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PubMed code 1317923

Compile data set for download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma


(HUMAN)
BDBM50421946
PNG
(CHEMBL1788383)
Show SMILES C(N1CCC2(CCc3ccccc23)CC1)c1ccccc1
Show InChI InChI=1S/C20H23N/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)20/h1-9H,10-16H2
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n/an/a 0.720n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421940
PNG
(CHEMBL62770)
Show SMILES CC(C)=CCN1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C19H27N/c1-16(2)9-13-20-14-11-19(12-15-20)10-5-7-17-6-3-4-8-18(17)19/h3-4,6,8-9H,5,7,10-15H2,1-2H3
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n/an/a 1n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421930
PNG
(CHEMBL1788382)
Show SMILES CC(C)=CCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C18H25N/c1-15(2)8-12-19-13-10-18(11-14-19)9-7-16-5-3-4-6-17(16)18/h3-6,8H,7,9-14H2,1-2H3
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n/an/a 1.20n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50170657
PNG
(1''-butyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-p...)
Show SMILES CCCCN1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C18H27N/c1-2-3-13-19-14-11-18(12-15-19)10-6-8-16-7-4-5-9-17(16)18/h4-5,7,9H,2-3,6,8,10-15H2,1H3
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n/an/a 1.20n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421932
PNG
(CHEMBL1743999)
Show SMILES C(C1CCCCC1)N1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C20H29N/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)20/h4-5,8-9,17H,1-3,6-7,10-16H2
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n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421939
PNG
(CHEMBL1744003)
Show SMILES Cc1ccc(CN2CCC3(CCCc4ccccc34)CC2)cc1
Show InChI InChI=1S/C22H27N/c1-18-8-10-19(11-9-18)17-23-15-13-22(14-16-23)12-4-6-20-5-2-3-7-21(20)22/h2-3,5,7-11H,4,6,12-17H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421954
PNG
(CHEMBL1744015)
Show SMILES CCCCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C19H29N/c1-2-3-4-7-14-20-15-12-19(13-16-20)11-10-17-8-5-6-9-18(17)19/h5-6,8-9H,2-4,7,10-16H2,1H3
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n/an/a 1.5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421951
PNG
(CHEMBL1744002)
Show SMILES COc1ccc(CN2CCC3(CCCc4ccccc34)CC2)cc1
Show InChI InChI=1S/C22H27NO/c1-24-20-10-8-18(9-11-20)17-23-15-13-22(14-16-23)12-4-6-19-5-2-3-7-21(19)22/h2-3,5,7-11H,4,6,12-17H2,1H3
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n/an/a 1.70n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421945
PNG
(CHEMBL1744017)
Show SMILES CCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C17H25N/c1-2-3-12-18-13-10-17(11-14-18)9-8-15-6-4-5-7-16(15)17/h4-7H,2-3,8-14H2,1H3
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n/an/a 2n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421934
PNG
(CHEMBL1744000)
Show SMILES C(C1CCCCC1)N1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C21H31N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h4-5,9,11,18H,1-3,6-8,10,12-17H2
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n/an/a 2.30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421937
PNG
(CHEMBL1744014)
Show SMILES C(Cc1ccccc1)N1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C21H25N/c1-2-6-18(7-3-1)11-15-22-16-13-21(14-17-22)12-10-19-8-4-5-9-20(19)21/h1-9H,10-17H2
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n/an/a 2.80n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421941
PNG
(CHEMBL1744001)
Show SMILES CCCCCCN1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C20H31N/c1-2-3-4-7-15-21-16-13-20(14-17-21)12-8-10-18-9-5-6-11-19(18)20/h5-6,9,11H,2-4,7-8,10,12-17H2,1H3
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n/an/a 2.90n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421942
PNG
(CHEMBL1744005)
Show SMILES C(C1CCCO1)N1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C18H25NO/c1-2-6-17-15(4-1)7-8-18(17)9-11-19(12-10-18)14-16-5-3-13-20-16/h1-2,4,6,16H,3,5,7-14H2
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n/an/a 3.20n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421933
PNG
(CHEMBL1744016)
Show SMILES COc1ccc(CN2CCC3(CCc4ccccc34)CC2)cc1
Show InChI InChI=1S/C21H25NO/c1-23-19-8-6-17(7-9-19)16-22-14-12-21(13-15-22)11-10-18-4-2-3-5-20(18)21/h2-9H,10-16H2,1H3
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n/an/a 3.5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50035097
PNG
(1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...)
Show SMILES C(N1CCC2(CCCc3ccccc23)CC1)c1ccccc1
Show InChI InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2
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n/an/a 3.80n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421935
PNG
(CHEMBL1744010)
Show SMILES CCCCN1CCC2(CC1)CCCCc1ccccc21
Show InChI InChI=1S/C19H29N/c1-2-3-14-20-15-12-19(13-16-20)11-7-6-9-17-8-4-5-10-18(17)19/h4-5,8,10H,2-3,6-7,9,11-16H2,1H3
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n/an/a 4.80n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421931
PNG
(CHEMBL1744009)
Show SMILES C(Cc1ccccc1)N1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C22H27N/c1-2-7-19(8-3-1)12-16-23-17-14-22(15-18-23)13-6-10-20-9-4-5-11-21(20)22/h1-5,7-9,11H,6,10,12-18H2
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n/an/a 5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421938
PNG
(CHEMBL1743991)
Show SMILES C(C1CCCO1)N1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C19H27NO/c1-2-8-18-16(5-1)6-3-9-19(18)10-12-20(13-11-19)15-17-7-4-14-21-17/h1-2,5,8,17H,3-4,6-7,9-15H2
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n/an/a 5.5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421958
PNG
(CHEMBL1743998)
Show SMILES Cc1ccc2c(CCCC22CCN(Cc3ccccc3)CC2)c1
Show InChI InChI=1S/C22H27N/c1-18-9-10-21-20(16-18)8-5-11-22(21)12-14-23(15-13-22)17-19-6-3-2-4-7-19/h2-4,6-7,9-10,16H,5,8,11-15,17H2,1H3
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n/an/a 5.5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421943
PNG
(CHEMBL1744006)
Show SMILES Cc1ccc(CN2CCC3(CCc4ccccc34)CC2)cc1
Show InChI InChI=1S/C21H25N/c1-17-6-8-18(9-7-17)16-22-14-12-21(13-15-22)11-10-19-4-2-3-5-20(19)21/h2-9H,10-16H2,1H3
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n/an/a 5.90n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421955
PNG
(CHEMBL1743994)
Show SMILES C(N1CCC2(CCCc3ccccc23)CC1)c1cccs1
Show InChI InChI=1S/C19H23NS/c1-2-8-18-16(5-1)6-3-9-19(18)10-12-20(13-11-19)15-17-7-4-14-21-17/h1-2,4-5,7-8,14H,3,6,9-13,15H2
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n/an/a 6.30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421959
PNG
(CHEMBL1743996)
Show SMILES C=CCCN1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C18H25N/c1-2-3-13-19-14-11-18(12-15-19)10-6-8-16-7-4-5-9-17(16)18/h2,4-5,7,9H,1,3,6,8,10-15H2
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n/an/a 6.60n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421944
PNG
(CHEMBL1744011)
Show SMILES C(N1CCC2(CC1)CCCCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C22H27N/c1-2-8-19(9-3-1)18-23-16-14-22(15-17-23)13-7-6-11-20-10-4-5-12-21(20)22/h1-5,8-10,12H,6-7,11,13-18H2
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n/an/a 6.80n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421960
PNG
(CHEMBL1743995)
Show SMILES Clc1ccc(CN2CCC3(CCCc4ccccc34)CC2)cc1
Show InChI InChI=1S/C21H24ClN/c22-19-9-7-17(8-10-19)16-23-14-12-21(13-15-23)11-3-5-18-4-1-2-6-20(18)21/h1-2,4,6-10H,3,5,11-16H2
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n/an/a 6.80n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421962
PNG
(CHEMBL1744007)
Show SMILES Clc1ccc2c(CCCC22CCN(Cc3ccccc3)CC2)c1
Show InChI InChI=1S/C21H24ClN/c22-19-8-9-20-18(15-19)7-4-10-21(20)11-13-23(14-12-21)16-17-5-2-1-3-6-17/h1-3,5-6,8-9,15H,4,7,10-14,16H2
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n/an/a 6.80n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421947
PNG
(CHEMBL1743993)
Show SMILES C(N1CCC2(CCCc3ccccc23)CC1)c1ccco1
Show InChI InChI=1S/C19H23NO/c1-2-8-18-16(5-1)6-3-9-19(18)10-12-20(13-11-19)15-17-7-4-14-21-17/h1-2,4-5,7-8,14H,3,6,9-13,15H2
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n/an/a 9.5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421961
PNG
(CHEMBL1744008)
Show SMILES C(C1CC1)N1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C18H25N/c1-2-6-17-16(4-1)5-3-9-18(17)10-12-19(13-11-18)14-15-7-8-15/h1-2,4,6,15H,3,5,7-14H2
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n/an/a 10n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421952
PNG
(CHEMBL64511)
Show SMILES C(N1CCC2(CCCc3ccccc23)CC1)c1ccccn1
Show InChI InChI=1S/C20H24N2/c1-2-9-19-17(6-1)7-5-10-20(19)11-14-22(15-12-20)16-18-8-3-4-13-21-18/h1-4,6,8-9,13H,5,7,10-12,14-16H2
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n/an/a 11n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421948
PNG
(CHEMBL1743992)
Show SMILES [O-][N+](=O)c1ccc(CN2CCC3(CCCc4ccccc34)CC2)cc1
Show InChI InChI=1S/C21H24N2O2/c24-23(25)19-9-7-17(8-10-19)16-22-14-12-21(13-15-22)11-3-5-18-4-1-2-6-20(18)21/h1-2,4,6-10H,3,5,11-16H2
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n/an/a 14n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421949
PNG
(CHEMBL1744004)
Show SMILES C(N1CCC2(CCc3ccccc23)CC1)c1ccccn1
Show InChI InChI=1S/C19H22N2/c1-2-7-18-16(5-1)8-9-19(18)10-13-21(14-11-19)15-17-6-3-4-12-20-17/h1-7,12H,8-11,13-15H2
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n/an/a 16n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421957
PNG
(CHEMBL1743997)
Show SMILES C=CCN1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C17H23N/c1-2-12-18-13-10-17(11-14-18)9-5-7-15-6-3-4-8-16(15)17/h2-4,6,8H,1,5,7,9-14H2
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n/an/a 18n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421936
PNG
(CHEMBL1744013)
Show SMILES Oc1ccc2CCCC3(CCN(Cc4ccccc4)CC3)c2c1
Show InChI InChI=1S/C21H25NO/c23-19-9-8-18-7-4-10-21(20(18)15-19)11-13-22(14-12-21)16-17-5-2-1-3-6-17/h1-3,5-6,8-9,15,23H,4,7,10-14,16H2
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n/an/a 69n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50421956
PNG
(CHEMBL1744012)
Show SMILES COc1ccc2CCCC3(CCN(Cc4ccccc4)CC3)c2c1
Show InChI InChI=1S/C22H27NO/c1-24-20-10-9-19-8-5-11-22(21(19)16-20)12-14-23(15-13-22)17-18-6-3-2-4-7-18/h2-4,6-7,9-10,16H,5,8,11-15,17H2,1H3
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n/an/a 74n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421951
PNG
(CHEMBL1744002)
Show SMILES COc1ccc(CN2CCC3(CCCc4ccccc34)CC2)cc1
Show InChI InChI=1S/C22H27NO/c1-24-20-10-8-18(9-11-20)17-23-15-13-22(14-16-23)12-4-6-19-5-2-3-7-21(19)22/h2-3,5,7-11H,4,6,12-17H2,1H3
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n/an/a 120n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421939
PNG
(CHEMBL1744003)
Show SMILES Cc1ccc(CN2CCC3(CCCc4ccccc34)CC2)cc1
Show InChI InChI=1S/C22H27N/c1-18-8-10-19(11-9-18)17-23-15-13-22(14-16-23)12-4-6-20-5-2-3-7-21(20)22/h2-3,5,7-11H,4,6,12-17H2,1H3
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n/an/a 174n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421933
PNG
(CHEMBL1744016)
Show SMILES COc1ccc(CN2CCC3(CCc4ccccc34)CC2)cc1
Show InChI InChI=1S/C21H25NO/c1-23-19-8-6-17(7-9-19)16-22-14-12-21(13-15-22)11-10-18-4-2-3-5-20(18)21/h2-9H,10-16H2,1H3
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n/an/a 617n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421946
PNG
(CHEMBL1788383)
Show SMILES C(N1CCC2(CCc3ccccc23)CC1)c1ccccc1
Show InChI InChI=1S/C20H23N/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)20/h1-9H,10-16H2
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n/an/a 891n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50035097
PNG
(1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...)
Show SMILES C(N1CCC2(CCCc3ccccc23)CC1)c1ccccc1
Show InChI InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2
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n/an/a 955n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421934
PNG
(CHEMBL1744000)
Show SMILES C(C1CCCCC1)N1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C21H31N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h4-5,9,11,18H,1-3,6-8,10,12-17H2
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n/an/a 1.95E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421941
PNG
(CHEMBL1744001)
Show SMILES CCCCCCN1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C20H31N/c1-2-3-4-7-15-21-16-13-20(14-17-21)12-8-10-18-9-5-6-11-19(18)20/h5-6,9,11H,2-4,7-8,10,12-17H2,1H3
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n/an/a 2.04E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421935
PNG
(CHEMBL1744010)
Show SMILES CCCCN1CCC2(CC1)CCCCc1ccccc21
Show InChI InChI=1S/C19H29N/c1-2-3-14-20-15-12-19(13-16-20)11-7-6-9-17-8-4-5-10-18(17)19/h4-5,8,10H,2-3,6-7,9,11-16H2,1H3
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n/an/a 2.51E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421944
PNG
(CHEMBL1744011)
Show SMILES C(N1CCC2(CC1)CCCCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C22H27N/c1-2-8-19(9-3-1)18-23-16-14-22(15-17-23)13-7-6-11-20-10-4-5-12-21(20)22/h1-5,8-10,12H,6-7,11,13-18H2
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n/an/a 3.72E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421945
PNG
(CHEMBL1744017)
Show SMILES CCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C17H25N/c1-2-3-12-18-13-10-17(11-14-18)9-8-15-6-4-5-7-16(15)17/h4-7H,2-3,8-14H2,1H3
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n/an/a 3.98E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421940
PNG
(CHEMBL62770)
Show SMILES CC(C)=CCN1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C19H27N/c1-16(2)9-13-20-14-11-19(12-15-20)10-5-7-17-6-3-4-8-18(17)19/h3-4,6,8-9H,5,7,10-15H2,1-2H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421954
PNG
(CHEMBL1744015)
Show SMILES CCCCCCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C19H29N/c1-2-3-4-7-14-20-15-12-19(13-16-20)11-10-17-8-5-6-9-18(17)19/h5-6,8-9H,2-4,7,10-16H2,1H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421932
PNG
(CHEMBL1743999)
Show SMILES C(C1CCCCC1)N1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C20H29N/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)20/h4-5,8-9,17H,1-3,6-7,10-16H2
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n/an/a 6.61E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50170657
PNG
(1''-butyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-p...)
Show SMILES CCCCN1CCC2(CCCc3ccccc23)CC1
Show InChI InChI=1S/C18H27N/c1-2-3-13-19-14-11-18(12-15-19)10-6-8-16-7-4-5-9-17(16)18/h4-5,7,9H,2-3,6,8,10-15H2,1H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50421930
PNG
(CHEMBL1788382)
Show SMILES CC(C)=CCN1CCC2(CCc3ccccc23)CC1
Show InChI InChI=1S/C18H25N/c1-15(2)8-12-19-13-10-18(11-14-19)9-7-16-5-3-4-6-17(16)18/h3-6,8H,7,9-14H2,1-2H3
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n/an/a 1.70E+4n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro for the binding affinity against dopamine receptor D2 by using [3H](-)-sulpiride as radioligand in rat striatum.


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%