O=C(Nc1nc(nc2nc(cn12)-c1ccccc1)-c1ccccc1)C1CCCC1
Show InChI InChI=1S/C23H21N5O/c29-21(18-13-7-8-14-18)27-23-26-20(17-11-5-2-6-12-17)25-22-24-19(15-28(22)23)16-9-3-1-4-10-16/h1-6,9-12,15,18H,7-8,13-14H2,(H,24,25,26,27,29)
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1.24E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120757
PNG
(7-Methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-4-y...)
Show SMILES Cc1cn2c(N)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C12H11N5/c1-8-7-17-11(13)15-10(16-12(17)14-8)9-5-3-2-4-6-9/h2-7H,1H3,(H2,13,14,15,16)
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2.00E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120754
PNG
(CHEMBL147913 | Cyclohexylmethyl-(7-methyl-2-phenyl...)
Show SMILES Cc1cn2c(NCC3CCCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H23N5/c1-14-13-24-18(20-12-15-8-4-2-5-9-15)22-17(23-19(24)21-14)16-10-6-3-7-11-16/h3,6-7,10-11,13,15H,2,4-5,8-9,12H2,1H3,(H,20,21,22,23)
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2.10E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120758
PNG
(CHEMBL148074 | Cyclopentyl-(7-methyl-2-phenyl-imid...)
Show SMILES Cc1cn2c(NC3CCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C17H19N5/c1-12-11-22-16(18-12)20-15(13-7-3-2-4-8-13)21-17(22)19-14-9-5-6-10-14/h2-4,7-8,11,14H,5-6,9-10H2,1H3,(H,18,19,20,21)
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2.25E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120768
PNG
(1-(7-Isopropyl-2-phenyl-imidazo[1,2-a][1,3,5]triaz...)
Show SMILES CC(C)c1cn2c(NCC(C)=O)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C17H19N5O/c1-11(2)14-10-22-16(18-9-12(3)23)20-15(21-17(22)19-14)13-7-5-4-6-8-13/h4-8,10-11H,9H2,1-3H3,(H,18,19,20,21)
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2.36E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120764
PNG
(CHEMBL149732 | Cyclopentanecarboxylic acid (2,7-di...)
Show SMILES O=C(Nc1nc(nc2nc(cn12)-c1ccccc1)-c1ccccc1)C1CCCC1
Show InChI InChI=1S/C23H21N5O/c29-21(18-13-7-8-14-18)27-23-26-20(17-11-5-2-6-12-17)25-22-24-19(15-28(22)23)16-9-3-1-4-10-16/h1-6,9-12,15,18H,7-8,13-14H2,(H,24,25,26,27,29)
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2.50E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120763
PNG
(CHEMBL358076 | Cyclopentanecarboxylic acid (7-ethy...)
Show SMILES CCc1cn2c(NC(=O)C3CCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H21N5O/c1-2-15-12-24-18(20-15)21-16(13-8-4-3-5-9-13)22-19(24)23-17(25)14-10-6-7-11-14/h3-5,8-9,12,14H,2,6-7,10-11H2,1H3,(H,20,21,22,23,25)
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2.60E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120768
PNG
(1-(7-Isopropyl-2-phenyl-imidazo[1,2-a][1,3,5]triaz...)
Show SMILES CC(C)c1cn2c(NCC(C)=O)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C17H19N5O/c1-11(2)14-10-22-16(18-9-12(3)23)20-15(21-17(22)19-14)13-7-5-4-6-8-13/h4-8,10-11H,9H2,1-3H3,(H,18,19,20,21)
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3.05E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120766
PNG
(CHEMBL147582 | N-(2,7-Diphenyl-imidazo[1,2-a][1,3,...)
Show SMILES CC(=O)Nc1nc(nc2nc(cn12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C19H15N5O/c1-13(25)20-18-22-17(15-10-6-3-7-11-15)23-19-21-16(12-24(18)19)14-8-4-2-5-9-14/h2-12H,1H3,(H,20,21,22,23,25)
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3.20E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120769
PNG
(Benzyl-(7-methyl-2-phenyl-imidazo[1,2-a][1,3,5]tri...)
Show SMILES Cc1cn2c(NCc3ccccc3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H17N5/c1-14-13-24-18(20-12-15-8-4-2-5-9-15)22-17(23-19(24)21-14)16-10-6-3-7-11-16/h2-11,13H,12H2,1H3,(H,20,21,22,23)
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3.90E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120758
PNG
(CHEMBL148074 | Cyclopentyl-(7-methyl-2-phenyl-imid...)
Show SMILES Cc1cn2c(NC3CCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C17H19N5/c1-12-11-22-16(18-12)20-15(13-7-3-2-4-8-13)21-17(22)19-14-9-5-6-10-14/h2-4,7-8,11,14H,5-6,9-10H2,1H3,(H,18,19,20,21)
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4.10E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120761
PNG
(CHEMBL355898 | Cyclopentanecarboxylic acid (7-meth...)
Show SMILES Cc1cn2c(NC(=O)C3CCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C18H19N5O/c1-12-11-23-17(19-12)20-15(13-7-3-2-4-8-13)21-18(23)22-16(24)14-9-5-6-10-14/h2-4,7-8,11,14H,5-6,9-10H2,1H3,(H,19,20,21,22,24)
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4.30E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120762
PNG
(1-(2,7-Diphenyl-imidazo[1,2-a][1,3,5]triazin-4-yla...)
Show SMILES CC(=O)CNc1nc(nc2nc(cn12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C20H17N5O/c1-14(26)12-21-19-23-18(16-10-6-3-7-11-16)24-20-22-17(13-25(19)20)15-8-4-2-5-9-15/h2-11,13H,12H2,1H3,(H,21,22,23,24)
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5.80E+3n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120769
PNG
(Benzyl-(7-methyl-2-phenyl-imidazo[1,2-a][1,3,5]tri...)
Show SMILES Cc1cn2c(NCc3ccccc3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H17N5/c1-14-13-24-18(20-12-15-8-4-2-5-9-15)22-17(23-19(24)21-14)16-10-6-3-7-11-16/h2-11,13H,12H2,1H3,(H,20,21,22,23)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120767
PNG
(CHEMBL148464 | Cyclopentanecarboxylic acid (7-isop...)
Show SMILES CC(C)c1cn2c(NC(=O)C3CCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C20H23N5O/c1-13(2)16-12-25-19(21-16)22-17(14-8-4-3-5-9-14)23-20(25)24-18(26)15-10-6-7-11-15/h3-5,8-9,12-13,15H,6-7,10-11H2,1-2H3,(H,21,22,23,24,26)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120765
PNG
(1-(7-Methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-...)
Show SMILES CC(=O)CNc1nc(nc2nc(C)cn12)-c1ccccc1
Show InChI InChI=1S/C15H15N5O/c1-10-9-20-14(16-8-11(2)21)18-13(19-15(20)17-10)12-6-4-3-5-7-12/h3-7,9H,8H2,1-2H3,(H,16,17,18,19)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120768
PNG
(1-(7-Isopropyl-2-phenyl-imidazo[1,2-a][1,3,5]triaz...)
Show SMILES CC(C)c1cn2c(NCC(C)=O)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C17H19N5O/c1-11(2)14-10-22-16(18-9-12(3)23)20-15(21-17(22)19-14)13-7-5-4-6-8-13/h4-8,10-11H,9H2,1-3H3,(H,18,19,20,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120755
PNG
(1-(7-Ethyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-4...)
Show SMILES CCc1cn2c(NCC(C)=O)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C16H17N5O/c1-3-13-10-21-15(17-9-11(2)22)19-14(20-16(21)18-13)12-7-5-4-6-8-12/h4-8,10H,3,9H2,1-2H3,(H,17,18,19,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120769
PNG
(Benzyl-(7-methyl-2-phenyl-imidazo[1,2-a][1,3,5]tri...)
Show SMILES Cc1cn2c(NCc3ccccc3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H17N5/c1-14-13-24-18(20-12-15-8-4-2-5-9-15)22-17(23-19(24)21-14)16-10-6-3-7-11-16/h2-11,13H,12H2,1H3,(H,20,21,22,23)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120755
PNG
(1-(7-Ethyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-4...)
Show SMILES CCc1cn2c(NCC(C)=O)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C16H17N5O/c1-3-13-10-21-15(17-9-11(2)22)19-14(20-16(21)18-13)12-7-5-4-6-8-12/h4-8,10H,3,9H2,1-2H3,(H,17,18,19,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120756
PNG
(1-(7-Methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-...)
Show SMILES CCC(=O)CNc1nc(nc2nc(C)cn12)-c1ccccc1
Show InChI InChI=1S/C16H17N5O/c1-3-13(22)9-17-15-19-14(12-7-5-4-6-8-12)20-16-18-11(2)10-21(15)16/h4-8,10H,3,9H2,1-2H3,(H,17,18,19,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120756
PNG
(1-(7-Methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-...)
Show SMILES CCC(=O)CNc1nc(nc2nc(C)cn12)-c1ccccc1
Show InChI InChI=1S/C16H17N5O/c1-3-13(22)9-17-15-19-14(12-7-5-4-6-8-12)20-16-18-11(2)10-21(15)16/h4-8,10H,3,9H2,1-2H3,(H,17,18,19,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120759
PNG
(CHEMBL146479 | N-(7-Methyl-2-phenyl-imidazo[1,2-a]...)
Show SMILES Cc1cn2c(NC(=O)c3ccccc3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H15N5O/c1-13-12-24-18(20-13)21-16(14-8-4-2-5-9-14)22-19(24)23-17(25)15-10-6-3-7-11-15/h2-12H,1H3,(H,20,21,22,23,25)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120760
PNG
(CHEMBL343256 | Cyclohexanecarboxylic acid (7-methy...)
Show SMILES Cc1cn2c(NC(=O)C3CCCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H21N5O/c1-13-12-24-18(20-13)21-16(14-8-4-2-5-9-14)22-19(24)23-17(25)15-10-6-3-7-11-15/h2,4-5,8-9,12,15H,3,6-7,10-11H2,1H3,(H,20,21,22,23,25)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120762
PNG
(1-(2,7-Diphenyl-imidazo[1,2-a][1,3,5]triazin-4-yla...)
Show SMILES CC(=O)CNc1nc(nc2nc(cn12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C20H17N5O/c1-14(26)12-21-19-23-18(16-10-6-3-7-11-16)24-20-22-17(13-25(19)20)15-8-4-2-5-9-15/h2-11,13H,12H2,1H3,(H,21,22,23,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120755
PNG
(1-(7-Ethyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-4...)
Show SMILES CCc1cn2c(NCC(C)=O)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C16H17N5O/c1-3-13-10-21-15(17-9-11(2)22)19-14(20-16(21)18-13)12-7-5-4-6-8-12/h4-8,10H,3,9H2,1-2H3,(H,17,18,19,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120753
PNG
(CHEMBL421782 | N-(7-Methyl-2-phenyl-imidazo[1,2-a]...)
Show SMILES CC(=O)Nc1nc(nc2nc(C)cn12)-c1ccccc1
Show InChI InChI=1S/C14H13N5O/c1-9-8-19-13(15-9)17-12(11-6-4-3-5-7-11)18-14(19)16-10(2)20/h3-8H,1-2H3,(H,15,16,17,18,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50120765
PNG
(1-(7-Methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-...)
Show SMILES CC(=O)CNc1nc(nc2nc(C)cn12)-c1ccccc1
Show InChI InChI=1S/C15H15N5O/c1-10-9-20-14(16-8-11(2)21)18-13(19-15(20)17-10)12-6-4-3-5-7-12/h3-7,9H,8H2,1-2H3,(H,16,17,18,19)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120754
PNG
(CHEMBL147913 | Cyclohexylmethyl-(7-methyl-2-phenyl...)
Show SMILES Cc1cn2c(NCC3CCCCC3)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C19H23N5/c1-14-13-24-18(20-12-15-8-4-2-5-9-15)22-17(23-19(24)21-14)16-10-6-3-7-11-16/h3,6-7,10-11,13,15H,2,4-5,8-9,12H2,1H3,(H,20,21,22,23)
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Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120770
PNG
(Adamantan-1-yl-(7-methyl-2-phenyl-imidazo[1,2-a][1...)
Show SMILES Cc1cn2c(NC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)nc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C22H25N5/c1-14-13-27-20(23-14)24-19(18-5-3-2-4-6-18)25-21(27)26-22-10-15-7-16(11-22)9-17(8-15)12-22/h2-6,13,15-17H,7-12H2,1H3,(H,23,24,25,26)/t15-,16+,17-,22?
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Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50120762
PNG
(1-(2,7-Diphenyl-imidazo[1,2-a][1,3,5]triazin-4-yla...)
Show SMILES CC(=O)CNc1nc(nc2nc(cn12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C20H17N5O/c1-14(26)12-21-19-23-18(16-10-6-3-7-11-16)24-20-22-17(13-25(19)20)15-8-4-2-5-9-15/h2-11,13H,12H2,1H3,(H,21,22,23,24)
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Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(BOVINE)
BDBM50120756
PNG
(1-(7-Methyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-...)
Show SMILES CCC(=O)CNc1nc(nc2nc(C)cn12)-c1ccccc1
Show InChI InChI=1S/C16H17N5O/c1-3-13(22)9-17-15-19-14(12-7-5-4-6-8-12)20-16-18-11(2)10-21(15)16/h4-8,10H,3,9H2,1-2H3,(H,17,18,19,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes.


J Med Chem 45: 5030-6 (2002)


Article DOI: 10.1021/jm020911e
BindingDB Entry DOI: 10.7270/Q2JH3KHN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%