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PubMed code 1336053

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001790
PNG
(1-(2-{4-[6-Fluoro-1-(4-fluoro-phenyl)-1H-indol-3-y...)
Show SMILES Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C24H26F2N4O/c25-18-1-4-20(5-2-18)30-16-22(21-6-3-19(26)15-23(21)30)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)
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n/an/a 3.60n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001786
PNG
(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Show SMILES Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2cc(Cl)ccc12
Show InChI InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)
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n/an/a 4.10n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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n/an/a 12n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Compound was tested for the displacement of [3H]-spiperone from dopamine receptor D2 from rat striatal membranes.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001778
PNG
((Lu 23-086)1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3...)
Show SMILES Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2ccccc12
Show InChI InChI=1S/C24H27FN4O/c25-19-5-7-20(8-6-19)29-17-22(21-3-1-2-4-23(21)29)18-9-12-27(13-10-18)15-16-28-14-11-26-24(28)30/h1-8,17-18H,9-16H2,(H,26,30)
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n/an/a 18n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001784
PNG
(3-(2-{4-[6-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-y...)
Show SMILES CN(C)C(=O)NCCN1CCC(CC1)c1cn(-c2ccc(F)cc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C24H28ClFN4O/c1-28(2)24(31)27-11-14-29-12-9-17(10-13-29)22-16-30(20-6-4-19(26)5-7-20)23-15-18(25)3-8-21(22)23/h3-8,15-17H,9-14H2,1-2H3,(H,27,31)
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n/an/a 27n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001789
PNG
(1-(2-{4-[6-Fluoro-1-(4-fluoro-phenyl)-1H-indol-3-y...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2cn(-c3ccc(F)cc3)c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C27H32F2N4O/c1-19(2)32-16-15-31(27(32)34)14-13-30-11-9-20(10-12-30)25-18-33(23-6-3-21(28)4-7-23)26-17-22(29)5-8-24(25)26/h3-8,17-20H,9-16H2,1-2H3
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n/an/a 28n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001787
PNG
(3-(2-{4-[1-(4-Fluoro-phenyl)-6-methyl-1H-indol-3-y...)
Show SMILES CN(C)C(=O)NCCN1CCC(CC1)c1cn(-c2ccc(F)cc2)c2cc(C)ccc12
Show InChI InChI=1S/C25H31FN4O/c1-18-4-9-22-23(17-30(24(22)16-18)21-7-5-20(26)6-8-21)19-10-13-29(14-11-19)15-12-27-25(31)28(2)3/h4-9,16-17,19H,10-15H2,1-3H3,(H,27,31)
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n/an/a 38n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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n/an/a 47n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Compound was tested for the displacement of [3H]-prazosin from alpha-1 adrenergic receptor of rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001772
PNG
(1-(2-{4-[6-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-y...)
Show SMILES Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H26ClFN4O/c25-18-1-6-21-22(16-30(23(21)15-18)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)
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n/an/a 56n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001785
PNG
(1-(2-{4-[6-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-y...)
Show SMILES CC(C)NC(=O)N(C)CCN1CCC(CC1)c1cn(-c2ccc(F)cc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C26H32ClFN4O/c1-18(2)29-26(33)30(3)14-15-31-12-10-19(11-13-31)24-17-32(22-7-5-21(28)6-8-22)25-16-20(27)4-9-23(24)25/h4-9,16-19H,10-15H2,1-3H3,(H,29,33)
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n/an/a 74n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001791
PNG
(1-(2-{4-[6-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-y...)
Show SMILES CNC(=O)N(C)CCN1CCC(CC1)c1cn(-c2ccc(F)cc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C24H28ClFN4O/c1-27-24(31)28(2)13-14-29-11-9-17(10-12-29)22-16-30(20-6-4-19(26)5-7-20)23-15-18(25)3-8-21(22)23/h3-8,15-17H,9-14H2,1-2H3,(H,27,31)
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n/an/a 82n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001782
PNG
((Lu 26-042)1-(2-{4-[6-Chloro-1-(4-fluoro-phenyl)-1...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2cn(-c3ccc(F)cc3)c3cc(Cl)ccc23)C1=O
Show InChI InChI=1S/C27H32ClFN4O/c1-19(2)32-16-15-31(27(32)34)14-13-30-11-9-20(10-12-30)25-18-33(23-6-4-22(29)5-7-23)26-17-21(28)3-8-24(25)26/h3-8,17-20H,9-16H2,1-2H3
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n/an/a 130n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Compound was tested for the displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes.


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001776
PNG
(1-(2-{4-[1-(4-Fluoro-phenyl)-2-methyl-1H-indol-3-y...)
Show SMILES Cc1c(C2=CCN(CCN3CCNC3=O)CC2)c2ccccc2n1-c1ccc(F)cc1
Show InChI InChI=1S/C25H27FN4O/c1-18-24(19-10-13-28(14-11-19)16-17-29-15-12-27-25(29)31)22-4-2-3-5-23(22)30(18)21-8-6-20(26)7-9-21/h2-10H,11-17H2,1H3,(H,27,31)
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n/an/a 160n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001794
PNG
(1-(2-{4-[1-(4-Fluoro-phenyl)-6-methyl-1H-indol-3-y...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2cn(-c3ccc(F)cc3)c3cc(C)ccc23)C1=O
Show InChI InChI=1S/C28H35FN4O/c1-20(2)32-17-16-31(28(32)34)15-14-30-12-10-22(11-13-30)26-19-33(24-7-5-23(29)6-8-24)27-18-21(3)4-9-25(26)27/h4-9,18-20,22H,10-17H2,1-3H3
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n/an/a 190n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001774
PNG
(1-{2-[4-(6-Chloro-1H-indol-3-yl)-piperidin-1-yl]-e...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2c[nH]c3cc(Cl)ccc23)C1=O
Show InChI InChI=1S/C21H29ClN4O/c1-15(2)26-12-11-25(21(26)27)10-9-24-7-5-16(6-8-24)19-14-23-20-13-17(22)3-4-18(19)20/h3-4,13-16,23H,5-12H2,1-2H3
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n/an/a 200n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001771
PNG
(1-(2-{4-[1-(4-Fluoro-phenyl)-6-trifluoromethyl-1H-...)
Show SMILES Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C25H26F4N4O/c26-19-2-4-20(5-3-19)33-16-22(21-6-1-18(15-23(21)33)25(27,28)29)17-7-10-31(11-8-17)13-14-32-12-9-30-24(32)34/h1-6,15-17H,7-14H2,(H,30,34)
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n/an/a 260n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001796
PNG
(1-(2-{4-[1-(4-Fluoro-phenyl)-6-methyl-1H-indol-3-y...)
Show SMILES Cc1ccc2c(cn(-c3ccc(F)cc3)c2c1)C1CCN(CCN2CCNC2=O)CC1
Show InChI InChI=1S/C25H29FN4O/c1-18-2-7-22-23(17-30(24(22)16-18)21-5-3-20(26)4-6-21)19-8-11-28(12-9-19)14-15-29-13-10-27-25(29)31/h2-7,16-17,19H,8-15H2,1H3,(H,27,31)
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n/an/a 270n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001799
PNG
(1-(2-{4-[1-(4-Fluoro-phenyl)-6-trifluoromethyl-1H-...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2cn(-c3ccc(F)cc3)c3cc(ccc23)C(F)(F)F)C1=O
Show InChI InChI=1S/C28H32F4N4O/c1-19(2)35-16-15-34(27(35)37)14-13-33-11-9-20(10-12-33)25-18-36(23-6-4-22(29)5-7-23)26-17-21(28(30,31)32)3-8-24(25)26/h3-8,17-20H,9-16H2,1-2H3
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n/an/a 280n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001798
PNG
(1-{2-[4-(6-Chloro-1-phenyl-1H-indol-3-yl)-piperidi...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2cn(-c3ccccc3)c3cc(Cl)ccc23)C1=O
Show InChI InChI=1S/C27H33ClN4O/c1-20(2)31-17-16-30(27(31)33)15-14-29-12-10-21(11-13-29)25-19-32(23-6-4-3-5-7-23)26-18-22(28)8-9-24(25)26/h3-9,18-21H,10-17H2,1-2H3
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n/an/a 290n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001783
PNG
(1-(2-{4-[1-(4-Fluoro-phenyl)-6-methyl-1H-indol-3-y...)
Show SMILES CC(C)NC(=O)NCCN1CCC(CC1)c1cn(-c2ccc(F)cc2)c2cc(C)ccc12
Show InChI InChI=1S/C26H33FN4O/c1-18(2)29-26(32)28-12-15-30-13-10-20(11-14-30)24-17-31(22-7-5-21(27)6-8-22)25-16-19(3)4-9-23(24)25/h4-9,16-18,20H,10-15H2,1-3H3,(H2,28,29,32)
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n/an/a 300n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001795
PNG
(1-(2-{4-[6-Chloro-1-(2-fluoro-phenyl)-1H-indol-3-y...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2cn(-c3ccccc3F)c3cc(Cl)ccc23)C1=O
Show InChI InChI=1S/C27H32ClFN4O/c1-19(2)32-16-15-31(27(32)34)14-13-30-11-9-20(10-12-30)23-18-33(25-6-4-3-5-24(25)29)26-17-21(28)7-8-22(23)26/h3-8,17-20H,9-16H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001797
PNG
(1-(2-{4-[1-(4-Fluoro-phenyl)-2-methyl-1H-indol-3-y...)
Show SMILES Cc1c(C2CCN(CCN3CCNC3=O)CC2)c2ccccc2n1-c1ccc(F)cc1
Show InChI InChI=1S/C25H29FN4O/c1-18-24(19-10-13-28(14-11-19)16-17-29-15-12-27-25(29)31)22-4-2-3-5-23(22)30(18)21-8-6-20(26)7-9-21/h2-9,19H,10-17H2,1H3,(H,27,31)
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n/an/a 380n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001792
PNG
(1-Isopropyl-3-{2-[4-(6-methyl-1-phenyl-1H-indol-3-...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2cn(-c3ccccc3)c3cc(C)ccc23)C1=O
Show InChI InChI=1S/C28H36N4O/c1-21(2)31-18-17-30(28(31)33)16-15-29-13-11-23(12-14-29)26-20-32(24-7-5-4-6-8-24)27-19-22(3)9-10-25(26)27/h4-10,19-21,23H,11-18H2,1-3H3
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n/an/a 500n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001793
PNG
(1-Isopropyl-3-{2-[4-(6-methyl-1H-indol-3-yl)-piper...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2c[nH]c3cc(C)ccc23)C1=O
Show InChI InChI=1S/C22H32N4O/c1-16(2)26-13-12-25(22(26)27)11-10-24-8-6-18(7-9-24)20-15-23-21-14-17(3)4-5-19(20)21/h4-5,14-16,18,23H,6-13H2,1-3H3
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n/an/a 590n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001780
PNG
(1-(2-{4-[1-(4-Chloro-phenyl)-6-methyl-1H-indol-3-y...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2cn(-c3ccc(Cl)cc3)c3cc(C)ccc23)C1=O
Show InChI InChI=1S/C28H35ClN4O/c1-20(2)32-17-16-31(28(32)34)15-14-30-12-10-22(11-13-30)26-19-33(24-7-5-23(29)6-8-24)27-18-21(3)4-9-25(26)27/h4-9,18-20,22H,10-17H2,1-3H3
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n/an/a 620n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001781
PNG
(1-(2-{4-[1-(2-Fluoro-phenyl)-6-methyl-1H-indol-3-y...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2cn(-c3ccccc3F)c3cc(C)ccc23)C1=O
Show InChI InChI=1S/C28H35FN4O/c1-20(2)32-17-16-31(28(32)34)15-14-30-12-10-22(11-13-30)24-19-33(26-7-5-4-6-25(26)29)27-18-21(3)8-9-23(24)27/h4-9,18-20,22H,10-17H2,1-3H3
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n/an/a 730n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001779
PNG
(1-(2-{4-[1-(4-Fluoro-phenyl)-6-isopropyl-1H-indol-...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2cn(-c3ccc(F)cc3)c3cc(ccc23)C(C)C)C1=O
Show InChI InChI=1S/C30H39FN4O/c1-21(2)24-5-10-27-28(20-35(29(27)19-24)26-8-6-25(31)7-9-26)23-11-13-32(14-12-23)15-16-33-17-18-34(22(3)4)30(33)36/h5-10,19-23H,11-18H2,1-4H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001773
PNG
(1-(2-{4-[1-(4-Fluoro-phenyl)-6-isopropyl-1H-indol-...)
Show SMILES CC(C)c1ccc2c(cn(-c3ccc(F)cc3)c2c1)C1CCN(CCN2CCNC2=O)CC1
Show InChI InChI=1S/C27H33FN4O/c1-19(2)21-3-8-24-25(18-32(26(24)17-21)23-6-4-22(28)5-7-23)20-9-12-30(13-10-20)15-16-31-14-11-29-27(31)33/h3-8,17-20H,9-16H2,1-2H3,(H,29,33)
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n/an/a 2.60E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001788
PNG
(1-(2-{4-[1-(3-Fluoro-phenyl)-6-methyl-1H-indol-3-y...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2cn(-c3cccc(F)c3)c3cc(C)ccc23)C1=O
Show InChI InChI=1S/C28H35FN4O/c1-20(2)32-16-15-31(28(32)34)14-13-30-11-9-22(10-12-30)26-19-33(24-6-4-5-23(29)18-24)27-17-21(3)7-8-25(26)27/h4-8,17-20,22H,9-16H2,1-3H3
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n/an/a 3.20E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001777
PNG
(1-Isopropyl-3-(2-{4-[6-methyl-1-(3-trifluoromethyl...)
Show SMILES CC(C)N1CCN(CCN2CCC(CC2)c2cn(-c3cccc(c3)C(F)(F)F)c3cc(C)ccc23)C1=O
Show InChI InChI=1S/C29H35F3N4O/c1-20(2)35-16-15-34(28(35)37)14-13-33-11-9-22(10-12-33)26-19-36(27-17-21(3)7-8-25(26)27)24-6-4-5-23(18-24)29(30,31)32/h4-8,17-20,22H,9-16H2,1-3H3
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n/an/a 3.20E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%