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PubMed code 12798334

Compile data set for download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129484
PNG
(CHEMBL308050 | N-(2-Amino-ethyl)-2-[(S)-2-{3-[1-(2...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1)C(=O)NCCN
Show InChI InChI=1S/C37H43Cl2F2N7O3S/c1-52-16-11-32(35(49)43-13-12-42)45-36(50)33(18-23-7-10-30(40)31(41)17-23)46-37(51)44-25-8-9-26-24(20-47-14-2-3-15-47)21-48(34(26)19-25)22-27-28(38)5-4-6-29(27)39/h4-10,17,19,21,32-33H,2-3,11-16,18,20,22,42H2,1H3,(H,43,49)(H,45,50)(H2,44,46,51)/t32-,33-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129486
PNG
((S)-N-[1-((S)-2-Amino-ethylcarbamoyl)-2-thiophen-2...)
Show SMILES NCCNC(=O)[C@H](Cc1cccs1)NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1
Show InChI InChI=1S/C39H41Cl2F2N7O3S/c40-30-6-3-7-31(41)29(30)23-50-22-25(21-49-14-1-2-15-49)28-10-9-26(19-36(28)50)46-39(53)48-34(18-24-8-11-32(42)33(43)17-24)38(52)47-35(37(51)45-13-12-44)20-27-5-4-16-54-27/h3-11,16-17,19,22,34-35H,1-2,12-15,18,20-21,23,44H2,(H,45,51)(H,47,52)(H2,46,48,53)/t34-,35-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129487
PNG
((S)-N-[1-((R)-2-Amino-ethylcarbamoyl)-2-methylsulf...)
Show SMILES CSC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1)C(=O)NCCN
Show InChI InChI=1S/C36H41Cl2F2N7O3S/c1-51-21-32(34(48)42-12-11-41)44-35(49)31(16-22-7-10-29(39)30(40)15-22)45-36(50)43-24-8-9-25-23(18-46-13-2-3-14-46)19-47(33(25)17-24)20-26-27(37)5-4-6-28(26)38/h4-10,15,17,19,31-32H,2-3,11-14,16,18,20-21,41H2,1H3,(H,42,48)(H,44,49)(H2,43,45,50)/t31-,32-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129478
PNG
(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Show SMILES NCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C40H48Cl2F2N8O3/c41-31-6-5-7-32(42)30(31)25-52-24-27(23-51-17-3-4-18-51)29-10-9-28(22-37(29)52)47-40(55)49-36(21-26-8-11-33(43)34(44)20-26)39(54)48-35(12-13-45)38(53)46-14-19-50-15-1-2-16-50/h5-11,20,22,24,35-36H,1-4,12-19,21,23,25,45H2,(H,46,53)(H,48,54)(H2,47,49,55)/t35-,36-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129488
PNG
((S)-N-[1-((S)-2-Amino-ethylcarbamoyl)-2-pyridin-4-...)
Show SMILES NCCNC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](Cc1ccccc1F)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1
Show InChI InChI=1S/C40H43Cl2FN8O3/c41-32-7-5-8-33(42)31(32)25-51-24-28(23-50-18-3-4-19-50)30-11-10-29(22-37(30)51)47-40(54)49-36(21-27-6-1-2-9-34(27)43)39(53)48-35(38(52)46-17-14-44)20-26-12-15-45-16-13-26/h1-2,5-13,15-16,22,24,35-36H,3-4,14,17-21,23,25,44H2,(H,46,52)(H,48,53)(H2,47,49,54)/t35-,36-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129495
PNG
(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Show SMILES CCNCCNC(=O)[C@H](CCN)NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1
Show InChI InChI=1S/C38H46Cl2F2N8O3/c1-2-44-14-15-45-36(51)33(12-13-43)47-37(52)34(19-24-8-11-31(41)32(42)18-24)48-38(53)46-26-9-10-27-25(21-49-16-3-4-17-49)22-50(35(27)20-26)23-28-29(39)6-5-7-30(28)40/h5-11,18,20,22,33-34,44H,2-4,12-17,19,21,23,43H2,1H3,(H,45,51)(H,47,52)(H2,46,48,53)/t33-,34-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129493
PNG
(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Show SMILES NCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C42H45Cl2F2N7O3/c43-33-9-6-10-34(44)32(33)26-53-25-29(24-52-19-4-5-20-52)31-13-12-30(23-39(31)53)49-42(56)51-38(22-28-11-14-35(45)36(46)21-28)41(55)50-37(15-17-47)40(54)48-18-16-27-7-2-1-3-8-27/h1-3,6-14,21,23,25,37-38H,4-5,15-20,22,24,26,47H2,(H,48,54)(H,50,55)(H2,49,51,56)/t37-,38-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129491
PNG
((S)-N-[1-((S)-3-Amino-propylcarbamoyl)-2-(1H-imida...)
Show SMILES NCCCNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1
Show InChI InChI=1S/C39H44Cl3N9O3/c40-27-9-7-25(8-10-27)17-34(38(53)48-35(18-29-20-44-24-46-29)37(52)45-14-4-13-43)49-39(54)47-28-11-12-30-26(21-50-15-1-2-16-50)22-51(36(30)19-28)23-31-32(41)5-3-6-33(31)42/h3,5-12,19-20,22,24,34-35H,1-2,4,13-18,21,23,43H2,(H,44,46)(H,45,52)(H,48,53)(H2,47,49,54)/t34-,35-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129489
PNG
(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Show SMILES NCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1)C(=O)NCc1ccco1
Show InChI InChI=1S/C39H41Cl2F2N7O4/c40-30-6-3-7-31(41)29(30)23-50-22-25(21-49-14-1-2-15-49)28-10-9-26(19-36(28)50)46-39(53)48-35(18-24-8-11-32(42)33(43)17-24)38(52)47-34(12-13-44)37(51)45-20-27-5-4-16-54-27/h3-11,16-17,19,22,34-35H,1-2,12-15,18,20-21,23,44H2,(H,45,51)(H,47,52)(H2,46,48,53)/t34-,35-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129490
PNG
(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Show SMILES NCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1)C(=O)NCc1cccs1
Show InChI InChI=1S/C39H41Cl2F2N7O3S/c40-30-6-3-7-31(41)29(30)23-50-22-25(21-49-14-1-2-15-49)28-10-9-26(19-36(28)50)46-39(53)48-35(18-24-8-11-32(42)33(43)17-24)38(52)47-34(12-13-44)37(51)45-20-27-5-4-16-54-27/h3-11,16-17,19,22,34-35H,1-2,12-15,18,20-21,23,44H2,(H,45,51)(H,47,52)(H2,46,48,53)/t34-,35-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129480
PNG
(5-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Show SMILES NCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C41H50Cl2F2N8O3/c42-32-7-5-8-33(43)31(32)26-53-25-28(24-52-18-3-4-19-52)30-12-11-29(23-38(30)53)48-41(56)50-37(22-27-10-13-34(44)35(45)21-27)40(55)49-36(9-6-14-46)39(54)47-15-20-51-16-1-2-17-51/h5,7-8,10-13,21,23,25,36-37H,1-4,6,9,14-20,22,24,26,46H2,(H,47,54)(H,49,55)(H2,48,50,56)/t36-,37-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129485
PNG
(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Show SMILES NCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1)C(=O)NCc1ccccn1
Show InChI InChI=1S/C40H42Cl2F2N8O3/c41-31-7-5-8-32(42)30(31)24-52-23-26(22-51-16-3-4-17-51)29-11-10-27(20-37(29)52)48-40(55)50-36(19-25-9-12-33(43)34(44)18-25)39(54)49-35(13-14-45)38(53)47-21-28-6-1-2-15-46-28/h1-2,5-12,15,18,20,23,35-36H,3-4,13-14,16-17,19,21-22,24,45H2,(H,47,53)(H,49,54)(H2,48,50,55)/t35-,36-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129492
PNG
(4-Amino-N-(3-amino-propyl)-2-((S)-3-(4-chloro-phen...)
Show SMILES NCCCNC(=O)[C@H](CCN)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1
Show InChI InChI=1S/C37H45Cl3N8O3/c38-26-9-7-24(8-10-26)19-33(36(50)45-32(13-15-42)35(49)43-16-4-14-41)46-37(51)44-27-11-12-28-25(21-47-17-1-2-18-47)22-48(34(28)20-27)23-29-30(39)5-3-6-31(29)40/h3,5-12,20,22,32-33H,1-2,4,13-19,21,23,41-42H2,(H,43,49)(H,45,50)(H2,44,46,51)/t32-,33-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129481
PNG
(4-Amino-N-benzyl-2-[(S)-2-{3-[1-(2,6-dichloro-benz...)
Show SMILES NCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C41H43Cl2F2N7O3/c42-32-9-6-10-33(43)31(32)25-52-24-28(23-51-17-4-5-18-51)30-13-12-29(21-38(30)52)48-41(55)50-37(20-27-11-14-34(44)35(45)19-27)40(54)49-36(15-16-46)39(53)47-22-26-7-2-1-3-8-26/h1-3,6-14,19,21,24,36-37H,4-5,15-18,20,22-23,25,46H2,(H,47,53)(H,49,54)(H2,48,50,55)/t36-,37-/m0/s1
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n/an/a 440n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129482
PNG
(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Show SMILES COc1ccc(CNC(=O)[C@H](CCN)NC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)Nc2ccc3c(CN4CCCC4)cn(Cc4c(Cl)cccc4Cl)c3c2)cc1
Show InChI InChI=1S/C42H45Cl2F2N7O4/c1-57-30-11-7-26(8-12-30)22-48-40(54)37(15-16-47)50-41(55)38(20-27-9-14-35(45)36(46)19-27)51-42(56)49-29-10-13-31-28(23-52-17-2-3-18-52)24-53(39(31)21-29)25-32-33(43)5-4-6-34(32)44/h4-14,19,21,24,37-38H,2-3,15-18,20,22-23,25,47H2,1H3,(H,48,54)(H,50,55)(H2,49,51,56)/t37-,38-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129479
PNG
(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Show SMILES NCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1)C(=O)NCCc1ccccn1
Show InChI InChI=1S/C41H44Cl2F2N8O3/c42-32-7-5-8-33(43)31(32)25-53-24-27(23-52-18-3-4-19-52)30-11-10-29(22-38(30)53)49-41(56)51-37(21-26-9-12-34(44)35(45)20-26)40(55)50-36(13-15-46)39(54)48-17-14-28-6-1-2-16-47-28/h1-2,5-12,16,20,22,24,36-37H,3-4,13-15,17-19,21,23,25,46H2,(H,48,54)(H,50,55)(H2,49,51,56)/t36-,37-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129483
PNG
(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Show SMILES NCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1cccc2n(Cc3c(Cl)cccc3Cl)cc(CN3CCCC3)c12)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C40H48Cl2F2N8O3/c41-29-7-5-8-30(42)28(29)25-52-24-27(23-51-18-3-4-19-51)37-33(9-6-10-36(37)52)48-40(55)49-35(22-26-11-12-31(43)32(44)21-26)39(54)47-34(13-14-45)38(53)46-15-20-50-16-1-2-17-50/h5-12,21,24,34-35H,1-4,13-20,22-23,25,45H2,(H,46,53)(H,47,54)(H2,48,49,55)/t34-,35-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50129494
PNG
(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Show SMILES NCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1cccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c12)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C40H48Cl2F2N8O3/c41-30-8-6-9-31(42)29(30)25-52-24-27(23-51-18-3-4-19-51)28-7-5-10-34(37(28)52)48-40(55)49-36(22-26-11-12-32(43)33(44)21-26)39(54)47-35(13-14-45)38(53)46-15-20-50-16-1-2-17-50/h5-12,21,24,35-36H,1-4,13-20,22-23,25,45H2,(H,46,53)(H,47,54)(H2,48,49,55)/t35-,36-/m0/s1
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cells


Bioorg Med Chem Lett 13: 2199-203 (2003)


Article DOI: 10.1016/s0960-894x(03)00325-1
BindingDB Entry DOI: 10.7270/Q2NS0T8Z
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%