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PubMed code 1348089

Compile data set for download or QSAR
Found 71 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001974
PNG
(6-Dipropylamino-1,2,6,7-tetrahydro-5H-pyrido[3,2,1...)
Show SMILES CCCN(CCC)C1CN2C(=O)CCc3cccc(C1)c23
Show InChI InChI=1S/C18H26N2O/c1-3-10-19(11-4-2)16-12-15-7-5-6-14-8-9-17(21)20(13-16)18(14)15/h5-7,16H,3-4,8-13H2,1-2H3
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 2.40n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001969
PNG
(6-Dipropylamino-1,2,6,7-tetrahydro-5H-pyrido[3,2,1...)
Show SMILES CCCN(CCC)C1CN2C(=O)NCc3cccc(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-3-8-19(9-4-2)15-10-13-6-5-7-14-11-18-17(21)20(12-15)16(13)14/h5-7,15H,3-4,8-12H2,1-2H3,(H,18,21)
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 3.20n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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 6.60n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368591
PNG
(CHEMBL1794795)
Show SMILES CCCN(CCC)C1CN2C(=O)COc3cccc(C1)c23
Show InChI InChI=1S/C17H24N2O2/c1-3-8-18(9-4-2)14-10-13-6-5-7-15-17(13)19(11-14)16(20)12-21-15/h5-7,14H,3-4,8-12H2,1-2H3
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 12n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368582
PNG
(CHEMBL1794997)
Show SMILES CCCN(CCC)C1CN2CCc3cccc(C1)c23
Show InChI InChI=1S/C17H26N2/c1-3-9-18(10-4-2)16-12-15-7-5-6-14-8-11-19(13-16)17(14)15/h5-7,16H,3-4,8-13H2,1-2H3
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 13n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001977
PNG
(6-Dipropylamino-6,7-dihydro-5H-pyrido[3,2,1-ij]qui...)
Show SMILES CCCN(CCC)C1Cc2cccc3ccc(=O)n(C1)c23
Show InChI InChI=1S/C18H24N2O/c1-3-10-19(11-4-2)16-12-15-7-5-6-14-8-9-17(21)20(13-16)18(14)15/h5-9,16H,3-4,10-13H2,1-2H3
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 17n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368584
PNG
(CHEMBL1202415)
Show SMILES CCCN(CCC)C1CN2CC(=O)Nc3cccc(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-3-8-19(9-4-2)14-10-13-6-5-7-15-17(13)20(11-14)12-16(21)18-15/h5-7,14H,3-4,8-12H2,1-2H3,(H,18,21)
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 30n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368593
PNG
(CHEMBL1202416)
Show SMILES CCCN(CCC)C1CN2C(=O)OCc3cccc(C1)c23
Show InChI InChI=1S/C17H24N2O2/c1-3-8-18(9-4-2)15-10-13-6-5-7-14-12-21-17(20)19(11-15)16(13)14/h5-7,15H,3-4,8-12H2,1-2H3
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 31n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368594
PNG
(CHEMBL1794998)
Show SMILES CCCN(CCC)C1CN2CCCc3cccc(C1)c23
Show InChI InChI=1S/C18H28N2/c1-3-10-19(11-4-2)17-13-16-8-5-7-15-9-6-12-20(14-17)18(15)16/h5,7-8,17H,3-4,6,9-14H2,1-2H3
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 35n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001979
PNG
(5-Dipropylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-ij...)
Show SMILES CCCN(CCC)C1Cc2cccc3[nH]c(=S)n(C1)c23
Show InChI InChI=1S/C16H23N3S/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14/h5-7,13H,3-4,8-11H2,1-2H3,(H,17,20)
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 40n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368590
PNG
(CHEMBL1202409)
Show SMILES NC1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C10H11N3O/c11-7-4-6-2-1-3-8-9(6)13(5-7)10(14)12-8/h1-3,7H,4-5,11H2,(H,12,14)
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 44n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001955
PNG
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
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 46n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001971
PNG
(6-Dipropylamino-1,2,6,7-tetrahydro-5H-pyrido[1,2,3...)
Show SMILES CCCN(CCC)C1CN2C(=O)CNc3cccc(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-3-8-19(9-4-2)14-10-13-6-5-7-15-17(13)20(12-14)16(21)11-18-15/h5-7,14,18H,3-4,8-12H2,1-2H3
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 49n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM84637
PNG
(CAS_85760-74-3 | CHEMBL240773 | NSC_54562 | QUINPI...)
Show SMILES CCCN1CCC[C@@H]2Cc3[nH]ncc3C[C@@H]12
Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1
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 54n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368595
PNG
(CHEMBL1744080)
Show SMILES CCCN(CCC)[C@@H]1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C16H23N3O/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14/h5-7,13H,3-4,8-11H2,1-2H3,(H,17,20)/t13-/m1/s1
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 68n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001971
PNG
(6-Dipropylamino-1,2,6,7-tetrahydro-5H-pyrido[1,2,3...)
Show SMILES CCCN(CCC)C1CN2C(=O)CNc3cccc(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-3-8-19(9-4-2)14-10-13-6-5-7-15-17(13)20(12-14)16(21)11-18-15/h5-7,14,18H,3-4,8-12H2,1-2H3
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 80n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001974
PNG
(6-Dipropylamino-1,2,6,7-tetrahydro-5H-pyrido[3,2,1...)
Show SMILES CCCN(CCC)C1CN2C(=O)CCc3cccc(C1)c23
Show InChI InChI=1S/C18H26N2O/c1-3-10-19(11-4-2)16-12-15-7-5-6-14-8-9-17(21)20(13-16)18(14)15/h5-7,16H,3-4,8-13H2,1-2H3
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 83n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368592
PNG
(CHEMBL1202412)
Show SMILES O=c1[nH]c2cccc3CC(Cn1c23)NCC1CC1
Show InChI InChI=1S/C14H17N3O/c18-14-16-12-3-1-2-10-6-11(8-17(14)13(10)12)15-7-9-4-5-9/h1-3,9,11,15H,4-8H2,(H,16,18)
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 84n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001979
PNG
(5-Dipropylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-ij...)
Show SMILES CCCN(CCC)C1Cc2cccc3[nH]c(=S)n(C1)c23
Show InChI InChI=1S/C16H23N3S/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14/h5-7,13H,3-4,8-11H2,1-2H3,(H,17,20)
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 90n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368595
PNG
(CHEMBL1744080)
Show SMILES CCCN(CCC)[C@@H]1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C16H23N3O/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14/h5-7,13H,3-4,8-11H2,1-2H3,(H,17,20)/t13-/m1/s1
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 92n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368588
PNG
(CHEMBL1202413)
Show SMILES CCCNC1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C13H17N3O/c1-2-6-14-10-7-9-4-3-5-11-12(9)16(8-10)13(17)15-11/h3-5,10,14H,2,6-8H2,1H3,(H,15,17)
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 94n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001964
PNG
(5-(Bis-cyclopropylmethyl-amino)-5,6-dihydro-1H,4H-...)
Show SMILES O=c1[nH]c2cccc3CC(Cn1c23)N(CC1CC1)CC1CC1
Show InChI InChI=1S/C18H23N3O/c22-18-19-16-3-1-2-14-8-15(11-21(18)17(14)16)20(9-12-4-5-12)10-13-6-7-13/h1-3,12-13,15H,4-11H2,(H,19,22)
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 95n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368587
PNG
(CHEMBL1202407)
Show SMILES CCCN(CCC)C1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C16H23N3O/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14/h5-7,13H,3-4,8-11H2,1-2H3,(H,17,20)
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 102n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368594
PNG
(CHEMBL1794998)
Show SMILES CCCN(CCC)C1CN2CCCc3cccc(C1)c23
Show InChI InChI=1S/C18H28N2/c1-3-10-19(11-4-2)17-13-16-8-5-7-15-9-6-12-20(14-17)18(15)16/h5,7-8,17H,3-4,6,9-14H2,1-2H3
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 105n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001976
PNG
(5-Dipropylamino-5,6-dihydro-1H,4H-pyrrolo[3,2,1-ij...)
Show SMILES CCCN(CCC)C1CN2C(=O)Cc3cccc(C1)c23
Show InChI InChI=1S/C17H24N2O/c1-3-8-18(9-4-2)15-10-13-6-5-7-14-11-16(20)19(12-15)17(13)14/h5-7,15H,3-4,8-12H2,1-2H3
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 108n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368586
PNG
(CHEMBL1202410)
Show SMILES C=CCNC1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C13H15N3O/c1-2-6-14-10-7-9-4-3-5-11-12(9)16(8-10)13(17)15-11/h2-5,10,14H,1,6-8H2,(H,15,17)
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 109n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001972
PNG
(5-Dipropylamino-1-methyl-5,6-dihydro-1H,4H-imidazo...)
Show SMILES CCCN(CCC)C1Cc2cccc3n(C)c(=O)n(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-4-9-19(10-5-2)14-11-13-7-6-8-15-16(13)20(12-14)17(21)18(15)3/h6-8,14H,4-5,9-12H2,1-3H3
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 124n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]DPAT from 5-HT1A receptor in homogenates of bovine hippocampus

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368596
PNG
(CHEMBL1202414)
Show SMILES CCCN(CCC)C1Cc2cccc3[nH]c(=O)c(=O)n(C1)c23
Show InChI InChI=1S/C17H23N3O2/c1-3-8-19(9-4-2)13-10-12-6-5-7-14-15(12)20(11-13)17(22)16(21)18-14/h5-7,13H,3-4,8-11H2,1-2H3,(H,18,21)
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 150n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001978
PNG
(5-(Butyl-propyl-amino)-5,6-dihydro-1H,4H-imidazo[4...)
Show SMILES CCCCN(CCC)C1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-3-5-10-19(9-4-2)14-11-13-7-6-8-15-16(13)20(12-14)17(21)18-15/h6-8,14H,3-5,9-12H2,1-2H3,(H,18,21)
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 167n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001978
PNG
(5-(Butyl-propyl-amino)-5,6-dihydro-1H,4H-imidazo[4...)
Show SMILES CCCCN(CCC)C1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-3-5-10-19(9-4-2)14-11-13-7-6-8-15-16(13)20(12-14)17(21)18-15/h6-8,14H,3-5,9-12H2,1-2H3,(H,18,21)
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 171n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001958
PNG
((2-Methylsulfanyl-5,6-dihydro-4H-imidazo[4,5,1-ij]...)
Show SMILES CCCN(CCC)C1Cc2cccc3nc(SC)n(C1)c23
Show InChI InChI=1S/C17H25N3S/c1-4-9-19(10-5-2)14-11-13-7-6-8-15-16(13)20(12-14)17(18-15)21-3/h6-8,14H,4-5,9-12H2,1-3H3
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 173n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368587
PNG
(CHEMBL1202407)
Show SMILES CCCN(CCC)C1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C16H23N3O/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14/h5-7,13H,3-4,8-11H2,1-2H3,(H,17,20)
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 207n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368583
PNG
(CHEMBL1794999)
Show SMILES CCCN(CCC)C1Cc2cccc3ccn(C1)c23
Show InChI InChI=1S/C17H24N2/c1-3-9-18(10-4-2)16-12-15-7-5-6-14-8-11-19(13-16)17(14)15/h5-8,11,16H,3-4,9-10,12-13H2,1-2H3
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 210n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368583
PNG
(CHEMBL1794999)
Show SMILES CCCN(CCC)C1Cc2cccc3ccn(C1)c23
Show InChI InChI=1S/C17H24N2/c1-3-9-18(10-4-2)16-12-15-7-5-6-14-8-11-19(13-16)17(14)15/h5-8,11,16H,3-4,9-10,12-13H2,1-2H3
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 252n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368593
PNG
(CHEMBL1202416)
Show SMILES CCCN(CCC)C1CN2C(=O)OCc3cccc(C1)c23
Show InChI InChI=1S/C17H24N2O2/c1-3-8-18(9-4-2)15-10-13-6-5-7-14-12-21-17(20)19(11-15)16(13)14/h5-7,15H,3-4,8-12H2,1-2H3
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 292n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368584
PNG
(CHEMBL1202415)
Show SMILES CCCN(CCC)C1CN2CC(=O)Nc3cccc(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-3-8-19(9-4-2)14-10-13-6-5-7-15-17(13)20(11-14)12-16(21)18-15/h5-7,14H,3-4,8-12H2,1-2H3,(H,18,21)
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 304n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001977
PNG
(6-Dipropylamino-6,7-dihydro-5H-pyrido[3,2,1-ij]qui...)
Show SMILES CCCN(CCC)C1Cc2cccc3ccc(=O)n(C1)c23
Show InChI InChI=1S/C18H24N2O/c1-3-10-19(11-4-2)16-12-15-7-5-6-14-8-9-17(21)20(13-16)18(14)15/h5-9,16H,3-4,10-13H2,1-2H3
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 315n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368589
PNG
(CHEMBL1202411)
Show SMILES CN(C)C1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C12H15N3O/c1-14(2)9-6-8-4-3-5-10-11(8)15(7-9)12(16)13-10/h3-5,9H,6-7H2,1-2H3,(H,13,16)
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 350n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368586
PNG
(CHEMBL1202410)
Show SMILES C=CCNC1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C13H15N3O/c1-2-6-14-10-7-9-4-3-5-11-12(9)16(8-10)13(17)15-11/h2-5,10,14H,1,6-8H2,(H,15,17)
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 363n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001955
PNG
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
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 534n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50453287
PNG
(CHEMBL2092845)
Show SMILES CCCN(CCC)[C@H]1Cc2cccc3nc(O)n(C1)c23
Show InChI InChI=1S/C16H23N3O.ClH/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14;/h5-7,13H,3-4,8-11H2,1-2H3,(H,17,20);1H/t13-;/m0./s1
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 569n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]DPAT from 5-HT1A receptor in homogenates of bovine hippocampus

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001966
PNG
(5-Dipropylamino-5,6-dihydro-4H-pyrrolo[3,2,1-ij]qu...)
Show SMILES CCCN(CCC)C1CN2C(=O)C(=O)c3cccc(C1)c23
Show InChI InChI=1S/C17H22N2O2/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)17(21)16(14)20/h5-7,13H,3-4,8-11H2,1-2H3
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 687n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001962
PNG
((5,6-Dihydro-4H-imidazo[4,5,1-ij]quinolin-5-yl)-di...)
Show SMILES CCCN(CCC)C1Cc2cccc3ncn(C1)c23
Show InChI InChI=1S/C16H23N3/c1-3-8-18(9-4-2)14-10-13-6-5-7-15-16(13)19(11-14)12-17-15/h5-7,12,14H,3-4,8-11H2,1-2H3
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 827n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001957
PNG
(5-Dipropylamino-5,6-dihydro-4H-oxazolo[5,4,3-ij]qu...)
Show SMILES CCCN(CCC)C1Cc2cccc3oc(=O)n(C1)c23
Show InChI InChI=1S/C16H22N2O2/c1-3-8-17(9-4-2)13-10-12-6-5-7-14-15(12)18(11-13)16(19)20-14/h5-7,13H,3-4,8-11H2,1-2H3
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 899n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001972
PNG
(5-Dipropylamino-1-methyl-5,6-dihydro-1H,4H-imidazo...)
Show SMILES CCCN(CCC)C1Cc2cccc3n(C)c(=O)n(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-4-9-19(10-5-2)14-11-13-7-6-8-15-16(13)20(12-14)17(21)18(15)3/h6-8,14H,4-5,9-12H2,1-3H3
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 924n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001980
PNG
(6-Dipropylamino-6,7-dihydro-5H-pyrido[1,2,3-de]qui...)
Show SMILES CCCN(CCC)C1Cc2cccc3ncc(=O)n(C1)c23
Show InChI InChI=1S/C17H23N3O/c1-3-8-19(9-4-2)14-10-13-6-5-7-15-17(13)20(12-14)16(21)11-18-15/h5-7,11,14H,3-4,8-10,12H2,1-2H3
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 933n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001958
PNG
((2-Methylsulfanyl-5,6-dihydro-4H-imidazo[4,5,1-ij]...)
Show SMILES CCCN(CCC)C1Cc2cccc3nc(SC)n(C1)c23
Show InChI InChI=1S/C17H25N3S/c1-4-9-19(10-5-2)14-11-13-7-6-8-15-16(13)20(12-14)17(18-15)21-3/h6-8,14H,4-5,9-12H2,1-3H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368596
PNG
(CHEMBL1202414)
Show SMILES CCCN(CCC)C1Cc2cccc3[nH]c(=O)c(=O)n(C1)c23
Show InChI InChI=1S/C17H23N3O2/c1-3-8-19(9-4-2)13-10-12-6-5-7-14-15(12)20(11-13)17(22)16(21)18-14/h5-7,13H,3-4,8-11H2,1-2H3,(H,18,21)
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50453287
PNG
(CHEMBL2092845)
Show SMILES CCCN(CCC)[C@H]1Cc2cccc3nc(O)n(C1)c23
Show InChI InChI=1S/C16H23N3O.ClH/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14;/h5-7,13H,3-4,8-11H2,1-2H3,(H,17,20);1H/t13-;/m0./s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368585
PNG
(CHEMBL1202408)
Show SMILES CCCN(CCC)C1Cc2cccc3nc(C)n(C1)c23
Show InChI InChI=1S/C17H25N3/c1-4-9-19(10-5-2)15-11-14-7-6-8-16-17(14)20(12-15)13(3)18-16/h6-8,15H,4-5,9-12H2,1-3H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]raclopride from Dopamine receptor D2 in rat striatal homogenates

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001962
PNG
((5,6-Dihydro-4H-imidazo[4,5,1-ij]quinolin-5-yl)-di...)
Show SMILES CCCN(CCC)C1Cc2cccc3ncn(C1)c23
Show InChI InChI=1S/C16H23N3/c1-3-8-18(9-4-2)14-10-13-6-5-7-15-16(13)19(11-14)12-17-15/h5-7,12,14H,3-4,8-11H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368582
PNG
(CHEMBL1794997)
Show SMILES CCCN(CCC)C1CN2CCc3cccc(C1)c23
Show InChI InChI=1S/C17H26N2/c1-3-9-18(10-4-2)16-12-15-7-5-6-14-8-11-19(13-16)17(14)15/h5-7,16H,3-4,8-13H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001966
PNG
(5-Dipropylamino-5,6-dihydro-4H-pyrrolo[3,2,1-ij]qu...)
Show SMILES CCCN(CCC)C1CN2C(=O)C(=O)c3cccc(C1)c23
Show InChI InChI=1S/C17H22N2O2/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)17(21)16(14)20/h5-7,13H,3-4,8-11H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001957
PNG
(5-Dipropylamino-5,6-dihydro-4H-oxazolo[5,4,3-ij]qu...)
Show SMILES CCCN(CCC)C1Cc2cccc3oc(=O)n(C1)c23
Show InChI InChI=1S/C16H22N2O2/c1-3-8-17(9-4-2)13-10-12-6-5-7-14-15(12)18(11-13)16(19)20-14/h5-7,13H,3-4,8-11H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001960
PNG
(5-(Benzyl-propyl-amino)-5,6-dihydro-1H,4H-imidazo[...)
Show SMILES CCCN(Cc1ccccc1)C1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C20H23N3O/c1-2-11-22(13-15-7-4-3-5-8-15)17-12-16-9-6-10-18-19(16)23(14-17)20(24)21-18/h3-10,17H,2,11-14H2,1H3,(H,21,24)
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001986
PNG
(5-Butylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-ij]qu...)
Show SMILES CCCCNC1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C14H19N3O/c1-2-3-7-15-11-8-10-5-4-6-12-13(10)17(9-11)14(18)16-12/h4-6,11,15H,2-3,7-9H2,1H3,(H,16,18)
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]DPAT from 5-HT1A receptor in homogenates of bovine hippocampus

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001969
PNG
(6-Dipropylamino-1,2,6,7-tetrahydro-5H-pyrido[3,2,1...)
Show SMILES CCCN(CCC)C1CN2C(=O)NCc3cccc(C1)c23
Show InChI InChI=1S/C17H25N3O/c1-3-8-19(9-4-2)15-10-13-6-5-7-14-11-18-17(21)20(12-15)16(13)14/h5-7,15H,3-4,8-12H2,1-2H3,(H,18,21)
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001980
PNG
(6-Dipropylamino-6,7-dihydro-5H-pyrido[1,2,3-de]qui...)
Show SMILES CCCN(CCC)C1Cc2cccc3ncc(=O)n(C1)c23
Show InChI InChI=1S/C17H23N3O/c1-3-8-19(9-4-2)14-10-13-6-5-7-15-17(13)20(12-14)16(21)11-18-15/h5-7,11,14H,3-4,8-10,12H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50001987
PNG
(5-Diallylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-ij]...)
Show SMILES C=CCN(CC=C)C1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C16H19N3O/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14/h3-7,13H,1-2,8-11H2,(H,17,20)
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>1.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368588
PNG
(CHEMBL1202413)
Show SMILES CCCNC1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C13H17N3O/c1-2-6-14-10-7-9-4-3-5-11-12(9)16(8-10)13(17)15-11/h3-5,10,14H,2,6-8H2,1H3,(H,15,17)
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 1.04E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001976
PNG
(5-Dipropylamino-5,6-dihydro-1H,4H-pyrrolo[3,2,1-ij...)
Show SMILES CCCN(CCC)C1CN2C(=O)Cc3cccc(C1)c23
Show InChI InChI=1S/C17H24N2O/c1-3-8-18(9-4-2)15-10-13-6-5-7-14-11-16(20)19(12-15)17(13)14/h5-7,15H,3-4,8-12H2,1-2H3
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 1.08E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368591
PNG
(CHEMBL1794795)
Show SMILES CCCN(CCC)C1CN2C(=O)COc3cccc(C1)c23
Show InChI InChI=1S/C17H24N2O2/c1-3-8-18(9-4-2)14-10-13-6-5-7-15-17(13)19(11-14)16(20)12-21-15/h5-7,14H,3-4,8-12H2,1-2H3
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 1.35E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001960
PNG
(5-(Benzyl-propyl-amino)-5,6-dihydro-1H,4H-imidazo[...)
Show SMILES CCCN(Cc1ccccc1)C1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C20H23N3O/c1-2-11-22(13-15-7-4-3-5-8-15)17-12-16-9-6-10-18-19(16)23(14-17)20(24)21-18/h3-10,17H,2,11-14H2,1H3,(H,21,24)
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 1.91E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368592
PNG
(CHEMBL1202412)
Show SMILES O=c1[nH]c2cccc3CC(Cn1c23)NCC1CC1
Show InChI InChI=1S/C14H17N3O/c18-14-16-12-3-1-2-10-6-11(8-17(14)13(10)12)15-7-9-4-5-9/h1-3,9,11,15H,4-8H2,(H,16,18)
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 4.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50368585
PNG
(CHEMBL1202408)
Show SMILES CCCN(CCC)C1Cc2cccc3nc(C)n(C1)c23
Show InChI InChI=1S/C17H25N3/c1-4-9-19(10-5-2)15-11-14-7-6-8-16-17(14)20(12-15)13(3)18-16/h6-8,15H,4-5,9-12H2,1-3H3
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 4.49E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001964
PNG
(5-(Bis-cyclopropylmethyl-amino)-5,6-dihydro-1H,4H-...)
Show SMILES O=c1[nH]c2cccc3CC(Cn1c23)N(CC1CC1)CC1CC1
Show InChI InChI=1S/C18H23N3O/c22-18-19-16-3-1-2-14-8-15(11-21(18)17(14)16)20(9-12-4-5-12)10-13-6-7-13/h1-3,12-13,15H,4-11H2,(H,19,22)
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 7.73E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001987
PNG
(5-Diallylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-ij]...)
Show SMILES C=CCN(CC=C)C1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C16H19N3O/c1-3-8-18(9-4-2)13-10-12-6-5-7-14-15(12)19(11-13)16(20)17-14/h3-7,13H,1-2,8-11H2,(H,17,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001986
PNG
(5-Butylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-ij]qu...)
Show SMILES CCCCNC1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C14H19N3O/c1-2-3-7-15-11-8-10-5-4-6-12-13(10)17(9-11)14(18)16-12/h4-6,11,15H,2-3,7-9H2,1H3,(H,16,18)
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>1.00E+4n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368589
PNG
(CHEMBL1202411)
Show SMILES CN(C)C1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C12H15N3O/c1-14(2)9-6-8-4-3-5-10-11(8)15(7-9)12(16)13-10/h3-5,9H,6-7H2,1-2H3,(H,13,16)
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>1.00E+4n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50001956
PNG
(5-Dibutylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-ij]...)
Show SMILES CCCCN(CCCC)C1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C18H27N3O/c1-3-5-10-20(11-6-4-2)15-12-14-8-7-9-16-17(14)21(13-15)18(22)19-16/h7-9,15H,3-6,10-13H2,1-2H3,(H,19,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))		BDBM50368590
PNG
(CHEMBL1202409)
Show SMILES NC1Cc2cccc3[nH]c(=O)n(C1)c23
Show InChI InChI=1S/C10H11N3O/c11-7-4-6-2-1-3-8-9(6)13(5-7)10(14)12-8/h1-3,7H,4-5,11H2,(H,12,14)
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>1.00E+4n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]raclopride from dopamine receptor D2 in rat striatal homogenates.

J Med Chem 35: 1076-92 (1992)


Article DOI: 10.1021/jm00084a013
BindingDB Entry DOI: 10.7270/Q2DB82GX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%