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PubMed code 12773050

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128787
PNG
(4-[4-(2-Bromo-phenyl)-3-nitro-1-pyridin-3-ylmethyl...)
Show SMILES Oc1ccc(cc1O)[C@@H]1[C@H](C(CCN1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H22BrN3O4/c24-19-6-2-1-5-17(19)18-9-11-26(14-15-4-3-10-25-13-15)22(23(18)27(30)31)16-7-8-20(28)21(29)12-16/h1-8,10,12-13,18,22-23,28-29H,9,11,14H2/t18?,22-,23+/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128787
PNG
(4-[4-(2-Bromo-phenyl)-3-nitro-1-pyridin-3-ylmethyl...)
Show SMILES Oc1ccc(cc1O)[C@@H]1[C@H](C(CCN1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H22BrN3O4/c24-19-6-2-1-5-17(19)18-9-11-26(14-15-4-3-10-25-13-15)22(23(18)27(30)31)16-7-8-20(28)21(29)12-16/h1-8,10,12-13,18,22-23,28-29H,9,11,14H2/t18?,22-,23+/m1/s1
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n/an/a 3.70n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128790
PNG
(4-[4-(2-Bromo-phenyl)-3-nitro-1-pyridin-3-ylmethyl...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CCN1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H22BrN3O3/c24-21-6-2-1-5-19(21)20-11-13-26(15-16-4-3-12-25-14-16)22(23(20)27(29)30)17-7-9-18(28)10-8-17/h1-10,12,14,20,22-23,28H,11,13,15H2/t20?,22-,23+/m1/s1
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n/an/a 5.80n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128790
PNG
(4-[4-(2-Bromo-phenyl)-3-nitro-1-pyridin-3-ylmethyl...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CCN1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H22BrN3O3/c24-21-6-2-1-5-19(21)20-11-13-26(15-16-4-3-12-25-14-16)22(23(20)27(29)30)17-7-9-18(28)10-8-17/h1-10,12,14,20,22-23,28H,11,13,15H2/t20?,22-,23+/m1/s1
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n/an/a 8.20n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128796
PNG
(4-[4-(2-Bromo-phenyl)-3-nitro-1-pyridin-3-ylmethyl...)
Show SMILES Oc1ccc(cc1O)[C@@H]1[C@H](C(C=CN1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O4/c24-19-6-2-1-5-17(19)18-9-11-26(14-15-4-3-10-25-13-15)22(23(18)27(30)31)16-7-8-20(28)21(29)12-16/h1-13,18,22-23,28-29H,14H2/t18?,22-,23+/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128795
PNG
(4-(2-Bromo-phenyl)-6-(3,4-dihydroxy-phenyl)-5-nitr...)
Show SMILES Oc1ccc(cc1O)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O5/c24-18-6-2-1-5-16(18)17-11-21(30)26(13-14-4-3-9-25-12-14)22(23(17)27(31)32)15-7-8-19(28)20(29)10-15/h1-10,12,17,22-23,28-29H,11,13H2/t17?,22-,23+/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128795
PNG
(4-(2-Bromo-phenyl)-6-(3,4-dihydroxy-phenyl)-5-nitr...)
Show SMILES Oc1ccc(cc1O)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O5/c24-18-6-2-1-5-16(18)17-11-21(30)26(13-14-4-3-9-25-12-14)22(23(17)27(31)32)15-7-8-19(28)20(29)10-15/h1-10,12,17,22-23,28-29H,11,13H2/t17?,22-,23+/m1/s1
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n/an/a 46n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128789
PNG
(4-(2-Bromo-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1-...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O4/c24-20-6-2-1-5-18(20)19-12-21(29)26(14-15-4-3-11-25-13-15)22(23(19)27(30)31)16-7-9-17(28)10-8-16/h1-11,13,19,22-23,28H,12,14H2/t19?,22-,23+/m1/s1
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n/an/a 75n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128800
PNG
(6-(3-Amino-4-hydroxy-phenyl)-4-(2-bromo-phenyl)-5-...)
Show SMILES Nc1cc(ccc1O)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H21BrN4O4/c24-18-6-2-1-5-16(18)17-11-21(30)27(13-14-4-3-9-26-12-14)22(23(17)28(31)32)15-7-8-20(29)19(25)10-15/h1-10,12,17,22-23,29H,11,13,25H2/t17?,22-,23+/m1/s1
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n/an/a 97n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128789
PNG
(4-(2-Bromo-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1-...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O4/c24-20-6-2-1-5-18(20)19-12-21(29)26(14-15-4-3-11-25-13-15)22(23(19)27(30)31)16-7-9-17(28)10-8-16/h1-11,13,19,22-23,28H,12,14H2/t19?,22-,23+/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128790
PNG
(4-[4-(2-Bromo-phenyl)-3-nitro-1-pyridin-3-ylmethyl...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CCN1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H22BrN3O3/c24-21-6-2-1-5-19(21)20-11-13-26(15-16-4-3-12-25-14-16)22(23(20)27(29)30)17-7-9-18(28)10-8-17/h1-10,12,14,20,22-23,28H,11,13,15H2/t20?,22-,23+/m1/s1
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n/an/a>310n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128787
PNG
(4-[4-(2-Bromo-phenyl)-3-nitro-1-pyridin-3-ylmethyl...)
Show SMILES Oc1ccc(cc1O)[C@@H]1[C@H](C(CCN1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H22BrN3O4/c24-19-6-2-1-5-17(19)18-9-11-26(14-15-4-3-10-25-13-15)22(23(18)27(30)31)16-7-8-20(28)21(29)12-16/h1-8,10,12-13,18,22-23,28-29H,9,11,14H2/t18?,22-,23+/m1/s1
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n/an/a>310n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128793
PNG
(4-(3-Chloro-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1cccc(Cl)c1)[N+]([O-])=O
Show InChI InChI=1S/C23H20ClN3O4/c24-18-5-1-4-17(11-18)20-12-21(29)26(14-15-3-2-10-25-13-15)22(23(20)27(30)31)16-6-8-19(28)9-7-16/h1-11,13,20,22-23,28H,12,14H2/t20?,22-,23+/m1/s1
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n/an/a 320n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128794
PNG
(4-(3-Bromo-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1-...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1cccc(Br)c1)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O4/c24-18-5-1-4-17(11-18)20-12-21(29)26(14-15-3-2-10-25-13-15)22(23(20)27(30)31)16-6-8-19(28)9-7-16/h1-11,13,20,22-23,28H,12,14H2/t20?,22-,23+/m1/s1
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n/an/a 350n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128801
PNG
(6-(4-Hydroxy-phenyl)-5-nitro-1-pyridin-3-ylmethyl-...)
Show SMILES Cc1cccc(c1)C1CC(=O)N(Cc2cccnc2)[C@@H]([C@H]1[N+]([O-])=O)c1ccc(O)cc1
Show InChI InChI=1S/C24H23N3O4/c1-16-4-2-6-19(12-16)21-13-22(29)26(15-17-5-3-11-25-14-17)23(24(21)27(30)31)18-7-9-20(28)10-8-18/h2-12,14,21,23-24,28H,13,15H2,1H3/t21?,23-,24+/m1/s1
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n/an/a 410n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128794
PNG
(4-(3-Bromo-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1-...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1cccc(Br)c1)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O4/c24-18-5-1-4-17(11-18)20-12-21(29)26(14-15-3-2-10-25-13-15)22(23(20)27(30)31)16-6-8-19(28)9-7-16/h1-11,13,20,22-23,28H,12,14H2/t20?,22-,23+/m1/s1
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n/an/a 420n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128789
PNG
(4-(2-Bromo-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1-...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O4/c24-20-6-2-1-5-18(20)19-12-21(29)26(14-15-4-3-11-25-13-15)22(23(19)27(30)31)16-7-9-17(28)10-8-16/h1-11,13,19,22-23,28H,12,14H2/t19?,22-,23+/m1/s1
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n/an/a 950n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128802
PNG
(6-(4-Hydroxy-phenyl)-5-nitro-4-phenyl-1-pyridin-3-...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1ccccc1)[N+]([O-])=O
Show InChI InChI=1S/C23H21N3O4/c27-19-10-8-18(9-11-19)22-23(26(29)30)20(17-6-2-1-3-7-17)13-21(28)25(22)15-16-5-4-12-24-14-16/h1-12,14,20,22-23,27H,13,15H2/t20?,22-,23+/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128795
PNG
(4-(2-Bromo-phenyl)-6-(3,4-dihydroxy-phenyl)-5-nitr...)
Show SMILES Oc1ccc(cc1O)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O5/c24-18-6-2-1-5-16(18)17-11-21(30)26(13-14-4-3-9-25-12-14)22(23(17)27(31)32)15-7-8-19(28)20(29)10-15/h1-10,12,17,22-23,28-29H,11,13H2/t17?,22-,23+/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128803
PNG
(4-(2-Bromo-phenyl)-6-(4-methoxy-phenyl)-5-nitro-1-...)
Show SMILES COc1ccc(cc1)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C24H22BrN3O4/c1-32-18-10-8-17(9-11-18)23-24(28(30)31)20(19-6-2-3-7-21(19)25)13-22(29)27(23)15-16-5-4-12-26-14-16/h2-12,14,20,23-24H,13,15H2,1H3/t20?,23-,24+/m1/s1
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n/an/a>1.20E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128791
PNG
(4-(2-Bromo-phenyl)-6-(4-hydroxy-3-hydroxymethyl-ph...)
Show SMILES OCc1cc(ccc1O)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C24H22BrN3O5/c25-20-6-2-1-5-18(20)19-11-22(31)27(13-15-4-3-9-26-12-15)23(24(19)28(32)33)16-7-8-21(30)17(10-16)14-29/h1-10,12,19,23-24,29-30H,11,13-14H2/t19?,23-,24+/m1/s1
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n/an/a>1.20E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128797
PNG
(4-(4-Bromo-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1-...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CC(=O)N1Cc1cccnc1)c1ccc(Br)cc1)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O4/c24-18-7-3-16(4-8-18)20-12-21(29)26(14-15-2-1-11-25-13-15)22(23(20)27(30)31)17-5-9-19(28)10-6-17/h1-11,13,20,22-23,28H,12,14H2/t20?,22-,23+/m1/s1
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n/an/a>3.70E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128788
PNG
(4-(3-Bromo-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1-...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CC(=O)N1Cc1ccc[n+]([O-])c1)c1cccc(Br)c1)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O5/c24-18-5-1-4-17(11-18)20-12-21(29)26(14-15-3-2-10-25(30)13-15)22(23(20)27(31)32)16-6-8-19(28)9-7-16/h1-11,13,20,22-23,28H,12,14H2/t20?,22-,23+/m1/s1
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Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128798
PNG
(4-(3-Bromo-phenyl)-5-hydroxyamino-6-(4-hydroxy-phe...)
Show SMILES ON[C@H]1C(CC(=O)N(Cc2cccnc2)[C@@H]1c1ccc(O)cc1)c1cccc(Br)c1
Show InChI InChI=1S/C23H22BrN3O3/c24-18-5-1-4-17(11-18)20-12-21(29)27(14-15-3-2-10-25-13-15)23(22(20)26-30)16-6-8-19(28)9-7-16/h1-11,13,20,22-23,26,28,30H,12,14H2/t20?,22-,23+/m0/s1
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n/an/a>3.70E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128799
PNG
(4-(3-Bromo-phenyl)-6-(4-hydroxy-phenyl)-5-nitro-1-...)
Show SMILES Oc1ccc(cc1)[C@@H]1[C@H](C(CC(=O)N1Cc1ccncc1)c1cccc(Br)c1)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O4/c24-18-3-1-2-17(12-18)20-13-21(29)26(14-15-8-10-25-11-9-15)22(23(20)27(30)31)16-4-6-19(28)7-5-16/h1-12,20,22-23,28H,13-14H2/t20?,22-,23+/m1/s1
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n/an/a>3.70E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128792
PNG
(5-Amino-4-(3-bromo-phenyl)-6-(4-hydroxy-phenyl)-1-...)
Show SMILES N[C@H]1C(CC(=O)N(Cc2cccnc2)[C@@H]1c1ccc(O)cc1)c1cccc(Br)c1
Show InChI InChI=1S/C23H22BrN3O2/c24-18-5-1-4-17(11-18)20-12-21(29)27(14-15-3-2-10-26-13-15)23(22(20)25)16-6-8-19(28)9-7-16/h1-11,13,20,22-23,28H,12,14,25H2/t20?,22-,23+/m0/s1
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n/an/a>3.70E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%