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PubMed code 1326634

Compile data set for download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001224
PNG
((8-Methoxy-quinolin-4-yl)-o-tolyl-amine | CHEMBL11...)
Show SMILES COc1cccc2c(Nc3ccccc3C)ccnc12
Show InChI InChI=1S/C17H16N2O/c1-12-6-3-4-8-14(12)19-15-10-11-18-17-13(15)7-5-9-16(17)20-2/h3-11H,1-2H3,(H,18,19)
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n/an/a 100n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001235
PNG
(1-(8-Methoxy-4-o-tolylamino-quinolin-3-yl)-propan-...)
Show SMILES CCC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C20H20N2O2/c1-4-17(23)15-12-21-20-14(9-7-11-18(20)24-3)19(15)22-16-10-6-5-8-13(16)2/h5-12H,4H2,1-3H3,(H,21,22)
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n/an/a 400n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001259
PNG
(4-o-Tolylamino-quinoline-3-carboxylic acid ethyl e...)
Show SMILES CCOC(=O)c1cnc2ccccc2c1Nc1ccccc1C
Show InChI InChI=1S/C19H18N2O2/c1-3-23-19(22)15-12-20-17-11-7-5-9-14(17)18(15)21-16-10-6-4-8-13(16)2/h4-12H,3H2,1-2H3,(H,20,21)
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n/an/a 600n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001247
PNG
(8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic ac...)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C20H20N2O3/c1-4-25-20(23)15-12-21-19-14(9-7-11-17(19)24-3)18(15)22-16-10-6-5-8-13(16)2/h5-12H,4H2,1-3H3,(H,21,22)
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n/an/a 850n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of gastric H+/K+ ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001240
PNG
(1-(4-o-Tolylamino-quinolin-3-yl)-butan-1-one | CHE...)
Show SMILES CCCC(=O)c1cnc2ccccc2c1Nc1ccccc1C
Show InChI InChI=1S/C20H20N2O/c1-3-8-19(23)16-13-21-18-12-7-5-10-15(18)20(16)22-17-11-6-4-9-14(17)2/h4-7,9-13H,3,8H2,1-2H3,(H,21,22)
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n/an/a 970n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001254
PNG
(1-(8-Methoxy-4-o-tolylamino-quinolin-3-yl)-butan-1...)
Show SMILES CCCC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C21H22N2O2/c1-4-8-18(24)16-13-22-21-15(10-7-12-19(21)25-3)20(16)23-17-11-6-5-9-14(17)2/h5-7,9-13H,4,8H2,1-3H3,(H,22,23)
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n/an/a 1.05E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001232
PNG
(1-(8-Methoxy-4-o-tolylamino-quinolin-3-yl)-2-methy...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(cnc12)C(=O)C(C)C
Show InChI InChI=1S/C21H22N2O2/c1-13(2)21(24)16-12-22-20-15(9-7-11-18(20)25-4)19(16)23-17-10-6-5-8-14(17)3/h5-13H,1-4H3,(H,22,23)
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n/an/a 1.09E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001239
PNG
(CHEMBL116272 | Cyclobutyl-(8-methoxy-4-o-tolylamin...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(cnc12)C(=O)C1CCC1
Show InChI InChI=1S/C22H22N2O2/c1-14-7-3-4-11-18(14)24-20-16-10-6-12-19(26-2)21(16)23-13-17(20)22(25)15-8-5-9-15/h3-4,6-7,10-13,15H,5,8-9H2,1-2H3,(H,23,24)
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n/an/a 1.20E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001257
PNG
(CHEMBL545745 | Quinolin-4-yl-o-tolyl-amine; hydroc...)
Show SMILES Cc1ccccc1Nc1ccnc2ccccc12
Show InChI InChI=1S/C16H14N2/c1-12-6-2-4-8-14(12)18-16-10-11-17-15-9-5-3-7-13(15)16/h2-11H,1H3,(H,17,18)
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n/an/a 1.43E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001258
PNG
(CHEMBL326168 | Cyclopentyl-(8-methoxy-4-o-tolylami...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(cnc12)C(=O)C1CCCC1
Show InChI InChI=1S/C23H24N2O2/c1-15-8-3-6-12-19(15)25-21-17-11-7-13-20(27-2)22(17)24-14-18(21)23(26)16-9-4-5-10-16/h3,6-8,11-14,16H,4-5,9-10H2,1-2H3,(H,24,25)
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n/an/a 1.70E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001237
PNG
(2-Ethyl-1-(8-methoxy-4-o-tolylamino-quinolin-3-yl)...)
Show SMILES CCC(CC)C(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C23H26N2O2/c1-5-16(6-2)23(26)18-14-24-22-17(11-9-13-20(22)27-4)21(18)25-19-12-8-7-10-15(19)3/h7-14,16H,5-6H2,1-4H3,(H,24,25)
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n/an/a 1.80E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001243
PNG
(1-(8-Methoxy-4-o-tolylamino-quinolin-3-yl)-2,2-dim...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(cnc12)C(=O)C(C)(C)C
Show InChI InChI=1S/C22H24N2O2/c1-14-9-6-7-11-17(14)24-19-15-10-8-12-18(26-5)20(15)23-13-16(19)21(25)22(2,3)4/h6-13H,1-5H3,(H,23,24)
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n/an/a 2.60E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001230
PNG
(1-(8-Methoxy-4-o-tolylamino-quinolin-3-yl)-hexan-1...)
Show SMILES CCCCCC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C23H26N2O2/c1-4-5-6-13-20(26)18-15-24-23-17(11-9-14-21(23)27-3)22(18)25-19-12-8-7-10-16(19)2/h7-12,14-15H,4-6,13H2,1-3H3,(H,24,25)
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n/an/a 2.77E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001227
PNG
(8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic ac...)
Show SMILES CCNC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C20H21N3O2/c1-4-21-20(24)15-12-22-19-14(9-7-11-17(19)25-3)18(15)23-16-10-6-5-8-13(16)2/h5-12H,4H2,1-3H3,(H,21,24)(H,22,23)
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n/an/a 2.94E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001253
PNG
(8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic ac...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(cnc12)C(=O)NCC=C
Show InChI InChI=1S/C21H21N3O2/c1-4-12-22-21(25)16-13-23-20-15(9-7-11-18(20)26-3)19(16)24-17-10-6-5-8-14(17)2/h4-11,13H,1,12H2,2-3H3,(H,22,25)(H,23,24)
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n/an/a 3.45E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001234
PNG
(8-Methoxy-4-phenylamino-quinoline-3-carboxylic aci...)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1
Show InChI InChI=1S/C19H18N2O3/c1-3-24-19(22)15-12-20-18-14(10-7-11-16(18)23-2)17(15)21-13-8-5-4-6-9-13/h4-12H,3H2,1-2H3,(H,20,21)
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n/an/a 3.54E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of gastric H+/K+ ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001255
PNG
(CHEMBL115240 | Cyclohexyl-(8-methoxy-4-o-tolylamin...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(cnc12)C(=O)C1CCCCC1
Show InChI InChI=1S/C24H26N2O2/c1-16-9-6-7-13-20(16)26-22-18-12-8-14-21(28-2)23(18)25-15-19(22)24(27)17-10-4-3-5-11-17/h6-9,12-15,17H,3-5,10-11H2,1-2H3,(H,25,26)
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n/an/a 3.80E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001231
PNG
(1-(8-Methoxy-4-phenylamino-quinolin-3-yl)-butan-1-...)
Show SMILES CCCC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1
Show InChI InChI=1S/C20H20N2O2/c1-3-8-17(23)16-13-21-20-15(11-7-12-18(20)24-2)19(16)22-14-9-5-4-6-10-14/h4-7,9-13H,3,8H2,1-2H3,(H,21,22)
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n/an/a 4.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001236
PNG
(1-(8-Methoxy-4-o-tolylamino-quinolin-3-yl)-ethanon...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(cnc12)C(C)=O
Show InChI InChI=1S/C19H18N2O2/c1-12-7-4-5-9-16(12)21-18-14-8-6-10-17(23-3)19(14)20-11-15(18)13(2)22/h4-11H,1-3H3,(H,20,21)
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n/an/a 4.80E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001226
PNG
((3-Propylsulfanyl-quinolin-4-yl)-o-tolyl-amine | C...)
Show SMILES CCCSc1cnc2ccccc2c1Nc1ccccc1C
Show InChI InChI=1S/C19H20N2S/c1-3-12-22-18-13-20-17-11-7-5-9-15(17)19(18)21-16-10-6-4-8-14(16)2/h4-11,13H,3,12H2,1-2H3,(H,20,21)
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n/an/a 5.14E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001244
PNG
((8-Methoxy-3-methyl-quinolin-4-yl)-o-tolyl-amine |...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(C)cnc12
Show InChI InChI=1S/C18H18N2O/c1-12-7-4-5-9-15(12)20-17-13(2)11-19-18-14(17)8-6-10-16(18)21-3/h4-11H,1-3H3,(H,19,20)
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n/an/a 6.10E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001242
PNG
(8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic ac...)
Show SMILES CNC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C19H19N3O2/c1-12-7-4-5-9-15(12)22-17-13-8-6-10-16(24-3)18(13)21-11-14(17)19(23)20-2/h4-11H,1-3H3,(H,20,23)(H,21,22)
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n/an/a 6.73E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of gastric H+/K+ ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001225
PNG
((8-Methoxy-3-propyl-quinolin-4-yl)-o-tolyl-amine(0...)
Show SMILES CCCc1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C20H22N2O/c1-4-8-15-13-21-20-16(10-7-12-18(20)23-3)19(15)22-17-11-6-5-9-14(17)2/h5-7,9-13H,4,8H2,1-3H3,(H,21,22)
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n/an/a 8.63E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001249
PNG
((8-Methoxy-4-o-tolylamino-quinolin-3-yl)-methanol ...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(CO)cnc12
Show InChI InChI=1S/C18H18N2O2/c1-12-6-3-4-8-15(12)20-17-13(11-21)10-19-18-14(17)7-5-9-16(18)22-2/h3-10,21H,11H2,1-2H3,(H,19,20)
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n/an/a 1.16E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of gastric H+/K+ ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001246
PNG
(CHEMBL543879 | [3-(1-Methyl-1H-tetrazol-5-yl)-quin...)
Show SMILES Cc1ccccc1Nc1c(cnc2ccccc12)-c1nnnn1C
Show InChI InChI=1S/C18H16N6/c1-12-7-3-5-9-15(12)20-17-13-8-4-6-10-16(13)19-11-14(17)18-21-22-23-24(18)2/h3-11H,1-2H3,(H,19,20)
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n/an/a 1.20E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50406683
PNG
(CHEMBL2111758)
Show SMILES COCC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C20H20N2O3/c1-13-7-4-5-9-16(13)22-19-14-8-6-10-18(25-3)20(14)21-11-15(19)17(23)12-24-2/h4-11H,12H2,1-3H3,(H,21,22)
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n/an/a 1.21E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001238
PNG
((3-Bromo-quinolin-4-yl)-o-tolyl-amine | CHEMBL1152...)
Show SMILES Cc1ccccc1Nc1c(Br)cnc2ccccc12
Show InChI InChI=1S/C16H13BrN2/c1-11-6-2-4-8-14(11)19-16-12-7-3-5-9-15(12)18-10-13(16)17/h2-10H,1H3,(H,18,19)
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n/an/a 1.41E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001229
PNG
(8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic ac...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(cnc12)C(N)=O
Show InChI InChI=1S/C18H17N3O2/c1-11-6-3-4-8-14(11)21-16-12-7-5-9-15(23-2)17(12)20-10-13(16)18(19)22/h3-10H,1-2H3,(H2,19,22)(H,20,21)
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n/an/a 1.53E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of gastric H+/K+ ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001233
PNG
((8-Methoxy-4-o-tolylamino-quinolin-3-yl)-phenyl-me...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(cnc12)C(=O)c1ccccc1
Show InChI InChI=1S/C24H20N2O2/c1-16-9-6-7-13-20(16)26-22-18-12-8-14-21(28-2)23(18)25-15-19(22)24(27)17-10-4-3-5-11-17/h3-15H,1-2H3,(H,25,26)
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n/an/a 1.61E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001223
PNG
(1-(8-Methoxy-4-o-tolylamino-quinolin-3-yl)-ethanon...)
Show SMILES CO\N=C(/C)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C20H21N3O2/c1-13-8-5-6-10-17(13)22-19-15-9-7-11-18(24-3)20(15)21-12-16(19)14(2)23-25-4/h5-12H,1-4H3,(H,21,22)/b23-14+
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n/an/a 2.05E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001256
PNG
(8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic ac...)
Show SMILES CCCNC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C21H23N3O2/c1-4-12-22-21(25)16-13-23-20-15(9-7-11-18(20)26-3)19(16)24-17-10-6-5-8-14(17)2/h5-11,13H,4,12H2,1-3H3,(H,22,25)(H,23,24)
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n/an/a 2.20E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001250
PNG
(1-(8-Methoxy-4-o-tolylamino-quinolin-3-yl)-ethanol...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(cnc12)C(C)O
Show InChI InChI=1S/C19H20N2O2/c1-12-7-4-5-9-16(12)21-18-14-8-6-10-17(23-3)19(14)20-11-15(18)13(2)22/h4-11,13,22H,1-3H3,(H,20,21)
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n/an/a 2.40E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50368384
PNG
(CHEMBL1203150)
Show SMILES Cc1ccccc1Nc1c(N)cnc2ccccc12
Show InChI InChI=1S/C16H15N3/c1-11-6-2-4-8-14(11)19-16-12-7-3-5-9-15(12)18-10-13(16)17/h2-10H,17H2,1H3,(H,18,19)
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n/an/a 3.06E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001241
PNG
(8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic ac...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(cnc12)C(=O)OCCN(C)C
Show InChI InChI=1S/C22H25N3O3/c1-15-8-5-6-10-18(15)24-20-16-9-7-11-19(27-4)21(16)23-14-17(20)22(26)28-13-12-25(2)3/h5-11,14H,12-13H2,1-4H3,(H,23,24)
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n/an/a 4.40E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001245
PNG
(8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic ac...)
Show SMILES COc1cccc2c(Nc3ccccc3C)c(cnc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C25H23N3O2/c1-17-9-6-7-13-21(17)28-23-19-12-8-14-22(30-2)24(19)26-16-20(23)25(29)27-15-18-10-4-3-5-11-18/h3-14,16H,15H2,1-2H3,(H,26,28)(H,27,29)
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n/an/a 4.90E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001251
PNG
(1-(8-Methoxy-4-o-tolylamino-quinolin-3-yl)-butan-1...)
Show SMILES CCCC(O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C21H24N2O2/c1-4-8-18(24)16-13-22-21-15(10-7-12-19(21)25-3)20(16)23-17-11-6-5-9-14(17)2/h5-7,9-13,18,24H,4,8H2,1-3H3,(H,22,23)
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n/an/a 5.50E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001228
PNG
(8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic ac...)
Show SMILES CCCCNC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Show InChI InChI=1S/C22H25N3O2/c1-4-5-13-23-22(26)17-14-24-21-16(10-8-12-19(21)27-3)20(17)25-18-11-7-6-9-15(18)2/h6-12,14H,4-5,13H2,1-3H3,(H,23,26)(H,24,25)
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n/an/a 6.50E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
Potassium-transporting ATPase


(Sus scrofa (Pig))
BDBM50001248
PNG
(8-Methoxy-4-(methyl-phenyl-amino)-quinoline-3-carb...)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1N(C)c1ccccc1
Show InChI InChI=1S/C20H20N2O3/c1-4-25-20(23)16-13-21-18-15(11-8-12-17(18)24-3)19(16)22(2)14-9-6-5-7-10-14/h5-13H,4H2,1-3H3
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n/an/a 8.90E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Concentration required to inhibit the activity of K+ stimulated gastric ATPase


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%