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PubMed code 1333012

Compile data set for download or QSAR
Found 106 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
LTB4R


(HUMAN)
BDBM50001668
PNG
(6-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyridin-2-ylox...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C24H23NO5/c26-24(27)9-5-2-6-12-28-23-15-19(13-20(25-23)17-7-3-1-4-8-17)18-10-11-21-22(14-18)30-16-29-21/h1,3-4,7-8,10-11,13-15H,2,5-6,9,12,16H2,(H,26,27)
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n/an/a 1n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001657
PNG
(6-[4-Benzo[1,3]dioxol-5-yl-6-(2-chloro-phenyl)-pyr...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1Cl)-c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C25H24ClNO5/c1-16(25(28)29)6-4-5-11-30-24-14-18(17-9-10-22-23(13-17)32-15-31-22)12-21(27-24)19-7-2-3-8-20(19)26/h2-3,7-10,12-14,16H,4-6,11,15H2,1H3,(H,28,29)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001637
PNG
(6-[4-(3-Methoxy-phenyl)-6-phenyl-pyridin-2-yloxy]-...)
Show SMILES COc1cccc(c1)-c1cc(OCCCCC(C)C(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C25H27NO4/c1-18(25(27)28)9-6-7-14-30-24-17-21(20-12-8-13-22(15-20)29-2)16-23(26-24)19-10-4-3-5-11-19/h3-5,8,10-13,15-18H,6-7,9,14H2,1-2H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001667
PNG
(6-[4-(4-Amino-phenyl)-6-phenyl-pyridin-2-yloxy]-he...)
Show SMILES Nc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C23H24N2O3/c24-20-12-10-17(11-13-20)19-15-21(18-7-3-1-4-8-18)25-22(16-19)28-14-6-2-5-9-23(26)27/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14,24H2,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001611
PNG
((E)-3-{3-(2-Carboxy-ethyl)-4-[6-(4-methoxy-phenyl)...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc(cc2CCC(O)=O)C(=O)c2cccc(c2)C(O)=O)cc1
Show InChI InChI=1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001658
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-hexanoic acid | C...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H23NO3/c25-23(26)14-8-3-9-15-27-22-17-20(18-10-4-1-5-11-18)16-21(24-22)19-12-6-2-7-13-19/h1-2,4-7,10-13,16-17H,3,8-9,14-15H2,(H,25,26)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001611
PNG
((E)-3-{3-(2-Carboxy-ethyl)-4-[6-(4-methoxy-phenyl)...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc(cc2CCC(O)=O)C(=O)c2cccc(c2)C(O)=O)cc1
Show InChI InChI=1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+
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n/an/a 3.5n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001641
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-2-methyl-hexanoic...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H25NO3/c1-18(24(26)27)10-8-9-15-28-23-17-21(19-11-4-2-5-12-19)16-22(25-23)20-13-6-3-7-14-20/h2-7,11-14,16-18H,8-10,15H2,1H3,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001645
PNG
(6-[6-(2-Fluoro-phenyl)-4-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1F)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H24FNO3/c1-17(24(27)28)9-7-8-14-29-23-16-19(18-10-3-2-4-11-18)15-22(26-23)20-12-5-6-13-21(20)25/h2-6,10-13,15-17H,7-9,14H2,1H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001661
PNG
(6-[4-(4-Methoxy-phenyl)-6-phenyl-pyridin-2-yloxy]-...)
Show SMILES COc1ccc(cc1)-c1cc(OCCCCC(C)C(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C25H27NO4/c1-18(25(27)28)8-6-7-15-30-24-17-21(19-11-13-22(29-2)14-12-19)16-23(26-24)20-9-4-3-5-10-20/h3-5,9-14,16-18H,6-8,15H2,1-2H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001647
PNG
(6-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyridin-2-ylox...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C25H25NO5/c1-17(25(27)28)7-5-6-12-29-24-15-20(13-21(26-24)18-8-3-2-4-9-18)19-10-11-22-23(14-19)31-16-30-22/h2-4,8-11,13-15,17H,5-7,12,16H2,1H3,(H,27,28)
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n/an/a 4.20n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001636
PNG
(6-[4-(3-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C24H24ClNO3/c1-17(24(27)28)8-5-6-13-29-23-16-20(19-11-7-12-21(25)14-19)15-22(26-23)18-9-3-2-4-10-18/h2-4,7,9-12,14-17H,5-6,8,13H2,1H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001642
PNG
(6-[4-(4-Amino-phenyl)-6-phenyl-pyridin-2-yloxy]-2-...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C24H26N2O3/c1-17(24(27)28)7-5-6-14-29-23-16-20(18-10-12-21(25)13-11-18)15-22(26-23)19-8-3-2-4-9-19/h2-4,8-13,15-17H,5-7,14,25H2,1H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001644
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-hexa...)
Show SMILES CC(C)(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H27NO3/c1-25(2,24(27)28)15-9-10-16-29-23-18-21(19-11-5-3-6-12-19)17-22(26-23)20-13-7-4-8-14-20/h3-8,11-14,17-18H,9-10,15-16H2,1-2H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001653
PNG
(6-[4-(4-Methylamino-phenyl)-6-phenyl-pyridin-2-ylo...)
Show SMILES CNc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C24H26N2O3/c1-25-21-13-11-18(12-14-21)20-16-22(19-8-4-2-5-9-19)26-23(17-20)29-15-7-3-6-10-24(27)28/h2,4-5,8-9,11-14,16-17,25H,3,6-7,10,15H2,1H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001664
PNG
(6-[4-(4-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C24H24ClNO3/c1-17(24(27)28)7-5-6-14-29-23-16-20(18-10-12-21(25)13-11-18)15-22(26-23)19-8-3-2-4-9-19/h2-4,8-13,15-17H,5-7,14H2,1H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001668
PNG
(6-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyridin-2-ylox...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C24H23NO5/c26-24(27)9-5-2-6-12-28-23-15-19(13-20(25-23)17-7-3-1-4-8-17)18-10-11-21-22(14-18)30-16-29-21/h1,3-4,7-8,10-11,13-15H,2,5-6,9,12,16H2,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001670
PNG
(6-[6-(2-Chloro-phenyl)-4-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1Cl)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H24ClNO3/c1-17(24(27)28)9-7-8-14-29-23-16-19(18-10-3-2-4-11-18)15-22(26-23)20-12-5-6-13-21(20)25/h2-6,10-13,15-17H,7-9,14H2,1H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001647
PNG
(6-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyridin-2-ylox...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C25H25NO5/c1-17(25(27)28)7-5-6-12-29-24-15-20(13-21(26-24)18-8-3-2-4-9-18)19-10-11-22-23(14-19)31-16-30-22/h2-4,8-11,13-15,17H,5-7,12,16H2,1H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001652
PNG
(6-[4-(4-Amino-phenyl)-6-phenyl-pyridin-2-yloxy]-2,...)
Show SMILES CC(C)(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C25H28N2O3/c1-25(2,24(28)29)14-6-7-15-30-23-17-20(18-10-12-21(26)13-11-18)16-22(27-23)19-8-4-3-5-9-19/h3-5,8-13,16-17H,6-7,14-15,26H2,1-2H3,(H,28,29)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001637
PNG
(6-[4-(3-Methoxy-phenyl)-6-phenyl-pyridin-2-yloxy]-...)
Show SMILES COc1cccc(c1)-c1cc(OCCCCC(C)C(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C25H27NO4/c1-18(25(27)28)9-6-7-14-30-24-17-21(20-12-8-13-22(15-20)29-2)16-23(26-24)19-10-4-3-5-11-19/h3-5,8,10-13,15-18H,6-7,9,14H2,1-2H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001655
PNG
(6-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyridin-2-ylox...)
Show SMILES CC(C)(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C26H27NO5/c1-26(2,25(28)29)12-6-7-13-30-24-16-20(14-21(27-24)18-8-4-3-5-9-18)19-10-11-22-23(15-19)32-17-31-22/h3-5,8-11,14-16H,6-7,12-13,17H2,1-2H3,(H,28,29)
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n/an/a 7n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001672
PNG
(2,4-Diphenyl-6-(5-tetrazol-1-yl-hexyloxy)-pyridine...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)n1cnnn1
Show InChI InChI=1S/C24H25N5O/c1-19(29-18-25-27-28-29)10-8-9-15-30-24-17-22(20-11-4-2-5-12-20)16-23(26-24)21-13-6-3-7-14-21/h2-7,11-14,16-19H,8-10,15H2,1H3
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n/an/a 7n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001672
PNG
(2,4-Diphenyl-6-(5-tetrazol-1-yl-hexyloxy)-pyridine...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)n1cnnn1
Show InChI InChI=1S/C24H25N5O/c1-19(29-18-25-27-28-29)10-8-9-15-30-24-17-22(20-11-4-2-5-12-20)16-23(26-24)21-13-6-3-7-14-21/h2-7,11-14,16-19H,8-10,15H2,1H3
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n/an/a 8n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001652
PNG
(6-[4-(4-Amino-phenyl)-6-phenyl-pyridin-2-yloxy]-2,...)
Show SMILES CC(C)(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C25H28N2O3/c1-25(2,24(28)29)14-6-7-15-30-23-17-20(18-10-12-21(26)13-11-18)16-22(27-23)19-8-4-3-5-9-19/h3-5,8-13,16-17H,6-7,14-15,26H2,1-2H3,(H,28,29)
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n/an/a 9.5n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001649
PNG
(2,4-Diphenyl-6-(5-tetrazol-1-yl-pentyloxy)-pyridin...)
Show SMILES C(CCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)CCn1cnnn1
Show InChI InChI=1S/C23H23N5O/c1-4-10-19(11-5-1)21-16-22(20-12-6-2-7-13-20)25-23(17-21)29-15-9-3-8-14-28-18-24-26-27-28/h1-2,4-7,10-13,16-18H,3,8-9,14-15H2
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n/an/a 10n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001659
PNG
(6-[6-Phenyl-4-(4-trifluoromethyl-phenyl)-pyridin-2...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H22F3NO3/c25-24(26,27)20-12-10-17(11-13-20)19-15-21(18-7-3-1-4-8-18)28-22(16-19)31-14-6-2-5-9-23(29)30/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,29,30)
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n/an/a 10n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001651
PNG
(6-[4-(2-Fluoro-phenyl)-6-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1F
Show InChI InChI=1S/C23H22FNO3/c24-20-12-7-6-11-19(20)18-15-21(17-9-3-1-4-10-17)25-22(16-18)28-14-8-2-5-13-23(26)27/h1,3-4,6-7,9-12,15-16H,2,5,8,13-14H2,(H,26,27)
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n/an/a 10n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001661
PNG
(6-[4-(4-Methoxy-phenyl)-6-phenyl-pyridin-2-yloxy]-...)
Show SMILES COc1ccc(cc1)-c1cc(OCCCCC(C)C(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C25H27NO4/c1-18(25(27)28)8-6-7-15-30-24-17-21(19-11-13-22(29-2)14-12-19)16-23(26-24)20-9-4-3-5-10-20/h3-5,9-14,16-18H,6-8,15H2,1-2H3,(H,27,28)
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n/an/a 11n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001657
PNG
(6-[4-Benzo[1,3]dioxol-5-yl-6-(2-chloro-phenyl)-pyr...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1Cl)-c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C25H24ClNO5/c1-16(25(28)29)6-4-5-11-30-24-14-18(17-9-10-22-23(13-17)32-15-31-22)12-21(27-24)19-7-2-3-8-20(19)26/h2-3,7-10,12-14,16H,4-6,11,15H2,1H3,(H,28,29)
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n/an/a 12n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001657
PNG
(6-[4-Benzo[1,3]dioxol-5-yl-6-(2-chloro-phenyl)-pyr...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1Cl)-c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C25H24ClNO5/c1-16(25(28)29)6-4-5-11-30-24-14-18(17-9-10-22-23(13-17)32-15-31-22)12-21(27-24)19-7-2-3-8-20(19)26/h2-3,7-10,12-14,16H,4-6,11,15H2,1H3,(H,28,29)
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n/an/a 12n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001660
PNG
(2-Methyl-6-(6-phenyl-4-p-tolyl-pyridin-2-yloxy)-he...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C25H27NO3/c1-18-11-13-20(14-12-18)22-16-23(21-9-4-3-5-10-21)26-24(17-22)29-15-7-6-8-19(2)25(27)28/h3-5,9-14,16-17,19H,6-8,15H2,1-2H3,(H,27,28)
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n/an/a 13n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001642
PNG
(6-[4-(4-Amino-phenyl)-6-phenyl-pyridin-2-yloxy]-2-...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C24H26N2O3/c1-17(24(27)28)7-5-6-14-29-23-16-20(18-10-12-21(25)13-11-18)15-22(26-23)19-8-3-2-4-9-19/h2-4,8-13,15-17H,5-7,14,25H2,1H3,(H,27,28)
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n/an/a 15n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001652
PNG
(6-[4-(4-Amino-phenyl)-6-phenyl-pyridin-2-yloxy]-2,...)
Show SMILES CC(C)(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C25H28N2O3/c1-25(2,24(28)29)14-6-7-15-30-23-17-20(18-10-12-21(26)13-11-18)16-22(27-23)19-8-4-3-5-9-19/h3-5,8-13,16-17H,6-7,14-15,26H2,1-2H3,(H,28,29)
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n/an/a 15n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001669
PNG
(7-(4,6-Diphenyl-pyridin-2-yloxy)-heptanoic acid | ...)
Show SMILES OC(=O)CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H25NO3/c26-24(27)15-9-1-2-10-16-28-23-18-21(19-11-5-3-6-12-19)17-22(25-23)20-13-7-4-8-14-20/h3-8,11-14,17-18H,1-2,9-10,15-16H2,(H,26,27)
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n/an/a 15n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001650
PNG
(7-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-hept...)
Show SMILES CC(C)(CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29NO3/c1-26(2,25(28)29)16-10-5-11-17-30-24-19-22(20-12-6-3-7-13-20)18-23(27-24)21-14-8-4-9-15-21/h3-4,6-9,12-15,18-19H,5,10-11,16-17H2,1-2H3,(H,28,29)
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n/an/a 15n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001645
PNG
(6-[6-(2-Fluoro-phenyl)-4-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1F)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H24FNO3/c1-17(24(27)28)9-7-8-14-29-23-16-19(18-10-3-2-4-11-18)15-22(26-23)20-12-5-6-13-21(20)25/h2-6,10-13,15-17H,7-9,14H2,1H3,(H,27,28)
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n/an/a 18n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001655
PNG
(6-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyridin-2-ylox...)
Show SMILES CC(C)(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C26H27NO5/c1-26(2,25(28)29)12-6-7-13-30-24-16-20(14-21(27-24)18-8-4-3-5-9-18)19-10-11-22-23(15-19)32-17-31-22/h3-5,8-11,14-16H,6-7,12-13,17H2,1-2H3,(H,28,29)
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n/an/a 20n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001672
PNG
(2,4-Diphenyl-6-(5-tetrazol-1-yl-hexyloxy)-pyridine...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)n1cnnn1
Show InChI InChI=1S/C24H25N5O/c1-19(29-18-25-27-28-29)10-8-9-15-30-24-17-22(20-11-4-2-5-12-20)16-23(26-24)21-13-6-3-7-14-21/h2-7,11-14,16-19H,8-10,15H2,1H3
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n/an/a 20n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001634
PNG
(8-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-octa...)
Show SMILES CC(C)(CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31NO3/c1-27(2,26(29)30)17-11-3-4-12-18-31-25-20-23(21-13-7-5-8-14-21)19-24(28-25)22-15-9-6-10-16-22/h5-10,13-16,19-20H,3-4,11-12,17-18H2,1-2H3,(H,29,30)
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n/an/a 22n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001646
PNG
(6-[4-(4-Isopropylamino-phenyl)-6-phenyl-pyridin-2-...)
Show SMILES CC(C)Nc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C26H30N2O3/c1-19(2)27-23-14-12-20(13-15-23)22-17-24(21-9-5-3-6-10-21)28-25(18-22)31-16-8-4-7-11-26(29)30/h3,5-6,9-10,12-15,17-19,27H,4,7-8,11,16H2,1-2H3,(H,29,30)
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n/an/a 22n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001641
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-2-methyl-hexanoic...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H25NO3/c1-18(24(26)27)10-8-9-15-28-23-17-21(19-11-4-2-5-12-19)16-22(25-23)20-13-6-3-7-14-20/h2-7,11-14,16-18H,8-10,15H2,1H3,(H,26,27)
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n/an/a 22n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001669
PNG
(7-(4,6-Diphenyl-pyridin-2-yloxy)-heptanoic acid | ...)
Show SMILES OC(=O)CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H25NO3/c26-24(27)15-9-1-2-10-16-28-23-18-21(19-11-5-3-6-12-19)17-22(25-23)20-13-7-4-8-14-20/h3-8,11-14,17-18H,1-2,9-10,15-16H2,(H,26,27)
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n/an/a 25n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001648
PNG
(6-[4-(4-Dimethylamino-phenyl)-6-phenyl-pyridin-2-y...)
Show SMILES CN(C)c1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C25H28N2O3/c1-27(2)22-14-12-19(13-15-22)21-17-23(20-9-5-3-6-10-20)26-24(18-21)30-16-8-4-7-11-25(28)29/h3,5-6,9-10,12-15,17-18H,4,7-8,11,16H2,1-2H3,(H,28,29)
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n/an/a 30n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001665
PNG
(6-[6-(4-Fluoro-phenyl)-4-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccc(F)cc1)-c1ccccc1
Show InChI InChI=1S/C23H22FNO3/c24-20-12-10-18(11-13-20)21-15-19(17-7-3-1-4-8-17)16-22(25-21)28-14-6-2-5-9-23(26)27/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001644
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-hexa...)
Show SMILES CC(C)(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H27NO3/c1-25(2,24(27)28)15-9-10-16-29-23-18-21(19-11-5-3-6-12-19)17-22(26-23)20-13-7-4-8-14-20/h3-8,11-14,17-18H,9-10,15-16H2,1-2H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001660
PNG
(2-Methyl-6-(6-phenyl-4-p-tolyl-pyridin-2-yloxy)-he...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C25H27NO3/c1-18-11-13-20(14-12-18)22-16-23(21-9-4-3-5-10-21)26-24(17-22)29-15-7-6-8-19(2)25(27)28/h3-5,9-14,16-17,19H,6-8,15H2,1-2H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001665
PNG
(6-[6-(4-Fluoro-phenyl)-4-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccc(F)cc1)-c1ccccc1
Show InChI InChI=1S/C23H22FNO3/c24-20-12-10-18(11-13-20)21-15-19(17-7-3-1-4-8-17)16-22(25-21)28-14-6-2-5-9-23(26)27/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001651
PNG
(6-[4-(2-Fluoro-phenyl)-6-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1F
Show InChI InChI=1S/C23H22FNO3/c24-20-12-7-6-11-19(20)18-15-21(17-9-3-1-4-10-17)25-22(16-18)28-14-8-2-5-13-23(26)27/h1,3-4,6-7,9-12,15-16H,2,5,8,13-14H2,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001641
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-2-methyl-hexanoic...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H25NO3/c1-18(24(26)27)10-8-9-15-28-23-17-21(19-11-4-2-5-12-19)16-22(25-23)20-13-6-3-7-14-20/h2-7,11-14,16-18H,8-10,15H2,1H3,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001658
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-hexanoic acid | C...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H23NO3/c25-23(26)14-8-3-9-15-27-22-17-20(18-10-4-1-5-11-18)16-21(24-22)19-12-6-2-7-13-19/h1-2,4-7,10-13,16-17H,3,8-9,14-15H2,(H,25,26)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001642
PNG
(6-[4-(4-Amino-phenyl)-6-phenyl-pyridin-2-yloxy]-2-...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C24H26N2O3/c1-17(24(27)28)7-5-6-14-29-23-16-20(18-10-12-21(25)13-11-18)15-22(26-23)19-8-3-2-4-9-19/h2-4,8-13,15-17H,5-7,14,25H2,1H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001670
PNG
(6-[6-(2-Chloro-phenyl)-4-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1Cl)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H24ClNO3/c1-17(24(27)28)9-7-8-14-29-23-16-19(18-10-3-2-4-11-18)15-22(26-23)20-12-5-6-13-21(20)25/h2-6,10-13,15-17H,7-9,14H2,1H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001664
PNG
(6-[4-(4-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C24H24ClNO3/c1-17(24(27)28)7-5-6-14-29-23-16-20(18-10-12-21(25)13-11-18)15-22(26-23)19-8-3-2-4-9-19/h2-4,8-13,15-17H,5-7,14H2,1H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001636
PNG
(6-[4-(3-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C24H24ClNO3/c1-17(24(27)28)8-5-6-13-29-23-16-20(19-11-7-12-21(25)14-19)15-22(26-23)18-9-3-2-4-10-18/h2-4,7,9-12,14-17H,5-6,8,13H2,1H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001656
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-hexanoic acid met...)
Show SMILES COC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H25NO3/c1-27-24(26)15-9-4-10-16-28-23-18-21(19-11-5-2-6-12-19)17-22(25-23)20-13-7-3-8-14-20/h2-3,5-8,11-14,17-18H,4,9-10,15-16H2,1H3
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001667
PNG
(6-[4-(4-Amino-phenyl)-6-phenyl-pyridin-2-yloxy]-he...)
Show SMILES Nc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C23H24N2O3/c24-20-12-10-17(11-13-20)19-15-21(18-7-3-1-4-8-18)25-22(16-19)28-14-6-2-5-9-23(26)27/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14,24H2,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001649
PNG
(2,4-Diphenyl-6-(5-tetrazol-1-yl-pentyloxy)-pyridin...)
Show SMILES C(CCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)CCn1cnnn1
Show InChI InChI=1S/C23H23N5O/c1-4-10-19(11-5-1)21-16-22(20-12-6-2-7-13-20)25-23(17-21)29-15-9-3-8-14-28-18-24-26-27-28/h1-2,4-7,10-13,16-18H,3,8-9,14-15H2
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001666
PNG
(5-(4,6-Diphenyl-pyridin-2-yloxy)-pentanoic acid | ...)
Show SMILES OC(=O)CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H21NO3/c24-22(25)13-7-8-14-26-21-16-19(17-9-3-1-4-10-17)15-20(23-21)18-11-5-2-6-12-18/h1-6,9-12,15-16H,7-8,13-14H2,(H,24,25)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001650
PNG
(7-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-hept...)
Show SMILES CC(C)(CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29NO3/c1-26(2,25(28)29)16-10-5-11-17-30-24-19-22(20-12-6-3-7-13-20)18-23(27-24)21-14-8-4-9-15-21/h3-4,6-9,12-15,18-19H,5,10-11,16-17H2,1-2H3,(H,28,29)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001662
PNG
(6-[4-(4-Nitro-phenyl)-6-phenyl-pyridin-2-yloxy]-he...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C23H22N2O5/c26-23(27)9-5-2-6-14-30-22-16-19(17-10-12-20(13-11-17)25(28)29)15-21(24-22)18-7-3-1-4-8-18/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,26,27)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001634
PNG
(8-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-octa...)
Show SMILES CC(C)(CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31NO3/c1-27(2,26(29)30)17-11-3-4-12-18-31-25-20-23(21-13-7-5-8-14-21)19-24(28-25)22-15-9-6-10-16-22/h5-10,13-16,19-20H,3-4,11-12,17-18H2,1-2H3,(H,29,30)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001645
PNG
(6-[6-(2-Fluoro-phenyl)-4-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1F)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C24H24FNO3/c1-17(24(27)28)9-7-8-14-29-23-16-19(18-10-3-2-4-11-18)15-22(26-23)20-12-5-6-13-21(20)25/h2-6,10-13,15-17H,7-9,14H2,1H3,(H,27,28)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001656
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-hexanoic acid met...)
Show SMILES COC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H25NO3/c1-27-24(26)15-9-4-10-16-28-23-18-21(19-11-5-2-6-12-19)17-22(25-23)20-13-7-3-8-14-20/h2-3,5-8,11-14,17-18H,4,9-10,15-16H2,1H3
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001634
PNG
(8-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-octa...)
Show SMILES CC(C)(CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31NO3/c1-27(2,26(29)30)17-11-3-4-12-18-31-25-20-23(21-13-7-5-8-14-21)19-24(28-25)22-15-9-6-10-16-22/h5-10,13-16,19-20H,3-4,11-12,17-18H2,1-2H3,(H,29,30)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001650
PNG
(7-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-hept...)
Show SMILES CC(C)(CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C26H29NO3/c1-26(2,25(28)29)16-10-5-11-17-30-24-19-22(20-12-6-3-7-13-20)18-23(27-24)21-14-8-4-9-15-21/h3-4,6-9,12-15,18-19H,5,10-11,16-17H2,1-2H3,(H,28,29)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001648
PNG
(6-[4-(4-Dimethylamino-phenyl)-6-phenyl-pyridin-2-y...)
Show SMILES CN(C)c1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C25H28N2O3/c1-27(2)22-14-12-19(13-15-22)21-17-23(20-9-5-3-6-10-20)26-24(18-21)30-16-8-4-7-11-25(28)29/h3,5-6,9-10,12-15,17-18H,4,7-8,11,16H2,1-2H3,(H,28,29)
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Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001655
PNG
(6-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyridin-2-ylox...)
Show SMILES CC(C)(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C26H27NO5/c1-26(2,25(28)29)12-6-7-13-30-24-16-20(14-21(27-24)18-8-4-3-5-9-18)19-10-11-22-23(15-19)32-17-31-22/h3-5,8-11,14-16H,6-7,12-13,17H2,1-2H3,(H,28,29)
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n/an/a 120n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001647
PNG
(6-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyridin-2-ylox...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C25H25NO5/c1-17(25(27)28)7-5-6-12-29-24-15-20(13-21(26-24)18-8-3-2-4-9-18)19-10-11-22-23(14-19)31-16-30-22/h2-4,8-11,13-15,17H,5-7,12,16H2,1H3,(H,27,28)
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n/an/a 120n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001640
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-hexanoic acid ami...)
Show SMILES NC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H24N2O2/c24-22(26)14-8-3-9-15-27-23-17-20(18-10-4-1-5-11-18)16-21(25-23)19-12-6-2-7-13-19/h1-2,4-7,10-13,16-17H,3,8-9,14-15H2,(H2,24,26)
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n/an/a 150n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001638
PNG
(6-{6-Phenyl-4-[4-(2,2,2-trifluoro-acetylamino)-phe...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(NC(=O)C(F)(F)F)cc1
Show InChI InChI=1S/C25H23F3N2O4/c26-25(27,28)24(33)29-20-12-10-17(11-13-20)19-15-21(18-7-3-1-4-8-18)30-22(16-19)34-14-6-2-5-9-23(31)32/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,29,33)(H,31,32)
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n/an/a 150n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001659
PNG
(6-[6-Phenyl-4-(4-trifluoromethyl-phenyl)-pyridin-2...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H22F3NO3/c25-24(26,27)20-12-10-17(11-13-20)19-15-21(18-7-3-1-4-8-18)28-22(16-19)31-14-6-2-5-9-23(29)30/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,29,30)
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n/an/a 150n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001653
PNG
(6-[4-(4-Methylamino-phenyl)-6-phenyl-pyridin-2-ylo...)
Show SMILES CNc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C24H26N2O3/c1-25-21-13-11-18(12-14-21)20-16-22(19-8-4-2-5-9-19)26-23(17-20)29-15-7-3-6-10-24(27)28/h2,4-5,8-9,11-14,16-17,25H,3,6-7,10,15H2,1H3,(H,27,28)
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n/an/a 150n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001644
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-hexa...)
Show SMILES CC(C)(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H27NO3/c1-25(2,24(27)28)15-9-10-16-29-23-18-21(19-11-5-3-6-12-19)17-22(26-23)20-13-7-4-8-14-20/h3-8,11-14,17-18H,9-10,15-16H2,1-2H3,(H,27,28)
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n/an/a 160n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001640
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-hexanoic acid ami...)
Show SMILES NC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H24N2O2/c24-22(26)14-8-3-9-15-27-23-17-20(18-10-4-1-5-11-18)16-21(25-23)19-12-6-2-7-13-19/h1-2,4-7,10-13,16-17H,3,8-9,14-15H2,(H2,24,26)
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n/an/a 160n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001649
PNG
(2,4-Diphenyl-6-(5-tetrazol-1-yl-pentyloxy)-pyridin...)
Show SMILES C(CCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)CCn1cnnn1
Show InChI InChI=1S/C23H23N5O/c1-4-10-19(11-5-1)21-16-22(20-12-6-2-7-13-20)25-23(17-21)29-15-9-3-8-14-28-18-24-26-27-28/h1-2,4-7,10-13,16-18H,3,8-9,14-15H2
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n/an/a 200n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001639
PNG
(6-[4-(2-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1Cl
Show InChI InChI=1S/C23H22ClNO3/c24-20-12-7-6-11-19(20)18-15-21(17-9-3-1-4-10-17)25-22(16-18)28-14-8-2-5-13-23(26)27/h1,3-4,6-7,9-12,15-16H,2,5,8,13-14H2,(H,26,27)
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n/an/a 200n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001646
PNG
(6-[4-(4-Isopropylamino-phenyl)-6-phenyl-pyridin-2-...)
Show SMILES CC(C)Nc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C26H30N2O3/c1-19(2)27-23-14-12-20(13-15-23)22-17-24(21-9-5-3-6-10-21)28-25(18-22)31-16-8-4-7-11-26(29)30/h3,5-6,9-10,12-15,17-19,27H,4,7-8,11,16H2,1-2H3,(H,29,30)
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n/an/a 300n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001635
PNG
(6-(4-Phenyl-6-p-tolyl-pyridin-2-yloxy)-hexanoic ac...)
Show SMILES Cc1ccc(cc1)-c1cc(cc(OCCCCCC(O)=O)n1)-c1ccccc1
Show InChI InChI=1S/C24H25NO3/c1-18-11-13-20(14-12-18)22-16-21(19-8-4-2-5-9-19)17-23(25-22)28-15-7-3-6-10-24(26)27/h2,4-5,8-9,11-14,16-17H,3,6-7,10,15H2,1H3,(H,26,27)
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n/an/a 300n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001666
PNG
(5-(4,6-Diphenyl-pyridin-2-yloxy)-pentanoic acid | ...)
Show SMILES OC(=O)CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H21NO3/c24-22(25)13-7-8-14-26-21-16-19(17-9-3-1-4-10-17)15-20(23-21)18-11-5-2-6-12-18/h1-6,9-12,15-16H,7-8,13-14H2,(H,24,25)
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n/an/a 300n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001671
PNG
(4-(4,6-Diphenyl-pyridin-2-yloxy)-butyric acid | CH...)
Show SMILES OC(=O)CCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H19NO3/c23-21(24)12-7-13-25-20-15-18(16-8-3-1-4-9-16)14-19(22-20)17-10-5-2-6-11-17/h1-6,8-11,14-15H,7,12-13H2,(H,23,24)
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n/an/a 300n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001643
PNG
(6-[6-(3-Methoxy-phenyl)-4-phenyl-pyridin-2-yloxy]-...)
Show SMILES COc1cccc(c1)-c1cc(cc(OCCCCCC(O)=O)n1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-28-21-12-8-11-19(15-21)22-16-20(18-9-4-2-5-10-18)17-23(25-22)29-14-7-3-6-13-24(26)27/h2,4-5,8-12,15-17H,3,6-7,13-14H2,1H3,(H,26,27)
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n/an/a 500n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001660
PNG
(2-Methyl-6-(6-phenyl-4-p-tolyl-pyridin-2-yloxy)-he...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C25H27NO3/c1-18-11-13-20(14-12-18)22-16-23(21-9-4-3-5-10-21)26-24(17-22)29-15-7-6-8-19(2)25(27)28/h3-5,9-14,16-17,19H,6-8,15H2,1-2H3,(H,27,28)
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n/an/a 570n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001662
PNG
(6-[4-(4-Nitro-phenyl)-6-phenyl-pyridin-2-yloxy]-he...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C23H22N2O5/c26-23(27)9-5-2-6-14-30-22-16-19(17-10-12-20(13-11-17)25(28)29)15-21(24-22)18-7-3-1-4-8-18/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,26,27)
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n/an/a 600n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001663
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-hexanenitrile | C...)
Show SMILES N#CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H22N2O/c24-15-9-1-2-10-16-26-23-18-21(19-11-5-3-6-12-19)17-22(25-23)20-13-7-4-8-14-20/h3-8,11-14,17-18H,1-2,9-10,16H2
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n/an/a 700n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001667
PNG
(6-[4-(4-Amino-phenyl)-6-phenyl-pyridin-2-yloxy]-he...)
Show SMILES Nc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C23H24N2O3/c24-20-12-10-17(11-13-20)19-15-21(18-7-3-1-4-8-18)25-22(16-19)28-14-6-2-5-9-23(26)27/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14,24H2,(H,26,27)
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n/an/a 900n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001673
PNG
(6-[6-(4-Methoxy-phenyl)-4-phenyl-pyridin-2-yloxy]-...)
Show SMILES COc1ccc(cc1)-c1cc(cc(OCCCCCC(O)=O)n1)-c1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-28-21-13-11-19(12-14-21)22-16-20(18-8-4-2-5-9-18)17-23(25-22)29-15-7-3-6-10-24(26)27/h2,4-5,8-9,11-14,16-17H,3,6-7,10,15H2,1H3,(H,26,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001653
PNG
(6-[4-(4-Methylamino-phenyl)-6-phenyl-pyridin-2-ylo...)
Show SMILES CNc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C24H26N2O3/c1-25-21-13-11-18(12-14-21)20-16-22(19-8-4-2-5-9-19)26-23(17-20)29-15-7-3-6-10-24(27)28/h2,4-5,8-9,11-14,16-17,25H,3,6-7,10,15H2,1H3,(H,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001656
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-hexanoic acid met...)
Show SMILES COC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H25NO3/c1-27-24(26)15-9-4-10-16-28-23-18-21(19-11-5-2-6-12-19)17-22(25-23)20-13-7-3-8-14-20/h2-3,5-8,11-14,17-18H,4,9-10,15-16H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001636
PNG
(6-[4-(3-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C24H24ClNO3/c1-17(24(27)28)8-5-6-13-29-23-16-20(19-11-7-12-21(25)14-19)15-22(26-23)18-9-3-2-4-10-18/h2-4,7,9-12,14-17H,5-6,8,13H2,1H3,(H,27,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001611
PNG
((E)-3-{3-(2-Carboxy-ethyl)-4-[6-(4-methoxy-phenyl)...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc(cc2CCC(O)=O)C(=O)c2cccc(c2)C(O)=O)cc1
Show InChI InChI=1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+
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n/an/a 1.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001654
PNG
(6-[4-Phenyl-6-(4-trifluoromethyl-phenyl)-pyridin-2...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccc(cc1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C24H22F3NO3/c25-24(26,27)20-12-10-18(11-13-20)21-15-19(17-7-3-1-4-8-17)16-22(28-21)31-14-6-2-5-9-23(29)30/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,29,30)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001637
PNG
(6-[4-(3-Methoxy-phenyl)-6-phenyl-pyridin-2-yloxy]-...)
Show SMILES COc1cccc(c1)-c1cc(OCCCCC(C)C(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C25H27NO4/c1-18(25(27)28)9-6-7-14-30-24-17-21(20-12-8-13-22(15-20)29-2)16-23(26-24)19-10-4-3-5-11-19/h3-5,8,10-13,15-18H,6-7,9,14H2,1-2H3,(H,27,28)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001668
PNG
(6-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyridin-2-ylox...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C24H23NO5/c26-24(27)9-5-2-6-12-28-23-15-19(13-20(25-23)17-7-3-1-4-8-17)18-10-11-21-22(14-18)30-16-29-21/h1,3-4,7-8,10-11,13-15H,2,5-6,9,12,16H2,(H,26,27)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001658
PNG
(6-(4,6-Diphenyl-pyridin-2-yloxy)-hexanoic acid | C...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H23NO3/c25-23(26)14-8-3-9-15-27-22-17-20(18-10-4-1-5-11-18)16-21(24-22)19-12-6-2-7-13-19/h1-2,4-7,10-13,16-17H,3,8-9,14-15H2,(H,25,26)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001669
PNG
(7-(4,6-Diphenyl-pyridin-2-yloxy)-heptanoic acid | ...)
Show SMILES OC(=O)CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H25NO3/c26-24(27)15-9-1-2-10-16-28-23-18-21(19-11-5-3-6-12-19)17-22(25-23)20-13-7-4-8-14-20/h3-8,11-14,17-18H,1-2,9-10,15-16H2,(H,26,27)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001664
PNG
(6-[4-(4-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-2...)
Show SMILES CC(CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C24H24ClNO3/c1-17(24(27)28)7-5-6-14-29-23-16-20(18-10-12-21(25)13-11-18)15-22(26-23)19-8-3-2-4-9-19/h2-4,8-13,15-17H,5-7,14H2,1H3,(H,27,28)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001661
PNG
(6-[4-(4-Methoxy-phenyl)-6-phenyl-pyridin-2-yloxy]-...)
Show SMILES COc1ccc(cc1)-c1cc(OCCCCC(C)C(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C25H27NO4/c1-18(25(27)28)8-6-7-15-30-24-17-21(19-11-13-22(29-2)14-12-19)16-23(26-24)20-9-4-3-5-10-20/h3-5,9-14,16-18H,6-8,15H2,1-2H3,(H,27,28)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001639
PNG
(6-[4-(2-Chloro-phenyl)-6-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1Cl
Show InChI InChI=1S/C23H22ClNO3/c24-20-12-7-6-11-19(20)18-15-21(17-9-3-1-4-10-17)25-22(16-18)28-14-8-2-5-13-23(26)27/h1,3-4,6-7,9-12,15-16H,2,5,8,13-14H2,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001638
PNG
(6-{6-Phenyl-4-[4-(2,2,2-trifluoro-acetylamino)-phe...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(NC(=O)C(F)(F)F)cc1
Show InChI InChI=1S/C25H23F3N2O4/c26-25(27,28)24(33)29-20-12-10-17(11-13-20)19-15-21(18-7-3-1-4-8-18)30-22(16-19)34-14-6-2-5-9-23(31)32/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,29,33)(H,31,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001665
PNG
(6-[6-(4-Fluoro-phenyl)-4-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccc(F)cc1)-c1ccccc1
Show InChI InChI=1S/C23H22FNO3/c24-20-12-10-18(11-13-20)21-15-19(17-7-3-1-4-8-17)16-22(25-21)28-14-6-2-5-9-23(26)27/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001659
PNG
(6-[6-Phenyl-4-(4-trifluoromethyl-phenyl)-pyridin-2...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H22F3NO3/c25-24(26,27)20-12-10-17(11-13-20)19-15-21(18-7-3-1-4-8-18)28-22(16-19)31-14-6-2-5-9-23(29)30/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,29,30)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001648
PNG
(6-[4-(4-Dimethylamino-phenyl)-6-phenyl-pyridin-2-y...)
Show SMILES CN(C)c1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C25H28N2O3/c1-27(2)22-14-12-19(13-15-22)21-17-23(20-9-5-3-6-10-20)26-24(18-21)30-16-8-4-7-11-25(28)29/h3,5-6,9-10,12-15,17-18H,4,7-8,11,16H2,1-2H3,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001654
PNG
(6-[4-Phenyl-6-(4-trifluoromethyl-phenyl)-pyridin-2...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccc(cc1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C24H22F3NO3/c25-24(26,27)20-12-10-18(11-13-20)21-15-19(17-7-3-1-4-8-17)16-22(28-21)31-14-6-2-5-9-23(29)30/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001651
PNG
(6-[4-(2-Fluoro-phenyl)-6-phenyl-pyridin-2-yloxy]-h...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1F
Show InChI InChI=1S/C23H22FNO3/c24-20-12-7-6-11-19(20)18-15-21(17-9-3-1-4-10-17)25-22(16-18)28-14-8-2-5-13-23(26)27/h1,3-4,6-7,9-12,15-16H,2,5,8,13-14H2,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50001666
PNG
(5-(4,6-Diphenyl-pyridin-2-yloxy)-pentanoic acid | ...)
Show SMILES OC(=O)CCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H21NO3/c24-22(25)13-7-8-14-26-21-16-19(17-9-3-1-4-10-17)15-20(23-21)18-11-5-2-6-12-18/h1-6,9-12,15-16H,7-8,13-14H2,(H,24,25)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%