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PubMed code 12646026

Compile data set for download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PA/PB1


(Hepatitis C virus)
BDBM50409783
PNG
(CHEMBL1626982 | CHEMBL2068710 | CHEMBL2068711 | CH...)
Show SMILES [O-]C(=O)C(=O)[CH-]C(=O)C1(Cc2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H23ClNO4/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18/h1-9,14H,10-13,15-16H2,(H,28,29)/q-1/p-1
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n/an/a 12n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409783
PNG
(CHEMBL1626982 | CHEMBL2068710 | CHEMBL2068711 | CH...)
Show SMILES [O-]C(=O)C(=O)[CH-]C(=O)C1(Cc2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H23ClNO4/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18/h1-9,14H,10-13,15-16H2,(H,28,29)/q-1/p-1
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n/an/a 31n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409783
PNG
(CHEMBL1626982 | CHEMBL2068710 | CHEMBL2068711 | CH...)
Show SMILES [O-]C(=O)C(=O)[CH-]C(=O)C1(Cc2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H23ClNO4/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18/h1-9,14H,10-13,15-16H2,(H,28,29)/q-1/p-1
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n/an/a 100n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125801
PNG
(4-[1-Benzyl-4-(4-chloro-benzyl)-piperidin-4-yl]-2-...)
Show SMILES OC(=O)C(=O)CC(=O)C1(Cc2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H24ClNO4/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18/h1-9H,10-16H2,(H,28,29)
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n/an/a 350n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125801
PNG
(4-[1-Benzyl-4-(4-chloro-benzyl)-piperidin-4-yl]-2-...)
Show SMILES OC(=O)C(=O)CC(=O)C1(Cc2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H24ClNO4/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18/h1-9H,10-16H2,(H,28,29)
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n/an/a 430n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409783
PNG
(CHEMBL1626982 | CHEMBL2068710 | CHEMBL2068711 | CH...)
Show SMILES [O-]C(=O)C(=O)[CH-]C(=O)C1(Cc2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H23ClNO4/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18/h1-9,14H,10-13,15-16H2,(H,28,29)/q-1/p-1
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n/an/a 600n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125833
PNG
(3-(4-Fluoro-benzylidene)-1-hydroxy-5-isobutyl-3H-p...)
Show SMILES CC(C)C=c1[nH]c(=Cc2ccc(F)cc2)c(=O)n(O)c1=O
Show InChI InChI=1S/C15H15FN2O3/c1-9(2)7-12-14(19)18(21)15(20)13(17-12)8-10-3-5-11(16)6-4-10/h3-9,17,21H,1-2H3
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n/an/a 900n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409783
PNG
(CHEMBL1626982 | CHEMBL2068710 | CHEMBL2068711 | CH...)
Show SMILES [O-]C(=O)C(=O)[CH-]C(=O)C1(Cc2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H23ClNO4/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18/h1-9,14H,10-13,15-16H2,(H,28,29)/q-1/p-1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409783
PNG
(CHEMBL1626982 | CHEMBL2068710 | CHEMBL2068711 | CH...)
Show SMILES [O-]C(=O)C(=O)[CH-]C(=O)C1(Cc2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H23ClNO4/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18/h1-9,14H,10-13,15-16H2,(H,28,29)/q-1/p-1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409801
PNG
(CHEMBL16525)
Show SMILES OC(=O)c1cccc(NC(=O)Nc2ccc3c(C(=O)c4ccccc4)c(O)n(O)c3c2)c1
Show InChI InChI=1S/C23H17N3O6/c27-20(13-5-2-1-3-6-13)19-17-10-9-16(12-18(17)26(32)21(19)28)25-23(31)24-15-8-4-7-14(11-15)22(29)30/h1-12,28,32H,(H,29,30)(H2,24,25,31)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125793
PNG
(4-(4-Cyclohexyl-phenyl)-2-hydroxy-4-oxo-but-2-enoi...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C16H18O4/c17-14(10-15(18)16(19)20)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h6-9,11H,1-5,10H2,(H,19,20)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125822
PNG
(1-Hydroxy-5-isobutyl-3-isobutylidene-3H-pyrazine-2...)
Show SMILES CC(C)C=c1[nH]c(=CC(C)C)c(=O)n(O)c1=O
Show InChI InChI=1S/C12H18N2O3/c1-7(2)5-9-11(15)14(17)12(16)10(13-9)6-8(3)4/h5-8,13,17H,1-4H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
Polymerase acidic protein


(Influenza B virus (B/Lee/40))
BDBM50409801
PNG
(CHEMBL16525)
Show SMILES OC(=O)c1cccc(NC(=O)Nc2ccc3c(C(=O)c4ccccc4)c(O)n(O)c3c2)c1
Show InChI InChI=1S/C23H17N3O6/c27-20(13-5-2-1-3-6-13)19-17-10-9-16(12-18(17)26(32)21(19)28)25-23(31)24-15-8-4-7-14(11-15)22(29)30/h1-12,28,32H,(H,29,30)(H2,24,25,31)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza B/Lee/40 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409805
PNG
(CHEMBL278443)
Show SMILES CCC(=O)c1c(O)n(O)c2cc(NC(=O)C=Cc3ccccc3Cl)ccc12
Show InChI InChI=1S/C20H17ClN2O4/c1-2-17(24)19-14-9-8-13(11-16(14)23(27)20(19)26)22-18(25)10-7-12-5-3-4-6-15(12)21/h3-11,26-27H,2H2,1H3,(H,22,25)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409780
PNG
(CHEMBL16239)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NC(=O)c3ccc4ccccc4c3)cc2n1O
Show InChI InChI=1S/C26H18N2O4/c29-24(17-7-2-1-3-8-17)23-21-13-12-20(15-22(21)28(32)26(23)31)27-25(30)19-11-10-16-6-4-5-9-18(16)14-19/h1-15,31-32H,(H,27,30)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409787
PNG
(CHEMBL16377)
Show SMILES CC(=O)c1c(O)n(O)c2cc(NC(=O)c3ccc4ccccc4c3)ccc12
Show InChI InChI=1S/C21H16N2O4/c1-12(24)19-17-9-8-16(11-18(17)23(27)21(19)26)22-20(25)15-7-6-13-4-2-3-5-14(13)10-15/h2-11,26-27H,1H3,(H,22,25)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409802
PNG
(CHEMBL277536)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NC(=O)\C=C\c3ccccc3Cl)cc2n1O
Show InChI InChI=1S/C24H17ClN2O4/c25-19-9-5-4-6-15(19)10-13-21(28)26-17-11-12-18-20(14-17)27(31)24(30)22(18)23(29)16-7-2-1-3-8-16/h1-14,30-31H,(H,26,28)/b13-10+
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n/an/a 9.50E+3n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409804
PNG
(CHEMBL16453)
Show SMILES Cc1cc(no1)C(=O)Nc1ccc2c(C(=O)c3ccccc3)c(O)n(O)c2c1
Show InChI InChI=1S/C20H15N3O5/c1-11-9-15(22-28-11)19(25)21-13-7-8-14-16(10-13)23(27)20(26)17(14)18(24)12-5-3-2-4-6-12/h2-10,26-27H,1H3,(H,21,25)
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n/an/a 9.50E+3n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409792
PNG
(CHEMBL275631)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NC(=O)c3ccccc3)cc2n1O
Show InChI InChI=1S/C22H16N2O4/c25-20(14-7-3-1-4-8-14)19-17-12-11-16(13-18(17)24(28)22(19)27)23-21(26)15-9-5-2-6-10-15/h1-13,27-28H,(H,23,26)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409789
PNG
(CHEMBL16579)
Show SMILES CCC(=O)c1c(O)n(O)c2cc(NC(=O)c3cnc4ccccc4n3)ccc12
Show InChI InChI=1S/C20H16N4O4/c1-2-17(25)18-12-8-7-11(9-16(12)24(28)20(18)27)22-19(26)15-10-21-13-5-3-4-6-14(13)23-15/h3-10,27-28H,2H2,1H3,(H,22,26)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409810
PNG
(CHEMBL16887)
Show SMILES CCC(=O)c1c(O)n(O)c2cc(NC(=O)Nc3cccc(c3)C(O)=O)ccc12
Show InChI InChI=1S/C19H17N3O6/c1-2-15(23)16-13-7-6-12(9-14(13)22(28)17(16)24)21-19(27)20-11-5-3-4-10(8-11)18(25)26/h3-9,24,28H,2H2,1H3,(H,25,26)(H2,20,21,27)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409785
PNG
(CHEMBL280445)
Show SMILES CC(=O)c1c(O)n(O)c2cc(NC(=O)c3cnc4ccccc4n3)ccc12
Show InChI InChI=1S/C19H14N4O4/c1-10(24)17-12-7-6-11(8-16(12)23(27)19(17)26)21-18(25)15-9-20-13-4-2-3-5-14(13)22-15/h2-9,26-27H,1H3,(H,21,25)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409796
PNG
(CHEMBL429766)
Show SMILES CC(=O)c1c(O)n(O)c2cc(NC(=O)Nc3cccc(c3)C(O)=O)ccc12
Show InChI InChI=1S/C18H15N3O6/c1-9(22)15-13-6-5-12(8-14(13)21(27)16(15)23)20-18(26)19-11-4-2-3-10(7-11)17(24)25/h2-8,23,27H,1H3,(H,24,25)(H2,19,20,26)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM33410
PNG
(CHEMBL16755 | N-hydroxyisoquinolinedione, 2)
Show SMILES ON1C(=O)Cc2ccccc2C1=O
Show InChI InChI=1S/C9H7NO3/c11-8-5-6-3-1-2-4-7(6)9(12)10(8)13/h1-4,13H,5H2
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n/an/a 1.50E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409793
PNG
(CHEMBL280446)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NC(=O)c3cnc4ccccc4n3)cc2n1O
Show InChI InChI=1S/C24H16N4O4/c29-22(14-6-2-1-3-7-14)21-16-11-10-15(12-20(16)28(32)24(21)31)26-23(30)19-13-25-17-8-4-5-9-18(17)27-19/h1-13,31-32H,(H,26,30)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409798
PNG
(CHEMBL16233)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NC(=O)C3CCCCC3)cc2n1O
Show InChI InChI=1S/C22H22N2O4/c25-20(14-7-3-1-4-8-14)19-17-12-11-16(13-18(17)24(28)22(19)27)23-21(26)15-9-5-2-6-10-15/h1,3-4,7-8,11-13,15,27-28H,2,5-6,9-10H2,(H,23,26)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
Polymerase acidic protein


(Influenza B virus (B/Lee/40))
BDBM50409787
PNG
(CHEMBL16377)
Show SMILES CC(=O)c1c(O)n(O)c2cc(NC(=O)c3ccc4ccccc4c3)ccc12
Show InChI InChI=1S/C21H16N2O4/c1-12(24)19-17-9-8-16(11-18(17)23(27)21(19)26)22-20(25)15-7-6-13-4-2-3-5-14(13)10-15/h2-11,26-27H,1H3,(H,22,25)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza B/Lee/40 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409800
PNG
(CHEMBL16336)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NC(=O)c3cccs3)cc2n1O
Show InChI InChI=1S/C20H14N2O4S/c23-18(12-5-2-1-3-6-12)17-14-9-8-13(11-15(14)22(26)20(17)25)21-19(24)16-7-4-10-27-16/h1-11,25-26H,(H,21,24)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50115579
PNG
((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid | 2-...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1
Show InChI InChI=1S/C10H8O4/c11-8(6-9(12)10(13)14)7-4-2-1-3-5-7/h1-5H,6H2,(H,13,14)
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n/an/a 2.13E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Polymerase acidic protein


(Influenza B virus (B/Lee/40))
BDBM50409802
PNG
(CHEMBL277536)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NC(=O)\C=C\c3ccccc3Cl)cc2n1O
Show InChI InChI=1S/C24H17ClN2O4/c25-19-9-5-4-6-15(19)10-13-21(28)26-17-11-12-18-20(14-17)27(31)24(30)22(18)23(29)16-7-2-1-3-8-16/h1-14,30-31H,(H,26,28)/b13-10+
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n/an/a 2.60E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza B/Lee/40 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409788
PNG
(CHEMBL276316)
Show SMILES CC(=O)c1c(O)n(O)c2cc(NC(=O)C=Cc3ccccc3Cl)ccc12
Show InChI InChI=1S/C19H15ClN2O4/c1-11(23)18-14-8-7-13(10-16(14)22(26)19(18)25)21-17(24)9-6-12-4-2-3-5-15(12)20/h2-10,25-26H,1H3,(H,21,24)
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n/an/a 2.60E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409779
PNG
(CHEMBL16299)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NC(=O)Nc3ccccc3)cc2n1O
Show InChI InChI=1S/C22H17N3O4/c26-20(14-7-3-1-4-8-14)19-17-12-11-16(13-18(17)25(29)21(19)27)24-22(28)23-15-9-5-2-6-10-15/h1-13,27,29H,(H2,23,24,28)
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n/an/a 2.90E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
Polymerase acidic protein


(Influenza B virus (B/Lee/40))
BDBM50409780
PNG
(CHEMBL16239)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NC(=O)c3ccc4ccccc4c3)cc2n1O
Show InChI InChI=1S/C26H18N2O4/c29-24(17-7-2-1-3-8-17)23-21-13-12-20(15-22(21)28(32)26(23)31)27-25(30)19-11-10-16-6-4-5-9-18(16)14-19/h1-15,31-32H,(H,27,30)
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n/an/a 2.90E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza B/Lee/40 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50024265
PNG
(CHEMBL2040641)
Show SMILES OC(=O)C(\O)=C\C(=O)C1CCCCC1
Show InChI InChI=1S/C10H14O4/c11-8(6-9(12)10(13)14)7-4-2-1-3-5-7/h6-7,12H,1-5H2,(H,13,14)/b9-6-
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n/an/a 2.94E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409803
PNG
(CHEMBL1907704)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(OC)c(CC)cc(OC)c1OC
Show InChI InChI=1S/C19H30N2O4/c1-6-13-11-15(23-3)18(25-5)16(17(13)24-4)19(22)20-12-14-9-8-10-21(14)7-2/h11,14H,6-10,12H2,1-5H3,(H,20,22)/t14-/m0/s1
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n/an/a 3.20E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409782
PNG
(CHEMBL279999)
Show SMILES CCC(=O)c1c(O)n(O)c2cc(NC(=O)c3cccs3)ccc12
Show InChI InChI=1S/C16H14N2O4S/c1-2-12(19)14-10-6-5-9(8-11(10)18(22)16(14)21)17-15(20)13-4-3-7-23-13/h3-8,21-22H,2H2,1H3,(H,17,20)
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n/an/a 3.50E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409797
PNG
(CHEMBL275420)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NC(=O)c3ccc(Cl)cc3Cl)cc2n1O
Show InChI InChI=1S/C22H14Cl2N2O4/c23-13-6-8-15(17(24)10-13)21(28)25-14-7-9-16-18(11-14)26(30)22(29)19(16)20(27)12-4-2-1-3-5-12/h1-11,29-30H,(H,25,28)
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n/an/a 3.80E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409791
PNG
(CHEMBL276589)
Show SMILES CCC(=O)c1c(O)n(O)c2cc(NC(=O)Nc3ccc(Cl)cc3)ccc12
Show InChI InChI=1S/C18H16ClN3O4/c1-2-15(23)16-13-8-7-12(9-14(13)22(26)17(16)24)21-18(25)20-11-5-3-10(19)4-6-11/h3-9,24,26H,2H2,1H3,(H2,20,21,25)
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n/an/a 3.80E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409784
PNG
(CHEMBL16050)
Show SMILES CC(=O)c1c(O)n(O)c2cc(NC(=O)c3cccs3)ccc12
Show InChI InChI=1S/C15H12N2O4S/c1-8(18)13-10-5-4-9(7-11(10)17(21)15(13)20)16-14(19)12-3-2-6-22-12/h2-7,20-21H,1H3,(H,16,19)
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n/an/a 4.00E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409794
PNG
(CHEMBL16313)
Show SMILES CCC(=O)c1c(O)n(O)c2cc(NC(=O)Nc3ccccc3)ccc12
Show InChI InChI=1S/C18H17N3O4/c1-2-15(22)16-13-9-8-12(10-14(13)21(25)17(16)23)20-18(24)19-11-6-4-3-5-7-11/h3-10,23,25H,2H2,1H3,(H2,19,20,24)
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n/an/a 4.00E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409809
PNG
(CHEMBL430143)
Show SMILES CCC(=O)c1c(O)n(O)c2cc(NC(=O)c3ccc(Cl)cc3Cl)ccc12
Show InChI InChI=1S/C18H14Cl2N2O4/c1-2-15(23)16-12-6-4-10(8-14(12)22(26)18(16)25)21-17(24)11-5-3-9(19)7-13(11)20/h3-8,25-26H,2H2,1H3,(H,21,24)
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n/an/a 4.50E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409781
PNG
(CHEMBL16406)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NS(=O)(=O)c3cccs3)cc2n1O
Show InChI InChI=1S/C19H14N2O5S2/c22-18(12-5-2-1-3-6-12)17-14-9-8-13(11-15(14)21(24)19(17)23)20-28(25,26)16-7-4-10-27-16/h1-11,20,23-24H
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n/an/a 4.80E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409807
PNG
(CHEMBL16665)
Show SMILES CCC(=O)c1c(O)n(O)c2cc(NC(=O)Nc3ccccc3Cl)ccc12
Show InChI InChI=1S/C18H16ClN3O4/c1-2-15(23)16-11-8-7-10(9-14(11)22(26)17(16)24)20-18(25)21-13-6-4-3-5-12(13)19/h3-9,24,26H,2H2,1H3,(H2,20,21,25)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50409795
PNG
(CHEMBL277284)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NC(=O)NC3CCCCC3)cc2n1O
Show InChI InChI=1S/C22H23N3O4/c26-20(14-7-3-1-4-8-14)19-17-12-11-16(13-18(17)25(29)21(19)27)24-22(28)23-15-9-5-2-6-10-15/h1,3-4,7-8,11-13,15,27,29H,2,5-6,9-10H2,(H2,23,24,28)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
Polymerase acidic protein


(Influenza B virus (B/Lee/40))
BDBM50409792
PNG
(CHEMBL275631)
Show SMILES Oc1c(C(=O)c2ccccc2)c2ccc(NC(=O)c3ccccc3)cc2n1O
Show InChI InChI=1S/C22H16N2O4/c25-20(14-7-3-1-4-8-14)19-17-12-11-16(13-18(17)24(28)22(19)27)23-21(26)15-9-5-2-6-10-15/h1-13,27-28H,(H,23,26)
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n/an/a 5.60E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza B/Lee/40 RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125803
PNG
(3-Hydroxy-1H-pteridine-2,4-dione | 3-hydroxypterid...)
Show SMILES On1c(=O)[nH]c2nccnc2c1=O
Show InChI InChI=1S/C6H4N4O3/c11-5-3-4(8-2-1-7-3)9-6(12)10(5)13/h1-2,13H,(H,8,9,12)
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n/an/a 9.50E+4n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM23987
PNG
(2-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-one | CH...)
Show SMILES ON1Cc2ccccc2CC1=O
Show InChI InChI=1S/C9H9NO2/c11-9-5-7-3-1-2-4-8(7)6-10(9)12/h1-4,12H,5-6H2
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n/an/a 1.00E+5n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125805
PNG
((3Z)-5-isobutyl-1-(methoxymethoxy)-3-(2-methylprop...)
Show SMILES COCOn1c(=O)c(=CC(C)C)[nH]c(=CC(C)C)c1=O
Show InChI InChI=1S/C14H22N2O4/c1-9(2)6-11-13(17)16(20-8-19-5)14(18)12(15-11)7-10(3)4/h6-7,9-10,15H,8H2,1-5H3
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n/an/a>3.55E+5n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125809
PNG
(3-(4-Fluoro-benzylidene)-5-isobutyl-3H-pyrazine-2,...)
Show SMILES CC(C)C=c1[nH]c(=Cc2ccc(F)cc2)c(=O)[nH]c1=O
Show InChI InChI=1S/C15H15FN2O2/c1-9(2)7-12-14(19)18-15(20)13(17-12)8-10-3-5-11(16)6-4-10/h3-9,17H,1-2H3,(H,18,19,20)
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n/an/a>3.65E+5n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125821
PNG
(4-Oxo-4-phenyl-but-2-enoic acid | 4-oxo-4-phenylbu...)
Show SMILES OC(=O)\C=C\C(=O)c1ccccc1
Show InChI InChI=1S/C10H8O3/c11-9(6-7-10(12)13)8-4-2-1-3-5-8/h1-7H,(H,12,13)/b7-6+
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n/an/a>5.00E+5n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50024266
PNG
(CHEMBL461059)
Show SMILES NC(=O)C(\O)=C\C(=O)C1CCCCC1
Show InChI InChI=1S/C10H15NO3/c11-10(14)9(13)6-8(12)7-4-2-1-3-5-7/h6-7,13H,1-5H2,(H2,11,14)/b9-6-
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n/an/a>5.00E+5n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125799
PNG
(3-Hydroxy-3H-pteridin-4-one | 3-hydroxypteridin-4(...)
Show SMILES On1cnc2nccnc2c1=O
Show InChI InChI=1S/C6H4N4O2/c11-6-4-5(8-2-1-7-4)9-3-10(6)12/h1-3,12H
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n/an/a>5.00E+5n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125832
PNG
((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid meth...)
Show SMILES COC(=O)C(=O)CC(=O)c1ccccc1
Show InChI InChI=1S/C11H10O4/c1-15-11(14)10(13)7-9(12)8-5-3-2-4-6-8/h2-6H,7H2,1H3
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n/an/a>5.00E+5n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50015184
PNG
(BENZHYDROXAMIC ACID | BENZOHYDROXAMATE | CHEMBL163...)
Show SMILES ONC(=O)c1ccccc1
Show InChI InChI=1S/C7H7NO2/c9-7(8-10)6-4-2-1-3-5-6/h1-5,10H,(H,8,9)
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n/an/a>5.00E+5n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125808
PNG
(2-Hydroxy-isoindole-1,3-dione | 2-hydroxyisoindoli...)
Show SMILES ON1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)8(11)9(7)12/h1-4,12H
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n/an/a>5.00E+5n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125828
PNG
(2-Oxo-4-phenyl-butyric acid | 2-oxo-4-phenylbutano...)
Show SMILES OC(=O)C(=O)CCc1ccccc1
Show InChI InChI=1S/C10H10O3/c11-9(10(12)13)7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,12,13)
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n/an/a>5.00E+5n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125811
PNG
(2-Methoxy-4H-isoquinoline-1,3-dione | CHEMBL275148)
Show SMILES CON1C(=O)Cc2ccccc2C1=O
Show InChI InChI=1S/C10H9NO3/c1-14-11-9(12)6-7-4-2-3-5-8(7)10(11)13/h2-5H,6H2,1H3
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n/an/a 7.10E+5n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125802
PNG
(2-Amino-4H-isoquinoline-1,3-dione | 2-aminoisoquin...)
Show SMILES NN1C(=O)Cc2ccccc2C1=O
Show InChI InChI=1S/C9H8N2O2/c10-11-8(12)5-6-3-1-2-4-7(6)9(11)13/h1-4H,5,10H2
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n/an/a 8.00E+5n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125823
PNG
(2-Hydroxy-4,5-dihydro-benzo[c]azepine-1,3-dione | ...)
Show SMILES ON1C(=O)CCc2ccccc2C1=O
Show InChI InChI=1S/C10H9NO3/c12-9-6-5-7-3-1-2-4-8(7)10(13)11(9)14/h1-4,14H,5-6H2
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n/an/a>1.00E+6n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50125806
PNG
(3-Hydroxy-1,5-dihydro-benzo[d]azepine-2,4-dione | ...)
Show SMILES ON1C(=O)Cc2ccccc2CC1=O
Show InChI InChI=1S/C10H9NO3/c12-9-5-7-3-1-2-4-8(7)6-10(13)11(9)14/h1-4,14H,5-6H2
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n/an/a>1.00E+6n/an/an/an/an/an/a



Roche Discovery Welwyn

Curated by ChEMBL


Assay Description
Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP


J Med Chem 46: 1153-64 (2003)


Article DOI: 10.1021/jm020334u
BindingDB Entry DOI: 10.7270/Q22J6B6V
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%