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PubMed code 1312599

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000438
PNG
(5-(4-Dimethylamino-phenylcarbamoyl)-pyridine-2-car...)
Show SMILES CN(C)c1ccc(NC(=O)c2ccc(nc2)C(O)=O)cc1
Show InChI InChI=1S/C15H15N3O3/c1-18(2)12-6-4-11(5-7-12)17-14(19)10-3-8-13(15(20)21)16-9-10/h3-9H,1-2H3,(H,17,19)(H,20,21)
KEGG

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n/an/a 4.10E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000430
PNG
(5-(4-Ethoxy-phenylcarbamoyl)-pyridine-2-carboxylic...)
Show SMILES CCOc1ccc(NC(=O)c2ccc(nc2)C(O)=O)cc1
Show InChI InChI=1S/C15H14N2O4/c1-2-21-12-6-4-11(5-7-12)17-14(18)10-3-8-13(15(19)20)16-9-10/h3-9H,2H2,1H3,(H,17,18)(H,19,20)
KEGG

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n/an/a 5.00E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM26114
PNG
(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Show SMILES OC(=O)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-5(7(11)12)8-3-4/h1-3H,(H,9,10)(H,11,12)
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n/an/a 5.50E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000437
PNG
(5-p-Tolylcarbamoyl-pyridine-2-carboxylic acid; ace...)
Show SMILES Cc1ccc(NC(=O)c2ccc(nc2)C(O)=O)cc1
Show InChI InChI=1S/C14H12N2O3/c1-9-2-5-11(6-3-9)16-13(17)10-4-7-12(14(18)19)15-8-10/h2-8H,1H3,(H,16,17)(H,18,19)
KEGG

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n/an/a 8.30E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000417
PNG
(5-(2-Fluoro-phenylcarbamoyl)-pyridine-2-carboxylic...)
Show SMILES OC(=O)c1ccc(cn1)C(=O)Nc1ccccc1F
Show InChI InChI=1S/C13H9FN2O3/c14-9-3-1-2-4-10(9)16-12(17)8-5-6-11(13(18)19)15-7-8/h1-7H,(H,16,17)(H,18,19)
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n/an/a 1.10E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000429
PNG
(5-(4-Ethoxy-benzoylamino)-pyridine-2-carboxylic ac...)
Show SMILES CCOc1ccc(cc1)C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C15H14N2O4/c1-2-21-12-6-3-10(4-7-12)14(18)17-11-5-8-13(15(19)20)16-9-11/h3-9H,2H2,1H3,(H,17,18)(H,19,20)
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n/an/a 1.12E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000420
PNG
(5-(4-Dimethylamino-benzoylamino)-pyridine-2-carbox...)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C15H15N3O3/c1-18(2)12-6-3-10(4-7-12)14(19)17-11-5-8-13(15(20)21)16-9-11/h3-9H,1-2H3,(H,17,19)(H,20,21)
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n/an/a 1.13E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000433
PNG
(5-(2-Methoxy-phenylcarbamoyl)-pyridine-2-carboxyli...)
Show SMILES COc1ccccc1NC(=O)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C14H12N2O4/c1-20-12-5-3-2-4-10(12)16-13(17)9-6-7-11(14(18)19)15-8-9/h2-8H,1H3,(H,16,17)(H,18,19)
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n/an/a 1.48E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000424
PNG
(5-(4-Fluoro-phenylcarbamoyl)-pyridine-2-carboxylic...)
Show SMILES OC(=O)c1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C13H9FN2O3/c14-9-2-4-10(5-3-9)16-12(17)8-1-6-11(13(18)19)15-7-8/h1-7H,(H,16,17)(H,18,19)
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n/an/a 1.61E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000441
PNG
(5-(2-Chloro-phenylcarbamoyl)-pyridine-2-carboxylic...)
Show SMILES OC(=O)c1ccc(cn1)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C13H9ClN2O3/c14-9-3-1-2-4-10(9)16-12(17)8-5-6-11(13(18)19)15-7-8/h1-7H,(H,16,17)(H,18,19)
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n/an/a 1.63E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000434
PNG
(5-(4-Methyl-benzoylamino)-pyridine-2-carboxylic ac...)
Show SMILES Cc1ccc(cc1)C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C14H12N2O3/c1-9-2-4-10(5-3-9)13(17)16-11-6-7-12(14(18)19)15-8-11/h2-8H,1H3,(H,16,17)(H,18,19)
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n/an/a 1.65E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000436
PNG
(5-(2,4-Dimethoxy-phenylcarbamoyl)-pyridine-2-carbo...)
Show SMILES COc1ccc(NC(=O)c2ccc(nc2)C(O)=O)c(OC)c1
Show InChI InChI=1S/C15H14N2O5/c1-21-10-4-6-11(13(7-10)22-2)17-14(18)9-3-5-12(15(19)20)16-8-9/h3-8H,1-2H3,(H,17,18)(H,19,20)
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n/an/a 1.66E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000432
PNG
(5-(4-Chloro-phenylcarbamoyl)-pyridine-2-carboxylic...)
Show SMILES OC(=O)c1ccc(cn1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C13H9ClN2O3/c14-9-2-4-10(5-3-9)16-12(17)8-1-6-11(13(18)19)15-7-8/h1-7H,(H,16,17)(H,18,19)
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n/an/a 1.74E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000442
PNG
(5-(4-Methoxy-phenylcarbamoyl)-pyridine-2-carboxyli...)
Show SMILES COc1ccc(NC(=O)c2ccc(nc2)C(O)=O)cc1
Show InChI InChI=1S/C14H12N2O4/c1-20-11-5-3-10(4-6-11)16-13(17)9-2-7-12(14(18)19)15-8-9/h2-8H,1H3,(H,16,17)(H,18,19)
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n/an/a 2.11E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000435
PNG
(5-(4-Chloro-benzoylamino)-pyridine-2-carboxylic ac...)
Show SMILES OC(=O)c1ccc(NC(=O)c2ccc(Cl)cc2)cn1
Show InChI InChI=1S/C13H9ClN2O3/c14-9-3-1-8(2-4-9)12(17)16-10-5-6-11(13(18)19)15-7-10/h1-7H,(H,16,17)(H,18,19)
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n/an/a 2.25E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000428
PNG
(5-Benzoylamino-pyridine-2-carboxylic acid | CHEMBL...)
Show SMILES OC(=O)c1ccc(NC(=O)c2ccccc2)cn1
Show InChI InChI=1S/C13H10N2O3/c16-12(9-4-2-1-3-5-9)15-10-6-7-11(13(17)18)14-8-10/h1-8H,(H,15,16)(H,17,18)
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n/an/a 2.56E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000421
PNG
(5-(3,4,5-Trimethoxy-phenylcarbamoyl)-pyridine-2-ca...)
Show SMILES COc1cc(NC(=O)c2ccc(nc2)C(O)=O)cc(OC)c1OC
Show InChI InChI=1S/C16H16N2O6/c1-22-12-6-10(7-13(23-2)14(12)24-3)18-15(19)9-4-5-11(16(20)21)17-8-9/h4-8H,1-3H3,(H,18,19)(H,20,21)
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n/an/a 2.65E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000440
PNG
(5-Phenylcarbamoyl-pyridine-2-carboxylic acid | CHE...)
Show SMILES OC(=O)c1ccc(cn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C13H10N2O3/c16-12(15-10-4-2-1-3-5-10)9-6-7-11(13(17)18)14-8-9/h1-8H,(H,15,16)(H,17,18)
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n/an/a 2.65E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000423
PNG
(5-(4-Fluoro-benzylamino)-pyridine-2-carboxylic aci...)
Show SMILES OC(=O)c1ccc(NCc2ccc(F)cc2)cn1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-15-11-5-6-12(13(17)18)16-8-11/h1-6,8,15H,7H2,(H,17,18)
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n/an/a 3.10E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000419
PNG
(5-(3-Chloro-phenylcarbamoyl)-pyridine-2-carboxylic...)
Show SMILES OC(=O)c1ccc(cn1)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C13H9ClN2O3/c14-9-2-1-3-10(6-9)16-12(17)8-4-5-11(13(18)19)15-7-8/h1-7H,(H,16,17)(H,18,19)
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n/an/a 3.22E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000418
PNG
(5-(2-Ethoxy-phenylcarbamoyl)-pyridine-2-carboxylic...)
Show SMILES CCOc1ccccc1NC(=O)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C15H14N2O4/c1-2-21-13-6-4-3-5-11(13)17-14(18)10-7-8-12(15(19)20)16-9-10/h3-9H,2H2,1H3,(H,17,18)(H,19,20)
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n/an/a 3.29E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000427
PNG
(5-(2-Fluoro-benzoylamino)-pyridine-2-carboxylic ac...)
Show SMILES OC(=O)c1ccc(NC(=O)c2ccccc2F)cn1
Show InChI InChI=1S/C13H9FN2O3/c14-10-4-2-1-3-9(10)12(17)16-8-5-6-11(13(18)19)15-7-8/h1-7H,(H,16,17)(H,18,19)
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n/an/a 3.38E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000431
PNG
(5-Benzyloxy-pyridine-2-carboxylic acid | CHEMBL166...)
Show SMILES OC(=O)c1ccc(OCc2ccccc2)cn1
Show InChI InChI=1S/C13H11NO3/c15-13(16)12-7-6-11(8-14-12)17-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,15,16)
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n/an/a 3.90E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000422
PNG
(5-(4-Nitro-phenylcarbamoyl)-pyridine-2-carboxylic ...)
Show SMILES OC(=O)c1ccc(cn1)C(=O)Nc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C13H9N3O5/c17-12(8-1-6-11(13(18)19)14-7-8)15-9-2-4-10(5-3-9)16(20)21/h1-7H,(H,15,17)(H,18,19)
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n/an/a 4.40E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000426
PNG
(5-(4-Fluoro-benzoylamino)-pyridine-2-carboxylic ac...)
Show SMILES OC(=O)c1ccc(NC(=O)c2ccc(F)cc2)cn1
Show InChI InChI=1S/C13H9FN2O3/c14-9-3-1-8(2-4-9)12(17)16-10-5-6-11(13(18)19)15-7-10/h1-7H,(H,16,17)(H,18,19)
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n/an/a 5.12E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000423
PNG
(5-(4-Fluoro-benzylamino)-pyridine-2-carboxylic aci...)
Show SMILES OC(=O)c1ccc(NCc2ccc(F)cc2)cn1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-15-11-5-6-12(13(17)18)16-8-11/h1-6,8,15H,7H2,(H,17,18)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PubMed
n/an/a 8.00E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of Prolyl 4-hydroxylase activity in cultured embryonic chick tendon cells


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000439
PNG
(5-Butyl-pyridine-2-carboxylic acid | 5-Butyl-pyrid...)
Show SMILES CCCCc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C10H13NO2/c1-2-3-4-8-5-6-9(10(12)13)11-7-8/h5-7H,2-4H2,1H3,(H,12,13)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 1.49E+5n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)


(Homo sapiens (Human))
BDBM50000425
PNG
(5-[2-(4-Chloro-phenyl)-vinyl]-pyridine-2-carboxyli...)
Show SMILES OC(=O)c1ccc(\C=C\c2ccc(Cl)cc2)cn1
Show InChI InChI=1S/C14H10ClNO2/c15-12-6-3-10(4-7-12)1-2-11-5-8-13(14(17)18)16-9-11/h1-9H,(H,17,18)/b2-1+
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.50E+5n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of prolyl 4-hydroxylase activity by an indirect assay


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%