Compile Data Set for Download or QSAR
maximum 50k data
Found 45 Enz. Inhib. hit(s) with all data for entry = 50012759
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122418(1-Benzo[1,3]dioxol-5-yl-4-[4-(2-fluoro-5-methoxy-b...)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122426(1-Benzo[1,3]dioxol-5-yl-4-[4-(2-bromo-benzyl)-pipe...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122429(1-Benzo[1,3]dioxol-5-yl-4-[4-(2-iodo-benzyl)-piper...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122428(1-Benzo[1,3]dioxol-5-yl-4-[4-(2-chloro-benzyl)-pip...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122437(1-Benzo[1,3]dioxol-5-yl-4-[4-(2,5-difluoro-benzyl)...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122433(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-bromo-benzyl)-pipe...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122431(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-chloro-benzyl)-pip...)
Affinity DataIC50:  6nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122423(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-ethoxy-benzyl)-pip...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122410(1-Benzo[1,3]dioxol-5-yl-4-[4-(2-fluoro-benzyl)-pip...)
Affinity DataIC50:  10nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122435(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-fluoro-benzyl)-pip...)
Affinity DataIC50:  13nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122436(1-Benzo[1,3]dioxol-5-yl-4-[4-(2,3-difluoro-benzyl)...)
Affinity DataIC50:  17nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122427(1-Benzo[1,3]dioxol-5-yl-4-[4-(2-fluoro-3-methoxy-b...)
Affinity DataIC50:  19nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122432(1-Benzo[1,3]dioxol-5-yl-4-[4-(3,5-difluoro-benzyl)...)
Affinity DataIC50:  21nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122421(1-Benzo[1,3]dioxol-5-yl-4-[4-(4-fluoro-benzyl)-pip...)
Affinity DataIC50:  27nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122419(1-Benzo[1,3]dioxol-5-yl-4-[4-(3,4-difluoro-benzyl)...)
Affinity DataIC50:  34nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122434(1-Benzo[1,3]dioxol-5-yl-4-[4-(2-methoxy-benzyl)-pi...)
Affinity DataIC50:  43nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122430(4-(4-Benzyl-piperazin-1-yl)-1-(4-methoxy-phenyl)-c...)
Affinity DataIC50:  50nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122425(4-(4-Benzyl-piperazin-1-yl)-1-(3-methoxy-phenyl)-c...)
Affinity DataIC50:  50nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122417(1-Benzo[1,3]dioxol-5-yl-4-[4-(2,4-difluoro-benzyl)...)
Affinity DataIC50:  57nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122412(4-(4-Benzyl-piperazin-1-yl)-1-(2-methoxy-phenyl)-c...)
Affinity DataIC50:  60nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122424(1-Benzo[1,3]dioxol-5-yl-4-[4-(4-chloro-benzyl)-pip...)
Affinity DataIC50:  79nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122414(1-Benzo[1,3]dioxol-5-yl-4-[4-(2,6-difluoro-benzyl)...)
Affinity DataIC50:  110nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122422(4-(4-Benzyl-piperazin-1-yl)-1-(3,4-dimethoxy-pheny...)
Affinity DataIC50:  140nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122416(4-(4-Benzyl-piperazin-1-yl)-1-(4-fluoro-phenyl)-cy...)
Affinity DataIC50:  260nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122420(1-Benzo[1,3]dioxol-5-yl-4-[4-(4-methoxy-benzyl)-pi...)
Affinity DataIC50:  380nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50:  410nMAssay Description:Inhibitory concentration required against Alpha-2 adrenergic receptor in rat cortex [3H]clonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122413(4-(4-Benzyl-piperazin-1-yl)-1-phenyl-cyclohexanol ...)
Affinity DataIC50:  460nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  700nMAssay Description:Inhibitory concentration of the compound required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50:  700nMAssay Description:Inhibitory concentration required against alpha-1 adrenergic receptor in rat cortex using [3H]-WB- 4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration of the compound required against 5-hydroxytryptamine 1C receptor in bovine choroid plexus using [3H]-mesulergineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration of the compound required against 5-HT uptake in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration of the compound required against 5-hydroxytryptamine 1B receptor in rat striatum using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory concentration required against Alpha-2 adrenergic receptor in rat cortex [3H]clonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory concentration required against alpha-1 adrenergic receptor in rat cortex using [3H]-WB- 4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory concentration of the compound required against Dopamine receptor D2 in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory concentration of the compound required against 5-HT uptake in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibitory concentration of the compound required against Dopamine receptor D2 in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory concentration required against 5-hydroxytryptamine 2 receptor in rat cortex using [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122415(1-Benzo[1,3]dioxol-5-yl-4-(4-benzyl-piperazin-1-yl...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibitory concentration of the compound required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibitory concentration required against 5-hydroxytryptamine 2 receptor in rat cortex using [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration of the compound required against 5-HT3 receptor in bovine area postrema using [3H]-GR 65630More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration of the compound required against 5-hydroxytryptamine 1B receptor in rat striatum using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration of the compound required against 5-hydroxytryptamine 1C receptor in bovine choroid plexus using [3H]-mesulergineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed