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PubMed code 1333011

Compile data set for download or QSAR
Found 29 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001611
PNG
((E)-3-{3-(2-Carboxy-ethyl)-4-[6-(4-methoxy-phenyl)...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc(cc2CCC(O)=O)C(=O)c2cccc(c2)C(O)=O)cc1
Show InChI InChI=1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+
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n/an/a 2n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001611
PNG
((E)-3-{3-(2-Carboxy-ethyl)-4-[6-(4-methoxy-phenyl)...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc(cc2CCC(O)=O)C(=O)c2cccc(c2)C(O)=O)cc1
Show InChI InChI=1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+
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n/an/a 3.5n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001622
PNG
(6-[4-(4-Methoxy-phenyl)-quinolin-2-yloxy]-2,2-dime...)
Show SMILES COc1ccc(cc1)-c1cc(OCCCCC(C)(C)C(O)=O)nc2ccccc12
Show InChI InChI=1S/C24H27NO4/c1-24(2,23(26)27)14-6-7-15-29-22-16-20(17-10-12-18(28-3)13-11-17)19-8-4-5-9-21(19)25-22/h4-5,8-13,16H,6-7,14-15H2,1-3H3,(H,26,27)
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n/an/a 10n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001619
PNG
(6-[4-(4-Chloro-phenyl)-quinolin-2-yloxy]-2,2-dimet...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)C(O)=O
Show InChI InChI=1S/C23H24ClNO3/c1-23(2,22(26)27)13-5-6-14-28-21-15-19(16-9-11-17(24)12-10-16)18-7-3-4-8-20(18)25-21/h3-4,7-12,15H,5-6,13-14H2,1-2H3,(H,26,27)
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n/an/a 15n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001628
PNG
(2,2-Dimethyl-6-(4-p-tolyl-quinolin-2-yloxy)-hexano...)
Show SMILES Cc1ccc(cc1)-c1cc(OCCCCC(C)(C)C(O)=O)nc2ccccc12
Show InChI InChI=1S/C24H27NO3/c1-17-10-12-18(13-11-17)20-16-22(25-21-9-5-4-8-19(20)21)28-15-7-6-14-24(2,3)23(26)27/h4-5,8-13,16H,6-7,14-15H2,1-3H3,(H,26,27)
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n/an/a 30n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001617
PNG
(6-[4-(4-Chloro-phenyl)-quinolin-2-yloxy]-hexanoic ...)
Show SMILES OC(=O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1
Show InChI InChI=1S/C21H20ClNO3/c22-16-11-9-15(10-12-16)18-14-20(23-19-7-4-3-6-17(18)19)26-13-5-1-2-8-21(24)25/h3-4,6-7,9-12,14H,1-2,5,8,13H2,(H,24,25)
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n/an/a 30n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001620
PNG
(4-(4-Chloro-phenyl)-2-[5-methyl-5-(1H-tetrazol-5-y...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1
Show InChI InChI=1S/C23H24ClN5O/c1-23(2,22-26-28-29-27-22)13-5-6-14-30-21-15-19(16-9-11-17(24)12-10-16)18-7-3-4-8-20(18)25-21/h3-4,7-12,15H,5-6,13-14H2,1-2H3,(H,26,27,28,29)
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n/an/a 30n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001616
PNG
(6-[4-(4-Amino-phenyl)-quinolin-2-yloxy]-2,2-dimeth...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(O)=O
Show InChI InChI=1S/C23H26N2O3/c1-23(2,22(26)27)13-5-6-14-28-21-15-19(16-9-11-17(24)12-10-16)18-7-3-4-8-20(18)25-21/h3-4,7-12,15H,5-6,13-14,24H2,1-2H3,(H,26,27)
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n/an/a 40n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001620
PNG
(4-(4-Chloro-phenyl)-2-[5-methyl-5-(1H-tetrazol-5-y...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1
Show InChI InChI=1S/C23H24ClN5O/c1-23(2,22-26-28-29-27-22)13-5-6-14-30-21-15-19(16-9-11-17(24)12-10-16)18-7-3-4-8-20(18)25-21/h3-4,7-12,15H,5-6,13-14H2,1-2H3,(H,26,27,28,29)
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n/an/a 50n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001628
PNG
(2,2-Dimethyl-6-(4-p-tolyl-quinolin-2-yloxy)-hexano...)
Show SMILES Cc1ccc(cc1)-c1cc(OCCCCC(C)(C)C(O)=O)nc2ccccc12
Show InChI InChI=1S/C24H27NO3/c1-17-10-12-18(13-11-17)20-16-22(25-21-9-5-4-8-19(20)21)28-15-7-6-14-24(2,3)23(26)27/h4-5,8-13,16H,6-7,14-15H2,1-3H3,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001622
PNG
(6-[4-(4-Methoxy-phenyl)-quinolin-2-yloxy]-2,2-dime...)
Show SMILES COc1ccc(cc1)-c1cc(OCCCCC(C)(C)C(O)=O)nc2ccccc12
Show InChI InChI=1S/C24H27NO4/c1-24(2,23(26)27)14-6-7-15-29-22-16-20(17-10-12-18(28-3)13-11-17)19-8-4-5-9-21(19)25-22/h4-5,8-13,16H,6-7,14-15H2,1-3H3,(H,26,27)
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n/an/a 140n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001617
PNG
(6-[4-(4-Chloro-phenyl)-quinolin-2-yloxy]-hexanoic ...)
Show SMILES OC(=O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1
Show InChI InChI=1S/C21H20ClNO3/c22-16-11-9-15(10-12-16)18-14-20(23-19-7-4-3-6-17(18)19)26-13-5-1-2-8-21(24)25/h3-4,6-7,9-12,14H,1-2,5,8,13H2,(H,24,25)
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n/an/a 150n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001630
PNG
(2,2-Dimethyl-6-[4-(4-nitro-phenyl)-quinolin-2-ylox...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccc(cc2)[N+]([O-])=O)c2ccccc2n1)C(O)=O
Show InChI InChI=1S/C23H24N2O5/c1-23(2,22(26)27)13-5-6-14-30-21-15-19(18-7-3-4-8-20(18)24-21)16-9-11-17(12-10-16)25(28)29/h3-4,7-12,15H,5-6,13-14H2,1-2H3,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001625
PNG
(2,2-Dimethyl-6-(4-phenyl-quinolin-2-yloxy)-hexanoi...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(O)=O
Show InChI InChI=1S/C23H25NO3/c1-23(2,22(25)26)14-8-9-15-27-21-16-19(17-10-4-3-5-11-17)18-12-6-7-13-20(18)24-21/h3-7,10-13,16H,8-9,14-15H2,1-2H3,(H,25,26)
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n/an/a 183n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001616
PNG
(6-[4-(4-Amino-phenyl)-quinolin-2-yloxy]-2,2-dimeth...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(O)=O
Show InChI InChI=1S/C23H26N2O3/c1-23(2,22(26)27)13-5-6-14-28-21-15-19(16-9-11-17(24)12-10-16)18-7-3-4-8-20(18)25-21/h3-4,7-12,15H,5-6,13-14,24H2,1-2H3,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001627
PNG
(2,2-Dimethyl-6-[4-(4-trifluoromethyl-phenyl)-quino...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccc(cc2)C(F)(F)F)c2ccccc2n1)C(O)=O
Show InChI InChI=1S/C24H24F3NO3/c1-23(2,22(29)30)13-5-6-14-31-21-15-19(18-7-3-4-8-20(18)28-21)16-9-11-17(12-10-16)24(25,26)27/h3-4,7-12,15H,5-6,13-14H2,1-2H3,(H,29,30)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001629
PNG
(6-[4-(3-Methoxy-phenyl)-quinolin-2-yloxy]-2,2-dime...)
Show SMILES COc1cccc(c1)-c1cc(OCCCCC(C)(C)C(O)=O)nc2ccccc12
Show InChI InChI=1S/C24H27NO4/c1-24(2,23(26)27)13-6-7-14-29-22-16-20(17-9-8-10-18(15-17)28-3)19-11-4-5-12-21(19)25-22/h4-5,8-12,15-16H,6-7,13-14H2,1-3H3,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001623
PNG
(2-[5-Methyl-5-(1H-tetrazol-5-yl)-hexyloxy]-4-pheny...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)c1nnn[nH]1
Show InChI InChI=1S/C23H25N5O/c1-23(2,22-25-27-28-26-22)14-8-9-15-29-21-16-19(17-10-4-3-5-11-17)18-12-6-7-13-20(18)24-21/h3-7,10-13,16H,8-9,14-15H2,1-2H3,(H,25,26,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001631
PNG
(4-Phenyl-2-[5-(1H-tetrazol-5-yl)-pentyloxy]-quinol...)
Show SMILES C(CCOc1cc(-c2ccccc2)c2ccccc2n1)CCc1nnn[nH]1
Show InChI InChI=1S/C21H21N5O/c1-3-9-16(10-4-1)18-15-21(22-19-12-7-6-11-17(18)19)27-14-8-2-5-13-20-23-25-26-24-20/h1,3-4,6-7,9-12,15H,2,5,8,13-14H2,(H,23,24,25,26)
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n/an/a 500n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001615
PNG
(2-Methyl-6-(4-phenyl-quinolin-2-yloxy)-hexanoic ac...)
Show SMILES CC(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(O)=O
Show InChI InChI=1S/C22H23NO3/c1-16(22(24)25)9-7-8-14-26-21-15-19(17-10-3-2-4-11-17)18-12-5-6-13-20(18)23-21/h2-6,10-13,15-16H,7-9,14H2,1H3,(H,24,25)
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n/an/a 550n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001632
PNG
(6-(4-Phenyl-quinolin-2-yloxy)-hexanoic acid | CHEM...)
Show SMILES OC(=O)CCCCCOc1cc(-c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C21H21NO3/c23-21(24)13-5-2-8-14-25-20-15-18(16-9-3-1-4-10-16)17-11-6-7-12-19(17)22-20/h1,3-4,6-7,9-12,15H,2,5,8,13-14H2,(H,23,24)
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n/an/a 700n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001624
PNG
(6-[4-(2-Fluoro-phenyl)-quinolin-2-yloxy]-2,2-dimet...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccccc2F)c2ccccc2n1)C(O)=O
Show InChI InChI=1S/C23H24FNO3/c1-23(2,22(26)27)13-7-8-14-28-21-15-18(16-9-3-5-11-19(16)24)17-10-4-6-12-20(17)25-21/h3-6,9-12,15H,7-8,13-14H2,1-2H3,(H,26,27)
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n/an/a 800n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001626
PNG
(6-[4-(3-Chloro-phenyl)-quinolin-2-yloxy]-2,2-dimet...)
Show SMILES CC(C)(CCCCOc1cc(-c2cccc(Cl)c2)c2ccccc2n1)C(O)=O
Show InChI InChI=1S/C23H24ClNO3/c1-23(2,22(26)27)12-5-6-13-28-21-15-19(16-8-7-9-17(24)14-16)18-10-3-4-11-20(18)25-21/h3-4,7-11,14-15H,5-6,12-13H2,1-2H3,(H,26,27)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001613
PNG
(7-(4-Phenyl-quinolin-2-yloxy)-heptanoic acid | CHE...)
Show SMILES OC(=O)CCCCCCOc1cc(-c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C22H23NO3/c24-22(25)14-6-1-2-9-15-26-21-16-19(17-10-4-3-5-11-17)18-12-7-8-13-20(18)23-21/h3-5,7-8,10-13,16H,1-2,6,9,14-15H2,(H,24,25)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001621
PNG
(6-(7-Chloro-4-phenyl-quinolin-2-yloxy)-2,2-dimethy...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccccc2)c2ccc(Cl)cc2n1)C(O)=O
Show InChI InChI=1S/C23H24ClNO3/c1-23(2,22(26)27)12-6-7-13-28-21-15-19(16-8-4-3-5-9-16)18-11-10-17(24)14-20(18)25-21/h3-5,8-11,14-15H,6-7,12-13H2,1-2H3,(H,26,27)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001633
PNG
(8-(4-Phenyl-quinolin-2-yloxy)-octanoic acid | CHEM...)
Show SMILES OC(=O)CCCCCCCOc1cc(-c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C23H25NO3/c25-23(26)15-7-2-1-3-10-16-27-22-17-20(18-11-5-4-6-12-18)19-13-8-9-14-21(19)24-22/h4-6,8-9,11-14,17H,1-3,7,10,15-16H2,(H,25,26)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001618
PNG
(6-(6-Chloro-4-phenyl-quinolin-2-yloxy)-2,2-dimethy...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccccc2)c2cc(Cl)ccc2n1)C(O)=O
Show InChI InChI=1S/C23H24ClNO3/c1-23(2,22(26)27)12-6-7-13-28-21-15-18(16-8-4-3-5-9-16)19-14-17(24)10-11-20(19)25-21/h3-5,8-11,14-15H,6-7,12-13H2,1-2H3,(H,26,27)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001625
PNG
(2,2-Dimethyl-6-(4-phenyl-quinolin-2-yloxy)-hexanoi...)
Show SMILES CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(O)=O
Show InChI InChI=1S/C23H25NO3/c1-23(2,22(25)26)14-8-9-15-27-21-16-19(17-10-4-3-5-11-17)18-12-6-7-13-20(18)24-21/h3-7,10-13,16H,8-9,14-15H2,1-2H3,(H,25,26)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM50001614
PNG
(2,2-Dimethyl-6-(3-methyl-4-phenyl-quinolin-2-yloxy...)
Show SMILES Cc1c(OCCCCC(C)(C)C(O)=O)nc2ccccc2c1-c1ccccc1
Show InChI InChI=1S/C24H27NO3/c1-17-21(18-11-5-4-6-12-18)19-13-7-8-14-20(19)25-22(17)28-16-10-9-15-24(2,3)23(26)27/h4-8,11-14H,9-10,15-16H2,1-3H3,(H,26,27)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes

J Med Chem 35: 4306-14 (1992)


Article DOI: 10.1021/jm00101a007
BindingDB Entry DOI: 10.7270/Q2VH5MS6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%