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PubMed code 1321910

Compile data set for download or QSAR
Found 160 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000868
PNG
(CHEMBL88444 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Show SMILES CCOC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C24H30N4O5/c1-2-32-22(30)15-28(17-7-4-3-5-8-17)21(29)9-6-12-33-18-10-11-19-16(13-18)14-20-23(25-19)27-24(31)26-20/h10-11,13-14,17H,2-9,12,15H2,1H3,(H2,25,26,27,31)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000915
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-27(17-8-4-2-3-5-9-17)21(28)10-6-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)26-23(29)25-20/h11-12,14-15,17H,2-10,13H2,1H3,(H2,24,25,26,29)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000892
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H28N4O3/c1-26(16-7-3-2-4-8-16)20(27)9-5-6-12-29-17-10-11-18-15(13-17)14-19-21(23-18)25-22(28)24-19/h10-11,13-14,16H,2-9,12H2,1H3,(H2,23,24,25,28)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000900
PNG
(CHEMBL90804 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Show SMILES COC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H28N4O5/c1-31-21(29)14-27(16-6-3-2-4-7-16)20(28)8-5-11-32-17-9-10-18-15(12-17)13-19-22(24-18)26-23(30)25-19/h9-10,12-13,16H,2-8,11,14H2,1H3,(H2,24,25,26,30)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000931
PNG
(CHEMBL91368 | N-Cyclohexyl-N-methyl-4-(2-oxo-2,3-d...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C21H26N4O3/c1-25(15-6-3-2-4-7-15)19(26)8-5-11-28-16-9-10-17-14(12-16)13-18-20(22-17)24-21(27)23-18/h9-10,12-13,15H,2-8,11H2,1H3,(H2,22,23,24,27)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000910
PNG
(6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-27(17-8-4-2-5-9-17)21(28)10-6-3-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)26-23(29)25-20/h11-12,14-15,17H,2-10,13H2,1H3,(H2,24,25,26,29)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000873
PNG
(6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c20-14(21)4-2-1-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(22)18-13/h5-6,8-9H,1-4,7H2,(H,20,21)(H2,17,18,19,22)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000903
PNG
(CHEMBL91422 | N-Cycloheptyl-N-methyl-4-(1-methyl-2...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-26(17-8-5-3-4-6-9-17)21(28)10-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)25-23(29)27(20)2/h11-12,14-15,17H,3-10,13H2,1-2H3,(H,24,25,29)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000908
PNG
(CHEMBL92363 | N-Cyclohexyl-N-methyl-4-(1-methyl-2-...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C22H28N4O3/c1-25(16-7-4-3-5-8-16)20(27)9-6-12-29-17-10-11-18-15(13-17)14-19-21(23-18)24-22(28)26(19)2/h10-11,13-14,16H,3-9,12H2,1-2H3,(H,23,24,28)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000930
PNG
(4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C15H15N3O4/c1-18-12-8-9-7-10(22-6-2-3-13(19)20)4-5-11(9)16-14(12)17-15(18)21/h4-5,7-8H,2-3,6H2,1H3,(H,19,20)(H,16,17,21)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000891
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C24H32N4O3/c1-27(18-9-5-3-4-6-10-18)22(29)11-7-8-14-31-19-12-13-20-17(15-19)16-21-23(25-20)26-24(30)28(21)2/h12-13,15-16,18H,3-11,14H2,1-2H3,(H,25,26,30)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000904
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-2-4-14(20)21)5-6-12(10)17-15(13)18-16(19)22/h5-6,8-9H,2-4,7H2,1H3,(H,20,21)(H,17,18,22)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000922
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O3/c19-13(20)4-2-1-3-9-5-6-11-10(7-9)8-12-14(16-11)18-15(21)17-12/h5-8H,1-4H2,(H,19,20)(H2,16,17,18,21)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000925
PNG
(7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1C
Show InChI InChI=1S/C12H11N3O/c1-6-3-4-9-8(7(6)2)5-10-11(13-9)15-12(16)14-10/h3-5H,1-2H3,(H2,13,14,15,16)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000918
PNG
(7-(4-Hydroxy-butoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H15N3O3/c18-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(15-11)17-14(19)16-12/h3-4,7-8,18H,1-2,5-6H2,(H2,15,16,17,19)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000886
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H13N3O4/c18-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(15-10)17-14(20)16-11/h3-4,6-7H,1-2,5H2,(H,18,19)(H2,15,16,17,20)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000889
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c19-13(20)3-1-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(21)17-12/h4-5,7-8H,1-3,6H2,(H,19,20)(H2,16,17,18,21)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/a 3.40E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000906
PNG
(7-(4-Morpholin-4-yl-4-oxo-butoxy)-1,3-dihydro-imid...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)N1CCOCC1
Show InChI InChI=1S/C18H20N4O4/c23-16(22-5-8-25-9-6-22)2-1-7-26-13-3-4-14-12(10-13)11-15-17(19-14)21-18(24)20-15/h3-4,10-11H,1-2,5-9H2,(H2,19,20,21,24)
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n/an/a 4.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000937
PNG
((2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-ylo...)
Show SMILES OC(=O)COc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C12H9N3O4/c16-10(17)5-19-7-1-2-8-6(3-7)4-9-11(13-8)15-12(18)14-9/h1-4H,5H2,(H,16,17)(H2,13,14,15,18)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000882
PNG
(7-(3-Hydroxy-propoxy)-1,3-dihydro-imidazo[4,5-b]qu...)
Show SMILES OCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C13H13N3O3/c17-4-1-5-19-9-2-3-10-8(6-9)7-11-12(14-10)16-13(18)15-11/h2-3,6-7,17H,1,4-5H2,(H2,14,15,16,18)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000928
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-26(17-8-4-3-5-9-17)21(28)10-6-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)25-23(29)27(20)2/h11-12,14-15,17H,3-10,13H2,1-2H3,(H,24,25,29)
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n/an/a 6.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000883
PNG
(1-Methyl-7-(4-oxo-4-piperidin-1-yl-butoxy)-1,3-dih...)
Show SMILES Cn1c2cc3cc(OCCCC(=O)N4CCCCC4)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C20H24N4O3/c1-23-17-13-14-12-15(7-8-16(14)21-19(17)22-20(23)26)27-11-5-6-18(25)24-9-3-2-4-10-24/h7-8,12-13H,2-6,9-11H2,1H3,(H,21,22,26)
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n/an/a 6.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000901
PNG
(4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-4-14(20)22-2)5-6-12(10)17-15(13)18-16(19)21/h5-6,8-9H,3-4,7H2,1-2H3,(H,17,18,21)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000890
PNG
(6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-23-15(21)5-3-2-4-8-24-12-6-7-13-11(9-12)10-14-16(18-13)20-17(22)19-14/h6-7,9-10H,2-5,8H2,1H3,(H2,18,19,20,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000893
PNG
(CHEMBL91356 | N-Cyclohexyl-4-(1-methyl-2-oxo-2,3-d...)
Show SMILES Cn1c2cc3cc(OCCCC(=O)NC4CCCCC4)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C21H26N4O3/c1-25-18-13-14-12-16(9-10-17(14)23-20(18)24-21(25)27)28-11-5-8-19(26)22-15-6-3-2-4-7-15/h9-10,12-13,15H,2-8,11H2,1H3,(H,22,26)(H,23,24,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000880
PNG
(7-(2-Hydroxy-ethoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C12H11N3O3/c16-3-4-18-8-1-2-9-7(5-8)6-10-11(13-9)15-12(17)14-10/h1-2,5-6,16H,3-4H2,(H2,13,14,15,17)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000909
PNG
(7-(4-Benzenesulfonyl-butoxy)-1,3-dihydro-imidazo[4...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]1
Show InChI InChI=1S/C20H19N3O4S/c24-20-22-18-13-14-12-15(8-9-17(14)21-19(18)23-20)27-10-4-5-11-28(25,26)16-6-2-1-3-7-16/h1-3,6-9,12-13H,4-5,10-11H2,(H2,21,22,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000875
PNG
(1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-...)
Show SMILES CCOC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H26N4O5/c1-2-30-21(28)14-7-9-26(10-8-14)19(27)4-3-11-31-16-5-6-17-15(12-16)13-18-20(23-17)25-22(29)24-18/h5-6,12-14H,2-4,7-11H2,1H3,(H2,23,24,25,29)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000942
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-20-14-10-11-9-12(24-8-4-3-5-15(21)23-2)6-7-13(11)18-16(14)19-17(20)22/h6-7,9-10H,3-5,8H2,1-2H3,(H,18,19,22)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000933
PNG
(CHEMBL92264 | N-Adamantan-1-yl-4-(2-oxo-2,3-dihydr...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2
Show InChI InChI=1S/C24H28N4O3/c29-21(28-24-11-14-6-15(12-24)8-16(7-14)13-24)2-1-5-31-18-3-4-19-17(9-18)10-20-22(25-19)27-23(30)26-20/h3-4,9-10,14-16H,1-2,5-8,11-13H2,(H,28,29)(H2,25,26,27,30)/t14-,15+,16-,24?
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n/an/a 1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000897
PNG
(7-(4-Oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imid...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)N1CCCCC1
Show InChI InChI=1S/C19H22N4O3/c24-17(23-8-2-1-3-9-23)5-4-10-26-14-6-7-15-13(11-14)12-16-18(20-15)22-19(25)21-16/h6-7,11-12H,1-5,8-10H2,(H2,20,21,22,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000879
PNG
(7-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1,3-d...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCc4nnnn4C4CCCCC4)ccc3nc2[nH]1
Show InChI InChI=1S/C21H25N7O2/c29-21-23-18-13-14-12-16(9-10-17(14)22-20(18)24-21)30-11-5-4-8-19-25-26-27-28(19)15-6-2-1-3-7-15/h9-10,12-13,15H,1-8,11H2,(H2,22,23,24,29)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000885
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-22-14(20)4-2-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(21)18-13/h5-6,8-9H,2-4,7H2,1H3,(H2,17,18,19,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000919
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES NC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H14N4O3/c15-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(16-10)18-14(20)17-11/h3-4,6-7H,1-2,5H2,(H2,15,19)(H2,16,17,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000920
PNG
(CHEMBL88218 | N-Cyclohexyl-4-(2-oxo-2,3-dihydro-1H...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC1CCCCC1
Show InChI InChI=1S/C20H24N4O3/c25-18(21-14-5-2-1-3-6-14)7-4-10-27-15-8-9-16-13(11-15)12-17-19(22-16)24-20(26)23-17/h8-9,11-12,14H,1-7,10H2,(H,21,25)(H2,22,23,24,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50000870
PNG
(7-(3-Benzenesulfonyl-propoxy)-1,3-dihydro-imidazo[...)
Show SMILES O=c1[nH]c2cc3cc(OCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]1
Show InChI InChI=1S/C19H17N3O4S/c23-19-21-17-12-13-11-14(7-8-16(13)20-18(17)22-19)26-9-4-10-27(24,25)15-5-2-1-3-6-15/h1-3,5-8,11-12H,4,9-10H2,(H2,20,21,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000867
PNG
(7-(4-Hydroxy-pentyloxy)-1,3-dihydro-imidazo[4,5-b]...)
Show SMILES CC(O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H17N3O3/c1-9(19)3-2-6-21-11-4-5-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h4-5,7-9,19H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 100n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000891
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C24H32N4O3/c1-27(18-9-5-3-4-6-10-18)22(29)11-7-8-14-31-19-12-13-20-17(15-19)16-21-23(25-20)26-24(30)28(21)2/h12-13,15-16,18H,3-11,14H2,1-2H3,(H,25,26,30)
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n/an/an/an/a 140n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000916
PNG
(4-(3-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCOc1ccc2nc3n(C)c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-19-15-13(18-16(19)21)9-10-8-11(5-6-12(10)17-15)23-7-3-4-14(20)22-2/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,21)
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n/an/an/an/a 2.99E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000872
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H28N4O2/c1-26(17-8-3-2-4-9-17)20(27)10-6-5-7-15-11-12-18-16(13-15)14-19-21(23-18)25-22(28)24-19/h11-14,17H,2-10H2,1H3,(H2,23,24,25,28)
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n/an/an/an/a 210n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000924
PNG
(4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b...)
Show SMILES COC(=O)CCCOc1ccc2nc3n(C)c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-19-14-10-11-9-12(24-8-4-5-15(21)23-3)6-7-13(11)18-16(14)20(2)17(19)22/h6-7,9-10H,4-5,8H2,1-3H3
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n/an/an/an/a>8.75E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000883
PNG
(1-Methyl-7-(4-oxo-4-piperidin-1-yl-butoxy)-1,3-dih...)
Show SMILES Cn1c2cc3cc(OCCCC(=O)N4CCCCC4)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C20H24N4O3/c1-23-17-13-14-12-15(7-8-16(14)21-19(17)22-20(23)26)27-11-5-6-18(25)24-9-3-2-4-10-24/h7-8,12-13H,2-6,9-11H2,1H3,(H,21,22,26)
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n/an/an/an/a 1.09E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000913
PNG
(7-(2,3-Dihydroxy-propoxy)-1,3-dihydro-imidazo[4,5-...)
Show SMILES OCC(O)COc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C13H13N3O4/c17-5-8(18)6-20-9-1-2-10-7(3-9)4-11-12(14-10)16-13(19)15-11/h1-4,8,17-18H,5-6H2,(H2,14,15,16,19)
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n/an/an/an/a 260n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000903
PNG
(CHEMBL91422 | N-Cycloheptyl-N-methyl-4-(1-methyl-2...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-26(17-8-5-3-4-6-9-17)21(28)10-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)25-23(29)27(20)2/h11-12,14-15,17H,3-10,13H2,1-2H3,(H,24,25,29)
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n/an/an/an/a 70n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000879
PNG
(7-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1,3-d...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCc4nnnn4C4CCCCC4)ccc3nc2[nH]1
Show InChI InChI=1S/C21H25N7O2/c29-21-23-18-13-14-12-16(9-10-17(14)22-20(18)24-21)30-11-5-4-8-19-25-26-27-28(19)15-6-2-1-3-7-15/h9-10,12-13,15H,1-8,11H2,(H2,22,23,24,29)
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n/an/an/an/a 250n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000934
PNG
(3-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CCOC(=O)CCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O3/c1-2-21-13(19)6-4-9-3-5-11-10(7-9)8-12-14(16-11)18-15(20)17-12/h3,5,7-8H,2,4,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 440n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000899
PNG
(CHEMBL93688 | N-Cycloheptyl-4-(2-oxo-2,3-dihydro-1...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC1CCCCCC1
Show InChI InChI=1S/C21H26N4O3/c26-19(22-15-6-3-1-2-4-7-15)8-5-11-28-16-9-10-17-14(12-16)13-18-20(23-17)25-21(27)24-18/h9-10,12-13,15H,1-8,11H2,(H,22,26)(H2,23,24,25,27)
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n/an/an/an/a 390n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000912
PNG
(CHEMBL90958 | N,N-Dimethyl-4-(2-oxo-2,3-dihydro-1H...)
Show SMILES CN(C)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H18N4O3/c1-20(2)14(21)4-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(22)18-13/h5-6,8-9H,3-4,7H2,1-2H3,(H2,17,18,19,22)
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n/an/an/an/a 190n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000922
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O3/c19-13(20)4-2-1-3-9-5-6-11-10(7-9)8-12-14(16-11)18-15(21)17-12/h5-8H,1-4H2,(H,19,20)(H2,16,17,18,21)
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n/an/an/an/a>1.12E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000886
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H13N3O4/c18-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(15-10)17-14(20)16-11/h3-4,6-7H,1-2,5H2,(H,18,19)(H2,15,16,17,20)
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n/an/an/an/a 1.04E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000897
PNG
(7-(4-Oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imid...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)N1CCCCC1
Show InChI InChI=1S/C19H22N4O3/c24-17(23-8-2-1-3-9-23)5-4-10-26-14-6-7-15-13(11-14)12-16-18(20-15)22-19(25)21-16/h6-7,11-12H,1-5,8-10H2,(H2,20,21,22,25)
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n/an/an/an/a 130n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000873
PNG
(6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c20-14(21)4-2-1-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(22)18-13/h5-6,8-9H,1-4,7H2,(H,20,21)(H2,17,18,19,22)
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n/an/an/an/a 3.17E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000939
PNG
(1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-...)
Show SMILES OC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C20H22N4O5/c25-17(24-7-5-12(6-8-24)19(26)27)2-1-9-29-14-3-4-15-13(10-14)11-16-18(21-15)23-20(28)22-16/h3-4,10-12H,1-2,5-9H2,(H,26,27)(H2,21,22,23,28)
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n/an/an/an/a 4.53E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000892
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H28N4O3/c1-26(16-7-3-2-4-8-16)20(27)9-5-6-12-29-17-10-11-18-15(13-17)14-19-21(23-18)25-22(28)24-19/h10-11,13-14,16H,2-9,12H2,1H3,(H2,23,24,25,28)
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n/an/an/an/a 1n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000905
PNG
(CHEMBL91259 | N-Cyclopentyl-4-(2-oxo-2,3-dihydro-1...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC1CCCC1
Show InChI InChI=1S/C19H22N4O3/c24-17(20-13-4-1-2-5-13)6-3-9-26-14-7-8-15-12(10-14)11-16-18(21-15)23-19(25)22-16/h7-8,10-11,13H,1-6,9H2,(H,20,24)(H2,21,22,23,25)
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n/an/an/an/a 420n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000918
PNG
(7-(4-Hydroxy-butoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H15N3O3/c18-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(15-11)17-14(19)16-12/h3-4,7-8,18H,1-2,5-6H2,(H2,15,16,17,19)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000929
PNG
(4-(3-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2nc3ccc(OCCCC(O)=O)cc3cc2[nH]c1=O
Show InChI InChI=1S/C15H15N3O4/c1-18-14-12(17-15(18)21)8-9-7-10(4-5-11(9)16-14)22-6-2-3-13(19)20/h4-5,7-8H,2-3,6H2,1H3,(H,17,21)(H,19,20)
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n/an/an/an/a>2.65E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000910
PNG
(6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-27(17-8-4-2-5-9-17)21(28)10-6-3-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)26-23(29)25-20/h11-12,14-15,17H,2-10,13H2,1H3,(H2,24,25,26,29)
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n/an/an/an/a 540n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000923
PNG
(Acetic acid 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]...)
Show SMILES CC(=O)OCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-10(20)22-6-2-3-7-23-12-4-5-13-11(8-12)9-14-15(17-13)19-16(21)18-14/h4-5,8-9H,2-3,6-7H2,1H3,(H2,17,18,19,21)
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n/an/an/an/a 950n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000895
PNG
(4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b...)
Show SMILES Cn1c2cc3cc(OCCCC(O)=O)ccc3nc2n(C)c1=O
Show InChI InChI=1S/C16H17N3O4/c1-18-13-9-10-8-11(23-7-3-4-14(20)21)5-6-12(10)17-15(13)19(2)16(18)22/h5-6,8-9H,3-4,7H2,1-2H3,(H,20,21)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000878
PNG
(7-[3-(1H-Tetrazol-5-yl)-propoxy]-1,3-dihydro-imida...)
Show SMILES O=c1[nH]c2cc3cc(OCCCc4nnn[nH]4)ccc3nc2[nH]1
Show InChI InChI=1S/C14H13N7O2/c22-14-16-11-7-8-6-9(3-4-10(8)15-13(11)17-14)23-5-1-2-12-18-20-21-19-12/h3-4,6-7H,1-2,5H2,(H2,15,16,17,22)(H,18,19,20,21)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000900
PNG
(CHEMBL90804 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Show SMILES COC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H28N4O5/c1-31-21(29)14-27(16-6-3-2-4-7-16)20(28)8-5-11-32-17-9-10-18-15(12-17)13-19-22(24-18)26-23(30)25-19/h9-10,12-13,16H,2-8,11,14H2,1H3,(H2,24,25,26,30)
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n/an/an/an/a 6n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000935
PNG
(7-(5-Oxo-5-piperidin-1-yl-pentyl)-1,3-dihydro-imid...)
Show SMILES O=C(CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)N1CCCCC1
Show InChI InChI=1S/C20H24N4O2/c25-18(24-10-4-1-5-11-24)7-3-2-6-14-8-9-16-15(12-14)13-17-19(21-16)23-20(26)22-17/h8-9,12-13H,1-7,10-11H2,(H2,21,22,23,26)
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n/an/an/an/a 1.55E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000929
PNG
(4-(3-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2nc3ccc(OCCCC(O)=O)cc3cc2[nH]c1=O
Show InChI InChI=1S/C15H15N3O4/c1-18-14-12(17-15(18)21)8-9-7-10(4-5-11(9)16-14)22-6-2-3-13(19)20/h4-5,7-8H,2-3,6H2,1H3,(H,17,21)(H,19,20)
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n/an/an/an/a 1.66E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000916
PNG
(4-(3-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCOc1ccc2nc3n(C)c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-19-15-13(18-16(19)21)9-10-8-11(5-6-12(10)17-15)23-7-3-4-14(20)22-2/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,21)
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n/an/an/an/a 360n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000921
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O3/c1-22-14(20)5-3-2-4-10-6-7-12-11(8-10)9-13-15(17-12)19-16(21)18-13/h6-9H,2-5H2,1H3,(H2,17,18,19,21)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000938
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)C=CC=Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H13N3O3/c1-22-14(20)5-3-2-4-10-6-7-12-11(8-10)9-13-15(17-12)19-16(21)18-13/h2-9H,1H3,(H2,17,18,19,21)
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n/an/an/an/a 2.69E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000887
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=C(CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC1CCCCC1
Show InChI InChI=1S/C21H26N4O2/c26-19(22-16-7-2-1-3-8-16)9-5-4-6-14-10-11-17-15(12-14)13-18-20(23-17)25-21(27)24-18/h10-13,16H,1-9H2,(H,22,26)(H2,23,24,25,27)
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n/an/an/an/a 1.07E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000927
PNG
(CHEMBL88108 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Show SMILES OC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H26N4O5/c27-19(26(13-20(28)29)15-5-2-1-3-6-15)7-4-10-31-16-8-9-17-14(11-16)12-18-21(23-17)25-22(30)24-18/h8-9,11-12,15H,1-7,10,13H2,(H,28,29)(H2,23,24,25,30)
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n/an/an/an/a 910n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000868
PNG
(CHEMBL88444 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Show SMILES CCOC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C24H30N4O5/c1-2-32-22(30)15-28(17-7-4-3-5-8-17)21(29)9-6-12-33-18-10-11-19-16(13-18)14-20-23(25-19)27-24(31)26-20/h10-11,13-14,17H,2-9,12,15H2,1H3,(H2,25,26,27,31)
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n/an/an/an/a 80n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000898
PNG
(4-(2-Oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazol...)
Show SMILES OC(=O)CCCOc1ccc2N=C3NC(=O)CN3Cc2c1
Show InChI InChI=1S/C14H15N3O4/c18-12-8-17-7-9-6-10(21-5-1-2-13(19)20)3-4-11(9)15-14(17)16-12/h3-4,6H,1-2,5,7-8H2,(H,19,20)(H,15,16,18)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000897
PNG
(7-(4-Oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imid...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)N1CCCCC1
Show InChI InChI=1S/C19H22N4O3/c24-17(23-8-2-1-3-9-23)5-4-10-26-14-6-7-15-13(11-14)12-16-18(20-15)22-19(25)21-16/h6-7,11-12H,1-5,8-10H2,(H2,20,21,22,25)
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n/an/an/an/a 110n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000889
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c19-13(20)3-1-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(21)17-12/h4-5,7-8H,1-3,6H2,(H,19,20)(H2,16,17,18,21)
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n/an/an/an/a>1.06E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000885
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-22-14(20)4-2-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(21)18-13/h5-6,8-9H,2-4,7H2,1H3,(H2,17,18,19,21)
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n/an/an/an/a 950n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000927
PNG
(CHEMBL88108 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Show SMILES OC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H26N4O5/c27-19(26(13-20(28)29)15-5-2-1-3-6-15)7-4-10-31-16-8-9-17-14(11-16)12-18-21(23-17)25-22(30)24-18/h8-9,11-12,15H,1-7,10,13H2,(H,28,29)(H2,23,24,25,30)
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n/an/an/an/a 9.60E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000930
PNG
(4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C15H15N3O4/c1-18-12-8-9-7-10(22-6-2-3-13(19)20)4-5-11(9)16-14(12)17-15(18)21/h4-5,7-8H,2-3,6H2,1H3,(H,19,20)(H,16,17,21)
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n/an/an/an/a>1.06E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000877
PNG
(CHEMBL88955 | N-Cycloheptyl-N-methyl-4-(2-oxo-2,3-...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H28N4O3/c1-26(16-7-4-2-3-5-8-16)20(27)9-6-12-29-17-10-11-18-15(13-17)14-19-21(23-18)25-22(28)24-19/h10-11,13-14,16H,2-9,12H2,1H3,(H2,23,24,25,28)
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n/an/an/an/a 60n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000886
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H13N3O4/c18-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(15-10)17-14(20)16-11/h3-4,6-7H,1-2,5H2,(H,18,19)(H2,15,16,17,20)
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n/an/an/an/a 1.50E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000925
PNG
(7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1C
Show InChI InChI=1S/C12H11N3O/c1-6-3-4-9-8(7(6)2)5-10-11(13-9)15-12(16)14-10/h3-5H,1-2H3,(H2,13,14,15,16)
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n/an/an/an/a 20n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000888
PNG
(CHEMBL90168 | N-Methyl-4-(2-oxo-2,3-dihydro-1H-imi...)
Show SMILES CNC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H16N4O3/c1-16-13(20)3-2-6-22-10-4-5-11-9(7-10)8-12-14(17-11)19-15(21)18-12/h4-5,7-8H,2-3,6H2,1H3,(H,16,20)(H2,17,18,19,21)
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n/an/an/an/a 1.33E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000921
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O3/c1-22-14(20)5-3-2-4-10-6-7-12-11(8-10)9-13-15(17-12)19-16(21)18-13/h6-9H,2-5H2,1H3,(H2,17,18,19,21)
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n/an/an/an/a 430n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000908
PNG
(CHEMBL92363 | N-Cyclohexyl-N-methyl-4-(1-methyl-2-...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C22H28N4O3/c1-25(16-7-4-3-5-8-16)20(27)9-6-12-29-17-10-11-18-15(13-17)14-19-21(23-18)24-22(28)26(19)2/h10-11,13-14,16H,3-9,12H2,1-2H3,(H,23,24,28)
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n/an/an/an/a 50n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/an/an/a 1.05E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000904
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES Cn1c2cc3cc(OCCCCC(O)=O)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-2-4-14(20)21)5-6-12(10)17-15(13)18-16(19)22/h5-6,8-9H,2-4,7H2,1H3,(H,20,21)(H,17,18,22)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000870
PNG
(7-(3-Benzenesulfonyl-propoxy)-1,3-dihydro-imidazo[...)
Show SMILES O=c1[nH]c2cc3cc(OCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]1
Show InChI InChI=1S/C19H17N3O4S/c23-19-21-17-12-13-11-14(7-8-16(13)20-18(17)22-19)26-9-4-10-27(24,25)15-5-2-1-3-6-15/h1-3,5-8,11-12H,4,9-10H2,(H2,20,21,22,23)
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n/an/an/an/a 390n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000919
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES NC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H14N4O3/c15-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(16-10)18-14(20)17-11/h3-4,6-7H,1-2,5H2,(H2,15,19)(H2,16,17,18,20)
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n/an/an/an/a 3.02E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000894
PNG
(CHEMBL420618 | N-Cyclohexyl-N-methyl-4-(3-methyl-2...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3n(C)c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H28N4O3/c1-25(16-7-4-3-5-8-16)20(27)9-6-12-29-17-10-11-18-15(13-17)14-19-21(23-18)26(2)22(28)24-19/h10-11,13-14,16H,3-9,12H2,1-2H3,(H,24,28)
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n/an/an/an/a 3.30E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000909
PNG
(7-(4-Benzenesulfonyl-butoxy)-1,3-dihydro-imidazo[4...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]1
Show InChI InChI=1S/C20H19N3O4S/c24-20-22-18-13-14-12-15(8-9-17(14)21-19(18)23-20)27-10-4-5-11-28(25,26)16-6-2-1-3-7-16/h1-3,6-9,12-13H,4-5,10-11H2,(H2,21,22,23,24)
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n/an/an/an/a 10n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000944
PNG
(3-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CCOC(=O)C=Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H13N3O3/c1-2-21-13(19)6-4-9-3-5-11-10(7-9)8-12-14(16-11)18-15(20)17-12/h3-8H,2H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 440n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000898
PNG
(4-(2-Oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazol...)
Show SMILES OC(=O)CCCOc1ccc2N=C3NC(=O)CN3Cc2c1
Show InChI InChI=1S/C14H15N3O4/c18-12-8-17-7-9-6-10(21-5-1-2-13(19)20)3-4-11(9)15-14(17)16-12/h3-4,6H,1-2,5,7-8H2,(H,19,20)(H,15,16,18)
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n/an/an/an/a 6.91E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000915
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-27(17-8-4-2-3-5-9-17)21(28)10-6-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)26-23(29)25-20/h11-12,14-15,17H,2-10,13H2,1H3,(H2,24,25,26,29)
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n/an/an/an/a 1n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000887
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=C(CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC1CCCCC1
Show InChI InChI=1S/C21H26N4O2/c26-19(22-16-7-2-1-3-8-16)9-5-4-6-14-10-11-17-15(12-14)13-18-20(23-17)25-21(27)24-18/h10-13,16H,1-9H2,(H,22,26)(H2,23,24,25,27)
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n/an/an/an/a 4.95E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000888
PNG
(CHEMBL90168 | N-Methyl-4-(2-oxo-2,3-dihydro-1H-imi...)
Show SMILES CNC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H16N4O3/c1-16-13(20)3-2-6-22-10-4-5-11-9(7-10)8-12-14(17-11)19-15(21)18-12/h4-5,7-8H,2-3,6H2,1H3,(H,16,20)(H2,17,18,19,21)
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n/an/an/an/a 7.16E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000868
PNG
(CHEMBL88444 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Show SMILES CCOC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C24H30N4O5/c1-2-32-22(30)15-28(17-7-4-3-5-8-17)21(29)9-6-12-33-18-10-11-19-16(13-18)14-20-23(25-19)27-24(31)26-20/h10-11,13-14,17H,2-9,12,15H2,1H3,(H2,25,26,27,31)
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n/an/an/an/a 20n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000922
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O3/c19-13(20)4-2-1-3-9-5-6-11-10(7-9)8-12-14(16-11)18-15(21)17-12/h5-8H,1-4H2,(H,19,20)(H2,16,17,18,21)
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n/an/an/an/a 6.31E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000918
PNG
(7-(4-Hydroxy-butoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H15N3O3/c18-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(15-11)17-14(19)16-12/h3-4,7-8,18H,1-2,5-6H2,(H2,15,16,17,19)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000893
PNG
(CHEMBL91356 | N-Cyclohexyl-4-(1-methyl-2-oxo-2,3-d...)
Show SMILES Cn1c2cc3cc(OCCCC(=O)NC4CCCCC4)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C21H26N4O3/c1-25-18-13-14-12-16(9-10-17(14)23-20(18)24-21(25)27)28-11-5-8-19(26)22-15-6-3-2-4-7-15/h9-10,12-13,15H,2-8,11H2,1H3,(H,22,26)(H,23,24,27)
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n/an/an/an/a 7.84E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000933
PNG
(CHEMBL92264 | N-Adamantan-1-yl-4-(2-oxo-2,3-dihydr...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2
Show InChI InChI=1S/C24H28N4O3/c29-21(28-24-11-14-6-15(12-24)8-16(7-14)13-24)2-1-5-31-18-3-4-19-17(9-18)10-20-22(25-19)27-23(30)26-20/h3-4,9-10,14-16H,1-2,5-8,11-13H2,(H,28,29)(H2,25,26,27,30)/t14-,15+,16-,24?
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n/an/an/an/a 20n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000933
PNG
(CHEMBL92264 | N-Adamantan-1-yl-4-(2-oxo-2,3-dihydr...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2
Show InChI InChI=1S/C24H28N4O3/c29-21(28-24-11-14-6-15(12-24)8-16(7-14)13-24)2-1-5-31-18-3-4-19-17(9-18)10-20-22(25-19)27-23(30)26-20/h3-4,9-10,14-16H,1-2,5-8,11-13H2,(H,28,29)(H2,25,26,27,30)/t14-,15+,16-,24?
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n/an/an/an/a 120n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000919
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES NC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H14N4O3/c15-12(19)2-1-5-21-9-3-4-10-8(6-9)7-11-13(16-10)18-14(20)17-11/h3-4,6-7H,1-2,5H2,(H2,15,19)(H2,16,17,18,20)
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n/an/an/an/a 6.04E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000941
PNG
(Acetic acid 3-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]...)
Show SMILES CC(=O)OCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-9(19)21-5-2-6-22-11-3-4-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h3-4,7-8H,2,5-6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 330n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/an/an/a 1.05E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000931
PNG
(CHEMBL91368 | N-Cyclohexyl-N-methyl-4-(2-oxo-2,3-d...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C21H26N4O3/c1-25(15-6-3-2-4-7-15)19(26)8-5-11-28-16-9-10-17-14(12-16)13-18-20(22-17)24-21(27)23-18/h9-10,12-13,15H,2-8,11H2,1H3,(H2,22,23,24,27)
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n/an/an/an/a 5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 83n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma PRP


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000920
PNG
(CHEMBL88218 | N-Cyclohexyl-4-(2-oxo-2,3-dihydro-1H...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC1CCCCC1
Show InChI InChI=1S/C20H24N4O3/c25-18(21-14-5-2-1-3-6-14)7-4-10-27-15-8-9-16-13(11-15)12-17-19(22-16)24-20(26)23-17/h8-9,11-12,14H,1-7,10H2,(H,21,25)(H2,22,23,24,26)
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n/an/an/an/a 40n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000939
PNG
(1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-...)
Show SMILES OC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C20H22N4O5/c25-17(24-7-5-12(6-8-24)19(26)27)2-1-9-29-14-3-4-15-13(10-14)11-16-18(21-15)23-20(28)22-16/h3-4,10-12H,1-2,5-9H2,(H,26,27)(H2,21,22,23,28)
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n/an/an/an/a 380n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000880
PNG
(7-(2-Hydroxy-ethoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C12H11N3O3/c16-3-4-18-8-1-2-9-7(5-8)6-10-11(13-9)15-12(17)14-10/h1-2,5-6,16H,3-4H2,(H2,13,14,15,17)
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n/an/an/an/a 20n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000907
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=c1[nH]c2cc3cc(OCCCC#N)ccc3nc2[nH]1
Show InChI InChI=1S/C14H12N4O2/c15-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(16-11)18-14(19)17-12/h3-4,7-8H,1-2,6H2,(H2,16,17,18,19)
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n/an/an/an/a 600n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000896
PNG
(Acetic acid 2-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]...)
Show SMILES CC(=O)OCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H13N3O4/c1-8(18)20-4-5-21-10-2-3-11-9(6-10)7-12-13(15-11)17-14(19)16-12/h2-3,6-7H,4-5H2,1H3,(H2,15,16,17,19)
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n/an/an/an/a 870n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000913
PNG
(7-(2,3-Dihydroxy-propoxy)-1,3-dihydro-imidazo[4,5-...)
Show SMILES OCC(O)COc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C13H13N3O4/c17-5-8(18)6-20-9-1-2-10-7(3-9)4-11-12(14-10)16-13(19)15-11/h1-4,8,17-18H,5-6H2,(H2,14,15,16,19)
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n/an/an/an/a 260n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000881
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CC(C)OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-10(2)24-15(21)4-3-7-23-12-5-6-13-11(8-12)9-14-16(18-13)20-17(22)19-14/h5-6,8-10H,3-4,7H2,1-2H3,(H2,18,19,20,22)
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n/an/an/an/a 12n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000932
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CCOC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-2-22-14(20)4-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(21)18-13/h5-6,8-9H,2-4,7H2,1H3,(H2,17,18,19,21)
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n/an/an/an/a 38n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000899
PNG
(CHEMBL93688 | N-Cycloheptyl-4-(2-oxo-2,3-dihydro-1...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC1CCCCCC1
Show InChI InChI=1S/C21H26N4O3/c26-19(22-15-6-3-1-2-4-7-15)8-5-11-28-16-9-10-17-14(12-16)13-18-20(23-17)25-21(27)24-18/h9-10,12-13,15H,1-8,11H2,(H,22,26)(H2,23,24,25,27)
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n/an/an/an/a 16n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000890
PNG
(6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-23-15(21)5-3-2-4-8-24-12-6-7-13-11(9-12)10-14-16(18-13)20-17(22)19-14/h6-7,9-10H,2-5,8H2,1H3,(H2,18,19,20,22)
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n/an/an/an/a 90n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000917
PNG
(CHEMBL91340 | N-Cyclohexyl-4-(1,3-dimethyl-2-oxo-2...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3n(C)c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-25(17-8-5-4-6-9-17)21(28)10-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)27(3)23(29)26(20)2/h11-12,14-15,17H,4-10,13H2,1-3H3
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n/an/an/an/a 2.67E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000915
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-27(17-8-4-2-3-5-9-17)21(28)10-6-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)26-23(29)25-20/h11-12,14-15,17H,2-10,13H2,1H3,(H2,24,25,26,29)
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n/an/an/an/a 5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000935
PNG
(7-(5-Oxo-5-piperidin-1-yl-pentyl)-1,3-dihydro-imid...)
Show SMILES O=C(CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)N1CCCCC1
Show InChI InChI=1S/C20H24N4O2/c25-18(24-10-4-1-5-11-24)7-3-2-6-14-8-9-16-15(12-14)13-17-19(21-16)23-20(26)22-17/h8-9,12-13H,1-7,10-11H2,(H2,21,22,23,26)
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n/an/an/an/a 420n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000891
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C24H32N4O3/c1-27(18-9-5-3-4-6-10-18)22(29)11-7-8-14-31-19-12-13-20-17(15-19)16-21-23(25-20)26-24(30)28(21)2/h12-13,15-16,18H,3-11,14H2,1-2H3,(H,25,26,30)
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n/an/an/an/a 540n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000932
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CCOC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-2-22-14(20)4-3-7-23-11-5-6-12-10(8-11)9-13-15(17-12)19-16(21)18-13/h5-6,8-9H,2-4,7H2,1H3,(H2,17,18,19,21)
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n/an/an/an/a 630n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000875
PNG
(1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-...)
Show SMILES CCOC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H26N4O5/c1-2-30-21(28)14-7-9-26(10-8-14)19(27)4-3-11-31-16-5-6-17-15(12-16)13-18-20(23-17)25-22(29)24-18/h5-6,12-14H,2-4,7-11H2,1H3,(H2,23,24,25,29)
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n/an/an/an/a 90n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000926
PNG
(7-(2-Ethoxy-ethoxy)-1,3-dihydro-imidazo[4,5-b]quin...)
Show SMILES CCOCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H15N3O3/c1-2-19-5-6-20-10-3-4-11-9(7-10)8-12-13(15-11)17-14(18)16-12/h3-4,7-8H,2,5-6H2,1H3,(H2,15,16,17,18)
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n/an/an/an/a 4.84E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000881
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CC(C)OC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-10(2)24-15(21)4-3-7-23-12-5-6-13-11(8-12)9-14-16(18-13)20-17(22)19-14/h5-6,8-10H,3-4,7H2,1-2H3,(H2,18,19,20,22)
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n/an/an/an/a 590n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000907
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=c1[nH]c2cc3cc(OCCCC#N)ccc3nc2[nH]1
Show InChI InChI=1S/C14H12N4O2/c15-5-1-2-6-20-10-3-4-11-9(7-10)8-12-13(16-11)18-14(19)17-12/h3-4,7-8H,1-2,6H2,(H2,16,17,18,19)
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n/an/an/an/a 180n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000906
PNG
(7-(4-Morpholin-4-yl-4-oxo-butoxy)-1,3-dihydro-imid...)
Show SMILES O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)N1CCOCC1
Show InChI InChI=1S/C18H20N4O4/c23-16(22-5-8-25-9-6-22)2-1-7-26-13-3-4-14-12(10-13)11-15-17(19-14)21-18(24)20-15/h3-4,10-11H,1-2,5-9H2,(H2,19,20,21,24)
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n/an/an/an/a 280n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000869
PNG
(4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c1-21-13(19)3-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(20)17-12/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 66n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000895
PNG
(4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b...)
Show SMILES Cn1c2cc3cc(OCCCC(O)=O)ccc3nc2n(C)c1=O
Show InChI InChI=1S/C16H17N3O4/c1-18-13-9-10-8-11(23-7-3-4-14(20)21)5-6-12(10)17-15(13)19(2)16(18)22/h5-6,8-9H,3-4,7H2,1-2H3,(H,20,21)
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n/an/an/an/a 9.41E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000901
PNG
(4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C16H17N3O4/c1-19-13-9-10-8-11(23-7-3-4-14(20)22-2)5-6-12(10)17-15(13)18-16(19)21/h5-6,8-9H,3-4,7H2,1-2H3,(H,17,18,21)
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n/an/an/an/a 1.90E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000937
PNG
((2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-ylo...)
Show SMILES OC(=O)COc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C12H9N3O4/c16-10(17)5-19-7-1-2-8-6(3-7)4-9-11(13-8)15-12(18)14-9/h1-4H,5H2,(H,16,17)(H2,13,14,15,18)
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n/an/an/an/a 1.91E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000876
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=C(CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2
Show InChI InChI=1S/C25H30N4O2/c30-22(29-25-12-16-7-17(13-25)9-18(8-16)14-25)4-2-1-3-15-5-6-20-19(10-15)11-21-23(26-20)28-24(31)27-21/h5-6,10-11,16-18H,1-4,7-9,12-14H2,(H,29,30)(H2,26,27,28,31)/t16-,17+,18-,25?
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n/an/an/an/a 960n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000875
PNG
(1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-...)
Show SMILES CCOC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H26N4O5/c1-2-30-21(28)14-7-9-26(10-8-14)19(27)4-3-11-31-16-5-6-17-15(12-16)13-18-20(23-17)25-22(29)24-18/h5-6,12-14H,2-4,7-11H2,1H3,(H2,23,24,25,29)
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n/an/an/an/a 210n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000909
PNG
(7-(4-Benzenesulfonyl-butoxy)-1,3-dihydro-imidazo[4...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]1
Show InChI InChI=1S/C20H19N3O4S/c24-20-22-18-13-14-12-15(8-9-17(14)21-19(18)23-20)27-10-4-5-11-28(25,26)16-6-2-1-3-7-16/h1-3,6-9,12-13H,4-5,10-11H2,(H2,21,22,23,24)
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n/an/an/an/a 10n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000871
PNG
(CHEMBL69139 | N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2N=C3NC(=O)CN3Cc2c1
Show InChI InChI=1S/C21H28N4O3/c1-24(16-6-3-2-4-7-16)20(27)8-5-11-28-17-9-10-18-15(12-17)13-25-14-19(26)23-21(25)22-18/h9-10,12,16H,2-8,11,13-14H2,1H3,(H,22,23,26)
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n/an/an/an/a 440n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000943
PNG
(7-[4-(1H-Tetrazol-5-yl)-butoxy]-1,3-dihydro-imidaz...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCc4nnn[nH]4)ccc3nc2[nH]1
Show InChI InChI=1S/C15H15N7O2/c23-15-17-12-8-9-7-10(4-5-11(9)16-14(12)18-15)24-6-2-1-3-13-19-21-22-20-13/h4-5,7-8H,1-3,6H2,(H2,16,17,18,23)(H,19,20,21,22)
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n/an/an/an/a 5.40E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000931
PNG
(CHEMBL91368 | N-Cyclohexyl-N-methyl-4-(2-oxo-2,3-d...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C21H26N4O3/c1-25(15-6-3-2-4-7-15)19(26)8-5-11-28-16-9-10-17-14(12-16)13-18-20(22-17)24-21(27)23-18/h9-10,12-13,15H,2-8,11H2,1H3,(H2,22,23,24,27)
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n/an/an/an/a 7n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000876
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=C(CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2
Show InChI InChI=1S/C25H30N4O2/c30-22(29-25-12-16-7-17(13-25)9-18(8-16)14-25)4-2-1-3-15-5-6-20-19(10-15)11-21-23(26-20)28-24(31)27-21/h5-6,10-11,16-18H,1-4,7-9,12-14H2,(H,29,30)(H2,26,27,28,31)/t16-,17+,18-,25?
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n/an/an/an/a 5.26E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000943
PNG
(7-[4-(1H-Tetrazol-5-yl)-butoxy]-1,3-dihydro-imidaz...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCc4nnn[nH]4)ccc3nc2[nH]1
Show InChI InChI=1S/C15H15N7O2/c23-15-17-12-8-9-7-10(4-5-11(9)16-14(12)18-15)24-6-2-1-3-13-19-21-22-20-13/h4-5,7-8H,1-3,6H2,(H2,16,17,18,23)(H,19,20,21,22)
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n/an/an/an/a 5.10E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000940
PNG
(7-(5-Hydroxy-pentyl)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H17N3O2/c19-7-3-1-2-4-10-5-6-12-11(8-10)9-13-14(16-12)18-15(20)17-13/h5-6,8-9,19H,1-4,7H2,(H2,16,17,18,20)
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n/an/an/an/a 2.95E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000910
PNG
(6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-27(17-8-4-2-5-9-17)21(28)10-6-3-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)26-23(29)25-20/h11-12,14-15,17H,2-10,13H2,1H3,(H2,24,25,26,29)
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n/an/an/an/a 540n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000880
PNG
(7-(2-Hydroxy-ethoxy)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C12H11N3O3/c16-3-4-18-8-1-2-9-7(5-8)6-10-11(13-9)15-12(17)14-10/h1-2,5-6,16H,3-4H2,(H2,13,14,15,17)
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n/an/an/an/a 4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000878
PNG
(7-[3-(1H-Tetrazol-5-yl)-propoxy]-1,3-dihydro-imida...)
Show SMILES O=c1[nH]c2cc3cc(OCCCc4nnn[nH]4)ccc3nc2[nH]1
Show InChI InChI=1S/C14H13N7O2/c22-14-16-11-7-8-6-9(3-4-10(8)15-13(11)17-14)23-5-1-2-12-18-20-21-19-12/h3-4,6-7H,1-2,5H2,(H2,15,16,17,22)(H,18,19,20,21)
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n/an/an/an/a 6.32E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000871
PNG
(CHEMBL69139 | N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2N=C3NC(=O)CN3Cc2c1
Show InChI InChI=1S/C21H28N4O3/c1-24(16-6-3-2-4-7-16)20(27)8-5-11-28-17-9-10-18-15(12-17)13-25-14-19(26)23-21(25)22-18/h9-10,12,16H,2-8,11,13-14H2,1H3,(H,22,23,26)
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n/an/an/an/a 440n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000928
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-26(17-8-4-3-5-9-17)21(28)10-6-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)25-23(29)27(20)2/h11-12,14-15,17H,3-10,13H2,1-2H3,(H,24,25,29)
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n/an/an/an/a 150n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000925
PNG
(7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1C
Show InChI InChI=1S/C12H11N3O/c1-6-3-4-9-8(7(6)2)5-10-11(13-9)15-12(16)14-10/h3-5H,1-2H3,(H2,13,14,15,16)
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n/an/an/an/a 390n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000872
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H28N4O2/c1-26(17-8-3-2-4-9-17)20(27)10-6-5-7-15-11-12-18-16(13-15)14-19-21(23-18)25-22(28)24-19/h11-14,17H,2-10H2,1H3,(H2,23,24,25,28)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000914
PNG
(7-(3-Hydroxy-propyl)-1,3-dihydro-imidazo[4,5-b]qui...)
Show SMILES OCCCc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C13H13N3O2/c17-5-1-2-8-3-4-10-9(6-8)7-11-12(14-10)16-13(18)15-11/h3-4,6-7,17H,1-2,5H2,(H2,14,15,16,18)
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n/an/an/an/a 2.47E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000903
PNG
(CHEMBL91422 | N-Cycloheptyl-N-methyl-4-(1-methyl-2...)
Show SMILES CN(C1CCCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C23H30N4O3/c1-26(17-8-5-3-4-6-9-17)21(28)10-7-13-30-18-11-12-19-16(14-18)15-20-22(24-19)25-23(29)27(20)2/h11-12,14-15,17H,3-10,13H2,1-2H3,(H,24,25,29)
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n/an/an/an/a 70n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000884
PNG
(7-(4-Oxo-pentyloxy)-1,3-dihydro-imidazo[4,5-b]quin...)
Show SMILES CC(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O3/c1-9(19)3-2-6-21-11-4-5-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h4-5,7-8H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000893
PNG
(CHEMBL91356 | N-Cyclohexyl-4-(1-methyl-2-oxo-2,3-d...)
Show SMILES Cn1c2cc3cc(OCCCC(=O)NC4CCCCC4)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C21H26N4O3/c1-25-18-13-14-12-16(9-10-17(14)23-20(18)24-21(25)27)28-11-5-8-19(26)22-15-6-3-2-4-7-15/h9-10,12-13,15H,2-8,11H2,1H3,(H,22,26)(H,23,24,27)
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n/an/an/an/a 180n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50000867
PNG
(7-(4-Hydroxy-pentyloxy)-1,3-dihydro-imidazo[4,5-b]...)
Show SMILES CC(O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H17N3O3/c1-9(19)3-2-6-21-11-4-5-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h4-5,7-9,19H,2-3,6H2,1H3,(H2,16,17,18,20)
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n/an/an/an/a 520n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ADP-induced platelet aggregation in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000874
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES O=c1[nH]c2cc3cc(OCCCCC#N)ccc3nc2[nH]1
Show InChI InChI=1S/C15H14N4O2/c16-6-2-1-3-7-21-11-4-5-12-10(8-11)9-13-14(17-12)19-15(20)18-13/h4-5,8-9H,1-3,7H2,(H2,17,18,19,20)
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n/an/an/an/a 1.32E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000911
PNG
(7-(3-Benzenesulfonyl-propoxy)-1-methyl-1,3-dihydro...)
Show SMILES Cn1c2cc3cc(OCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]c1=O
Show InChI InChI=1S/C20H19N3O4S/c1-23-18-13-14-12-15(8-9-17(14)21-19(18)22-20(23)24)27-10-5-11-28(25,26)16-6-3-2-4-7-16/h2-4,6-9,12-13H,5,10-11H2,1H3,(H,21,22,24)
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n/an/an/an/a 5.03E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000889
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES OC(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C15H15N3O4/c19-13(20)3-1-2-6-22-10-4-5-11-9(7-10)8-12-14(16-11)18-15(21)17-12/h4-5,7-8H,1-3,6H2,(H,19,20)(H2,16,17,18,21)
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n/an/an/an/a>1.06E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000882
PNG
(7-(3-Hydroxy-propoxy)-1,3-dihydro-imidazo[4,5-b]qu...)
Show SMILES OCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C13H13N3O3/c17-4-1-5-19-9-2-3-10-8(6-9)7-11-12(14-10)16-13(18)15-11/h2-3,6-7,17H,1,4-5H2,(H2,14,15,16,18)
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n/an/an/an/a 770n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000892
PNG
(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Show SMILES CN(C1CCCCC1)C(=O)CCCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H28N4O3/c1-26(16-7-3-2-4-8-16)20(27)9-5-6-12-29-17-10-11-18-15(13-17)14-19-21(23-18)25-22(28)24-19/h10-11,13-14,16H,2-9,12H2,1H3,(H2,23,24,25,28)
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n/an/an/an/a 8n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000936
PNG
((2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-ylo...)
Show SMILES CCOC(=O)COc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C14H13N3O4/c1-2-20-12(18)7-21-9-3-4-10-8(5-9)6-11-13(15-10)17-14(19)16-11/h3-6H,2,7H2,1H3,(H2,15,16,17,19)
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n/an/an/an/a 2.43E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000900
PNG
(CHEMBL90804 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Show SMILES COC(=O)CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C23H28N4O5/c1-31-21(29)14-27(16-6-3-2-4-7-16)20(28)8-5-11-32-17-9-10-18-15(12-17)13-19-22(24-18)26-23(30)25-19/h9-10,12-13,16H,2-8,11,14H2,1H3,(H2,24,25,26,30)
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n/an/an/an/a 0.700n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000942
PNG
(5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]qui...)
Show SMILES COC(=O)CCCCOc1ccc2nc3[nH]c(=O)n(C)c3cc2c1
Show InChI InChI=1S/C17H19N3O4/c1-20-14-10-11-9-12(24-8-4-3-5-15(21)23-2)6-7-13(11)18-16(14)19-17(20)22/h6-7,9-10H,3-5,8H2,1-2H3,(H,18,19,22)
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n/an/an/an/a 9.11E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Homo sapiens (Human))
BDBM50000894
PNG
(CHEMBL420618 | N-Cyclohexyl-N-methyl-4-(3-methyl-2...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3n(C)c(=O)[nH]c3cc2c1
Show InChI InChI=1S/C22H28N4O3/c1-25(16-7-4-3-5-8-16)20(27)9-6-12-29-17-10-11-18-15(13-17)14-19-21(23-18)26(2)22(28)24-19/h10-11,13-14,16H,3-9,12H2,1-2H3,(H,24,28)
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n/an/an/an/a 3.30E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%