Affinity Data by PubMed id=1350797

PubMed code 1350797

Found 21 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002099 (CHEMBL366965 \| Dimethyl-[3-(2-methyl-6H-dibenzo[b,...) Show SMILES CN(C)CC\C=C1/c2ccccc2COc2ccc(C)cc12 Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002087 (4-(1-Methyl-piperidin-4-ylidene)-4,9-dihydro-1-thi...) Show SMILES CN1CCC(CC1)=C1c2ccsc2C(=O)Cc2ccccc12 Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	0.310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand a...				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002083 (2-[11-(3-Dimethylamino-propylidene)-6,11-dihydro-d...) Show SMILES CN(C)CC\C=C1/c2ccccc2COc2ccc(CCO)cc12 Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002102 (2-[11-(3-Dimethylamino-propylidene)-6,11-dihydro-d...) Show SMILES CN(C)CC\C=C1\c2ccccc2COc2ccc(CCO)cc12 Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand a...				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002103 (3-[11-(3-Dimethylamino-propylidene)-6,11-dihydro-d...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002095 (11-(3-Dimethylamino-propylidene)-6,11-dihydro-dibe...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002085 (CHEMBL304185 \| [11-(4-Dimethylamino-butylidene)-6,...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002086 (11-(3-Pyrrolidin-1-yl-propylidene)-6,11-dihydro-di...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002093 (CHEMBL65699 \| [11-(3-Dimethylamino-propylidene)-6,...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002097 (11-(4-Dimethylamino-butylidene)-6,11-dihydro-diben...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand a...				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002098 (11-(4-Dimethylamino-butylidene)-6,11-dihydro-diben...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002092 (11-(3-Thiomorpholin-4-yl-propylidene)-6,11-dihydro...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002100 (11-(3-Diethylamino-propylidene)-6,11-dihydro-diben...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002088 (CHEMBL302005 \| [11-(2-Dimethylamino-ethylidene)-6,...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand a...				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002101 (11-(2-Dimethylamino-ethylidene)-6,11-dihydro-diben...) Show SMILES CN(C)C\C=C1/c2ccccc2COc2ccc(cc12)C(O)=O Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002084 (11-(2-Dimethylamino-ethylsulfanyl)-6,11-dihydro-di...) Show SMILES CN(C)CCSC1c2ccccc2COc2ccc(cc12)C(O)=O Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002089 (3-[11-(3-Dimethylamino-propylidene)-6,11-dihydro-d...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand a...				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002096 (ALO-4943A \| CHEMBL1719 \| KW-4679 \| OLOPATADINE HYD...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL DrugBank PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002091 (11-(3-Dimethylamino-propylidene)-6,11-dihydro-dibe...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002090 (11-(3-Dimethylamino-propylidene)-6,11-dihydro-dibe...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50002094 (3-[11-(3-Dimethylamino-propylidene)-6,11-dihydro-d...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM				J Med Chem 35: 2074-84 (1992) Article DOI: 10.1021/jm00089a020 BindingDB Entry DOI: 10.7270/Q2N87BC0
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%