BindingDB logo
myBDB logout

PubMed code 12824029

Compile data set for download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50130009
PNG
((4S,15R,18S,21S,24S)-5-((S)-2-Acetylamino-hexanoyl...)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O)C(N)=O
Show InChI InChI=1S/C49H69N13O9/c1-3-4-17-35(56-29(2)63)43(66)61-39-27-41(64)53-22-11-10-19-34(42(50)65)57-46(69)38(26-31-28-55-33-18-9-8-16-32(31)33)59-44(67)36(20-12-23-54-49(51)52)58-45(68)37(25-30-14-6-5-7-15-30)60-47(70)40-21-13-24-62(40)48(39)71/h5-9,14-16,18,28,34-40,55H,3-4,10-13,17,19-27H2,1-2H3,(H2,50,65)(H,53,64)(H,56,63)(H,57,69)(H,58,68)(H,59,67)(H,60,70)(H,61,66)(H4,51,52,54)/t34-,35+,36+,37+,38-,39+,40+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human melanocortin 4 receptor (hMC4R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor (M1 and M4)


(Homo sapiens (Human))
BDBM50130014
PNG
((R)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C34H47N7O3/c1-24(42)39-32(22-26-10-4-3-5-11-26)33(44)41(20-9-8-19-37-34(35)36)29-16-14-28(15-17-29)40(25(2)43)21-18-27-23-38-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,38H,8-9,14-22H2,1-2H3,(H,39,42)(H4,35,36,37)/t28?,29?,32-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.70n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular levels of cAMP in HEK 293 cells expressing human melanocortin 4 receptor (hMC4R)


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50130009
PNG
((4S,15R,18S,21S,24S)-5-((S)-2-Acetylamino-hexanoyl...)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O)C(N)=O
Show InChI InChI=1S/C49H69N13O9/c1-3-4-17-35(56-29(2)63)43(66)61-39-27-41(64)53-22-11-10-19-34(42(50)65)57-46(69)38(26-31-28-55-33-18-9-8-16-32(31)33)59-44(67)36(20-12-23-54-49(51)52)58-45(68)37(25-30-14-6-5-7-15-30)60-47(70)40-21-13-24-62(40)48(39)71/h5-9,14-16,18,28,34-40,55H,3-4,10-13,17,19-27H2,1-2H3,(H2,50,65)(H,53,64)(H,56,63)(H,57,69)(H,58,68)(H,59,67)(H,60,70)(H,61,66)(H4,51,52,54)/t34-,35+,36+,37+,38-,39+,40+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50130014
PNG
((R)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C34H47N7O3/c1-24(42)39-32(22-26-10-4-3-5-11-26)33(44)41(20-9-8-19-37-34(35)36)29-16-14-28(15-17-29)40(25(2)43)21-18-27-23-38-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,38H,8-9,14-22H2,1-2H3,(H,39,42)(H4,35,36,37)/t28?,29?,32-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 51n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards mouse Melanocortin 1 receptor (mMC1R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor (M3 and M4)


(Homo sapiens (Human))
BDBM50130014
PNG
((R)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C34H47N7O3/c1-24(42)39-32(22-26-10-4-3-5-11-26)33(44)41(20-9-8-19-37-34(35)36)29-16-14-28(15-17-29)40(25(2)43)21-18-27-23-38-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,38H,8-9,14-22H2,1-2H3,(H,39,42)(H4,35,36,37)/t28?,29?,32-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 280n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50130014
PNG
((R)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C34H47N7O3/c1-24(42)39-32(22-26-10-4-3-5-11-26)33(44)41(20-9-8-19-37-34(35)36)29-16-14-28(15-17-29)40(25(2)43)21-18-27-23-38-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,38H,8-9,14-22H2,1-2H3,(H,39,42)(H4,35,36,37)/t28?,29?,32-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human melanocortin 4 receptor (hMC4R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor (M1 and M4)


(Homo sapiens (Human))
BDBM50130014
PNG
((R)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C34H47N7O3/c1-24(42)39-32(22-26-10-4-3-5-11-26)33(44)41(20-9-8-19-37-34(35)36)29-16-14-28(15-17-29)40(25(2)43)21-18-27-23-38-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,38H,8-9,14-22H2,1-2H3,(H,39,42)(H4,35,36,37)/t28?,29?,32-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.50E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular levels of cAMP in HEK 293 cells expressing human melanocortin 4 receptor (hMC4R)


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50130013
PNG
((S)-2-Acetylamino-N-[4-(acetyl-methyl-amino)-cyclo...)
Show SMILES CN(C1CCC(CC1)N(CCCCNC(N)=N)C(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)=O
Show InChI InChI=1S/C25H40N6O3/c1-18(32)29-23(17-20-9-5-4-6-10-20)24(34)31(16-8-7-15-28-25(26)27)22-13-11-21(12-14-22)30(3)19(2)33/h4-6,9-10,21-23H,7-8,11-17H2,1-3H3,(H,29,32)(H4,26,27,28)/t21?,22?,23-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards mouse Melanocortin 1 receptor (mMC1R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50130011
PNG
((S)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCCN)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C33H45N5O3/c1-24(39)36-32(22-26-10-4-3-5-11-26)33(41)38(20-9-8-19-34)29-16-14-28(15-17-29)37(25(2)40)21-18-27-23-35-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,35H,8-9,14-22,34H2,1-2H3,(H,36,39)/t28?,29?,32-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.25E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human melanocortin 4 receptor (hMC4R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50130012
PNG
(CHEMBL75185 | N-{4-[Acetyl-(4-guanidino-butyl)-ami...)
Show SMILES CC(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C25H38N6O2/c1-18(32)30(15-6-5-14-28-25(26)27)21-9-11-22(12-10-21)31(19(2)33)16-13-20-17-29-24-8-4-3-7-23(20)24/h3-4,7-8,17,21-22,29H,5-6,9-16H2,1-2H3,(H4,26,27,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards mouse Melanocortin 1 receptor (mMC1R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50130011
PNG
((S)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCCN)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C33H45N5O3/c1-24(39)36-32(22-26-10-4-3-5-11-26)33(41)38(20-9-8-19-34)29-16-14-28(15-17-29)37(25(2)40)21-18-27-23-35-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,35H,8-9,14-22,34H2,1-2H3,(H,36,39)/t28?,29?,32-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards mouse Melanocortin 1 receptor (mMC1R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50130011
PNG
((S)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCCN)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C33H45N5O3/c1-24(39)36-32(22-26-10-4-3-5-11-26)33(41)38(20-9-8-19-34)29-16-14-28(15-17-29)37(25(2)40)21-18-27-23-35-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,35H,8-9,14-22,34H2,1-2H3,(H,36,39)/t28?,29?,32-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50130014
PNG
((R)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C34H47N7O3/c1-24(42)39-32(22-26-10-4-3-5-11-26)33(44)41(20-9-8-19-37-34(35)36)29-16-14-28(15-17-29)40(25(2)43)21-18-27-23-38-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,38H,8-9,14-22H2,1-2H3,(H,39,42)(H4,35,36,37)/t28?,29?,32-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50130012
PNG
(CHEMBL75185 | N-{4-[Acetyl-(4-guanidino-butyl)-ami...)
Show SMILES CC(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C25H38N6O2/c1-18(32)30(15-6-5-14-28-25(26)27)21-9-11-22(12-10-21)31(19(2)33)16-13-20-17-29-24-8-4-3-7-23(20)24/h3-4,7-8,17,21-22,29H,5-6,9-16H2,1-2H3,(H4,26,27,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human melanocortin 4 receptor (hMC4R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50130013
PNG
((S)-2-Acetylamino-N-[4-(acetyl-methyl-amino)-cyclo...)
Show SMILES CN(C1CCC(CC1)N(CCCCNC(N)=N)C(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)=O
Show InChI InChI=1S/C25H40N6O3/c1-18(32)29-23(17-20-9-5-4-6-10-20)24(34)31(16-8-7-15-28-25(26)27)22-13-11-21(12-14-22)30(3)19(2)33/h4-6,9-10,21-23H,7-8,11-17H2,1-3H3,(H,29,32)(H4,26,27,28)/t21?,22?,23-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human melanocortin 4 receptor (hMC4R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50130014
PNG
((R)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C34H47N7O3/c1-24(42)39-32(22-26-10-4-3-5-11-26)33(44)41(20-9-8-19-37-34(35)36)29-16-14-28(15-17-29)40(25(2)43)21-18-27-23-38-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,38H,8-9,14-22H2,1-2H3,(H,39,42)(H4,35,36,37)/t28?,29?,32-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards mouse Melanocortin 1 receptor (mMC1R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50130012
PNG
(CHEMBL75185 | N-{4-[Acetyl-(4-guanidino-butyl)-ami...)
Show SMILES CC(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C25H38N6O2/c1-18(32)30(15-6-5-14-28-25(26)27)21-9-11-22(12-10-21)31(19(2)33)16-13-20-17-29-24-8-4-3-7-23(20)24/h3-4,7-8,17,21-22,29H,5-6,9-16H2,1-2H3,(H4,26,27,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50130013
PNG
((S)-2-Acetylamino-N-[4-(acetyl-methyl-amino)-cyclo...)
Show SMILES CN(C1CCC(CC1)N(CCCCNC(N)=N)C(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)=O
Show InChI InChI=1S/C25H40N6O3/c1-18(32)29-23(17-20-9-5-4-6-10-20)24(34)31(16-8-7-15-28-25(26)27)22-13-11-21(12-14-22)30(3)19(2)33/h4-6,9-10,21-23H,7-8,11-17H2,1-3H3,(H,29,32)(H4,26,27,28)/t21?,22?,23-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligand


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor (M1 and M4)


(Homo sapiens (Human))
BDBM50130014
PNG
((R)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C34H47N7O3/c1-24(42)39-32(22-26-10-4-3-5-11-26)33(44)41(20-9-8-19-37-34(35)36)29-16-14-28(15-17-29)40(25(2)43)21-18-27-23-38-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,38H,8-9,14-22H2,1-2H3,(H,39,42)(H4,35,36,37)/t28?,29?,32-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 680n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular levels of cAMP in HEK 293 cells expressing human melanocortin 4 receptor (hMC4R)


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor (M1 and M4)


(Homo sapiens (Human))
BDBM50130009
PNG
((4S,15R,18S,21S,24S)-5-((S)-2-Acetylamino-hexanoyl...)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O)C(N)=O
Show InChI InChI=1S/C49H69N13O9/c1-3-4-17-35(56-29(2)63)43(66)61-39-27-41(64)53-22-11-10-19-34(42(50)65)57-46(69)38(26-31-28-55-33-18-9-8-16-32(31)33)59-44(67)36(20-12-23-54-49(51)52)58-45(68)37(25-30-14-6-5-7-15-30)60-47(70)40-21-13-24-62(40)48(39)71/h5-9,14-16,18,28,34-40,55H,3-4,10-13,17,19-27H2,1-2H3,(H2,50,65)(H,53,64)(H,56,63)(H,57,69)(H,58,68)(H,59,67)(H,60,70)(H,61,66)(H4,51,52,54)/t34-,35+,36+,37+,38-,39+,40+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.170n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular levels of cAMP in HEK 293 cells expressing human melanocortin 4 receptor (hMC4R)


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
Melanocortin receptor (M1 and M4)


(Homo sapiens (Human))
BDBM50130014
PNG
((R)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O
Show InChI InChI=1S/C34H47N7O3/c1-24(42)39-32(22-26-10-4-3-5-11-26)33(44)41(20-9-8-19-37-34(35)36)29-16-14-28(15-17-29)40(25(2)43)21-18-27-23-38-31-13-7-6-12-30(27)31/h3-7,10-13,23,28-29,32,38H,8-9,14-22H2,1-2H3,(H,39,42)(H4,35,36,37)/t28?,29?,32-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Intracellular levels of cAMP in HEK 293 cells expressing human melanocortin 4 receptor (hMC4R)


Bioorg Med Chem Lett 13: 2337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00412-8
BindingDB Entry DOI: 10.7270/Q21G0MTZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%