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PubMed code 1326635

Compile data set for download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate-NMDA


(RAT)
BDBM50001265
PNG
(3-(4-Amino-phenyl)-5,7-dichloro-4-hydroxy-1H-quino...)
Show SMILES Nc1ccc(cc1)-c1c(O)c2c(Cl)cc(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C15H10Cl2N2O2/c16-8-5-10(17)13-11(6-8)19-15(21)12(14(13)20)7-1-3-9(18)4-2-7/h1-6H,18H2,(H2,19,20,21)
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18n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001266
PNG
(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
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PubMed
40n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001264
PNG
(5,7-Dichloro-4-hydroxy-3-p-tolyl-1H-quinolin-2-one...)
Show SMILES Cc1ccc(cc1)-c1c(O)c2c(Cl)cc(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C16H11Cl2NO2/c1-8-2-4-9(5-3-8)13-15(20)14-11(18)6-10(17)7-12(14)19-16(13)21/h2-7H,1H3,(H2,19,20,21)
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300n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001268
PNG
(5,7-Dichloro-4-hydroxy-3-(4-nitro-phenyl)-1H-quino...)
Show SMILES Oc1c(-c2ccc(cc2)[N+]([O-])=O)c(=O)[nH]c2cc(Cl)cc(Cl)c12
Show InChI InChI=1S/C15H8Cl2N2O4/c16-8-5-10(17)13-11(6-8)18-15(21)12(14(13)20)7-1-3-9(4-2-7)19(22)23/h1-6H,(H2,18,20,21)
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860n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001260
PNG
(3-phenyl-4-hydroxyquinolin-2(1H)-one | 4-Hydroxy-3...)
Show SMILES Oc1c(-c2ccccc2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C15H11NO2/c17-14-11-8-4-5-9-12(11)16-15(18)13(14)10-6-2-1-3-7-10/h1-9H,(H2,16,17,18)
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4.50E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM81975
PNG
(4-hydroxyquinoline-2-carboxylic acid | CAS_492-27-...)
Show SMILES OC(=O)c1cc(O)c2ccccc2n1
Show InChI InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
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5.40E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001265
PNG
(3-(4-Amino-phenyl)-5,7-dichloro-4-hydroxy-1H-quino...)
Show SMILES Nc1ccc(cc1)-c1c(O)c2c(Cl)cc(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C15H10Cl2N2O2/c16-8-5-10(17)13-11(6-8)19-15(21)12(14(13)20)7-1-3-9(18)4-2-7/h1-6H,18H2,(H2,19,20,21)
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n/an/a 210n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001264
PNG
(5,7-Dichloro-4-hydroxy-3-p-tolyl-1H-quinolin-2-one...)
Show SMILES Cc1ccc(cc1)-c1c(O)c2c(Cl)cc(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C16H11Cl2NO2/c1-8-2-4-9(5-3-8)13-15(20)14-11(18)6-10(17)7-12(14)19-16(13)21/h2-7H,1H3,(H2,19,20,21)
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n/an/a 550n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001266
PNG
(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
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PubMed
n/an/a 860n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001260
PNG
(3-phenyl-4-hydroxyquinolin-2(1H)-one | 4-Hydroxy-3...)
Show SMILES Oc1c(-c2ccccc2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C15H11NO2/c17-14-11-8-4-5-9-12(11)16-15(18)13(14)10-6-2-1-3-7-10/h1-9H,(H2,16,17,18)
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n/an/a 7.29E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.


Citation and Details
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM81975
PNG
(4-hydroxyquinoline-2-carboxylic acid | CAS_492-27-...)
Show SMILES OC(=O)c1cc(O)c2ccccc2n1
Show InChI InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
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PubMed
n/an/a 4.02E+4n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%