Affinity Data by PubMed id=1347319

PubMed code 1347319

Found 15 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Adrenergic receptor alpha-2 (Homo sapiens-Homo sapiens (Human))	BDBM50001922 (2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; ...) Show SMILES C(C1=NCCN1)c1cccc2ccccc12 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.00110	n/a	n/a	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (Homo sapiens-Homo sapiens (Human))	BDBM50230389 (CHEMBL541105) Show SMILES Cl.CC(c1c[nH]cn1)c1cccc2ccccc12 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.00340	n/a	n/a	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was tested for Adrenergic activity against Alpha-2 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (Homo sapiens-Homo sapiens (Human))	BDBM50230393 (CHEMBL553231) Show SMILES Cl.CC(C1=NCCN1)c1cccc2ccccc12 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0140	n/a	n/a	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (Homo sapiens-Homo sapiens (Human))	BDBM50230395 (CHEMBL557985) Show SMILES Cl.CC(C1=NCCN1)c1ccc2ccccc2c1 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (Homo sapiens-Homo sapiens (Human))	BDBM50230388 (CHEMBL537830) Show SMILES Cl.C(c1ncc[nH]1)c1cccc2ccccc12 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0340	n/a	n/a	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (Homo sapiens-Homo sapiens (Human))	BDBM50230394 (CHEMBL538801) Show SMILES Cl.CC(c1c[nH]cn1)c1ccc2ccccc2c1 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (Homo sapiens-Homo sapiens (Human))	BDBM50230392 (CHEMBL554581) Show SMILES Cl.CC(c1ncc[nH]1)c1cccc2ccccc12 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (Homo sapiens-Homo sapiens (Human))	BDBM50230391 (CHEMBL164540) Show SMILES Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.610	n/a	n/a	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (Homo sapiens-Homo sapiens (Human))	BDBM50230390 (CHEBI:48556 \| MEDETOMIDINE HYDROCHLORIDE \| MPV-785...) Show SMILES Cl.CC(c1c[nH]cn1)c1cccc(C)c1C Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity in Alpha-2 adrenergic receptor of human platelets				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50230392 (CHEMBL554581) Show SMILES Cl.CC(c1ncc[nH]1)c1cccc2ccccc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.00770	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50001922 (2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; ...) Show SMILES C(C1=NCCN1)c1cccc2ccccc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50230393 (CHEMBL553231) Show SMILES Cl.CC(C1=NCCN1)c1cccc2ccccc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.000540	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50230389 (CHEMBL541105) Show SMILES Cl.CC(c1c[nH]cn1)c1cccc2ccccc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50230388 (CHEMBL537830) Show SMILES Cl.C(c1ncc[nH]1)c1cccc2ccccc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50230390 (CHEBI:48556 \| MEDETOMIDINE HYDROCHLORIDE \| MPV-785...) Show SMILES Cl.CC(c1c[nH]cn1)c1cccc(C)c1C Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	310	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) Article DOI: 10.1021/jm00082a017
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%