Affinity Data by PubMed id=1311763

PubMed code 1311763

Found 14 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50000334 (6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...) Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEBI CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2) (Homo sapiens (Human))	BDBM50000308 (6-(Imidazol-1-yl-phenyl-methyl)-3,4-dihydro-1H-qui...) Show SMILES O=C1CCc2cc(ccc2N1)C(c1ccccc1)n1ccnc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2) (Homo sapiens (Human))	BDBM50000318 (6-(2-Imidazol-1-yl-vinyl)-1H-quinolin-2-one \| CHEM...) Show SMILES O=c1ccc2cc(\C=C\n3ccnc3)ccc2[nH]1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2) (Homo sapiens (Human))	BDBM50000306 (6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one \| 6-P...) Show SMILES O=C1CCc2cc(ccc2N1)-c1cccnc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2) (Homo sapiens (Human))	BDBM50000310 (6-(2-Imidazol-1-yl-vinyl)-3,4-dihydro-1H-quinolin-...) Show SMILES O=C1CCc2cc(\C=C\n3ccnc3)ccc2N1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of human blood platelet thromboxane A2 synthase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2) (Homo sapiens (Human))	BDBM50000309 (6-Imidazol-1-yl-3,4-dihydro-1H-quinolin-2-one \| CH...) Show SMILES O=C1CCc2cc(ccc2N1)-n1ccnc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50000318 (6-(2-Imidazol-1-yl-vinyl)-1H-quinolin-2-one \| CHEM...) Show SMILES O=c1ccc2cc(\C=C\n3ccnc3)ccc2[nH]1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50000306 (6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one \| 6-P...) Show SMILES O=C1CCc2cc(ccc2N1)-c1cccnc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50000315 ((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...) Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50000310 (6-(2-Imidazol-1-yl-vinyl)-3,4-dihydro-1H-quinolin-...) Show SMILES O=C1CCc2cc(\C=C\n3ccnc3)ccc2N1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50000328 (6-(1-Imidazol-1-ylmethyl-hexyl)-3,4-dihydro-1H-qui...) Show SMILES CCCCCC(Cn1ccnc1)c1ccc2NC(=O)CCc2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50000309 (6-Imidazol-1-yl-3,4-dihydro-1H-quinolin-2-one \| CH...) Show SMILES O=C1CCc2cc(ccc2N1)-n1ccnc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2) (Homo sapiens (Human))	BDBM50000328 (6-(1-Imidazol-1-ylmethyl-hexyl)-3,4-dihydro-1H-qui...) Show SMILES CCCCCC(Cn1ccnc1)c1ccc2NC(=O)CCc2c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of human blood platelet thromboxane A2 synthase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50000308 (6-(Imidazol-1-yl-phenyl-methyl)-3,4-dihydro-1H-qui...) Show SMILES O=C1CCc2cc(ccc2N1)C(c1ccccc1)n1ccnc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Research Curated by ChEMBL					Assay Description Inhibition of human blood platelet c-AMP phosphodiesterase				J Med Chem 35: 620-8 (1992) Article DOI: 10.1021/jm00082a002 BindingDB Entry DOI: 10.7270/Q2PZ57SK
Syntex Research Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%