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PubMed code 12824047

Compile data set for download or QSAR
Found 99 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130245
PNG
(6,8-Dichloro-7-cyclopropylmethoxy-9H-beta-carbolin...)
Show SMILES Clc1cc2c(nc3c[nH]ccc23)c(Cl)c1OCC1CC1
Show InChI InChI=1S/C15H12Cl2N2O/c16-11-5-10-9-3-4-18-6-12(9)19-14(10)13(17)15(11)20-7-8-1-2-8/h3-6,8,18H,1-2,7H2
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n/an/a 80n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130248
PNG
(CHEMBL79004 | N-(6-Chloro-9H-beta-carbolin-8-yl)-n...)
Show SMILES Clc1cc(NC(=O)c2cccnc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)
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n/an/a 100n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130221
PNG
(6,8-Dichloro-7-ethoxy-9H-beta-carboline | CHEMBL81...)
Show SMILES CCOc1c(Cl)cc2c(nc3c[nH]ccc23)c1Cl
Show InChI InChI=1S/C13H10Cl2N2O/c1-2-18-13-9(14)5-8-7-3-4-16-6-10(7)17-12(8)11(13)15/h3-6,16H,2H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130224
PNG
(6,8-Dichloro-7-methoxy-9H-beta-carboline | CHEMBL3...)
Show SMILES COc1c(Cl)cc2c3cc[nH]cc3nc2c1Cl
Show InChI InChI=1S/C12H8Cl2N2O/c1-17-12-8(13)4-7-6-2-3-15-5-9(6)16-11(7)10(12)14/h2-5,15H,1H3
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n/an/a 170n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130238
PNG
(6,8-Dichloro-9H-beta-carboline | CHEMBL78464)
Show SMILES Clc1cc(Cl)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C11H6Cl2N2/c12-6-3-8-7-1-2-14-5-10(7)15-11(8)9(13)4-6/h1-5,15H
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n/an/a 200n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130246
PNG
(CHEMBL80843 | N-(6-Chloro-9H-beta-carbolin-8-yl)-i...)
Show SMILES Clc1cc(NC(=O)c2ccncc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H11ClN4O/c18-11-7-13-12-3-6-20-9-15(12)21-16(13)14(8-11)22-17(23)10-1-4-19-5-2-10/h1-9,21H,(H,22,23)
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n/an/a 300n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130243
PNG
(CHEMBL80121 | N-(6-Chloro-9H-beta-carbolin-8-yl)-a...)
Show SMILES CC(=O)Nc1cc(Cl)cc2c1nc1c[nH]ccc21
Show InChI InChI=1S/C13H10ClN3O/c1-7(18)16-11-5-8(14)4-10-9-2-3-15-6-12(9)17-13(10)11/h2-6,15H,1H3,(H,16,18)
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n/an/a 600n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130235
PNG
(6-Bromo-9H-beta-carboline | CHEMBL81169)
Show SMILES Brc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C11H7BrN2/c12-7-1-2-10-9(5-7)8-3-4-13-6-11(8)14-10/h1-6,14H
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n/an/a 600n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130225
PNG
(CHEMBL310179 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)
Show SMILES COc1cccc(c1)C(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C19H14ClN3O2/c1-25-13-4-2-3-11(7-13)19(24)23-16-9-12(20)8-15-14-5-6-21-10-17(14)22-18(15)16/h2-10,21H,1H3,(H,23,24)
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n/an/a 600n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130247
PNG
(6-Chloro-9H-beta-carboline | CHEMBL311201)
Show SMILES Clc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C11H7ClN2/c12-7-1-2-10-9(5-7)8-3-4-13-6-11(8)14-10/h1-6,14H
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n/an/a 600n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130222
PNG
((6-Chloro-9H-beta-carbolin-8-yl)-carbamic acid met...)
Show SMILES COC(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C13H10ClN3O2/c1-19-13(18)17-10-5-7(14)4-9-8-2-3-15-6-11(8)16-12(9)10/h2-6,15H,1H3,(H,17,18)
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n/an/a 700n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130230
PNG
(CHEMBL78862 | N-(6-Chloro-9H-beta-carbolin-8-yl)-b...)
Show SMILES Clc1cc(NC(=O)c2ccccc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C18H12ClN3O/c19-12-8-14-13-6-7-20-10-16(13)21-17(14)15(9-12)22-18(23)11-4-2-1-3-5-11/h1-10,21H,(H,22,23)
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n/an/a 700n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130233
PNG
(5-Bromo-6-methoxy-9H-beta-carboline | CHEMBL310975)
Show SMILES COc1ccc2[nH]c3cnccc3c2c1Br
Show InChI InChI=1S/C12H9BrN2O/c1-16-10-3-2-8-11(12(10)13)7-4-5-14-6-9(7)15-8/h2-6,15H,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130223
PNG
(CHEMBL78917 | Pyridine-2-carboxylic acid (6-chloro...)
Show SMILES Clc1cc(NC(=O)c2ccccn2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H11ClN4O/c18-10-7-12-11-4-6-19-9-15(11)21-16(12)14(8-10)22-17(23)13-3-1-2-5-20-13/h1-9,21H,(H,22,23)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130250
PNG
(6-Trifluoromethyl-9H-beta-carboline | CHEMBL78618)
Show SMILES FC(F)(F)c1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C12H7F3N2/c13-12(14,15)7-1-2-10-9(5-7)8-3-4-16-6-11(8)17-10/h1-6,17H
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n/an/a 1.10E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130218
PNG
(9H-beta-Carboline-6-carbonitrile | CHEMBL81214)
Show SMILES N#Cc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C12H7N3/c13-6-8-1-2-11-10(5-8)9-3-4-14-7-12(9)15-11/h1-5,7,15H
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n/an/a 1.10E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130227
PNG
(6-Chloro-9H-beta-carbolin-8-ylamine | CHEMBL81781)
Show SMILES Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C11H8ClN3/c12-6-3-8-7-1-2-14-5-10(7)15-11(8)9(13)4-6/h1-5,14H,13H2
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n/an/a 1.30E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130236
PNG
(CHEMBL78885 | N-(6-Chloro-9H-beta-carbolin-8-yl)-4...)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C19H14ClN3O2/c1-25-13-4-2-11(3-5-13)19(24)23-16-9-12(20)8-15-14-6-7-21-10-17(14)22-18(15)16/h2-10,21H,1H3,(H,23,24)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130237
PNG
((6-Chloro-9H-beta-carbolin-8-yl)-dimethyl-amine | ...)
Show SMILES CN(C)c1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C13H12ClN3/c1-17(2)12-6-8(14)5-10-9-3-4-15-7-11(9)16-13(10)12/h3-7,15H,1-2H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130249
PNG
((6-Chloro-9H-beta-carbolin-8-yl)-methyl-amine | CH...)
Show SMILES CNc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C12H10ClN3/c1-14-10-5-7(13)4-9-8-2-3-15-6-11(8)16-12(9)10/h2-6,14-15H,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130232
PNG
(6-Fluoro-9H-beta-carboline | CHEMBL81170)
Show SMILES Fc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C11H7FN2/c12-7-1-2-10-9(5-7)8-3-4-13-6-11(8)14-10/h1-6,14H
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n/an/a 2.00E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130228
PNG
(6,8-Dichloro-7-cyclohexylmethoxy-9H-beta-carboline...)
Show SMILES Clc1cc2c(nc3c[nH]ccc23)c(Cl)c1OCC1CCCCC1
Show InChI InChI=1S/C18H18Cl2N2O/c19-14-8-13-12-6-7-21-9-15(12)22-17(13)16(20)18(14)23-10-11-4-2-1-3-5-11/h6-9,11,21H,1-5,10H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130229
PNG
(CHEMBL82136 | N-(6-Chloro-9H-beta-carbolin-8-yl)-2...)
Show SMILES Clc1cc(NC(=O)Cc2ccccn2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C18H13ClN4O/c19-11-7-14-13-4-6-20-10-16(13)23-18(14)15(8-11)22-17(24)9-12-3-1-2-5-21-12/h1-8,10,23H,9H2,(H,22,24)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130219
PNG
(CHEMBL81809 | Morpholine-4-carboxylic acid 6,8-dic...)
Show SMILES Clc1cc2c3cc[nH]cc3nc2c(Cl)c1OC(=O)N1CCOCC1
Show InChI InChI=1S/C16H13Cl2N3O3/c17-11-7-10-9-1-2-19-8-12(9)20-14(10)13(18)15(11)24-16(22)21-3-5-23-6-4-21/h1-2,7-8,19H,3-6H2
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n/an/a 3.20E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130244
PNG
(6-Methoxy-9H-beta-carboline | 6-methoxy-9H-pyrido[...)
Show SMILES COc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C12H10N2O/c1-15-8-2-3-11-10(6-8)9-4-5-13-7-12(9)14-11/h2-7,14H,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130241
PNG
(6-Chloro-8-nitro-9H-beta-carboline | CHEMBL81838)
Show SMILES [O-][N+](=O)c1cc(Cl)cc2c1[nH]c1cnccc21
Show InChI InChI=1S/C11H6ClN3O2/c12-6-3-8-7-1-2-13-5-9(7)14-11(8)10(4-6)15(16)17/h1-5,14H
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n/an/a 4.00E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130217
PNG
(CHEMBL312676 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)
Show SMILES CS(=O)(=O)Nc1cc(Cl)cc2c1nc1c[nH]ccc21
Show InChI InChI=1S/C12H10ClN3O2S/c1-19(17,18)16-10-5-7(13)4-9-8-2-3-14-6-11(8)15-12(9)10/h2-6,14,16H,1H3
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n/an/a 8.30E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130240
PNG
(6,8-Dichloro-9H-beta-carbolin-7-ol | CHEMBL309953)
Show SMILES Oc1c(Cl)cc2c3cc[nH]cc3nc2c1Cl
Show InChI InChI=1S/C11H6Cl2N2O/c12-7-3-6-5-1-2-14-4-8(5)15-10(6)9(13)11(7)16/h1-4,14,16H
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n/an/a 1.10E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50013811
PNG
(9H-beta-Carboline | 9H-pyrido[3,4-b]indole | CHEMB...)
Show SMILES c1ccc2c(c1)[nH]c1cnccc21
Show InChI InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
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n/an/a 1.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130233
PNG
(5-Bromo-6-methoxy-9H-beta-carboline | CHEMBL310975)
Show SMILES COc1ccc2[nH]c3cnccc3c2c1Br
Show InChI InChI=1S/C12H9BrN2O/c1-16-10-3-2-8-11(12(10)13)7-4-5-14-6-9(7)15-8/h2-6,15H,1H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130231
PNG
(CHEMBL311306 | Morpholine-4-carboxylic acid (6-chl...)
Show SMILES Clc1cc(NC(=O)N2CCOCC2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C16H15ClN4O2/c17-10-7-12-11-1-2-18-9-14(11)19-15(12)13(8-10)20-16(22)21-3-5-23-6-4-21/h1-2,7-9,19H,3-6H2,(H,20,22)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130242
PNG
(CHEMBL82137 | N-(6-Chloro-9H-beta-carbolin-8-yl)-4...)
Show SMILES OCCCC(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C15H14ClN3O2/c16-9-6-11-10-3-4-17-8-13(10)19-15(11)12(7-9)18-14(21)2-1-5-20/h3-4,6-8,17,20H,1-2,5H2,(H,18,21)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130220
PNG
(Benzyl-(6-chloro-9H-beta-carbolin-8-yl)-amine | CH...)
Show SMILES Clc1cc(NCc2ccccc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C18H14ClN3/c19-13-8-15-14-6-7-20-11-17(14)22-18(15)16(9-13)21-10-12-4-2-1-3-5-12/h1-9,11,21-22H,10H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130226
PNG
(CHEMBL309265 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)
Show SMILES Clc1cc(NS(=O)(=O)c2ccccc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H12ClN3O2S/c18-11-8-14-13-6-7-19-10-16(13)20-17(14)15(9-11)21-24(22,23)12-4-2-1-3-5-12/h1-10,20-21H
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n/an/a>2.00E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130239
PNG
(CHEMBL312648 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)
Show SMILES COc1ccccc1C(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C19H14ClN3O2/c1-25-17-5-3-2-4-13(17)19(24)23-15-9-11(20)8-14-12-6-7-21-10-16(12)22-18(14)15/h2-10,21H,1H3,(H,23,24)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130234
PNG
(1-(6-Chloro-9H-beta-carbolin-8-yl)-3-methyl-urea |...)
Show SMILES CNC(=O)Nc1cc(Cl)cc2c1nc1c[nH]ccc21
Show InChI InChI=1S/C13H11ClN4O/c1-15-13(19)18-10-5-7(14)4-9-8-2-3-16-6-11(8)17-12(9)10/h2-6,16H,1H3,(H2,15,18,19)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130239
PNG
(CHEMBL312648 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)
Show SMILES COc1ccccc1C(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C19H14ClN3O2/c1-25-17-5-3-2-4-13(17)19(24)23-15-9-11(20)8-14-12-6-7-21-10-16(12)22-18(14)15/h2-10,21H,1H3,(H,23,24)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130236
PNG
(CHEMBL78885 | N-(6-Chloro-9H-beta-carbolin-8-yl)-4...)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C19H14ClN3O2/c1-25-13-4-2-11(3-5-13)19(24)23-16-9-12(20)8-15-14-6-7-21-10-17(14)22-18(15)16/h2-10,21H,1H3,(H,23,24)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130230
PNG
(CHEMBL78862 | N-(6-Chloro-9H-beta-carbolin-8-yl)-b...)
Show SMILES Clc1cc(NC(=O)c2ccccc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C18H12ClN3O/c19-12-8-14-13-6-7-20-10-16(13)21-17(14)15(9-12)22-18(23)11-4-2-1-3-5-11/h1-10,21H,(H,22,23)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130235
PNG
(6-Bromo-9H-beta-carboline | CHEMBL81169)
Show SMILES Brc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C11H7BrN2/c12-7-1-2-10-9(5-7)8-3-4-13-6-11(8)14-10/h1-6,14H
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130229
PNG
(CHEMBL82136 | N-(6-Chloro-9H-beta-carbolin-8-yl)-2...)
Show SMILES Clc1cc(NC(=O)Cc2ccccn2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C18H13ClN4O/c19-11-7-14-13-4-6-20-10-16(13)23-18(14)15(8-11)22-17(24)9-12-3-1-2-5-21-12/h1-8,10,23H,9H2,(H,22,24)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130226
PNG
(CHEMBL309265 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)
Show SMILES Clc1cc(NS(=O)(=O)c2ccccc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H12ClN3O2S/c18-11-8-14-13-6-7-19-10-16(13)20-17(14)15(9-11)21-24(22,23)12-4-2-1-3-5-12/h1-10,20-21H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130250
PNG
(6-Trifluoromethyl-9H-beta-carboline | CHEMBL78618)
Show SMILES FC(F)(F)c1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C12H7F3N2/c13-12(14,15)7-1-2-10-9(5-7)8-3-4-16-6-11(8)17-10/h1-6,17H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130242
PNG
(CHEMBL82137 | N-(6-Chloro-9H-beta-carbolin-8-yl)-4...)
Show SMILES OCCCC(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C15H14ClN3O2/c16-9-6-11-10-3-4-17-8-13(10)19-15(11)12(7-9)18-14(21)2-1-5-20/h3-4,6-8,17,20H,1-2,5H2,(H,18,21)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130228
PNG
(6,8-Dichloro-7-cyclohexylmethoxy-9H-beta-carboline...)
Show SMILES Clc1cc2c(nc3c[nH]ccc23)c(Cl)c1OCC1CCCCC1
Show InChI InChI=1S/C18H18Cl2N2O/c19-14-8-13-12-6-7-21-9-15(12)22-17(13)16(20)18(14)23-10-11-4-2-1-3-5-11/h6-9,11,21H,1-5,10H2
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130243
PNG
(CHEMBL80121 | N-(6-Chloro-9H-beta-carbolin-8-yl)-a...)
Show SMILES CC(=O)Nc1cc(Cl)cc2c1nc1c[nH]ccc21
Show InChI InChI=1S/C13H10ClN3O/c1-7(18)16-11-5-8(14)4-10-9-2-3-15-6-12(9)17-13(10)11/h2-6,15H,1H3,(H,16,18)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130248
PNG
(CHEMBL79004 | N-(6-Chloro-9H-beta-carbolin-8-yl)-n...)
Show SMILES Clc1cc(NC(=O)c2cccnc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130229
PNG
(CHEMBL82136 | N-(6-Chloro-9H-beta-carbolin-8-yl)-2...)
Show SMILES Clc1cc(NC(=O)Cc2ccccn2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C18H13ClN4O/c19-11-7-14-13-4-6-20-10-16(13)23-18(14)15(8-11)22-17(24)9-12-3-1-2-5-21-12/h1-8,10,23H,9H2,(H,22,24)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130238
PNG
(6,8-Dichloro-9H-beta-carboline | CHEMBL78464)
Show SMILES Clc1cc(Cl)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C11H6Cl2N2/c12-6-3-8-7-1-2-14-5-10(7)15-11(8)9(13)4-6/h1-5,15H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130235
PNG
(6-Bromo-9H-beta-carboline | CHEMBL81169)
Show SMILES Brc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C11H7BrN2/c12-7-1-2-10-9(5-7)8-3-4-13-6-11(8)14-10/h1-6,14H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130248
PNG
(CHEMBL79004 | N-(6-Chloro-9H-beta-carbolin-8-yl)-n...)
Show SMILES Clc1cc(NC(=O)c2cccnc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130231
PNG
(CHEMBL311306 | Morpholine-4-carboxylic acid (6-chl...)
Show SMILES Clc1cc(NC(=O)N2CCOCC2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C16H15ClN4O2/c17-10-7-12-11-1-2-18-9-14(11)19-15(12)13(8-10)20-16(22)21-3-5-23-6-4-21/h1-2,7-9,19H,3-6H2,(H,20,22)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130219
PNG
(CHEMBL81809 | Morpholine-4-carboxylic acid 6,8-dic...)
Show SMILES Clc1cc2c3cc[nH]cc3nc2c(Cl)c1OC(=O)N1CCOCC1
Show InChI InChI=1S/C16H13Cl2N3O3/c17-11-7-10-9-1-2-19-8-12(9)20-14(10)13(18)15(11)24-16(22)21-3-5-23-6-4-21/h1-2,7-8,19H,3-6H2
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50013811
PNG
(9H-beta-Carboline | 9H-pyrido[3,4-b]indole | CHEMB...)
Show SMILES c1ccc2c(c1)[nH]c1cnccc21
Show InChI InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130238
PNG
(6,8-Dichloro-9H-beta-carboline | CHEMBL78464)
Show SMILES Clc1cc(Cl)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C11H6Cl2N2/c12-6-3-8-7-1-2-14-5-10(7)15-11(8)9(13)4-6/h1-5,15H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130234
PNG
(1-(6-Chloro-9H-beta-carbolin-8-yl)-3-methyl-urea |...)
Show SMILES CNC(=O)Nc1cc(Cl)cc2c1nc1c[nH]ccc21
Show InChI InChI=1S/C13H11ClN4O/c1-15-13(19)18-10-5-7(14)4-9-8-2-3-16-6-11(8)17-12(9)10/h2-6,16H,1H3,(H2,15,18,19)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130225
PNG
(CHEMBL310179 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)
Show SMILES COc1cccc(c1)C(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C19H14ClN3O2/c1-25-13-4-2-3-11(7-13)19(24)23-16-9-12(20)8-15-14-5-6-21-10-17(14)22-18(15)16/h2-10,21H,1H3,(H,23,24)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130246
PNG
(CHEMBL80843 | N-(6-Chloro-9H-beta-carbolin-8-yl)-i...)
Show SMILES Clc1cc(NC(=O)c2ccncc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H11ClN4O/c18-11-7-13-12-3-6-20-9-15(12)21-16(13)14(8-11)22-17(23)10-1-4-19-5-2-10/h1-9,21H,(H,22,23)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130222
PNG
((6-Chloro-9H-beta-carbolin-8-yl)-carbamic acid met...)
Show SMILES COC(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C13H10ClN3O2/c1-19-13(18)17-10-5-7(14)4-9-8-2-3-15-6-11(8)16-12(9)10/h2-6,15H,1H3,(H,17,18)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130250
PNG
(6-Trifluoromethyl-9H-beta-carboline | CHEMBL78618)
Show SMILES FC(F)(F)c1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C12H7F3N2/c13-12(14,15)7-1-2-10-9(5-7)8-3-4-16-6-11(8)17-10/h1-6,17H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130246
PNG
(CHEMBL80843 | N-(6-Chloro-9H-beta-carbolin-8-yl)-i...)
Show SMILES Clc1cc(NC(=O)c2ccncc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H11ClN4O/c18-11-7-13-12-3-6-20-9-15(12)21-16(13)14(8-11)22-17(23)10-1-4-19-5-2-10/h1-9,21H,(H,22,23)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130244
PNG
(6-Methoxy-9H-beta-carboline | 6-methoxy-9H-pyrido[...)
Show SMILES COc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C12H10N2O/c1-15-8-2-3-11-10(6-8)9-4-5-13-7-12(9)14-11/h2-7,14H,1H3
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130239
PNG
(CHEMBL312648 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)
Show SMILES COc1ccccc1C(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C19H14ClN3O2/c1-25-17-5-3-2-4-13(17)19(24)23-15-9-11(20)8-14-12-6-7-21-10-16(12)22-18(14)15/h2-10,21H,1H3,(H,23,24)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130241
PNG
(6-Chloro-8-nitro-9H-beta-carboline | CHEMBL81838)
Show SMILES [O-][N+](=O)c1cc(Cl)cc2c1[nH]c1cnccc21
Show InChI InChI=1S/C11H6ClN3O2/c12-6-3-8-7-1-2-13-5-9(7)14-11(8)10(4-6)15(16)17/h1-5,14H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130232
PNG
(6-Fluoro-9H-beta-carboline | CHEMBL81170)
Show SMILES Fc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C11H7FN2/c12-7-1-2-10-9(5-7)8-3-4-13-6-11(8)14-10/h1-6,14H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130242
PNG
(CHEMBL82137 | N-(6-Chloro-9H-beta-carbolin-8-yl)-4...)
Show SMILES OCCCC(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C15H14ClN3O2/c16-9-6-11-10-3-4-17-8-13(10)19-15(11)12(7-9)18-14(21)2-1-5-20/h3-4,6-8,17,20H,1-2,5H2,(H,18,21)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130218
PNG
(9H-beta-Carboline-6-carbonitrile | CHEMBL81214)
Show SMILES N#Cc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C12H7N3/c13-6-8-1-2-11-10(5-8)9-3-4-14-7-12(9)15-11/h1-5,7,15H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130217
PNG
(CHEMBL312676 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)
Show SMILES CS(=O)(=O)Nc1cc(Cl)cc2c1nc1c[nH]ccc21
Show InChI InChI=1S/C12H10ClN3O2S/c1-19(17,18)16-10-5-7(13)4-9-8-2-3-14-6-11(8)15-12(9)10/h2-6,14,16H,1H3
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130230
PNG
(CHEMBL78862 | N-(6-Chloro-9H-beta-carbolin-8-yl)-b...)
Show SMILES Clc1cc(NC(=O)c2ccccc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C18H12ClN3O/c19-12-8-14-13-6-7-20-10-16(13)21-17(14)15(9-12)22-18(23)11-4-2-1-3-5-11/h1-10,21H,(H,22,23)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130241
PNG
(6-Chloro-8-nitro-9H-beta-carboline | CHEMBL81838)
Show SMILES [O-][N+](=O)c1cc(Cl)cc2c1[nH]c1cnccc21
Show InChI InChI=1S/C11H6ClN3O2/c12-6-3-8-7-1-2-13-5-9(7)14-11(8)10(4-6)15(16)17/h1-5,14H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130245
PNG
(6,8-Dichloro-7-cyclopropylmethoxy-9H-beta-carbolin...)
Show SMILES Clc1cc2c(nc3c[nH]ccc23)c(Cl)c1OCC1CC1
Show InChI InChI=1S/C15H12Cl2N2O/c16-11-5-10-9-3-4-18-6-12(9)19-14(10)13(17)15(11)20-7-8-1-2-8/h3-6,8,18H,1-2,7H2
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130228
PNG
(6,8-Dichloro-7-cyclohexylmethoxy-9H-beta-carboline...)
Show SMILES Clc1cc2c(nc3c[nH]ccc23)c(Cl)c1OCC1CCCCC1
Show InChI InChI=1S/C18H18Cl2N2O/c19-14-8-13-12-6-7-21-9-15(12)22-17(13)16(20)18(14)23-10-11-4-2-1-3-5-11/h6-9,11,21H,1-5,10H2
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130247
PNG
(6-Chloro-9H-beta-carboline | CHEMBL311201)
Show SMILES Clc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C11H7ClN2/c12-7-1-2-10-9(5-7)8-3-4-13-6-11(8)14-10/h1-6,14H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130236
PNG
(CHEMBL78885 | N-(6-Chloro-9H-beta-carbolin-8-yl)-4...)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C19H14ClN3O2/c1-25-13-4-2-11(3-5-13)19(24)23-16-9-12(20)8-15-14-6-7-21-10-17(14)22-18(15)16/h2-10,21H,1H3,(H,23,24)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130220
PNG
(Benzyl-(6-chloro-9H-beta-carbolin-8-yl)-amine | CH...)
Show SMILES Clc1cc(NCc2ccccc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C18H14ClN3/c19-13-8-15-14-6-7-20-11-17(14)22-18(15)16(9-13)21-10-12-4-2-1-3-5-12/h1-9,11,21-22H,10H2
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130222
PNG
((6-Chloro-9H-beta-carbolin-8-yl)-carbamic acid met...)
Show SMILES COC(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C13H10ClN3O2/c1-19-13(18)17-10-5-7(14)4-9-8-2-3-15-6-11(8)16-12(9)10/h2-6,15H,1H3,(H,17,18)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130224
PNG
(6,8-Dichloro-7-methoxy-9H-beta-carboline | CHEMBL3...)
Show SMILES COc1c(Cl)cc2c3cc[nH]cc3nc2c1Cl
Show InChI InChI=1S/C12H8Cl2N2O/c1-17-12-8(13)4-7-6-2-3-15-5-9(6)16-11(7)10(12)14/h2-5,15H,1H3
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130220
PNG
(Benzyl-(6-chloro-9H-beta-carbolin-8-yl)-amine | CH...)
Show SMILES Clc1cc(NCc2ccccc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C18H14ClN3/c19-13-8-15-14-6-7-20-11-17(14)22-18(15)16(9-13)21-10-12-4-2-1-3-5-12/h1-9,11,21-22H,10H2
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130231
PNG
(CHEMBL311306 | Morpholine-4-carboxylic acid (6-chl...)
Show SMILES Clc1cc(NC(=O)N2CCOCC2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C16H15ClN4O2/c17-10-7-12-11-1-2-18-9-14(11)19-15(12)13(8-10)20-16(22)21-3-5-23-6-4-21/h1-2,7-9,19H,3-6H2,(H,20,22)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130247
PNG
(6-Chloro-9H-beta-carboline | CHEMBL311201)
Show SMILES Clc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C11H7ClN2/c12-7-1-2-10-9(5-7)8-3-4-13-6-11(8)14-10/h1-6,14H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130218
PNG
(9H-beta-Carboline-6-carbonitrile | CHEMBL81214)
Show SMILES N#Cc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C12H7N3/c13-6-8-1-2-11-10(5-8)9-3-4-14-7-12(9)15-11/h1-5,7,15H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130240
PNG
(6,8-Dichloro-9H-beta-carbolin-7-ol | CHEMBL309953)
Show SMILES Oc1c(Cl)cc2c3cc[nH]cc3nc2c1Cl
Show InChI InChI=1S/C11H6Cl2N2O/c12-7-3-6-5-1-2-14-4-8(5)15-10(6)9(13)11(7)16/h1-4,14,16H
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130223
PNG
(CHEMBL78917 | Pyridine-2-carboxylic acid (6-chloro...)
Show SMILES Clc1cc(NC(=O)c2ccccn2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H11ClN4O/c18-10-7-12-11-4-6-19-9-15(11)21-16(12)14(8-10)22-17(23)13-3-1-2-5-20-13/h1-9,21H,(H,22,23)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130225
PNG
(CHEMBL310179 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)
Show SMILES COc1cccc(c1)C(=O)Nc1cc(Cl)cc2c3cc[nH]cc3nc12
Show InChI InChI=1S/C19H14ClN3O2/c1-25-13-4-2-3-11(7-13)19(24)23-16-9-12(20)8-15-14-5-6-21-10-17(14)22-18(15)16/h2-10,21H,1H3,(H,23,24)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130232
PNG
(6-Fluoro-9H-beta-carboline | CHEMBL81170)
Show SMILES Fc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C11H7FN2/c12-7-1-2-10-9(5-7)8-3-4-13-6-11(8)14-10/h1-6,14H
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130240
PNG
(6,8-Dichloro-9H-beta-carbolin-7-ol | CHEMBL309953)
Show SMILES Oc1c(Cl)cc2c3cc[nH]cc3nc2c1Cl
Show InChI InChI=1S/C11H6Cl2N2O/c12-7-3-6-5-1-2-14-4-8(5)15-10(6)9(13)11(7)16/h1-4,14,16H
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130219
PNG
(CHEMBL81809 | Morpholine-4-carboxylic acid 6,8-dic...)
Show SMILES Clc1cc2c3cc[nH]cc3nc2c(Cl)c1OC(=O)N1CCOCC1
Show InChI InChI=1S/C16H13Cl2N3O3/c17-11-7-10-9-1-2-19-8-12(9)20-14(10)13(18)15(11)24-16(22)21-3-5-23-6-4-21/h1-2,7-8,19H,3-6H2
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130226
PNG
(CHEMBL309265 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)
Show SMILES Clc1cc(NS(=O)(=O)c2ccccc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H12ClN3O2S/c18-11-8-14-13-6-7-19-10-16(13)20-17(14)15(9-11)21-24(22,23)12-4-2-1-3-5-12/h1-10,20-21H
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130224
PNG
(6,8-Dichloro-7-methoxy-9H-beta-carboline | CHEMBL3...)
Show SMILES COc1c(Cl)cc2c3cc[nH]cc3nc2c1Cl
Show InChI InChI=1S/C12H8Cl2N2O/c1-17-12-8(13)4-7-6-2-3-15-5-9(6)16-11(7)10(12)14/h2-5,15H,1H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50013811
PNG
(9H-beta-Carboline | 9H-pyrido[3,4-b]indole | CHEMB...)
Show SMILES c1ccc2c(c1)[nH]c1cnccc21
Show InChI InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130234
PNG
(1-(6-Chloro-9H-beta-carbolin-8-yl)-3-methyl-urea |...)
Show SMILES CNC(=O)Nc1cc(Cl)cc2c1nc1c[nH]ccc21
Show InChI InChI=1S/C13H11ClN4O/c1-15-13(19)18-10-5-7(14)4-9-8-2-3-16-6-11(8)17-12(9)10/h2-6,16H,1H3,(H2,15,18,19)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50130221
PNG
(6,8-Dichloro-7-ethoxy-9H-beta-carboline | CHEMBL81...)
Show SMILES CCOc1c(Cl)cc2c(nc3c[nH]ccc23)c1Cl
Show InChI InChI=1S/C13H10Cl2N2O/c1-2-18-13-9(14)5-8-7-3-4-16-6-10(7)17-12(8)11(13)15/h3-6,16H,2H2,1H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase C.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130243
PNG
(CHEMBL80121 | N-(6-Chloro-9H-beta-carbolin-8-yl)-a...)
Show SMILES CC(=O)Nc1cc(Cl)cc2c1nc1c[nH]ccc21
Show InChI InChI=1S/C13H10ClN3O/c1-7(18)16-11-5-8(14)4-10-9-2-3-15-6-12(9)17-13(10)11/h2-6,15H,1H3,(H,16,18)
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130244
PNG
(6-Methoxy-9H-beta-carboline | 6-methoxy-9H-pyrido[...)
Show SMILES COc1ccc2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C12H10N2O/c1-15-8-2-3-11-10(6-8)9-4-5-13-7-12(9)14-11/h2-7,14H,1H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130245
PNG
(6,8-Dichloro-7-cyclopropylmethoxy-9H-beta-carbolin...)
Show SMILES Clc1cc2c(nc3c[nH]ccc23)c(Cl)c1OCC1CC1
Show InChI InChI=1S/C15H12Cl2N2O/c16-11-5-10-9-3-4-18-6-12(9)19-14(10)13(17)15(11)20-7-8-1-2-8/h3-6,8,18H,1-2,7H2
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130221
PNG
(6,8-Dichloro-7-ethoxy-9H-beta-carboline | CHEMBL81...)
Show SMILES CCOc1c(Cl)cc2c(nc3c[nH]ccc23)c1Cl
Show InChI InChI=1S/C13H10Cl2N2O/c1-2-18-13-9(14)5-8-7-3-4-16-6-10(7)17-12(8)11(13)15/h3-6,16H,2H2,1H3
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130217
PNG
(CHEMBL312676 | N-(6-Chloro-9H-beta-carbolin-8-yl)-...)
Show SMILES CS(=O)(=O)Nc1cc(Cl)cc2c1nc1c[nH]ccc21
Show InChI InChI=1S/C12H10ClN3O2S/c1-19(17,18)16-10-5-7(13)4-9-8-2-3-14-6-11(8)15-12(9)10/h2-6,14,16H,1H3
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Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
cAMP-dependent protein kinase (PKA)


(Homo sapiens-Homo sapiens (human))
BDBM50130223
PNG
(CHEMBL78917 | Pyridine-2-carboxylic acid (6-chloro...)
Show SMILES Clc1cc(NC(=O)c2ccccn2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H11ClN4O/c18-10-7-12-11-4-6-19-9-15(11)21-16(12)14(8-10)22-17(23)13-3-1-2-5-20-13/h1-9,21H,(H,22,23)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against protein kinase A.


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens)
BDBM50130248
PNG
(CHEMBL79004 | N-(6-Chloro-9H-beta-carbolin-8-yl)-n...)
Show SMILES Clc1cc(NC(=O)c2cccnc2)c2[nH]c3cnccc3c2c1
Show InChI InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)
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n/an/an/an/a 5.00E+3n/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-IkB phosphorylation by TNF-alpha stimulated HeLa cell lysate (IP-IKKgamma)


Bioorg Med Chem Lett 13: 2419-22 (2003)


Article DOI: 10.1016/s0960-894x(03)00408-6
BindingDB Entry DOI: 10.7270/Q2PK0FJ7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%