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PubMed code 12672227

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126676
PNG
(2-[4-(4'-Chloro-4-methoxy-biphenyl-2-ylmethoxy)-ph...)
Show SMILES COc1ccc(c(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C34H31ClN2O4/c1-40-29-16-17-30(22-7-12-26(35)13-8-22)25(19-29)21-41-28-14-9-23(10-15-28)33-36-31-20-24(34(38)39)11-18-32(31)37(33)27-5-3-2-4-6-27/h7-20,27H,2-6,21H2,1H3,(H,38,39)
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n/an/a 620n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126679
PNG
((S)-2-(2,4-dichloro-N-(3-nitrobenzyl)benzamido)-3-...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1cccc(c1)[N+]([O-])=O)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H18Cl2N2O5/c24-17-9-10-19(20(25)13-17)22(28)26(14-16-7-4-8-18(11-16)27(31)32)21(23(29)30)12-15-5-2-1-3-6-15/h1-11,13,21H,12,14H2,(H,29,30)/t21-/m0/s1
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Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126666
PNG
(2-[(3-Cyano-benzyl)-(2,4-dichloro-benzoyl)-amino]-...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1cccc(c1)C#N)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H18Cl2N2O3/c25-19-9-10-20(21(26)13-19)23(29)28(15-18-8-4-7-17(11-18)14-27)22(24(30)31)12-16-5-2-1-3-6-16/h1-11,13,22H,12,15H2,(H,30,31)
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Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126663
PNG
((S)-2-(2,4-dichloro-N-(3-chlorobenzyl)benzamido)-3...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1cccc(Cl)c1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H18Cl3NO3/c24-17-8-4-7-16(11-17)14-27(22(28)19-10-9-18(25)13-20(19)26)21(23(29)30)12-15-5-2-1-3-6-15/h1-11,13,21H,12,14H2,(H,29,30)/t21-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126661
PNG
((2S)-2-[(2,4-DICHLORO-BENZOYL)-(3-TRIFLUOROMETHYL-...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1cccc(c1)C(F)(F)F)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H18Cl2F3NO3/c25-18-9-10-19(20(26)13-18)22(31)30(14-16-7-4-8-17(11-16)24(27,28)29)21(23(32)33)12-15-5-2-1-3-6-15/h1-11,13,21H,12,14H2,(H,32,33)/t21-/m0/s1
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Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126668
PNG
((S)-2-(2,4-dichloro-N-(3-methylbenzyl)benzamido)-3...)
Show SMILES Cc1cccc(CN([C@@H](Cc2ccccc2)C(O)=O)C(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C24H21Cl2NO3/c1-16-6-5-9-18(12-16)15-27(23(28)20-11-10-19(25)14-21(20)26)22(24(29)30)13-17-7-3-2-4-8-17/h2-12,14,22H,13,15H2,1H3,(H,29,30)/t22-/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126675
PNG
(2-[(2,4-Dichloro-benzoyl)-(1-oxy-pyridin-3-ylmethy...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1ccc[n+]([O-])c1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H18Cl2N2O4/c23-17-8-9-18(19(24)12-17)21(27)26(14-16-7-4-10-25(30)13-16)20(22(28)29)11-15-5-2-1-3-6-15/h1-10,12-13,20H,11,14H2,(H,28,29)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126671
PNG
(2-[(5-Bromo-thiophen-2-ylmethyl)-(2,4-dichloro-ben...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1ccc(Br)s1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H16BrCl2NO3S/c22-19-9-7-15(29-19)12-25(20(26)16-8-6-14(23)11-17(16)24)18(21(27)28)10-13-4-2-1-3-5-13/h1-9,11,18H,10,12H2,(H,27,28)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126673
PNG
((S)-2-(2,4-dichloro-N-(3-fluorobenzyl)benzamido)-3...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1cccc(F)c1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H18Cl2FNO3/c24-17-9-10-19(20(25)13-17)22(28)27(14-16-7-4-8-18(26)11-16)21(23(29)30)12-15-5-2-1-3-6-15/h1-11,13,21H,12,14H2,(H,29,30)/t21-/m0/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126667
PNG
((S)-2-(N-(3-bromobenzyl)-2,4-dichlorobenzamido)-3-...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1cccc(Br)c1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H18BrCl2NO3/c24-17-8-4-7-16(11-17)14-27(22(28)19-10-9-18(25)13-20(19)26)21(23(29)30)12-15-5-2-1-3-6-15/h1-11,13,21H,12,14H2,(H,29,30)/t21-/m0/s1
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n/an/a 3.50E+3n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126677
PNG
((S)-2-(2,4-dichloro-N-(4-(thiazol-2-yl)benzyl)benz...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1ccc(cc1)-c1nccs1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C26H20Cl2N2O3S/c27-20-10-11-21(22(28)15-20)25(31)30(23(26(32)33)14-17-4-2-1-3-5-17)16-18-6-8-19(9-7-18)24-29-12-13-34-24/h1-13,15,23H,14,16H2,(H,32,33)/t23-/m0/s1
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Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126680
PNG
((S)-2-(2,4-dichloro-N-(2-cyanobenzyl)benzamido)-3-...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1ccccc1C#N)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H18Cl2N2O3/c25-19-10-11-20(21(26)13-19)23(29)28(15-18-9-5-4-8-17(18)14-27)22(24(30)31)12-16-6-2-1-3-7-16/h1-11,13,22H,12,15H2,(H,30,31)/t22-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126674
PNG
((S)-2-(2,4-dichloro-N-(4-cyanobenzyl)benzamido)-3-...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1ccc(cc1)C#N)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H18Cl2N2O3/c25-19-10-11-20(21(26)13-19)23(29)28(15-18-8-6-17(14-27)7-9-18)22(24(30)31)12-16-4-2-1-3-5-16/h1-11,13,22H,12,15H2,(H,30,31)/t22-/m0/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126670
PNG
(2-[(2-Bromo-benzyl)-(2,4-dichloro-benzoyl)-amino]-...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1ccccc1Br)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H18BrCl2NO3/c24-19-9-5-4-8-16(19)14-27(22(28)18-11-10-17(25)13-20(18)26)21(23(29)30)12-15-6-2-1-3-7-15/h1-11,13,21H,12,14H2,(H,29,30)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126678
PNG
(2-[Benzyl-(2,4-dichloro-benzoyl)-amino]-3-phenyl-p...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1ccccc1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H19Cl2NO3/c24-18-11-12-19(20(25)14-18)22(27)26(15-17-9-5-2-6-10-17)21(23(28)29)13-16-7-3-1-4-8-16/h1-12,14,21H,13,15H2,(H,28,29)
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Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126669
PNG
((2S)-2-[(5-BENZOFURAN-2-YL-THIOPHEN-2-YLMETHYL)-(2...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1ccc(s1)-c1cc2ccccc2o1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C29H21Cl2NO4S/c30-20-10-12-22(23(31)16-20)28(33)32(24(29(34)35)14-18-6-2-1-3-7-18)17-21-11-13-27(37-21)26-15-19-8-4-5-9-25(19)36-26/h1-13,15-16,24H,14,17H2,(H,34,35)/t24-/m0/s1
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n/an/a 8.60E+3n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126659
PNG
(2-[(3-Bromo-benzyl)-(2,4-dichloro-benzoyl)-amino]-...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)N(Cc1cccc(Br)c1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H18BrCl2NO3/c24-17-8-4-7-16(11-17)14-27(22(28)19-10-9-18(25)13-20(19)26)21(23(29)30)12-15-5-2-1-3-6-15/h1-11,13,21H,12,14H2,(H,29,30)/t21-/m1/s1
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Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126665
PNG
(2-[(4-Bromo-benzyl)-(2,4-dichloro-benzoyl)-amino]-...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1ccc(Br)cc1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H18BrCl2NO3/c24-17-8-6-16(7-9-17)14-27(22(28)19-11-10-18(25)13-20(19)26)21(23(29)30)12-15-4-2-1-3-5-15/h1-11,13,21H,12,14H2,(H,29,30)
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n/an/a 9.10E+3n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126672
PNG
((S)-2-[(3-Bromo-benzyl)-(4-chloro-benzoyl)-amino]-...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1cccc(Br)c1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19BrClNO3/c24-19-8-4-7-17(13-19)15-26(22(27)18-9-11-20(25)12-10-18)21(23(28)29)14-16-5-2-1-3-6-16/h1-13,21H,14-15H2,(H,28,29)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126660
PNG
((S)-2-(2,4-dichloro-N-(pyridin-3-ylmethyl)benzamid...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1cccnc1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H18Cl2N2O3/c23-17-8-9-18(19(24)12-17)21(27)26(14-16-7-4-10-25-13-16)20(22(28)29)11-15-5-2-1-3-6-15/h1-10,12-13,20H,11,14H2,(H,28,29)/t20-/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126664
PNG
((S)-2-[(3-Bromo-benzyl)-(2-chloro-benzoyl)-amino]-...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)N(Cc1cccc(Br)c1)C(=O)c1ccccc1Cl
Show InChI InChI=1S/C23H19BrClNO3/c24-18-10-6-9-17(13-18)15-26(22(27)19-11-4-5-12-20(19)25)21(23(28)29)14-16-7-2-1-3-8-16/h1-13,21H,14-15H2,(H,28,29)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM50126662
PNG
(CHEMBL276969 | [(3-Bromo-benzyl)-(2,4-dichloro-ben...)
Show SMILES OC(=O)CN(Cc1cccc(Br)c1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H12BrCl2NO3/c17-11-3-1-2-10(6-11)8-20(9-15(21)22)16(23)13-5-4-12(18)7-14(13)19/h1-7H,8-9H2,(H,21,22)
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n/an/a 5.30E+4n/an/an/an/an/an/a



Shire BioChem Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected S...


J Med Chem 46: 1283-5 (2003)


Article DOI: 10.1021/jm0340400
BindingDB Entry DOI: 10.7270/Q2XP74BP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%