Affinity Data by PubMed id=1348542

PubMed code 1348542

Found 23 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neprilysin (Homo sapiens (Human))	BDBM50002022 ((2-Benzyl-3-hydroxycarbamoyl-propionylamino)-aceti...) Show SMILES ONC(=O)CC(Cc1ccccc1)C(=O)NCC(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibitory potency against neutral endopeptidase				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50002018 (2-(2-Mercaptomethyl-3-phenyl-propionylamino)-4-met...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibitory potency against neutral endopeptidase				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002031 (1-Mercaptomethyl-3-methylsulfanyl-propyl-ammonium) Show SMILES CSCCC([NH3+])CS Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50002035 ((2-Hydroxycarbamoyl-3-phenyl-propionylamino)-aceti...) Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)NCC(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibitory potency against neutral endopeptidase				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002026 (2-Mercapto-1-methylsulfanylmethyl-ethyl-ammonium) Show SMILES CSCC([NH3+])CS Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50368599 (CHEMBL1159809) Show SMILES CS(=O)CCC(N)CS Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50368598 (CHEMBL1159810) Show SMILES CS(=O)CC(N)CS Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002027 (1-Mercaptomethyl-3-methyl-butyl-ammonium) Show SMILES CC(C)CC([NH3+])CS Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002034 (2-Mercapto-1-phenyl-ethyl-ammonium) Show SMILES [NH3+]C(CS)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Compound was tested for inhibitory potency against aminopeptidase N from hog kidney, using [3H]Leu-enkephalin as substrate				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50036828 (1-Mercaptomethyl-2-phenyl-ethyl-ammonium \| 2-Amino...) Show SMILES NC(CS)Cc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Compound was tested for inhibitory potency against aminopeptidase N from hog kidney, using [3H]Leu-enkephalin as substrate				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002019 (2-tert-Butylsulfanyl-1-mercaptomethyl-ethyl-ammoni...) Show SMILES CC(C)(C)SCC([NH3+])CS Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002030 (2-Cyclohexyl-1-mercaptomethyl-ethyl-ammonium) Show SMILES [NH3+]C(CS)CC1CCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Compound was tested for inhibitory potency against aminopeptidase N from hog kidney, using [3H]Leu-enkephalin as substrate				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002037 (2-(4-Hydroxy-phenyl)-1-mercaptomethyl-ethyl-ammoni...) Show SMILES [NH3+]C(CS)Cc1ccc(O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Compound was tested for inhibitory potency against aminopeptidase N from hog kidney, using [3H]Leu-enkephalin as substrate				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50002038 (2-(2-Mercapto-3-phenyl-propionylamino)-4-methyl-pe...) Show SMILES CC(C)C[C@@H](NC(=O)C(S)Cc1ccccc1)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibitory potency against neutral endopeptidase				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002028 (1-Benzyloxymethyl-2-mercapto-ethyl-ammonium) Show SMILES [NH3+]C(CS)COCc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002020 (2-Benzylsulfanyl-1-mercaptomethyl-ethyl-ammonium) Show SMILES [NH3+]C(CS)CSCc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002017 (1-Mercaptomethyl-2-naphthalen-2-yl-ethyl-ammonium) Show SMILES [NH3+]C(CS)Cc1ccc2ccccc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002024 ((1-Mercaptomethyl-3-methyl-butyl)-methyl-ammonium) Show SMILES C[NH2+]C(CS)CC(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50036826 (1-Benzyl-2-hydroxycarbamoyl-ethyl-ammonium \| 3-Ami...) Show SMILES NC(CC(=O)NO)Cc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002033 (1-Benzylsulfanylmethyl-2-phenyl-ethyl-ammonium) Show SMILES [NH3+]C(CSCc1ccccc1)Cc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50002029 (Benzyl-(1-mercaptomethyl-2-phenyl-ethyl)-ammonium) Show SMILES SCC(Cc1ccccc1)[NH2+]Cc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	1.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50036832 ((2-Amino-3-phenyl-propyl)-phosphonic acid \| 1-Benz...) Show SMILES NC(Cc1ccccc1)CP(O)(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Sus scrofa (Pig))	BDBM50036830 (1-Benzyl-2-carboxy-ethyl-ammonium \| 3-Amino-4-phen...) Show SMILES NC(CC(O)=O)Cc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	8.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Compound was tested for inhibitory potency against aminopeptidase N from hog kidney, using [3H]Leu-enkephalin as substrate				Citation and Details
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%