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PubMed code 1322987

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001023
PNG
((2R,6R,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CC1CC1
Show InChI InChI=1S/C18H25NO/c1-12-17-9-14-5-6-15(20)10-16(14)18(12,2)7-8-19(17)11-13-3-4-13/h5-6,10,12-13,17,20H,3-4,7-9,11H2,1-2H3/t12-,17+,18+/m0/s1
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0.180n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001019
PNG
(6,11-Dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2CCc1ccccc1
Show InChI InChI=1S/C22H27NO/c1-16-21-14-18-8-9-19(24)15-20(18)22(16,2)11-13-23(21)12-10-17-6-4-3-5-7-17/h3-9,15-16,21,24H,10-14H2,1-2H3/t16-,21+,22-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001049
PNG
(3-(3-Chloro-allyl)-6,11-dimethyl-1,2,3,4,5,6-hexah...)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2C\C=C\Cl
Show InChI InChI=1S/C17H22ClNO/c1-12-16-10-13-4-5-14(20)11-15(13)17(12,2)6-9-19(16)8-3-7-18/h3-5,7,11-12,16,20H,6,8-10H2,1-2H3/b7-3+/t12-,16+,17-/m1/s1
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1.5n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001035
PNG
(6,11-Dimethyl-3-(1-methyl-allyl)-1,2,3,4,5,6-hexah...)
Show SMILES C[C@H](C=C)N1CC[C@]2(C)[C@H](C)[C@@H]1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H25NO/c1-5-12(2)19-9-8-18(4)13(3)17(19)10-14-6-7-15(20)11-16(14)18/h5-7,11-13,17,20H,1,8-10H2,2-4H3/t12-,13-,17+,18-/m1/s1
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3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001031
PNG
(3-Allyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-me...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2CC=C
Show InChI InChI=1S/C17H23NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h4-6,11-12,16,19H,1,7-10H2,2-3H3/t12-,16+,17-/m0/s1
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3.60n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001046
PNG
(6,11-Dimethyl-3-(4-phenyl-butyl)-1,2,3,4,5,6-hexah...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2CCCCc1ccccc1
Show InChI InChI=1S/C24H31NO/c1-18-23-16-20-11-12-21(26)17-22(20)24(18,2)13-15-25(23)14-7-6-10-19-8-4-3-5-9-19/h3-5,8-9,11-12,17-18,23,26H,6-7,10,13-16H2,1-2H3/t18-,23+,24-/m0/s1
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4n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001038
PNG
(6,11-Dimethyl-3-(3-methyl-butyl)-1,2,3,4,5,6-hexah...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2C
Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3/t10-,14+,15-/m0/s1
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4.90n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001026
PNG
(3-But-2-ynyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Show SMILES CC#CCN1CC[C@@]2(C)[C@@H](C)[C@H]1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H23NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h6-7,12-13,17,20H,8-11H2,1-3H3/t13-,17+,18-/m0/s1
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5.10n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001051
PNG
(6,11-Dimethyl-3-(1-methyl-allyl)-1,2,3,4,5,6-hexah...)
Show SMILES C[C@@H](C=C)N1CC[C@]2(C)[C@H](C)[C@@H]1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H25NO/c1-5-12(2)19-9-8-18(4)13(3)17(19)10-14-6-7-15(20)11-16(14)18/h5-7,11-13,17,20H,1,8-10H2,2-4H3/t12-,13+,17-,18+/m0/s1
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5.90n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001033
PNG
((-)-Pentazocine | 3-But-2-enyl-6,11-dimethyl-1,2,3...)
Show SMILES C[C@@H]1[C@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CC=C(C)C
Show InChI InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18-,19-/m1/s1
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9n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001027
PNG
(3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano...)
Show SMILES CC(C)CCN1CC[C@@]2(C)[C@@H](C)[C@H]1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-6,12-14,18,21H,7-11H2,1-4H3/t14-,18+,19-/m0/s1
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11n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001025
PNG
(3-But-2-enyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Show SMILES C\C=C/CN1CC[C@@]2(C)[C@@H](C)[C@H]1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H25NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h4-7,12-13,17,20H,8-11H2,1-3H3/b5-4-/t13-,17+,18-/m0/s1
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11n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001052
PNG
(6,11-Dimethyl-3-(3-phenyl-propyl)-1,2,3,4,5,6-hexa...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2CCCc1ccccc1
Show InChI InChI=1S/C23H29NO.ClH/c1-17-22-15-19-10-11-20(25)16-21(19)23(17,2)12-14-24(22)13-6-9-18-7-4-3-5-8-18;/h3-5,7-8,10-11,16-17,22,25H,6,9,12-15H2,1-2H3;1H/t17-,22+,23-;/m0./s1
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20n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001024
PNG
(6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-be...)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2
Show InChI InChI=1S/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3/t9-,13+,14-/m1/s1
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23n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001043
PNG
(6,11-Dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,...)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCc1ccccc1
Show InChI InChI=1S/C22H27NO/c1-16-21-14-18-8-9-19(24)15-20(18)22(16,2)11-13-23(21)12-10-17-6-4-3-5-7-17/h3-9,15-16,21,24H,10-14H2,1-2H3/t16-,21+,22-/m1/s1
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55n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001032
PNG
(6,11-Dimethyl-3-(5-phenyl-pentyl)-1,2,3,4,5,6-hexa...)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCCCCc1ccccc1
Show InChI InChI=1S/C25H33NO/c1-19-24-17-21-12-13-22(27)18-23(21)25(19,2)14-16-26(24)15-8-4-7-11-20-9-5-3-6-10-20/h3,5-6,9-10,12-13,18-19,24,27H,4,7-8,11,14-17H2,1-2H3/t19-,24+,25-/m1/s1
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68n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001029
PNG
(3-Benzyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2Cc1ccccc1
Show InChI InChI=1S/C21H25NO.ClH/c1-15-20-12-17-8-9-18(23)13-19(17)21(15,2)10-11-22(20)14-16-6-4-3-5-7-16;/h3-9,13,15,20,23H,10-12,14H2,1-2H3;1H/t15-,20+,21-;/m0./s1
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97n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001050
PNG
(6,11-Dimethyl-3-(5-phenyl-pentyl)-1,2,3,4,5,6-hexa...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2CCCCCc1ccccc1
Show InChI InChI=1S/C25H33NO/c1-19-24-17-21-12-13-22(27)18-23(21)25(19,2)14-16-26(24)15-8-4-7-11-20-9-5-3-6-10-20/h3,5-6,9-10,12-13,18-19,24,27H,4,7-8,11,14-17H2,1-2H3/t19-,24+,25-/m0/s1
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260n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001042
PNG
(6,11-Dimethyl-3-(4-phenyl-butyl)-1,2,3,4,5,6-hexah...)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCCCc1ccccc1
Show InChI InChI=1S/C24H31NO/c1-18-23-16-20-11-12-21(26)17-22(20)24(18,2)13-15-25(23)14-7-6-10-19-8-4-3-5-9-19/h3-5,8-9,11-12,17-18,23,26H,6-7,10,13-16H2,1-2H3/t18-,23+,24-/m1/s1
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270n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50455603
PNG
(CHEMBL2368631)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCCc1ccccc1
Show InChI InChI=1S/C23H29NO.ClH/c1-17-22-15-19-10-11-20(25)16-21(19)23(17,2)12-14-24(22)13-6-9-18-7-4-3-5-8-18;/h3-5,7-8,10-11,16-17,22,25H,6,9,12-15H2,1-2H3;1H/t17-,22+,23-;/m1./s1
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343n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001045
PNG
(6,11-Dimethyl-3-(3-phenyl-propyl)-1,2,3,4,5,6-hexa...)
Show SMILES CC(C)CCN1CC[C@]2(C)[C@H](C)[C@@H]1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-6,12-14,18,21H,7-11H2,1-4H3/t14-,18+,19-/m1/s1
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343n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001020
PNG
(6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-be...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2
Show InChI InChI=1S/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3/t9-,13+,14-/m0/s1
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470n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001039
PNG
(6,11-Dimethyl-3-(1-methyl-allyl)-1,2,3,4,5,6-hexah...)
Show SMILES C[C@@H](C=C)N1CC[C@@]2(C)[C@@H](C)[C@H]1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H25NO/c1-5-12(2)19-9-8-18(4)13(3)17(19)10-14-6-7-15(20)11-16(14)18/h5-7,11-13,17,20H,1,8-10H2,2-4H3/t12-,13-,17+,18-/m0/s1
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690n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001034
PNG
(3-But-2-ynyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Show SMILES CC#CCN1CC[C@]2(C)[C@H](C)[C@@H]1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H23NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h6-7,12-13,17,20H,8-11H2,1-3H3/t13-,17+,18-/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001030
PNG
(3-Benzyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2Cc1ccccc1
Show InChI InChI=1S/C21H25NO.ClH/c1-15-20-12-17-8-9-18(23)13-19(17)21(15,2)10-11-22(20)14-16-6-4-3-5-7-16;/h3-9,13,15,20,23H,10-12,14H2,1-2H3;1H/t15-,20+,21-;/m1./s1
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1.61E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50455604
PNG
(CHEMBL2367808)
Show SMILES C\C=C/CN1CC[C@]2(C)[C@H](C)[C@@H]1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H25NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h4-7,12-13,17,20H,8-11H2,1-3H3/b5-4-/t13-,17+,18-/m1/s1
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1.69E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001021
PNG
(3-But-2-enyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Show SMILES C\C=C\CN1CC[C@@]2(C)[C@@H](C)[C@H]1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H25NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h4-7,12-13,17,20H,8-11H2,1-3H3/b5-4+/t13-,17+,18-/m0/s1
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1.69E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50035131
PNG
((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2CC=C(C)C
Show InChI InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18+,19+/m1/s1
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1.70E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001036
PNG
(3-(3-Chloro-allyl)-6,11-dimethyl-1,2,3,4,5,6-hexah...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2C\C=C\Cl
Show InChI InChI=1S/C17H22ClNO/c1-12-16-10-13-4-5-14(20)11-15(13)17(12,2)6-9-19(16)8-3-7-18/h3-5,7,11-12,16,20H,6,8-10H2,1-2H3/b7-3+/t12-,16+,17-/m0/s1
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1.98E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001037
PNG
(6,11-Dimethyl-3-(1-methyl-allyl)-1,2,3,4,5,6-hexah...)
Show SMILES C[C@H](C=C)N1CC[C@@]2(C)[C@@H](C)[C@H]1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H25NO/c1-5-12(2)19-9-8-18(4)13(3)17(19)10-14-6-7-15(20)11-16(14)18/h5-7,11-13,17,20H,1,8-10H2,2-4H3/t12-,13+,17-,18+/m1/s1
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2.27E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001040
PNG
(6,11-Dimethyl-3-(3-methyl-butyl)-1,2,3,4,5,6-hexah...)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@@]1(C)CN2CC1CC1
Show InChI InChI=1S/C17H23NO/c1-11-16-7-13-5-6-14(19)8-15(13)17(11,2)10-18(16)9-12-3-4-12/h5-6,8,11-12,16,19H,3-4,7,9-10H2,1-2H3/t11-,16+,17+/m1/s1
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3.50E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001041
PNG
(3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano...)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2C
Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3/t10-,14+,15-/m1/s1
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4.97E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001048
PNG
(3-But-2-enyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Show SMILES C\C=C\CN1CC[C@]2(C)[C@H](C)[C@@H]1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H25NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h4-7,12-13,17,20H,8-11H2,1-3H3/b5-4+/t13-,17+,18-/m1/s1
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5.62E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50001044
PNG
((1S,9S,13S)-10-allyl-1,13-dimethyl-10-azatricyclo[...)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CC=C
Show InChI InChI=1S/C17H23NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h4-6,11-12,16,19H,1,7-10H2,2-3H3/t12-,16+,17-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%