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PubMed code 1352351

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406648
PNG
(CHEMBL82654)
Show SMILES CC(C)NC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C19H31N3O2/c1-16(2)21-19(23)20-10-7-13-24-18-9-6-8-17(14-18)15-22-11-4-3-5-12-22/h6,8-9,14,16H,3-5,7,10-13,15H2,1-2H3,(H2,20,21,23)
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n/an/an/a 43.6n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406663
PNG
(CHEMBL80069)
Show SMILES FC(F)(F)c1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C23H28F3N3O2/c24-23(25,26)19-8-5-9-20(16-19)28-22(30)27-11-6-14-31-21-10-4-7-18(15-21)17-29-12-2-1-3-13-29/h4-5,7-10,15-16H,1-3,6,11-14,17H2,(H2,27,28,30)
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n/an/an/a 813n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406659
PNG
(CHEMBL78339)
Show SMILES FCCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C18H28FN3O2/c19-8-10-21-18(23)20-9-5-13-24-17-7-4-6-16(14-17)15-22-11-2-1-3-12-22/h4,6-7,14H,1-3,5,8-13,15H2,(H2,20,21,23)
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n/an/an/a 85.1n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406665
PNG
(CHEMBL79507)
Show SMILES COc1ccc(NC(=S)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C23H31N3O2S/c1-27-21-11-9-20(10-12-21)25-23(29)24-13-6-16-28-22-8-5-7-19(17-22)18-26-14-3-2-4-15-26/h5,7-12,17H,2-4,6,13-16,18H2,1H3,(H2,24,25,29)
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n/an/an/a 4.37E+3n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406667
PNG
(CHEMBL80105)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)NCc1ccccc1
Show InChI InChI=1S/C23H31N3O2/c27-23(25-18-20-9-3-1-4-10-20)24-13-8-16-28-22-12-7-11-21(17-22)19-26-14-5-2-6-15-26/h1,3-4,7,9-12,17H,2,5-6,8,13-16,18-19H2,(H2,24,25,27)
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n/an/an/a 347n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50036754
PNG
((1Z)-N'-(aminosulfonyl)-3-[({2-[(diaminomethylene)...)
Show SMILES NC(N)=Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
Show InChI InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
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n/an/an/a 100n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406671
PNG
(CHEMBL312419)
Show SMILES COc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C23H31N3O3/c1-28-21-11-9-20(10-12-21)25-23(27)24-13-6-16-29-22-8-5-7-19(17-22)18-26-14-3-2-4-15-26/h5,7-12,17H,2-4,6,13-16,18H2,1H3,(H2,24,25,27)
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n/an/an/a 631n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406657
PNG
(CHEMBL309401)
Show SMILES Nc1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C22H30N4O2/c23-19-8-5-9-20(16-19)25-22(27)24-11-6-14-28-21-10-4-7-18(15-21)17-26-12-2-1-3-13-26/h4-5,7-10,15-16H,1-3,6,11-14,17,23H2,(H2,24,25,27)
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n/an/an/a 155n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro inhibitory activity against histamine H2 receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406660
PNG
(CHEMBL81545)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)NC1CCCCC1
Show InChI InChI=1S/C22H35N3O2/c26-22(24-20-10-3-1-4-11-20)23-13-8-16-27-21-12-7-9-19(17-21)18-25-14-5-2-6-15-25/h7,9,12,17,20H,1-6,8,10-11,13-16,18H2,(H2,23,24,26)
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n/an/an/a 43.6n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50403559
PNG
(Brumetadina | CIMETIDINE)
Show SMILES CNC(NCCSCc1[nH]cnc1C)=NC#N
Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
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n/an/an/a 263n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406646
PNG
(CHEMBL311272)
Show SMILES Cc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C23H31N3O2/c1-19-9-11-21(12-10-19)25-23(27)24-13-6-16-28-22-8-5-7-20(17-22)18-26-14-3-2-4-15-26/h5,7-12,17H,2-4,6,13-16,18H2,1H3,(H2,24,25,27)
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n/an/an/a 631n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406649
PNG
(CHEMBL81758)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)Nc1ccc2OCOc2c1
Show InChI InChI=1S/C23H29N3O4/c27-23(25-19-8-9-21-22(15-19)30-17-29-21)24-10-5-13-28-20-7-4-6-18(14-20)16-26-11-2-1-3-12-26/h4,6-9,14-15H,1-3,5,10-13,16-17H2,(H2,24,25,27)
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n/an/an/a 288n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406653
PNG
(CHEMBL313060)
Show SMILES COc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c(OC)c1
Show InChI InChI=1S/C24H33N3O4/c1-29-20-10-11-22(23(17-20)30-2)26-24(28)25-12-7-15-31-21-9-6-8-19(16-21)18-27-13-4-3-5-14-27/h6,8-11,16-17H,3-5,7,12-15,18H2,1-2H3,(H2,25,26,28)
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n/an/an/a 2.24E+3n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22893
PNG
(CHEMBL512 | Ranitidine | ZANTAC | dimethyl[(5-{[(2...)
Show SMILES CN\C([CH-][N+]([O-])=O)=[NH+]/CCSCc1ccc(CN(C)C)o1
Show InChI InChI=1S/C13H21N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9H,6-8,10H2,1-3H3,(H,14,15)/q-1/p+1
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n/an/an/a 64.6n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro inhibitory activity against histamine H2 receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406655
PNG
(CHEMBL432167)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)NC1CC1
Show InChI InChI=1S/C19H29N3O2/c23-19(21-17-8-9-17)20-10-5-13-24-18-7-4-6-16(14-18)15-22-11-2-1-3-12-22/h4,6-7,14,17H,1-3,5,8-13,15H2,(H2,20,21,23)
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n/an/an/a 47.9n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406661
PNG
(CHEMBL79974)
Show SMILES CC(C)CNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C20H33N3O2/c1-17(2)15-22-20(24)21-10-7-13-25-19-9-6-8-18(14-19)16-23-11-4-3-5-12-23/h6,8-9,14,17H,3-5,7,10-13,15-16H2,1-2H3,(H2,21,22,24)
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n/an/an/a 170n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406666
PNG
(CHEMBL80046)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)Nc1ccccc1
Show InChI InChI=1S/C22H29N3O2/c26-22(24-20-10-3-1-4-11-20)23-13-8-16-27-21-12-7-9-19(17-21)18-25-14-5-2-6-15-25/h1,3-4,7,9-12,17H,2,5-6,8,13-16,18H2,(H2,23,24,26)
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n/an/an/a 126n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406668
PNG
(CHEMBL81520)
Show SMILES Clc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C22H28ClN3O2/c23-19-8-10-20(11-9-19)25-22(27)24-12-5-15-28-21-7-4-6-18(16-21)17-26-13-2-1-3-14-26/h4,6-11,16H,1-3,5,12-15,17H2,(H2,24,25,27)
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n/an/an/a 631n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406651
PNG
(CHEMBL316154)
Show SMILES COc1ccccc1NC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C23H31N3O3/c1-28-22-12-4-3-11-21(22)25-23(27)24-13-8-16-29-20-10-7-9-19(17-20)18-26-14-5-2-6-15-26/h3-4,7,9-12,17H,2,5-6,8,13-16,18H2,1H3,(H2,24,25,27)
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n/an/an/a 776n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406652
PNG
(CHEMBL311978)
Show SMILES [O-][N+](=O)c1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C22H28N4O4/c27-22(24-19-8-5-9-20(16-19)26(28)29)23-11-6-14-30-21-10-4-7-18(15-21)17-25-12-2-1-3-13-25/h4-5,7-10,15-16H,1-3,6,11-14,17H2,(H2,23,24,27)
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n/an/an/a 269n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406656
PNG
(CHEMBL81039)
Show SMILES COc1ccc(OC)c(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C24H33N3O4/c1-29-20-10-11-23(30-2)22(17-20)26-24(28)25-12-7-15-31-21-9-6-8-19(16-21)18-27-13-4-3-5-14-27/h6,8-11,16-17H,3-5,7,12-15,18H2,1-2H3,(H2,25,26,28)
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n/an/an/a 158n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406658
PNG
(CHEMBL81750)
Show SMILES CCC(C)NC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C20H33N3O2/c1-3-17(2)22-20(24)21-11-8-14-25-19-10-7-9-18(15-19)16-23-12-5-4-6-13-23/h7,9-10,15,17H,3-6,8,11-14,16H2,1-2H3,(H2,21,22,24)
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n/an/an/a 95.5n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406673
PNG
(CHEMBL78519)
Show SMILES CCCCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C20H33N3O2/c1-2-3-11-21-20(24)22-12-8-15-25-19-10-7-9-18(16-19)17-23-13-5-4-6-14-23/h7,9-10,16H,2-6,8,11-15,17H2,1H3,(H2,21,22,24)
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n/an/an/a 81.3n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406647
PNG
(CHEMBL81506)
Show SMILES CNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C17H27N3O2/c1-18-17(21)19-9-6-12-22-16-8-5-7-15(13-16)14-20-10-3-2-4-11-20/h5,7-8,13H,2-4,6,9-12,14H2,1H3,(H2,18,19,21)
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n/an/an/a 155n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406672
PNG
(CHEMBL309659)
Show SMILES Clc1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C22H28ClN3O2/c23-19-8-5-9-20(16-19)25-22(27)24-11-6-14-28-21-10-4-7-18(15-21)17-26-12-2-1-3-13-26/h4-5,7-10,15-16H,1-3,6,11-14,17H2,(H2,24,25,27)
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n/an/an/a 316n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406662
PNG
(CHEMBL312601)
Show SMILES FC(F)(F)c1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C23H28F3N3O2/c24-23(25,26)19-8-10-20(11-9-19)28-22(30)27-12-5-15-31-21-7-4-6-18(16-21)17-29-13-2-1-3-14-29/h4,6-11,16H,1-3,5,12-15,17H2,(H2,27,28,30)
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n/an/an/a 1.70E+3n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406664
PNG
(CHEMBL81859)
Show SMILES [O-][N+](=O)c1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C22H28N4O4/c27-22(24-19-8-10-20(11-9-19)26(28)29)23-12-5-15-30-21-7-4-6-18(16-21)17-25-13-2-1-3-14-25/h4,6-11,16H,1-3,5,12-15,17H2,(H2,23,24,27)
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n/an/an/a 178n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro inhibitory activity against histamine H2 receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406669
PNG
(CHEMBL80084)
Show SMILES COc1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C23H31N3O3/c1-28-21-10-6-9-20(17-21)25-23(27)24-12-7-15-29-22-11-5-8-19(16-22)18-26-13-3-2-4-14-26/h5-6,8-11,16-17H,2-4,7,12-15,18H2,1H3,(H2,24,25,27)
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n/an/an/a 200n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406670
PNG
(DALCOTIDINE)
Show SMILES CCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C18H29N3O2/c1-2-19-18(22)20-10-7-13-23-17-9-6-8-16(14-17)15-21-11-4-3-5-12-21/h6,8-9,14H,2-5,7,10-13,15H2,1H3,(H2,19,20,22)
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n/an/an/a 40.7n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406650
PNG
(CHEMBL82430)
Show SMILES CCOc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C24H33N3O3/c1-2-29-22-12-10-21(11-13-22)26-24(28)25-14-7-17-30-23-9-6-8-20(18-23)19-27-15-4-3-5-16-27/h6,8-13,18H,2-5,7,14-17,19H2,1H3,(H2,25,26,28)
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n/an/an/a 490n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406674
PNG
(CHEMBL82599)
Show SMILES CCCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C19H31N3O2/c1-2-10-20-19(23)21-11-7-14-24-18-9-6-8-17(15-18)16-22-12-4-3-5-13-22/h6,8-9,15H,2-5,7,10-14,16H2,1H3,(H2,20,21,23)
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n/an/an/a 97.7n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406654
PNG
(CHEMBL81597)
Show SMILES CC(C)(C)NC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C20H33N3O2/c1-20(2,3)22-19(24)21-11-8-14-25-18-10-7-9-17(15-18)16-23-12-5-4-6-13-23/h7,9-10,15H,4-6,8,11-14,16H2,1-3H3,(H2,21,22,24)
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n/an/an/a 2.09E+3n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%