Affinity Data by PubMed id=1326635

PubMed code 1326635

Found 11 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ionotropic glutamate receptor NMDA 1/2D (RAT)	BDBM50001265 (3-(4-Amino-phenyl)-5,7-dichloro-4-hydroxy-1H-quino...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D (RAT)	BDBM50001266 (5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...) Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Ionotropic glutamate receptor NMDA 1/2D (RAT)	BDBM50001264 (5,7-Dichloro-4-hydroxy-3-p-tolyl-1H-quinolin-2-one...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D (RAT)	BDBM50001268 (5,7-Dichloro-4-hydroxy-3-(4-nitro-phenyl)-1H-quino...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	860	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D (RAT)	BDBM50001260 (3-phenyl-4-hydroxyquinolin-2(1H)-one \| 4-Hydroxy-3...) Show SMILES Oc1c(-c2ccccc2)c(=O)[nH]c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D (RAT)	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D (RAT)	BDBM50001265 (3-(4-Amino-phenyl)-5,7-dichloro-4-hydroxy-1H-quino...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D (RAT)	BDBM50001264 (5,7-Dichloro-4-hydroxy-3-p-tolyl-1H-quinolin-2-one...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D (RAT)	BDBM50001266 (5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...) Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Ionotropic glutamate receptor NMDA 1/2D (RAT)	BDBM50001260 (3-phenyl-4-hydroxyquinolin-2(1H)-one \| 4-Hydroxy-3...) Show SMILES Oc1c(-c2ccccc2)c(=O)[nH]c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D (RAT)	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%