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PubMed code 1279173

Compile data set for download or QSAR
Found 72 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1317
PNG
(3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-...)
Show SMILES CCc1cc(NCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H15Cl2N3O2/c1-3-9-6-12(16(22)20-8(9)2)19-7-13-21-14-10(17)4-5-11(18)15(14)23-13/h4-6,19H,3,7H2,1-2H3,(H,20,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1314
PNG
(3-[[(4,7-Dimethylbenzoxazol-2-yl)-methyl]amino]-5-...)
Show SMILES CCc1cc(NCc2nc3c(C)ccc(C)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H21N3O2/c1-5-13-8-14(18(22)20-12(13)4)19-9-15-21-16-10(2)6-7-11(3)17(16)23-15/h6-8,19H,5,9H2,1-4H3,(H,20,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1337
PNG
(3-Aminopyridin-2(1H)-one analogue 57 | 3-[[(4,7-Di...)
Show SMILES Cc1[nH]c(=O)c(NCc2nc3c(Cl)ccc(Cl)c3o2)cc1C=C
Show InChI InChI=1S/C16H13Cl2N3O2/c1-3-9-6-12(16(22)20-8(9)2)19-7-13-21-14-10(17)4-5-11(18)15(14)23-13/h3-6,19H,1,7H2,2H3,(H,20,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1057
PNG
(2-{[(5-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-y...)
Show SMILES CCc1cc(NCN2C(=O)c3ccccc3C2=O)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17N3O3/c1-3-11-8-14(15(21)19-10(11)2)18-9-20-16(22)12-6-4-5-7-13(12)17(20)23/h4-8,18H,3,9H2,1-2H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1339
PNG
(3-Aminopyridin-2(1H)-one analogue 59 | 3-{[(4,7-di...)
Show SMILES CCc1cc(NCc2nc3c(Cl)ccc(Cl)c3o2)c(=S)[nH]c1C
Show InChI InChI=1S/C16H15Cl2N3OS/c1-3-9-6-12(16(23)20-8(9)2)19-7-13-21-14-10(17)4-5-11(18)15(14)22-13/h4-6,19H,3,7H2,1-2H3,(H,20,23)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1338
PNG
(3-Aminopyridin-2(1H)-one analogue 58 | 3-{[(4,7-di...)
Show SMILES CSc1cc(NCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C15H13Cl2N3O2S/c1-7-11(23-2)5-10(15(21)19-7)18-6-12-20-13-8(16)3-4-9(17)14(13)22-12/h3-5,18H,6H2,1-2H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1312
PNG
(3-Aminopyridin-2(1H)-one analogue 32 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2nc3cccc(C)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H19N3O2/c1-4-12-8-14(17(21)19-11(12)3)18-9-15-20-13-7-5-6-10(2)16(13)22-15/h5-8,18H,4,9H2,1-3H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1328
PNG
(3-Aminopyridin-2(1H)-one analogue 48 | 3-{[(4,7-di...)
Show SMILES CCc1cc(NCc2cc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H16Cl2N2O2/c1-3-10-6-15(17(22)21-9(10)2)20-8-11-7-12-13(18)4-5-14(19)16(12)23-11/h4-7,20H,3,8H2,1-2H3,(H,21,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1331
PNG
(3-Aminopyridin-2(1H)-one analogue 51 | 3-[N-[(4,7-...)
Show SMILES CCc1cc(N(C)Cc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17Cl2N3O2/c1-4-10-7-13(17(23)20-9(10)2)22(3)8-14-21-15-11(18)5-6-12(19)16(15)24-14/h5-7H,4,8H2,1-3H3,(H,20,23)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1316
PNG
(3-Aminopyridin-2(1H)-one analogue 36 | 3-{[(7-chlo...)
Show SMILES CCc1cc(NCc2nc3cccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16ClN3O2/c1-3-10-7-13(16(21)19-9(10)2)18-8-14-20-12-6-4-5-11(17)15(12)22-14/h4-7,18H,3,8H2,1-2H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1323
PNG
(3-Aminopyridin-2(1H)-one analogue 43 | 3-{[(4,7-di...)
Show SMILES CCc1cc(NCc2nc3c(F)ccc(F)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H15F2N3O2/c1-3-9-6-12(16(22)20-8(9)2)19-7-13-21-14-10(17)4-5-11(18)15(14)23-13/h4-6,19H,3,7H2,1-2H3,(H,20,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1321
PNG
(3-Aminopyridin-2(1H)-one analogue 41 | 5-ethyl-3-{...)
Show SMILES CCc1cc(NCc2nc3cccc(F)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16FN3O2/c1-3-10-7-13(16(21)19-9(10)2)18-8-14-20-12-6-4-5-11(17)15(12)22-14/h4-7,18H,3,8H2,1-2H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1333
PNG
(3-Aminopyridin-2(1H)-one analogue 53 | 3-{[(4,7-di...)
Show SMILES CCc1cc(N(C)Cc2nc3c(C)ccc(C)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C19H23N3O2/c1-6-14-9-15(19(23)20-13(14)4)22(5)10-16-21-17-11(2)7-8-12(3)18(17)24-16/h7-9H,6,10H2,1-5H3,(H,20,23)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1322
PNG
(3-Aminopyridin-2(1H)-one analogue 42 | 3-{[(7-chlo...)
Show SMILES CCc1cc(NCc2nc3c(F)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H15ClFN3O2/c1-3-9-6-12(16(22)20-8(9)2)19-7-13-21-14-11(18)5-4-10(17)15(14)23-13/h4-6,19H,3,7H2,1-2H3,(H,20,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1318
PNG
(3-Aminopyridin-2(1H)-one analogue 38 | 5-ethyl-3-{...)
Show SMILES CCc1cc(NCc2nc3c(F)cccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16FN3O2/c1-3-10-7-12(16(21)19-9(10)2)18-8-14-20-15-11(17)5-4-6-13(15)22-14/h4-7,18H,3,8H2,1-2H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1340
PNG
(3-Aminopyridin-2(1H)-one analogue 60 | 5-{[(4,7-di...)
Show SMILES Cc1[nH]c(=O)c(NCc2nc3c(Cl)ccc(Cl)c3o2)c2Cc12
Show InChI InChI=1S/C15H11Cl2N3O2/c1-6-7-4-8(7)12(15(21)19-6)18-5-11-20-13-9(16)2-3-10(17)14(13)22-11/h2-3,18H,4-5H2,1H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1341
PNG
(3-Aminopyridin-2(1H)-one analogue 61 | 3-{[(4,7-di...)
Show SMILES COc1cc(NCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C15H13Cl2N3O3/c1-7-11(22-2)5-10(15(21)19-7)18-6-12-20-13-8(16)3-4-9(17)14(13)23-12/h3-5,18H,6H2,1-2H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1309
PNG
(3-Aminopyridin-2(1H)-one analogue 29 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2nc3c(C)cccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H19N3O2/c1-4-12-8-13(17(21)19-11(12)3)18-9-15-20-16-10(2)6-5-7-14(16)22-15/h5-8,18H,4,9H2,1-3H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1315
PNG
(3-Aminopyridin-2(1H)-one analogue 35 | 3-{[(4-chlo...)
Show SMILES CCc1cc(NCc2nc3c(Cl)cccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16ClN3O2/c1-3-10-7-12(16(21)19-9(10)2)18-8-14-20-15-11(17)5-4-6-13(15)22-14/h4-7,18H,3,8H2,1-2H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1324
PNG
(3-Aminopyridin-2(1H)-one analogue 44 | 5-ethyl-3-{...)
Show SMILES CCc1cc(NCc2nc3c(OC)cccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H19N3O3/c1-4-11-8-12(17(21)19-10(11)2)18-9-15-20-16-13(22-3)6-5-7-14(16)23-15/h5-8,18H,4,9H2,1-3H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1345
PNG
(3-Aminopyridin-2(1H)-one analogue 65 | 3-[(1,3-ben...)
Show SMILES CSc1cc(NCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C15H15N3O2S/c1-9-13(21-2)7-11(15(19)17-9)16-8-14-18-10-5-3-4-6-12(10)20-14/h3-7,16H,8H2,1-2H3,(H,17,19)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1283
PNG
(3-[(1,3-benzoxazol-2-ylmethyl)amino]-5-ethyl-6-met...)
Show SMILES CCc1cc(NCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17N3O2/c1-3-11-8-13(16(20)18-10(11)2)17-9-15-19-12-6-4-5-7-14(12)21-15/h4-8,17H,3,9H2,1-2H3,(H,18,20)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1313
PNG
(3-Aminopyridin-2(1H)-one analogue 33 | 5-ethyl-3-{...)
Show SMILES CCc1cc(NCc2nc3cccc(CC)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H21N3O2/c1-4-12-7-6-8-14-17(12)23-16(21-14)10-19-15-9-13(5-2)11(3)20-18(15)22/h6-9,19H,4-5,10H2,1-3H3,(H,20,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1285
PNG
(3-Aminopyridin-2(1H)-one analogue 5 | 5-ethyl-6-me...)
Show SMILES CCc1cc(NCc2nc3CCCCc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H21N3O2/c1-3-11-8-13(16(20)18-10(11)2)17-9-15-19-12-6-4-5-7-14(12)21-15/h8,17H,3-7,9H2,1-2H3,(H,18,20)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1342
PNG
(3-Aminopyridin-2(1H)-one analogue 62 | 3-{[(4,7-di...)
Show SMILES CC(=O)c1cc(NCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H13Cl2N3O3/c1-7-9(8(2)22)5-12(16(23)20-7)19-6-13-21-14-10(17)3-4-11(18)15(14)24-13/h3-5,19H,6H2,1-2H3,(H,20,23)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1351
PNG
(3-Aminopyridin-2(1H)-one analogue 71 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2ccc3ccccc3c2)c(=S)[nH]c1C
Show InChI InChI=1S/C19H20N2S/c1-3-15-11-18(19(22)21-13(15)2)20-12-14-8-9-16-6-4-5-7-17(16)10-14/h4-11,20H,3,12H2,1-2H3,(H,21,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1284
PNG
(3-Aminopyridin-2(1H)-one analogue 4 | 3-[(1-benzof...)
Show SMILES CCc1cc(NCc2cc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H18N2O2/c1-3-12-9-15(17(20)19-11(12)2)18-10-14-8-13-6-4-5-7-16(13)21-14/h4-9,18H,3,10H2,1-2H3,(H,19,20)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1329
PNG
(3-Aminopyridin-2(1H)-one analogue 49 | 3-{[(7-chlo...)
Show SMILES CCc1cc(NCc2cc3cccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17ClN2O2/c1-3-11-8-15(17(21)20-10(11)2)19-9-13-7-12-5-4-6-14(18)16(12)22-13/h4-8,19H,3,9H2,1-2H3,(H,20,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1286
PNG
(3-Aminopyridin-2(1H)-one analogue 6 | 5-ethyl-6-me...)
Show SMILES CCc1cc(NCc2cnc3ccccc3c2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H19N3O/c1-3-14-9-17(18(22)21-12(14)2)20-11-13-8-15-6-4-5-7-16(15)19-10-13/h4-10,20H,3,11H2,1-2H3,(H,21,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1287
PNG
(3-Aminopyridin-2(1H)-one analogue 7 | 3-[(1,3-benz...)
Show SMILES CCc1cc(NCc2nc3ccccc3s2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17N3OS/c1-3-11-8-13(16(20)18-10(11)2)17-9-15-19-12-6-4-5-7-14(12)21-15/h4-8,17H,3,9H2,1-2H3,(H,18,20)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1346
PNG
(3-Aminopyridin-2(1H)-one analogue 66 | 3-[(1,3-ben...)
Show SMILES CCSc1cc(NCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17N3O2S/c1-3-22-14-8-12(16(20)18-10(14)2)17-9-15-19-11-6-4-5-7-13(11)21-15/h4-8,17H,3,9H2,1-2H3,(H,18,20)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1325
PNG
(3-Aminopyridin-2(1H)-one analogue 45 | 5-ethyl-3-{...)
Show SMILES CCc1cc(NCc2nc3c(O)cccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17N3O3/c1-3-10-7-11(16(21)18-9(10)2)17-8-14-19-15-12(20)5-4-6-13(15)22-14/h4-7,17,20H,3,8H2,1-2H3,(H,18,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1288
PNG
(3-Aminopyridin-2(1H)-one analogue 8 | 5-ethyl-6-me...)
Show SMILES CCc1cc(NCc2ccc3ccccc3c2)c(=O)[nH]c1C
Show InChI InChI=1S/C19H20N2O/c1-3-15-11-18(19(22)21-13(15)2)20-12-14-8-9-16-6-4-5-7-17(16)10-14/h4-11,20H,3,12H2,1-2H3,(H,21,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1319
PNG
(3-Aminopyridin-2(1H)-one analogue 39 | 5-ethyl-3-{...)
Show SMILES CCc1cc(NCc2nc3cc(F)ccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16FN3O2/c1-3-10-6-13(16(21)19-9(10)2)18-8-15-20-12-7-11(17)4-5-14(12)22-15/h4-7,18H,3,8H2,1-2H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1289
PNG
(3-Aminopyridin-2(1H)-one analogue 9 | 3-[(1-benzot...)
Show SMILES CCc1cc(NCc2cc3ccccc3s2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H18N2OS/c1-3-12-9-15(17(20)19-11(12)2)18-10-14-8-13-6-4-5-7-16(13)21-14/h4-9,18H,3,10H2,1-2H3,(H,19,20)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1290
PNG
(3-Aminopyridin-2(1H)-one analogue 10 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2ccc3ccccc3n2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H19N3O/c1-3-13-10-17(18(22)20-12(13)2)19-11-15-9-8-14-6-4-5-7-16(14)21-15/h4-10,19H,3,11H2,1-2H3,(H,20,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1347
PNG
(3-Aminopyridin-2(1H)-one analogue 67 | 3-[(1,3-ben...)
Show SMILES CCc1c(C)[nH]c(=O)c(NCc2nc3ccccc3o2)c1C
Show InChI InChI=1S/C17H19N3O2/c1-4-12-10(2)16(17(21)19-11(12)3)18-9-15-20-13-7-5-6-8-14(13)22-15/h5-8,18H,4,9H2,1-3H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1332
PNG
(3-Aminopyridin-2(1H)-one analogue 52 | 3-{[(4,7-di...)
Show SMILES CCN(Cc1nc2c(Cl)ccc(Cl)c2o1)c1cc(CC)c(C)[nH]c1=O
Show InChI InChI=1S/C18H19Cl2N3O2/c1-4-11-8-14(18(24)21-10(11)3)23(5-2)9-15-22-16-12(19)6-7-13(20)17(16)25-15/h6-8H,4-5,9H2,1-3H3,(H,21,24)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1334
PNG
(3-Aminopyridin-2(1H)-one analogue 54 | 3-{[1-(1-be...)
Show SMILES CCc1cc(NC(C)c2cc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-4-13-9-15(18(21)20-11(13)2)19-12(3)17-10-14-7-5-6-8-16(14)22-17/h5-10,12,19H,4H2,1-3H3,(H,20,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1335
PNG
(3-Aminopyridin-2(1H)-one analogue 55 | 3-{[(4,7-di...)
Show SMILES CCc1cc(N(C)Cc2cc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H18Cl2N2O2/c1-4-11-7-16(18(23)21-10(11)2)22(3)9-12-8-13-14(19)5-6-15(20)17(13)24-12/h5-8H,4,9H2,1-3H3,(H,21,23)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1343
PNG
(3-Aminopyridin-2(1H)-one analogue 63 | 3-[(Benzoxa...)
Show SMILES CC(O)c1cc(NCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H15Cl2N3O3/c1-7-9(8(2)22)5-12(16(23)20-7)19-6-13-21-14-10(17)3-4-11(18)15(14)24-13/h3-5,8,19,22H,6H2,1-2H3,(H,20,23)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1291
PNG
(3-Aminopyridin-2(1H)-one analogue 11 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2coc3ccccc3c2=O)c(=O)[nH]c1C
Show InChI InChI=1S/C18H18N2O3/c1-3-12-8-15(18(22)20-11(12)2)19-9-13-10-23-16-7-5-4-6-14(16)17(13)21/h4-8,10,19H,3,9H2,1-2H3,(H,20,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1336
PNG
(3-Aminopyridin-2(1H)-one analogue 56 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NC(C)c2ccc3ccccc3c2)c(=O)[nH]c1C
Show InChI InChI=1S/C20H22N2O/c1-4-15-12-19(20(23)22-13(15)2)21-14(3)17-10-9-16-7-5-6-8-18(16)11-17/h5-12,14,21H,4H2,1-3H3,(H,22,23)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1348
PNG
(3-Aminopyridin-2(1H)-one analogue 68 | 3-[(1,3-ben...)
Show SMILES Cc1[nH]c(=O)c(NCc2nc3ccccc3o2)cc1S(C)(=O)=O
Show InChI InChI=1S/C15H15N3O4S/c1-9-13(23(2,20)21)7-11(15(19)17-9)16-8-14-18-10-5-3-4-6-12(10)22-14/h3-7,16H,8H2,1-2H3,(H,17,19)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1320
PNG
(3-Aminopyridin-2(1H)-one analogue 40 | 5-ethyl-3-{...)
Show SMILES CCc1cc(NCc2nc3ccc(F)cc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16FN3O2/c1-3-10-6-13(16(21)19-9(10)2)18-8-15-20-12-5-4-11(17)7-14(12)22-15/h4-7,18H,3,8H2,1-2H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1310
PNG
(3-Aminopyridin-2(1H)-one analogue 30 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2nc3cc(C)ccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H19N3O2/c1-4-12-8-14(17(21)19-11(12)3)18-9-16-20-13-7-10(2)5-6-15(13)22-16/h5-8,18H,4,9H2,1-3H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1311
PNG
(3-Aminopyridin-2(1H)-one analogue 31 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2nc3ccc(C)cc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H19N3O2/c1-4-12-8-14(17(21)19-11(12)3)18-9-16-20-13-6-5-10(2)7-15(13)22-16/h5-8,18H,4,9H2,1-3H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1349
PNG
(3-Aminopyridin-2(1H)-one analogue 69 | ethyl 5-[(1...)
Show SMILES CCOC(=O)c1cc(NCc2nc3ccccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H17N3O4/c1-3-23-17(22)11-8-13(16(21)19-10(11)2)18-9-15-20-12-6-4-5-7-14(12)24-15/h4-8,18H,3,9H2,1-2H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1292
PNG
(3-Aminopyridin-2(1H)-one analogue 12 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2nc3ncccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C15H16N4O2/c1-3-10-7-11(15(20)18-9(10)2)17-8-13-19-14-12(21-13)5-4-6-16-14/h4-7,17H,3,8H2,1-2H3,(H,18,20)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1330
PNG
(3-Aminopyridin-2(1H)-one analogue 50 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2oc3ccccc3c2C)c(=O)[nH]c1C
Show InChI InChI=1S/C18H20N2O2/c1-4-13-9-15(18(21)20-12(13)3)19-10-17-11(2)14-7-5-6-8-16(14)22-17/h5-9,19H,4,10H2,1-3H3,(H,20,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1293
PNG
(3-Aminopyridin-2(1H)-one analogue 13 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2cccc3ccccc23)c(=O)[nH]c1C
Show InChI InChI=1S/C19H20N2O/c1-3-14-11-18(19(22)21-13(14)2)20-12-16-9-6-8-15-7-4-5-10-17(15)16/h4-11,20H,3,12H2,1-2H3,(H,21,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1294
PNG
(3-Aminopyridin-2(1H)-one analogue 14 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2ncc(o2)-c2ccccc2)c(=O)[nH]c1C
Show InChI InChI=1S/C18H19N3O2/c1-3-13-9-15(18(22)21-12(13)2)19-11-17-20-10-16(23-17)14-7-5-4-6-8-14/h4-10,19H,3,11H2,1-2H3,(H,21,22)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1295
PNG
(2-{[(5-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-y...)
Show SMILES CCc1cc(NCc2nc3ccccc3c(=O)[nH]2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H18N4O2/c1-3-11-8-14(17(23)19-10(11)2)18-9-15-20-13-7-5-4-6-12(13)16(22)21-15/h4-8,18H,3,9H2,1-2H3,(H,19,23)(H,20,21,22)
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n/an/a 2.50E+3n/an/an/an/a8.2n/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1296
PNG
(3-Aminopyridin-2(1H)-one analogue 16 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2nc3c(ccc4ccccc34)o2)c(=O)[nH]c1C
Show InChI InChI=1S/C20H19N3O2/c1-3-13-10-16(20(24)22-12(13)2)21-11-18-23-19-15-7-5-4-6-14(15)8-9-17(19)25-18/h4-10,21H,3,11H2,1-2H3,(H,22,24)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1344
PNG
(3-Aminopyridin-2(1H)-one analogue 64 | 3-{[(4,7-di...)
Show SMILES Cc1cc(C)c(NCc2nc3c(Cl)ccc(Cl)c3o2)c(=O)[nH]1
Show InChI InChI=1S/C15H13Cl2N3O2/c1-7-5-8(2)19-15(21)12(7)18-6-11-20-13-9(16)3-4-10(17)14(13)22-11/h3-5,18H,6H2,1-2H3,(H,19,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1297
PNG
(3-Aminopyridin-2(1H)-one analogue 17 | 5-ethyl-3-[...)
Show SMILES CCc1cc(NCc2cc3ccccc3[nH]2)c(=O)[nH]c1C
Show InChI InChI=1S/C17H19N3O/c1-3-12-9-16(17(21)19-11(12)2)18-10-14-8-13-6-4-5-7-15(13)20-14/h4-9,18,20H,3,10H2,1-2H3,(H,19,21)
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n/an/a 4.40E+3n/an/an/an/a8.2n/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1298
PNG
(2-pyridinone deriv. 28 | 3-(benzylamino)-5-ethyl-6...)
Show SMILES CCc1cc(NCc2ccccc2)c(=O)[nH]c1C
Show InChI InChI=1S/C15H18N2O/c1-3-13-9-14(15(18)17-11(13)2)16-10-12-7-5-4-6-8-12/h4-9,16H,3,10H2,1-2H3,(H,17,18)
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n/an/a 5.33E+3n/an/an/an/a8.2n/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1299
PNG
(3-Aminopyridin-2(1H)-one analogue 19 | 3-[(1H-1,3-...)
Show SMILES CCc1cc(NCc2nc3ccccc3[nH]2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H18N4O/c1-3-11-8-14(16(21)18-10(11)2)17-9-15-19-12-6-4-5-7-13(12)20-15/h4-8,17H,3,9H2,1-2H3,(H,18,21)(H,19,20)
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n/an/a 7.58E+3n/an/an/an/a8.2n/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1300
PNG
(3-Aminopyridin-2(1H)-one analogue 20 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCC2CCCc3ccccc23)c(=O)[nH]c1C
Show InChI InChI=1S/C19H24N2O/c1-3-14-11-18(19(22)21-13(14)2)20-12-16-9-6-8-15-7-4-5-10-17(15)16/h4-5,7,10-11,16,20H,3,6,8-9,12H2,1-2H3,(H,21,22)
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n/an/a 9.50E+3n/an/an/an/a8.2n/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1301
PNG
(3-Aminopyridin-2(1H)-one analogue 21 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2nc3cc4ccccc4cc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C20H19N3O2/c1-3-13-8-17(20(24)22-12(13)2)21-11-19-23-16-9-14-6-4-5-7-15(14)10-18(16)25-19/h4-10,21H,3,11H2,1-2H3,(H,22,24)
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n/an/a 1.00E+4n/an/an/an/a8.2n/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1352
PNG
(3-Aminopyridin-2(1H)-one analogue 72 | 3-[(2-Napht...)
Show SMILES CCc1cc(NCc2ccc3ccccc3c2)c(=O)n(C)c1C
Show InChI InChI=1S/C20H22N2O/c1-4-16-12-19(20(23)22(3)14(16)2)21-13-15-9-10-17-7-5-6-8-18(17)11-15/h5-12,21H,4,13H2,1-3H3
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1302
PNG
(3-Aminopyridin-2(1H)-one analogue 22 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2ccccn2)c(=O)[nH]c1C
Show InChI InChI=1S/C14H17N3O/c1-3-11-8-13(14(18)17-10(11)2)16-9-12-6-4-5-7-15-12/h4-8,16H,3,9H2,1-2H3,(H,17,18)
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n/an/a 1.50E+4n/an/an/an/a8.2n/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1303
PNG
(3-Aminopyridin-2(1H)-one analogue 23 | 5-ethyl-3-[...)
Show SMILES CCc1cc(NCc2c[nH]c3ccccc23)c(=O)[nH]c1C
Show InChI InChI=1S/C17H19N3O/c1-3-12-8-16(17(21)20-11(12)2)19-10-13-9-18-15-7-5-4-6-14(13)15/h4-9,18-19H,3,10H2,1-2H3,(H,20,21)
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n/an/a 2.25E+4n/an/an/an/a8.2n/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1326
PNG
(3-Aminopyridin-2(1H)-one analogue 46 | 5-ethyl-6-m...)
Show SMILES CCc1cc(NCc2nc3c(cccc3o2)[N+]([O-])=O)c(=O)[nH]c1C
Show InChI InChI=1S/C16H16N4O4/c1-3-10-7-11(16(21)18-9(10)2)17-8-14-19-15-12(20(22)23)5-4-6-13(15)24-14/h4-7,17H,3,8H2,1-2H3,(H,18,21)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1304
PNG
(3-Aminopyridin-2(1H)-one analogue 24 | 5-ethyl-3-[...)
Show SMILES CCc1cc(NCc2ccco2)c(=O)[nH]c1C
Show InChI InChI=1S/C13H16N2O2/c1-3-10-7-12(13(16)15-9(10)2)14-8-11-5-4-6-17-11/h4-7,14H,3,8H2,1-2H3,(H,15,16)
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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1350
PNG
(3-Aminopyridin-2(1H)-one analogue 70 | 3-[(1,3-ben...)
Show SMILES Cc1[nH]c(=O)c(NCc2nc3ccccc3o2)cc1S(C)=O
Show InChI InChI=1S/C15H15N3O3S/c1-9-13(22(2)20)7-11(15(19)17-9)16-8-14-18-10-5-3-4-6-12(10)21-14/h3-7,16H,8H2,1-2H3,(H,17,19)
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n/an/a 3.15E+4n/an/an/an/an/an/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1305
PNG
(3-Aminopyridin-2(1H)-one analogue 25 | 5-ethyl-3-(...)
Show SMILES CCc1cc(NCc2cc3cnccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17N3O2/c1-3-11-7-14(16(20)19-10(11)2)18-9-13-6-12-8-17-5-4-15(12)21-13/h4-8,18H,3,9H2,1-2H3,(H,19,20)
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n/an/a 3.23E+4n/an/an/an/a8.2n/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1327
PNG
(3-Aminopyridin-2(1H)-one analogue 47 | 3-[[(4-Amin...)
Show SMILES CCc1cc(NCc2nc3c(N)cccc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H18N4O2/c1-3-10-7-12(16(21)19-9(10)2)18-8-14-20-15-11(17)5-4-6-13(15)22-14/h4-7,18H,3,8,17H2,1-2H3,(H,19,21)
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n/an/a 6.70E+4n/an/an/an/an/an/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1306
PNG
(3-Aminopyridin-2(1H)-one analogue 26 | 5-ethyl-3-(...)
Show SMILES CCc1cc(NCc2cc3ccncc3o2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17N3O2/c1-3-11-7-14(16(20)19-10(11)2)18-8-13-6-12-4-5-17-9-15(12)21-13/h4-7,9,18H,3,8H2,1-2H3,(H,19,20)
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n/an/a 1.05E+5n/an/an/an/a8.2n/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1307
PNG
(3-Aminopyridin-2(1H)-one analogue 27 | 5-Ethyl-3-[...)
Show SMILES CCc1cc(NCc2ccoc2)c(=O)[nH]c1C
Show InChI InChI=1S/C13H16N2O2/c1-3-11-6-12(13(16)15-9(11)2)14-7-10-4-5-17-8-10/h4-6,8,14H,3,7H2,1-2H3,(H,15,16)
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n/an/a 1.45E+5n/an/an/an/a8.2n/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1308
PNG
(2-pyridinone deriv. 26 | 3-Aminopyridin-2(1H)-one ...)
Show SMILES CCc1cc(NCc2cccnc2)c(=O)[nH]c1C
Show InChI InChI=1S/C14H17N3O/c1-3-12-7-13(14(18)17-10(12)2)16-9-11-5-4-6-15-8-11/h4-8,16H,3,9H2,1-2H3,(H,17,18)
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n/an/a 3.00E+5n/an/an/an/a8.2n/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1353
PNG
(3-Aminopyridin-2(1H)-one analogue 73 | 3-[(naphtha...)
Show SMILES O=c1[nH]c2ccccc2cc1NCc1ccc2ccccc2c1
Show InChI InChI=1S/C20H16N2O/c23-20-19(12-17-7-3-4-8-18(17)22-20)21-13-14-9-10-15-5-1-2-6-16(15)11-14/h1-12,21H,13H2,(H,22,23)
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n/an/a>3.00E+5n/an/an/an/an/an/a



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Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 3792-802 (1992)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%