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PubMed code 1321911

Compile data set for download or QSAR
Found 59 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229805
PNG
(CHEMBL327234)
Show SMILES Oc1nc2cc3cc(OCCCCC(=O)N4CCN(CC5CCCCC5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C26H35N5O3/c32-24(31-13-11-30(12-14-31)18-19-6-2-1-3-7-19)8-4-5-15-34-21-9-10-22-20(16-21)17-23-25(27-22)29-26(33)28-23/h9-10,16-17,19H,1-8,11-15,18H2,(H2,27,28,29,33)
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n/an/a 0.0300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229826
PNG
(CHEMBL88787)
Show SMILES Oc1nc2cc3cc(OCCCCC(=O)N4CCN(Cc5ccccc5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C26H29N5O3/c32-24(31-13-11-30(12-14-31)18-19-6-2-1-3-7-19)8-4-5-15-34-21-9-10-22-20(16-21)17-23-25(27-22)29-26(33)28-23/h1-3,6-7,9-10,16-17H,4-5,8,11-15,18H2,(H2,27,28,29,33)
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n/an/a 0.0800n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229833
PNG
(CHEMBL90877)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC5CCCCCC5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C26H35N5O3/c32-24(31-13-11-30(12-14-31)18-19-6-3-1-2-4-7-19)8-5-15-34-21-9-10-22-20(16-21)17-23-25(27-22)29-26(33)28-23/h9-10,16-17,19H,1-8,11-15,18H2,(H2,27,28,29,33)
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n/an/a 0.200n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229803
PNG
(CHEMBL329173)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CCC5CCCCC5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C26H35N5O3/c32-24(31-14-12-30(13-15-31)11-10-19-5-2-1-3-6-19)7-4-16-34-21-8-9-22-20(17-21)18-23-25(27-22)29-26(33)28-23/h8-9,17-19H,1-7,10-16H2,(H2,27,28,29,33)
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n/an/a 0.200n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229804
PNG
(CHEMBL90647)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC4)C(c4ccc(F)cc4)c4ccc(F)cc4)ccc3[nH]c2n1
Show InChI InChI=1S/C31H29F2N5O3/c32-23-7-3-20(4-8-23)29(21-5-9-24(33)10-6-21)38-15-13-37(14-16-38)28(39)2-1-17-41-25-11-12-26-22(18-25)19-27-30(34-26)36-31(40)35-27/h3-12,18-19,29H,1-2,13-17H2,(H2,34,35,36,40)
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n/an/a 0.300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229806
PNG
(CHEMBL91503)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CCc5ccccc5C(F)(F)F)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C27H28F3N5O3/c28-27(29,30)21-5-2-1-4-18(21)9-10-34-11-13-35(14-12-34)24(36)6-3-15-38-20-7-8-22-19(16-20)17-23-25(31-22)33-26(37)32-23/h1-2,4-5,7-8,16-17H,3,6,9-15H2,(H2,31,32,33,37)
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n/an/a 0.300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229802
PNG
(CHEMBL328543)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C23H29N5O5/c1-23(2,3)33-22(31)28-10-8-27(9-11-28)19(29)5-4-12-32-16-6-7-17-15(13-16)14-18-20(24-17)26-21(30)25-18/h6-7,13-14H,4-5,8-12H2,1-3H3,(H2,24,25,26,30)
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n/an/a 0.300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229764
PNG
(CHEMBL432057)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC5CCCCC5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C25H33N5O3/c31-23(30-12-10-29(11-13-30)17-18-5-2-1-3-6-18)7-4-14-33-20-8-9-21-19(15-20)16-22-24(26-21)28-25(32)27-22/h8-9,15-16,18H,1-7,10-14,17H2,(H2,26,27,28,32)
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n/an/a 0.400n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229821
PNG
(CHEMBL91388)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5ccc(cc5)C(F)(F)F)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C26H26F3N5O3/c27-26(28,29)19-5-3-17(4-6-19)16-33-9-11-34(12-10-33)23(35)2-1-13-37-20-7-8-21-18(14-20)15-22-24(30-21)32-25(36)31-22/h3-8,14-15H,1-2,9-13,16H2,(H2,30,31,32,36)
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n/an/a 0.400n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229792
PNG
(CHEMBL329788)
Show SMILES CCCC(CCC)CN1CCN(CC1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C26H37N5O3/c1-3-6-19(7-4-2)18-30-11-13-31(14-12-30)24(32)8-5-15-34-21-9-10-22-20(16-21)17-23-25(27-22)29-26(33)28-23/h9-10,16-17,19H,3-8,11-15,18H2,1-2H3,(H2,27,28,29,33)
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n/an/a 0.400n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229814
PNG
(CHEMBL92165)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC5CCCC5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C24H31N5O3/c30-22(29-11-9-28(10-12-29)16-17-4-1-2-5-17)6-3-13-32-19-7-8-20-18(14-19)15-21-23(25-20)27-24(31)26-21/h7-8,14-15,17H,1-6,9-13,16H2,(H2,25,26,27,31)
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n/an/a 0.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229771
PNG
(CHEMBL91088)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC4)c4cccc(c4)C(F)(F)F)ccc3[nH]c2n1
Show InChI InChI=1S/C25H24F3N5O3/c26-25(27,28)17-3-1-4-18(15-17)32-8-10-33(11-9-32)22(34)5-2-12-36-19-6-7-20-16(13-19)14-21-23(29-20)31-24(35)30-21/h1,3-4,6-7,13-15H,2,5,8-12H2,(H2,29,30,31,35)
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n/an/a 0.600n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229788
PNG
(CHEMBL91715)
Show SMILES Oc1nc2cc3cc(OCCCCCC(=O)N4CCN(CC5CCCCC5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C27H37N5O3/c33-25(32-14-12-31(13-15-32)19-20-7-3-1-4-8-20)9-5-2-6-16-35-22-10-11-23-21(17-22)18-24-26(28-23)30-27(34)29-24/h10-11,17-18,20H,1-9,12-16,19H2,(H2,28,29,30,34)
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n/an/a 0.600n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229796
PNG
(CHEMBL431085)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)NC4CCN(Cc5ccccc5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C26H29N5O3/c32-24(27-20-10-12-31(13-11-20)17-18-5-2-1-3-6-18)7-4-14-34-21-8-9-22-19(15-21)16-23-25(28-22)30-26(33)29-23/h1-3,5-6,8-9,15-16,20H,4,7,10-14,17H2,(H,27,32)(H2,28,29,30,33)
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n/an/a 0.700n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229790
PNG
(CHEMBL329573)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC5CCCCO5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C24H31N5O4/c30-22(29-10-8-28(9-11-29)16-19-4-1-2-12-33-19)5-3-13-32-18-6-7-20-17(14-18)15-21-23(25-20)27-24(31)26-21/h6-7,14-15,19H,1-5,8-13,16H2,(H2,25,26,27,31)
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n/an/a 0.700n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229830
PNG
(CHEMBL90876)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5cccs5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C23H25N5O3S/c29-21(28-9-7-27(8-10-28)15-18-3-2-12-32-18)4-1-11-31-17-5-6-19-16(13-17)14-20-22(24-19)26-23(30)25-20/h2-3,5-6,12-14H,1,4,7-11,15H2,(H2,24,25,26,30)
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n/an/a 0.700n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229791
PNG
(CHEMBL330086)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5ccsc5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C23H25N5O3S/c29-21(28-8-6-27(7-9-28)14-16-5-11-32-15-16)2-1-10-31-18-3-4-19-17(12-18)13-20-22(24-19)26-23(30)25-20/h3-5,11-13,15H,1-2,6-10,14H2,(H2,24,25,26,30)
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n/an/a 0.700n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229770
PNG
(CHEMBL433183)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5ccccc5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C25H27N5O3/c31-23(30-12-10-29(11-13-30)17-18-5-2-1-3-6-18)7-4-14-33-20-8-9-21-19(15-20)16-22-24(26-21)28-25(32)27-22/h1-3,5-6,8-9,15-16H,4,7,10-14,17H2,(H2,26,27,28,32)
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n/an/a 0.700n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229766
PNG
(CHEMBL91249)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC4)C4CCCCCC4)ccc3[nH]c2n1
Show InChI InChI=1S/C25H33N5O3/c31-23(30-13-11-29(12-14-30)19-6-3-1-2-4-7-19)8-5-15-33-20-9-10-21-18(16-20)17-22-24(26-21)28-25(32)27-22/h9-10,16-17,19H,1-8,11-15H2,(H2,26,27,28,32)
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n/an/a 0.900n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229768
PNG
(CHEMBL91014)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5ccc6OCOc6c5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C26H27N5O5/c32-24(31-9-7-30(8-10-31)15-17-3-6-22-23(12-17)36-16-35-22)2-1-11-34-19-4-5-20-18(13-19)14-21-25(27-20)29-26(33)28-21/h3-6,12-14H,1-2,7-11,15-16H2,(H2,27,28,29,33)
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n/an/a 0.900n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229794
PNG
(CHEMBL90176)
Show SMILES CC(C)CN1CCN(CC1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C22H29N5O3/c1-15(2)14-26-7-9-27(10-8-26)20(28)4-3-11-30-17-5-6-18-16(12-17)13-19-21(23-18)25-22(29)24-19/h5-6,12-13,15H,3-4,7-11,14H2,1-2H3,(H2,23,24,25,29)
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229762
PNG
(CHEMBL313021)
Show SMILES CCC(CC)CN1CCN(CC1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C24H33N5O3/c1-3-17(4-2)16-28-9-11-29(12-10-28)22(30)6-5-13-32-19-7-8-20-18(14-19)15-21-23(25-20)27-24(31)26-21/h7-8,14-15,17H,3-6,9-13,16H2,1-2H3,(H2,25,26,27,31)
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229799
PNG
(CHEMBL330737)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5ccc(Cl)cc5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C25H26ClN5O3/c26-19-5-3-17(4-6-19)16-30-9-11-31(12-10-30)23(32)2-1-13-34-20-7-8-21-18(14-20)15-22-24(27-21)29-25(33)28-22/h3-8,14-15H,1-2,9-13,16H2,(H2,27,28,29,33)
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n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229765
PNG
(CHEMBL89810)
Show SMILES CCOC(=O)CN1CCN(CC1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C22H27N5O5/c1-2-31-20(29)14-26-7-9-27(10-8-26)19(28)4-3-11-32-16-5-6-17-15(12-16)13-18-21(23-17)25-22(30)24-18/h5-6,12-13H,2-4,7-11,14H2,1H3,(H2,23,24,25,30)
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n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229822
PNG
(CHEMBL92205)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC4)c4ccccc4)ccc3[nH]c2n1
Show InChI InChI=1S/C24H25N5O3/c30-22(29-12-10-28(11-13-29)18-5-2-1-3-6-18)7-4-14-32-19-8-9-20-17(15-19)16-21-23(25-20)27-24(31)26-21/h1-3,5-6,8-9,15-16H,4,7,10-14H2,(H2,25,26,27,31)
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n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229818
PNG
(CHEMBL90546)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5ccc(F)cc5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C25H26FN5O3/c26-19-5-3-17(4-6-19)16-30-9-11-31(12-10-30)23(32)2-1-13-34-20-7-8-21-18(14-20)15-22-24(27-21)29-25(33)28-22/h3-8,14-15H,1-2,9-13,16H2,(H2,27,28,29,33)
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n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229811
PNG
(CHEMBL93730)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CCc5ccccc5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C26H29N5O3/c32-24(31-14-12-30(13-15-31)11-10-19-5-2-1-3-6-19)7-4-16-34-21-8-9-22-20(17-21)18-23-25(27-22)29-26(33)28-23/h1-3,5-6,8-9,17-18H,4,7,10-16H2,(H2,27,28,29,33)
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n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229769
PNG
(CHEMBL90380)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC4)C(c4ccccc4)c4ccccc4)ccc3[nH]c2n1
Show InChI InChI=1S/C31H31N5O3/c37-28(12-7-19-39-25-13-14-26-24(20-25)21-27-30(32-26)34-31(38)33-27)35-15-17-36(18-16-35)29(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-6,8-11,13-14,20-21,29H,7,12,15-19H2,(H2,32,33,34,38)
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229831
PNG
(CHEMBL327882)
Show SMILES COc1ccc(CN2CCN(CC2)C(=O)CCCOc2ccc3[nH]c4nc(O)nc4cc3c2)cc1
Show InChI InChI=1S/C26H29N5O4/c1-34-20-6-4-18(5-7-20)17-30-10-12-31(13-11-30)24(32)3-2-14-35-21-8-9-22-19(15-21)16-23-25(27-22)29-26(33)28-23/h4-9,15-16H,2-3,10-14,17H2,1H3,(H2,27,28,29,33)
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229819
PNG
(CHEMBL328711)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)NCCN4CCCCC4)ccc3[nH]c2n1
Show InChI InChI=1S/C21H27N5O3/c27-19(22-8-11-26-9-2-1-3-10-26)5-4-12-29-16-6-7-17-15(13-16)14-18-20(23-17)25-21(28)24-18/h6-7,13-14H,1-5,8-12H2,(H,22,27)(H2,23,24,25,28)
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229815
PNG
(CHEMBL90515)
Show SMILES CN(CCc1ccccn1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C22H23N5O3/c1-27(11-9-16-5-2-3-10-23-16)20(28)6-4-12-30-17-7-8-18-15(13-17)14-19-21(24-18)26-22(29)25-19/h2-3,5,7-8,10,13-14H,4,6,9,11-12H2,1H3,(H2,24,25,26,29)
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n/an/a 4.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229816
PNG
(CHEMBL89820)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC4)c4ccccn4)ccc3[nH]c2n1
Show InChI InChI=1S/C23H24N6O3/c30-21(29-11-9-28(10-12-29)20-4-1-2-8-24-20)5-3-13-32-17-6-7-18-16(14-17)15-19-22(25-18)27-23(31)26-19/h1-2,4,6-8,14-15H,3,5,9-13H2,(H2,25,26,27,31)
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n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229795
PNG
(CHEMBL92169)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCC(CC4)N4CCCCC4)ccc3[nH]c2n1
Show InChI InChI=1S/C24H31N5O3/c30-22(29-12-8-18(9-13-29)28-10-2-1-3-11-28)5-4-14-32-19-6-7-20-17(15-19)16-21-23(25-20)27-24(31)26-21/h6-7,15-16,18H,1-5,8-14H2,(H2,25,26,27,31)
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n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229789
PNG
(CHEMBL327786)
Show SMILES O=C(CCCOc1ccc2N=C3NC(=O)CN3Cc2c1)N1CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C25H35N5O3/c31-23-18-30-17-20-15-21(8-9-22(20)26-25(30)27-23)33-14-4-7-24(32)29-12-10-28(11-13-29)16-19-5-2-1-3-6-19/h8-9,15,19H,1-7,10-14,16-18H2,(H,26,27,31)
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n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229793
PNG
(CHEMBL316367)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC(=O)N5CCCC5)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C24H30N6O4/c31-21(30-11-9-28(10-12-30)16-22(32)29-7-1-2-8-29)4-3-13-34-18-5-6-19-17(14-18)15-20-23(25-19)27-24(33)26-20/h5-6,14-15H,1-4,7-13,16H2,(H2,25,26,27,33)
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n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet cAMP Phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229824
PNG
(CHEMBL91010)
Show SMILES CN1CCN(CC1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C19H23N5O3/c1-23-6-8-24(9-7-23)17(25)3-2-10-27-14-4-5-15-13(11-14)12-16-18(20-15)22-19(26)21-16/h4-5,11-12H,2-3,6-10H2,1H3,(H2,20,21,22,26)
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n/an/a 7n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229808
PNG
(CHEMBL329412)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(CC4)c4ncccn4)ccc3[nH]c2n1
Show InChI InChI=1S/C22H23N7O3/c30-19(28-8-10-29(11-9-28)21-23-6-2-7-24-21)3-1-12-32-16-4-5-17-15(13-16)14-18-20(25-17)27-22(31)26-18/h2,4-7,13-14H,1,3,8-12H2,(H2,25,26,27,31)
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n/an/a 7n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229825
PNG
(CHEMBL90230)
Show SMILES COCCN1CCN(CC1)C(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C21H27N5O4/c1-29-12-10-25-6-8-26(9-7-25)19(27)3-2-11-30-16-4-5-17-15(13-16)14-18-20(22-17)24-21(28)23-18/h4-5,13-14H,2-3,6-12H2,1H3,(H2,22,23,24,28)
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n/an/a 7n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229827
PNG
(CHEMBL327808)
Show SMILES O=C(CCCOc1ccc2N=C3NC(=O)CN3Cc2c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C25H29N5O3/c31-23-18-30-17-20-15-21(8-9-22(20)26-25(30)27-23)33-14-4-7-24(32)29-12-10-28(11-13-29)16-19-5-2-1-3-6-19/h1-3,5-6,8-9,15H,4,7,10-14,16-18H2,(H,26,27,31)
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n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229798
PNG
(CHEMBL314949)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCN(Cc5cccc(c5)C(F)(F)F)CC4)ccc3[nH]c2n1
Show InChI InChI=1S/C26H26F3N5O3/c27-26(28,29)19-4-1-3-17(13-19)16-33-8-10-34(11-9-33)23(35)5-2-12-37-20-6-7-21-18(14-20)15-22-24(30-21)32-25(36)31-22/h1,3-4,6-7,13-15H,2,5,8-12,16H2,(H2,30,31,32,36)
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n/an/a 9n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50000925
PNG
(7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)
Show SMILES Cc1ccc2nc3[nH]c(=O)[nH]c3cc2c1C
Show InChI InChI=1S/C12H11N3O/c1-6-3-4-9-8(7(6)2)5-10-11(13-9)15-12(16)14-10/h3-5H,1-2H3,(H2,13,14,15,16)
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229817
PNG
(CHEMBL328279)
Show SMILES CN1CCCC1CCNC(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C21H27N5O3/c1-26-10-2-4-15(26)8-9-22-19(27)5-3-11-29-16-6-7-17-14(12-16)13-18-20(23-17)25-21(28)24-18/h6-7,12-13,15H,2-5,8-11H2,1H3,(H,22,27)(H2,23,24,25,28)
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n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229809
PNG
(CHEMBL88182)
Show SMILES OC(=O)C1CCN(CC1)c1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C16H16N4O3/c21-15(22)9-3-5-20(6-4-9)11-1-2-12-10(7-11)8-13-14(17-12)19-16(23)18-13/h1-2,7-9H,3-6H2,(H,21,22)(H2,17,18,19,23)
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n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229800
PNG
(CHEMBL329248)
Show SMILES Oc1nc2cc3cc(ccc3[nH]c2n1)N1CCOCC1
Show InChI InChI=1S/C14H14N4O2/c19-14-16-12-8-9-7-10(18-3-5-20-6-4-18)1-2-11(9)15-13(12)17-14/h1-2,7-8H,3-6H2,(H2,15,16,17,19)
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n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229785
PNG
(CHEMBL92202)
Show SMILES Cn1c(O)nc2nc3ccc(OCCCC(=O)N4CCN(Cc5ccccc5)CC4)cc3cc12
Show InChI InChI=1S/C26H29N5O3/c1-29-23-17-20-16-21(9-10-22(20)27-25(23)28-26(29)33)34-15-5-8-24(32)31-13-11-30(12-14-31)18-19-6-3-2-4-7-19/h2-4,6-7,9-10,16-17H,5,8,11-15,18H2,1H3,(H,27,28,33)
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n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229801
PNG
(CHEMBL90183)
Show SMILES Oc1nc2cc3cc(ccc3[nH]c2n1)N1CCCCC1
Show InChI InChI=1S/C15H16N4O/c20-15-17-13-9-10-8-11(19-6-2-1-3-7-19)4-5-12(10)16-14(13)18-15/h4-5,8-9H,1-3,6-7H2,(H2,16,17,18,20)
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n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229763
PNG
(CHEMBL91724)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)N4CCNCC4)ccc3[nH]c2n1
Show InChI InChI=1S/C18H21N5O3/c24-16(23-7-5-19-6-8-23)2-1-9-26-13-3-4-14-12(10-13)11-15-17(20-14)22-18(25)21-15/h3-4,10-11,19H,1-2,5-9H2,(H2,20,21,22,25)
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n/an/a 40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229828
PNG
(CHEMBL92381)
Show SMILES Oc1nc2cc3cc(OCCCC(=O)NC4CN5CCC4CC5)ccc3[nH]c2n1
Show InChI InChI=1S/C21H25N5O3/c27-19(22-18-12-26-7-5-13(18)6-8-26)2-1-9-29-15-3-4-16-14(10-15)11-17-20(23-16)25-21(28)24-17/h3-4,10-11,13,18H,1-2,5-9,12H2,(H,22,27)(H2,23,24,25,28)
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n/an/a 40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229813
PNG
(CHEMBL330240)
Show SMILES CN1CCCC1CNC(=O)CCCOc1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C20H25N5O3/c1-25-8-2-4-14(25)12-21-18(26)5-3-9-28-15-6-7-16-13(10-15)11-17-19(22-16)24-20(27)23-17/h6-7,10-11,14H,2-5,8-9,12H2,1H3,(H,21,26)(H2,22,23,24,27)
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n/an/a 40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229767
PNG
(CHEMBL329344)
Show SMILES Oc1nc2cc3cc(ccc3[nH]c2n1)N1CCCC1
Show InChI InChI=1S/C14H14N4O/c19-14-16-12-8-9-7-10(18-5-1-2-6-18)3-4-11(9)15-13(12)17-14/h3-4,7-8H,1-2,5-6H2,(H2,15,16,17,19)
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n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229832
PNG
(CHEMBL91720)
Show SMILES CCN(CC)c1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C14H16N4O/c1-3-18(4-2)10-5-6-11-9(7-10)8-12-13(15-11)17-14(19)16-12/h5-8H,3-4H2,1-2H3,(H2,15,16,17,19)
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n/an/a 70n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet cAMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229807
PNG
(CHEMBL88797)
Show SMILES Cn1c(O)nc2nc3ccc(OCCCC(=O)N4CCN(CC5CCCCC5)CC4)cc3cc12
Show InChI InChI=1S/C26H35N5O3/c1-29-23-17-20-16-21(9-10-22(20)27-25(23)28-26(29)33)34-15-5-8-24(32)31-13-11-30(12-14-31)18-19-6-3-2-4-7-19/h9-10,16-17,19H,2-8,11-15,18H2,1H3,(H,27,28,33)
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n/an/a 80n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229810
PNG
(CHEMBL89395)
Show SMILES CN(C1CCCCC1)C(=O)C1CCN(CC1)c1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C23H29N5O2/c1-27(17-5-3-2-4-6-17)22(29)15-9-11-28(12-10-15)18-7-8-19-16(13-18)14-20-21(24-19)26-23(30)25-20/h7-8,13-15,17H,2-6,9-12H2,1H3,(H2,24,25,26,30)
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n/an/a 300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229797
PNG
(CHEMBL89276)
Show SMILES COC(=O)C1CCN(CC1)c1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C17H18N4O3/c1-24-16(22)10-4-6-21(7-5-10)12-2-3-13-11(8-12)9-14-15(18-13)20-17(23)19-14/h2-3,8-10H,4-7H2,1H3,(H2,18,19,20,23)
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n/an/a 300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229823
PNG
(CHEMBL328987)
Show SMILES COc1ccc(cc1OC)C(=O)N1CCN(CC1)c1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C23H23N5O4/c1-31-19-6-3-14(13-20(19)32-2)22(29)28-9-7-27(8-10-28)16-4-5-17-15(11-16)12-18-21(24-17)26-23(30)25-18/h3-6,11-13H,7-10H2,1-2H3,(H2,24,25,26,30)
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n/an/a 300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229829
PNG
(CHEMBL90849)
Show SMILES Oc1nc2cc3cc(ccc3[nH]c2n1)N1CCN(CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C21H19N5O2/c27-20(14-4-2-1-3-5-14)26-10-8-25(9-11-26)16-6-7-17-15(12-16)13-18-19(22-17)24-21(28)23-18/h1-7,12-13H,8-11H2,(H2,22,23,24,28)
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n/an/a 600n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229812
PNG
(CHEMBL89277)
Show SMILES CCOC(=O)N1CCN(CC1)c1ccc2[nH]c3nc(O)nc3cc2c1
Show InChI InChI=1S/C17H19N5O3/c1-2-25-17(24)22-7-5-21(6-8-22)12-3-4-13-11(9-12)10-14-15(18-13)20-16(23)19-14/h3-4,9-10H,2,5-8H2,1H3,(H2,18,19,20,23)
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n/an/a 700n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50000334
PNG
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Show SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50229820
PNG
(CHEMBL279859)
Show SMILES Oc1nc2cc3cc(ccc3[nH]c2n1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H19N5O/c26-20-22-18-13-14-12-16(6-7-17(14)21-19(18)23-20)25-10-8-24(9-11-25)15-4-2-1-3-5-15/h1-7,12-13H,8-11H2,(H2,21,22,23,26)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human platelet c-AMP phosphodiesterase PDE 3


J Med Chem 35: 2688-96 (1992)


Article DOI: 10.1021/jm00092a020
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%