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PubMed code 1315869

Compile Data Set for Download or QSAR

Found 231 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000624
PNG
(8-[6-(4-Oxo-2-phenyl-4H-chromen-6-yloxy)-hexyl]-1-...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)CC1
Show InChI InChI=1S/C34H37N3O4/c38-30-24-32(26-11-5-3-6-12-26)41-31-16-15-28(23-29(30)31)40-22-10-2-1-9-19-36-20-17-34(18-21-36)33(39)35-25-37(34)27-13-7-4-8-14-27/h3-8,11-16,23-24H,1-2,9-10,17-22,25H2,(H,35,39)
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180n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000632
PNG
(1-{1-[6-(4-Oxo-2-phenyl-4H-chromen-6-yloxy)-hexyl]...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)CC1
Show InChI InChI=1S/C33H35N3O4/c37-30-23-32(24-10-4-3-5-11-24)40-31-15-14-26(22-27(30)31)39-21-9-2-1-8-18-35-19-16-25(17-20-35)36-29-13-7-6-12-28(29)34-33(36)38/h3-7,10-15,22-23,25H,1-2,8-9,16-21H2,(H,34,38)
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220n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000634
PNG
(6-[6-(4-Methyl-piperidin-1-yl)-hexyloxy]-2-phenyl-...)
Show SMILES CC1CCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H33NO3/c1-21-13-16-28(17-14-21)15-7-2-3-8-18-30-23-11-12-26-24(19-23)25(29)20-27(31-26)22-9-5-4-6-10-22/h4-6,9-12,19-21H,2-3,7-8,13-18H2,1H3
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570n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000607
PNG
(1-[6-(4-Oxo-2-phenyl-4H-chromen-6-yloxy)-hexyl]-pi...)
Show SMILES CCOC(=O)C1CCCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)C1
Show InChI InChI=1S/C29H35NO5/c1-2-33-29(32)23-13-10-17-30(21-23)16-8-3-4-9-18-34-24-14-15-27-25(19-24)26(31)20-28(35-27)22-11-6-5-7-12-22/h5-7,11-12,14-15,19-20,23H,2-4,8-10,13,16-18,21H2,1H3
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700n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000574
PNG
(8-[6-(4-Hydroxy-piperidin-1-yl)-hexyloxy]-2-phenyl...)
Show SMILES OC1CCN(CCCCCCOc2cccc3c2oc(cc3=O)-c2ccccc2)CC1
Show InChI InChI=1S/C26H31NO4/c28-21-13-16-27(17-14-21)15-6-1-2-7-18-30-24-12-8-11-22-23(29)19-25(31-26(22)24)20-9-4-3-5-10-20/h3-5,8-12,19,21,28H,1-2,6-7,13-18H2
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940n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000614
PNG
(6-{6-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(CCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C32H34ClNO4/c33-26-12-10-25(11-13-26)32(36)16-19-34(20-17-32)18-6-1-2-7-21-37-27-14-15-30-28(22-27)29(35)23-31(38-30)24-8-4-3-5-9-24/h3-5,8-15,22-23,36H,1-2,6-7,16-21H2
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990n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000579
PNG
(7-[4-(4-Hydroxy-piperidin-1-yl)-butoxy]-2-phenyl-c...)
Show SMILES OC1CCN(CCCCOc2ccc3c(c2)oc(cc3=O)-c2ccccc2)CC1
Show InChI InChI=1S/C24H27NO4/c26-19-10-13-25(14-11-19)12-4-5-15-28-20-8-9-21-22(27)17-23(29-24(21)16-20)18-6-2-1-3-7-18/h1-3,6-9,16-17,19,26H,4-5,10-15H2
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1.00E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000606
PNG
(2-Phenyl-6-[6-(2-pyrimidin-2-yl-piperazin-1-yl)-he...)
Show SMILES O=c1cc(oc2ccc(OCCCCCCN3CCNCC3c3ncccn3)cc12)-c1ccccc1
Show InChI InChI=1S/C29H32N4O3/c34-26-20-28(22-9-4-3-5-10-22)36-27-12-11-23(19-24(26)27)35-18-7-2-1-6-16-33-17-15-30-21-25(33)29-31-13-8-14-32-29/h3-5,8-14,19-20,25,30H,1-2,6-7,15-18,21H2
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1.30E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000642
PNG
(6-{6-[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1...)
Show SMILES Clc1ccc(cc1)C1=CCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)CC1
Show InChI InChI=1S/C32H32ClNO3/c33-27-12-10-24(11-13-27)25-16-19-34(20-17-25)18-6-1-2-7-21-36-28-14-15-31-29(22-28)30(35)23-32(37-31)26-8-4-3-5-9-26/h3-5,8-16,22-23H,1-2,6-7,17-21H2
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1.30E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000646
PNG
(6-{6-[4-(4-Chloro-phenyl)-piperazin-1-yl]-hexyloxy...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)CC1
Show InChI InChI=1S/C31H33ClN2O3/c32-25-10-12-26(13-11-25)34-19-17-33(18-20-34)16-6-1-2-7-21-36-27-14-15-30-28(22-27)29(35)23-31(37-30)24-8-4-3-5-9-24/h3-5,8-15,22-23H,1-2,6-7,16-21H2
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1.30E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000582
PNG
(6-(6-Piperidin-1-yl-hexyloxy)-2-thiophen-2-yl-chro...)
Show SMILES O=c1cc(oc2ccc(OCCCCCCN3CCCCC3)cc12)-c1cccs1
Show InChI InChI=1S/C24H29NO3S/c26-21-18-23(24-9-8-16-29-24)28-22-11-10-19(17-20(21)22)27-15-7-2-1-4-12-25-13-5-3-6-14-25/h8-11,16-18H,1-7,12-15H2
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1.40E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000620
PNG
(6-(6-Piperidin-1-yl-hexyloxy)-2-pyridin-4-yl-chrom...)
Show SMILES O=c1cc(oc2ccc(OCCCCCCN3CCCCC3)cc12)-c1ccncc1
Show InChI InChI=1S/C25H30N2O3/c28-23-19-25(20-10-12-26-13-11-20)30-24-9-8-21(18-22(23)24)29-17-7-2-1-4-14-27-15-5-3-6-16-27/h8-13,18-19H,1-7,14-17H2
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1.80E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000578
PNG
(6-[6-(Benzyl-methyl-amino)-hexyloxy]-2-phenyl-chro...)
Show SMILES CN(CCCCCCOc1ccc2oc(cc(=O)c2c1)-c1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C29H31NO3/c1-30(22-23-12-6-4-7-13-23)18-10-2-3-11-19-32-25-16-17-28-26(20-25)27(31)21-29(33-28)24-14-8-5-9-15-24/h4-9,12-17,20-21H,2-3,10-11,18-19,22H2,1H3
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1.80E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000611
PNG
(6-(9-Dimethylamino-nonyloxy)-2-phenyl-chromen-4-on...)
Show SMILES CN(C)CCCCCCCCCOc1ccc2oc(cc(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C26H33NO3/c1-27(2)17-11-6-4-3-5-7-12-18-29-22-15-16-25-23(19-22)24(28)20-26(30-25)21-13-9-8-10-14-21/h8-10,13-16,19-20H,3-7,11-12,17-18H2,1-2H3
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2.20E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000622
PNG
(2-(2-Chloro-phenyl)-6-(6-piperidin-1-yl-hexyloxy)-...)
Show SMILES Clc1ccccc1-c1cc(=O)c2cc(OCCCCCCN3CCCCC3)ccc2o1
Show InChI InChI=1S/C26H30ClNO3/c27-23-11-5-4-10-21(23)26-19-24(29)22-18-20(12-13-25(22)31-26)30-17-9-2-1-6-14-28-15-7-3-8-16-28/h4-5,10-13,18-19H,1-3,6-9,14-17H2
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2.20E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000603
PNG
(6-(6-Azepan-1-yl-hexyloxy)-2-phenyl-chromen-4-one ...)
Show SMILES O=c1cc(oc2ccc(OCCCCCCN3CCCCCC3)cc12)-c1ccccc1
Show InChI InChI=1S/C27H33NO3/c29-25-21-27(22-12-6-5-7-13-22)31-26-15-14-23(20-24(25)26)30-19-11-4-3-10-18-28-16-8-1-2-9-17-28/h5-7,12-15,20-21H,1-4,8-11,16-19H2
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2.30E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000584
PNG
(2-Phenyl-6-(6-pyrrolidin-1-yl-hexyloxy)-chromen-4-...)
Show SMILES O=c1cc(oc2ccc(OCCCCCCN3CCCC3)cc12)-c1ccccc1
Show InChI InChI=1S/C25H29NO3/c27-23-19-25(20-10-4-3-5-11-20)29-24-13-12-21(18-22(23)24)28-17-9-2-1-6-14-26-15-7-8-16-26/h3-5,10-13,18-19H,1-2,6-9,14-17H2
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2.30E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000585
PNG
(6-(6-Piperidin-1-yl-hexyloxy)-2-pyridin-3-yl-chrom...)
Show SMILES O=c1cc(oc2ccc(OCCCCCCN3CCCCC3)cc12)-c1cccnc1
Show InChI InChI=1S/C25H30N2O3/c28-23-18-25(20-9-8-12-26-19-20)30-24-11-10-21(17-22(23)24)29-16-7-2-1-4-13-27-14-5-3-6-15-27/h8-12,17-19H,1-7,13-16H2
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2.30E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000580
PNG
(5-[7-(4-Hydroxy-piperidin-1-yl)-heptyloxy]-2-pheny...)
Show SMILES OC1CCN(CCCCCCCOc2cccc3oc(cc(=O)c23)-c2ccccc2)CC1
Show InChI InChI=1S/C27H33NO4/c29-22-14-17-28(18-15-22)16-7-2-1-3-8-19-31-24-12-9-13-25-27(24)23(30)20-26(32-25)21-10-5-4-6-11-21/h4-6,9-13,20,22,29H,1-3,7-8,14-19H2
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2.40E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000613
PNG
(6-[6-(4-Hydroxy-piperidin-1-yl)-hexyloxy]-3-methox...)
Show SMILES COc1c(oc2ccc(OCCCCCCN3CCC(O)CC3)cc2c1=O)-c1ccccc1
Show InChI InChI=1S/C27H33NO5/c1-31-27-25(30)23-19-22(11-12-24(23)33-26(27)20-9-5-4-6-10-20)32-18-8-3-2-7-15-28-16-13-21(29)14-17-28/h4-6,9-12,19,21,29H,2-3,7-8,13-18H2,1H3
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2.60E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000593
PNG
(6-(10-Dimethylamino-decyloxy)-2-phenyl-chromen-4-o...)
Show SMILES CN(C)CCCCCCCCCCOc1ccc2oc(cc(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C27H35NO3/c1-28(2)18-12-7-5-3-4-6-8-13-19-30-23-16-17-26-24(20-23)25(29)21-27(31-26)22-14-10-9-11-15-22/h9-11,14-17,20-21H,3-8,12-13,18-19H2,1-2H3
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2.70E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000573
PNG
(6-{6-[2-(2-Hydroxy-ethyl)-piperidin-4-yl]-hexyloxy...)
Show SMILES OCCC1CC(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)CCN1
Show InChI InChI=1S/C28H35NO4/c30-16-14-23-18-21(13-15-29-23)8-4-1-2-7-17-32-24-11-12-27-25(19-24)26(31)20-28(33-27)22-9-5-3-6-10-22/h3,5-6,9-12,19-21,23,29-30H,1-2,4,7-8,13-18H2
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2.70E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000594
PNG
(6-[6-(4-Hydroxy-piperidin-1-yl)-hex-4-enyloxy]-3-m...)
Show SMILES Cc1c(oc2ccc(OCCC\C=C\CN3CCC(O)CC3)cc2c1=O)-c1ccccc1
Show InChI InChI=1S/C27H31NO4/c1-20-26(30)24-19-23(11-12-25(24)32-27(20)21-9-5-4-6-10-21)31-18-8-3-2-7-15-28-16-13-22(29)14-17-28/h2,4-7,9-12,19,22,29H,3,8,13-18H2,1H3/b7-2+
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2.70E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000638
PNG
(6-[6-(4-Hydroxy-piperidin-1-yl)-hexyloxy]-3-methyl...)
Show SMILES Cc1c(oc2ccc(OCCCCCCN3CCC(O)CC3)cc2c1=O)-c1ccccc1
Show InChI InChI=1S/C27H33NO4/c1-20-26(30)24-19-23(11-12-25(24)32-27(20)21-9-5-4-6-10-21)31-18-8-3-2-7-15-28-16-13-22(29)14-17-28/h4-6,9-12,19,22,29H,2-3,7-8,13-18H2,1H3
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2.70E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000597
PNG
(1-[6-(4-Oxo-2-phenyl-4H-chromen-6-yloxy)-hexyl]-pi...)
Show SMILES CCOC(=O)C1CCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)CC1
Show InChI InChI=1S/C29H35NO5/c1-2-33-29(32)23-14-17-30(18-15-23)16-8-3-4-9-19-34-24-12-13-27-25(20-24)26(31)21-28(35-27)22-10-6-5-7-11-22/h5-7,10-13,20-21,23H,2-4,8-9,14-19H2,1H3
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2.80E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000629
PNG
(6-(8-Dimethylamino-octyloxy)-2-phenyl-chromen-4-on...)
Show SMILES CN(C)CCCCCCCCOc1ccc2oc(cc(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C25H31NO3/c1-26(2)16-10-5-3-4-6-11-17-28-21-14-15-24-22(18-21)23(27)19-25(29-24)20-12-8-7-9-13-20/h7-9,12-15,18-19H,3-6,10-11,16-17H2,1-2H3
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2.80E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000633
PNG
(7-[8-(4-Hydroxy-piperidin-1-yl)-octyloxy]-2-phenyl...)
Show SMILES OC1CCN(CCCCCCCCOc2ccc3c(c2)oc(cc3=O)-c2ccccc2)CC1
Show InChI InChI=1S/C28H35NO4/c30-23-14-17-29(18-15-23)16-8-3-1-2-4-9-19-32-24-12-13-25-26(31)21-27(33-28(25)20-24)22-10-6-5-7-11-22/h5-7,10-13,20-21,23,30H,1-4,8-9,14-19H2
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2.80E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000615
PNG
(2-Phenyl-6-[6-(2-pyridin-2-yl-piperazin-1-yl)-hexy...)
Show SMILES O=c1cc(oc2ccc(OCCCCCCN3CCNCC3c3ccccn3)cc12)-c1ccccc1
Show InChI InChI=1S/C30H33N3O3/c34-28-21-30(23-10-4-3-5-11-23)36-29-14-13-24(20-25(28)29)35-19-9-2-1-8-17-33-18-16-31-22-27(33)26-12-6-7-15-32-26/h3-7,10-15,20-21,27,31H,1-2,8-9,16-19,22H2
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3.00E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000623
PNG
(2-Cyclopentyl-6-(6-piperidin-1-yl-hexyloxy)-chrome...)
Show SMILES O=c1cc(oc2ccc(OCCCCCCN3CCCCC3)cc12)C1CCCC1
Show InChI InChI=1S/C25H35NO3/c27-23-19-25(20-10-4-5-11-20)29-24-13-12-21(18-22(23)24)28-17-9-2-1-6-14-26-15-7-3-8-16-26/h12-13,18-20H,1-11,14-17H2
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3.20E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000626
PNG
(6-[3-(4-Hydroxy-piperidin-1-yl)-propoxy]-2-phenyl-...)
Show SMILES OC1CCN(CCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)CC1
Show InChI InChI=1S/C23H25NO4/c25-18-9-12-24(13-10-18)11-4-14-27-19-7-8-22-20(15-19)21(26)16-23(28-22)17-5-2-1-3-6-17/h1-3,5-8,15-16,18,25H,4,9-14H2
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3.40E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000628
PNG
(6-(3-Dimethylamino-propoxy)-2-phenyl-chromen-4-one...)
Show SMILES CN(C)CCCOc1ccc2oc(cc(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C20H21NO3/c1-21(2)11-6-12-23-16-9-10-19-17(13-16)18(22)14-20(24-19)15-7-4-3-5-8-15/h3-5,7-10,13-14H,6,11-12H2,1-2H3
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3.60E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000595
PNG
(6-(6-Diethylamino-hexyloxy)-2-phenyl-chromen-4-one...)
Show SMILES CCN(CC)CCCCCCOc1ccc2oc(cc(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C25H31NO3/c1-3-26(4-2)16-10-5-6-11-17-28-21-14-15-24-22(18-21)23(27)19-25(29-24)20-12-8-7-9-13-20/h7-9,12-15,18-19H,3-6,10-11,16-17H2,1-2H3
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3.60E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000641
PNG
(6-[6-(4-Hydroxy-piperidin-1-yl)-hexyloxy]-2-(4-met...)
Show SMILES COc1ccc(cc1)-c1cc(=O)c2cc(OCCCCCCN3CCC(O)CC3)ccc2o1
Show InChI InChI=1S/C27H33NO5/c1-31-22-8-6-20(7-9-22)27-19-25(30)24-18-23(10-11-26(24)33-27)32-17-5-3-2-4-14-28-15-12-21(29)13-16-28/h6-11,18-19,21,29H,2-5,12-17H2,1H3
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3.70E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000645
PNG
(6-[6-(4-Hydroxy-piperidin-1-yl)-hexyloxy]-2-phenyl...)
Show SMILES OC1CCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H31NO4/c28-21-12-15-27(16-13-21)14-6-1-2-7-17-30-22-10-11-25-23(18-22)24(29)19-26(31-25)20-8-4-3-5-9-20/h3-5,8-11,18-19,21,28H,1-2,6-7,12-17H2
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3.70E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000639
PNG
(6-[6-(4-Hydroxy-piperidin-1-yl)-hexyloxy]-2-pyridi...)
Show SMILES OC1CCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2cccnc2)CC1
Show InChI InChI=1S/C25H30N2O4/c28-20-9-13-27(14-10-20)12-3-1-2-4-15-30-21-7-8-24-22(16-21)23(29)17-25(31-24)19-6-5-11-26-18-19/h5-8,11,16-18,20,28H,1-4,9-10,12-15H2
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3.80E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000577
PNG
(2-(4-Fluoro-phenyl)-6-[6-(4-hydroxy-piperidin-1-yl...)
Show SMILES OC1CCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C26H30FNO4/c27-20-7-5-19(6-8-20)26-18-24(30)23-17-22(9-10-25(23)32-26)31-16-4-2-1-3-13-28-14-11-21(29)12-15-28/h5-10,17-18,21,29H,1-4,11-16H2
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3.80E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000610
PNG
(7-[7-(4-Hydroxy-piperidin-1-yl)-heptyloxy]-2-pheny...)
Show SMILES OC1CCN(CCCCCCCOc2ccc3c(c2)oc(cc3=O)-c2ccccc2)CC1
Show InChI InChI=1S/C27H33NO4/c29-22-13-16-28(17-14-22)15-7-2-1-3-8-18-31-23-11-12-24-25(30)20-26(32-27(24)19-23)21-9-5-4-6-10-21/h4-6,9-12,19-20,22,29H,1-3,7-8,13-18H2
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4.00E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000604
PNG
(6-[6-(4-Hydroxy-piperidin-1-yl)-hexyloxy]-2-thioph...)
Show SMILES OC1CCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2cccs2)CC1
Show InChI InChI=1S/C24H29NO4S/c26-18-9-12-25(13-10-18)11-3-1-2-4-14-28-19-7-8-22-20(16-19)21(27)17-23(29-22)24-6-5-15-30-24/h5-8,15-18,26H,1-4,9-14H2
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4.00E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000583
PNG
(2-(2-Chloro-phenyl)-6-[6-(4-hydroxy-piperidin-1-yl...)
Show SMILES OC1CCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2Cl)CC1
Show InChI InChI=1S/C26H30ClNO4/c27-23-8-4-3-7-21(23)26-18-24(30)22-17-20(9-10-25(22)32-26)31-16-6-2-1-5-13-28-14-11-19(29)12-15-28/h3-4,7-10,17-19,29H,1-2,5-6,11-16H2
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4.10E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000601
PNG
(6-(4-Dimethylamino-butoxy)-2-phenyl-chromen-4-one ...)
Show SMILES CN(C)CCCCOc1ccc2oc(cc(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H23NO3/c1-22(2)12-6-7-13-24-17-10-11-20-18(14-17)19(23)15-21(25-20)16-8-4-3-5-9-16/h3-5,8-11,14-15H,6-7,12-13H2,1-2H3
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4.20E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000612
PNG
(6-[5-(4-Hydroxy-piperidin-1-yl)-pentyloxy]-2-(4-me...)
Show SMILES COc1ccc(cc1)-c1cc(=O)c2cc(OCCCCCN3CCC(O)CC3)ccc2o1
Show InChI InChI=1S/C26H31NO5/c1-30-21-7-5-19(6-8-21)26-18-24(29)23-17-22(9-10-25(23)32-26)31-16-4-2-3-13-27-14-11-20(28)12-15-27/h5-10,17-18,20,28H,2-4,11-16H2,1H3
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4.20E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000592
PNG
(2-Phenyl-6-(6-piperidin-1-yl-hexyloxy)-chromen-4-o...)
Show SMILES O=c1cc(oc2ccc(OCCCCCCN3CCCCC3)cc12)-c1ccccc1
Show InChI InChI=1S/C26H31NO3/c28-24-20-26(21-11-5-3-6-12-21)30-25-14-13-22(19-23(24)25)29-18-10-2-1-7-15-27-16-8-4-9-17-27/h3,5-6,11-14,19-20H,1-2,4,7-10,15-18H2
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4.50E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000649
PNG
(6-{6-[(2-Hydroxy-ethyl)-methyl-amino]-hexyloxy}-2-...)
Show SMILES CN(CCO)CCCCCCOc1ccc2oc(cc(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C24H29NO4/c1-25(14-15-26)13-7-2-3-8-16-28-20-11-12-23-21(17-20)22(27)18-24(29-23)19-9-5-4-6-10-19/h4-6,9-12,17-18,26H,2-3,7-8,13-16H2,1H3
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4.50E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000616
PNG
(6-(2-Dimethylamino-ethoxy)-2-phenyl-chromen-4-one ...)
Show SMILES CN(C)CCOc1ccc2oc(cc(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C19H19NO3/c1-20(2)10-11-22-15-8-9-18-16(12-15)17(21)13-19(23-18)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3
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4.50E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000631
PNG
(2-Cyclohexyl-6-[6-(4-hydroxy-piperidin-1-yl)-hexyl...)
Show SMILES Cc1c(oc2ccc(OCCCCCCN3CCC(O)CC3)cc2c1=O)C1CCCCC1
Show InChI InChI=1S/C27H39NO4/c1-20-26(30)24-19-23(11-12-25(24)32-27(20)21-9-5-4-6-10-21)31-18-8-3-2-7-15-28-16-13-22(29)14-17-28/h11-12,19,21-22,29H,2-10,13-18H2,1H3
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4.70E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000640
PNG
(5-[5-(4-Hydroxy-piperidin-1-yl)-pentyloxy]-2-pheny...)
Show SMILES OC1CCN(CCCCCOc2cccc3oc(cc(=O)c23)-c2ccccc2)CC1
Show InChI InChI=1S/C25H29NO4/c27-20-12-15-26(16-13-20)14-5-2-6-17-29-22-10-7-11-23-25(22)21(28)18-24(30-23)19-8-3-1-4-9-19/h1,3-4,7-11,18,20,27H,2,5-6,12-17H2
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5.10E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000589
PNG
(6-[5-(4-Hydroxy-piperidin-1-yl)-pentyloxy]-2-pheny...)
Show SMILES OC1CCN(CCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)CC1
Show InChI InChI=1S/C25H29NO4/c27-20-11-14-26(15-12-20)13-5-2-6-16-29-21-9-10-24-22(17-21)23(28)18-25(30-24)19-7-3-1-4-8-19/h1,3-4,7-10,17-18,20,27H,2,5-6,11-16H2
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5.10E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000643
PNG
(2-Cyclobutyl-6-(6-piperidin-1-yl-hexyloxy)-chromen...)
Show SMILES O=c1cc(oc2ccc(OCCCCCCN3CCCCC3)cc12)C1CCC1
Show InChI InChI=1S/C24H33NO3/c26-22-18-24(19-9-8-10-19)28-23-12-11-20(17-21(22)23)27-16-7-2-1-4-13-25-14-5-3-6-15-25/h11-12,17-19H,1-10,13-16H2
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5.50E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000600
PNG
(6-[6-(3-Hydroxy-piperidin-1-yl)-hexyloxy]-2-phenyl...)
Show SMILES OC1CCCN(CCCCCCOc2ccc3oc(cc(=O)c3c2)-c2ccccc2)C1
Show InChI InChI=1S/C26H31NO4/c28-21-11-8-15-27(19-21)14-6-1-2-7-16-30-22-12-13-25-23(17-22)24(29)18-26(31-25)20-9-4-3-5-10-20/h3-5,9-10,12-13,17-18,21,28H,1-2,6-8,11,14-16,19H2
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5.50E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50000605
PNG
(6-(6-Dimethylamino-hexyloxy)-2-phenyl-chromen-4-on...)
Show SMILES CN(C)CCCCCCOc1ccc2oc(cc(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C23H27NO3/c1-24(2)14-8-3-4-9-15-26-19-12-13-22-20(16-19)21(25)17-23(27-22)18-10-6-5-7-11-18/h5-7,10-13,16-17H,3-4,8-9,14-15H2,1-2H3
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5.60E+3n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Affinity towards dopamine receptor D2 was determined by competition studies using [3H]-sulpiride in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%