Found 14 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50000334
 (6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16) | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar
| Purchase
CHEBI CHEMBL DrugBank PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50000308
 (6-(Imidazol-1-yl-phenyl-methyl)-3,4-dihydro-1H-qui...)Show InChI InChI=1S/C19H17N3O/c23-18-9-7-15-12-16(6-8-17(15)21-18)19(22-11-10-20-13-22)14-4-2-1-3-5-14/h1-6,8,10-13,19H,7,9H2,(H,21,23) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50000318
 (6-(2-Imidazol-1-yl-vinyl)-1H-quinolin-2-one | CHEM...)Show InChI InChI=1S/C14H11N3O/c18-14-4-2-12-9-11(1-3-13(12)16-14)5-7-17-8-6-15-10-17/h1-10H,(H,16,18)/b7-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50000306
 (6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one | 6-P...)Show InChI InChI=1S/C14H12N2O/c17-14-6-4-11-8-10(3-5-13(11)16-14)12-2-1-7-15-9-12/h1-3,5,7-9H,4,6H2,(H,16,17) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50000310
 (6-(2-Imidazol-1-yl-vinyl)-3,4-dihydro-1H-quinolin-...)Show InChI InChI=1S/C14H13N3O/c18-14-4-2-12-9-11(1-3-13(12)16-14)5-7-17-8-6-15-10-17/h1,3,5-10H,2,4H2,(H,16,18)/b7-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibition of human blood platelet thromboxane A2 synthase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50000309
 (6-Imidazol-1-yl-3,4-dihydro-1H-quinolin-2-one | CH...)Show InChI InChI=1S/C12H11N3O/c16-12-4-1-9-7-10(2-3-11(9)14-12)15-6-5-13-8-15/h2-3,5-8H,1,4H2,(H,14,16) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50000318
 (6-(2-Imidazol-1-yl-vinyl)-1H-quinolin-2-one | CHEM...)Show InChI InChI=1S/C14H11N3O/c18-14-4-2-12-9-11(1-3-13(12)16-14)5-7-17-8-6-15-10-17/h1-10H,(H,16,18)/b7-5+ | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50000306
 (6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one | 6-P...)Show InChI InChI=1S/C14H12N2O/c17-14-6-4-11-8-10(3-5-13(11)16-14)12-2-1-7-15-9-12/h1-3,5,7-9H,4,6H2,(H,16,17) | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50000315
 ((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18) | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50000310
 (6-(2-Imidazol-1-yl-vinyl)-3,4-dihydro-1H-quinolin-...)Show InChI InChI=1S/C14H13N3O/c18-14-4-2-12-9-11(1-3-13(12)16-14)5-7-17-8-6-15-10-17/h1,3,5-10H,2,4H2,(H,16,18)/b7-5+ | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50000328
 (6-(1-Imidazol-1-ylmethyl-hexyl)-3,4-dihydro-1H-qui...)Show InChI InChI=1S/C19H25N3O/c1-2-3-4-5-17(13-22-11-10-20-14-22)15-6-8-18-16(12-15)7-9-19(23)21-18/h6,8,10-12,14,17H,2-5,7,9,13H2,1H3,(H,21,23) | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50000309
 (6-Imidazol-1-yl-3,4-dihydro-1H-quinolin-2-one | CH...)Show InChI InChI=1S/C12H11N3O/c16-12-4-1-9-7-10(2-3-11(9)14-12)15-6-5-13-8-15/h2-3,5-8H,1,4H2,(H,14,16) | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50000328
 (6-(1-Imidazol-1-ylmethyl-hexyl)-3,4-dihydro-1H-qui...)Show InChI InChI=1S/C19H25N3O/c1-2-3-4-5-17(13-22-11-10-20-14-22)15-6-8-18-16(12-15)7-9-19(23)21-18/h6,8,10-12,14,17H,2-5,7,9,13H2,1H3,(H,21,23) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibition of human blood platelet thromboxane A2 synthase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3
(Homo sapiens (Human)) | BDBM50000308
 (6-(Imidazol-1-yl-phenyl-methyl)-3,4-dihydro-1H-qui...)Show InChI InChI=1S/C19H17N3O/c23-18-9-7-15-12-16(6-8-17(15)21-18)19(22-11-10-20-13-22)14-4-2-1-3-5-14/h1-6,8,10-13,19H,7,9H2,(H,21,23) | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase |
J Med Chem 35: 620-8 (1992)
Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK |
More data for this Ligand-Target Pair | |