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PubMed code 1375965

Compile data set for download or QSAR
Found 47 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002533
PNG
(2-[2-(2-tert-Butoxycarbonylamino-4-carbamoyl-butyr...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C38H43N5O8/c1-38(2,3)51-37(49)42-29(18-19-33(39)45)34(46)40-30(21-27-22-43(24-44)32-17-11-10-16-28(27)32)35(47)41-31(20-25-12-6-4-7-13-25)36(48)50-23-26-14-8-5-9-15-26/h4-17,22,24,29-31H,18-21,23H2,1-3H3,(H2,39,45)(H,40,46)(H,41,47)(H,42,49)/t29-,30+,31-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002568
PNG
(CHEMBL304472 | benzyl 2-[2-(1-formyl-1H-3-indolyl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C36H40N4O8/c1-36(2,3)48-35(46)39-30(21-41)33(44)37-28(19-26-20-40(23-42)31-17-11-10-16-27(26)31)32(43)38-29(18-24-12-6-4-7-13-24)34(45)47-22-25-14-8-5-9-15-25/h4-17,20,23,28-30,41H,18-19,21-22H2,1-3H3,(H,37,44)(H,38,43)(H,39,46)/t28-,29+,30+/m1/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002552
PNG
(CHEMBL303337 | benzyl 2-[2-(1-formyl-1H-3-indolyl)...)
Show SMILES C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C37H42N4O8/c1-24(43)32(40-36(47)49-37(2,3)4)34(45)38-29(20-27-21-41(23-42)31-18-12-11-17-28(27)31)33(44)39-30(19-25-13-7-5-8-14-25)35(46)48-22-26-15-9-6-10-16-26/h5-18,21,23-24,29-30,32,43H,19-20,22H2,1-4H3,(H,38,45)(H,39,44)(H,40,47)/t24-,29-,30+,32+/m1/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002562
PNG
(CHEMBL294798 | benzyl 2-[1-[3-carbamoyl-1-neopenty...)
Show SMILES CC(C)(C)OC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C38H43N5O8/c1-38(2,3)51-37(49)42-29(18-19-33(39)45)34(46)40-30(21-27-22-43(24-44)32-17-11-10-16-28(27)32)35(47)41-31(20-25-12-6-4-7-13-25)36(48)50-23-26-14-8-5-9-15-26/h4-17,22,24,29-31H,18-21,23H2,1-3H3,(H2,39,45)(H,40,46)(H,41,47)(H,42,49)/t29-,30-,31+/m1/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002543
PNG
(CHEMBL59615 | benzyl 2-[2-[3-carbamoyl-1-neopentyl...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1Cc2ccccc2CC1C(=O)OCc1ccccc1
Show InChI InChI=1S/C39H43N5O8/c1-39(2,3)52-38(50)42-30(17-18-34(40)46)35(47)41-31(19-28-21-43(24-45)32-16-10-9-15-29(28)32)36(48)44-22-27-14-8-7-13-26(27)20-33(44)37(49)51-23-25-11-5-4-6-12-25/h4-16,21,24,30-31,33H,17-20,22-23H2,1-3H3,(H2,40,46)(H,41,47)(H,42,50)/t30-,31+,33?/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002545
PNG
(CHEMBL544284 | benzyl 2-[1-[1-amino-3-carbamoyl-(1...)
Show SMILES N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C33H35N5O6/c34-26(15-16-30(35)40)31(41)36-27(18-24-19-38(21-39)29-14-8-7-13-25(24)29)32(42)37-28(17-22-9-3-1-4-10-22)33(43)44-20-23-11-5-2-6-12-23/h1-14,19,21,26-28H,15-18,20,34H2,(H2,35,40)(H,36,41)(H,37,42)/t26-,27+,28-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002571
PNG
(CHEMBL293355 | benzyl 2-[1-[3-carbamoyl-1-neopenty...)
Show SMILES CN([C@@H](Cc1ccccc1)C(=O)OCc1ccccc1)C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C39H45N5O8/c1-39(2,3)52-38(50)42-30(19-20-34(40)46)35(47)41-31(22-28-23-44(25-45)32-18-12-11-17-29(28)32)36(48)43(4)33(21-26-13-7-5-8-14-26)37(49)51-24-27-15-9-6-10-16-27/h5-18,23,25,30-31,33H,19-22,24H2,1-4H3,(H2,40,46)(H,41,47)(H,42,50)/t30-,31+,33-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002573
PNG
(CHEMBL58245 | benzyl 2-[2-(1-formyl-1H-3-indolyl)-...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C42H44N4O8/c1-42(2,3)54-41(52)45-34(22-29-18-20-32(48)21-19-29)38(49)43-35(24-31-25-46(27-47)37-17-11-10-16-33(31)37)39(50)44-36(23-28-12-6-4-7-13-28)40(51)53-26-30-14-8-5-9-15-30/h4-21,25,27,34-36,48H,22-24,26H2,1-3H3,(H,43,49)(H,44,50)(H,45,52)/t34-,35+,36-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002563
PNG
(CHEMBL62357 | benzyl 2-[1-[3-carbamoyl-1-neopentyl...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C38H43N5O8/c1-38(2,3)51-37(49)42-29(18-19-33(39)45)34(46)40-30(21-27-22-43(24-44)32-17-11-10-16-28(27)32)35(47)41-31(20-25-12-6-4-7-13-25)36(48)50-23-26-14-8-5-9-15-26/h4-17,22,24,29-31H,18-21,23H2,1-3H3,(H2,39,45)(H,40,46)(H,41,47)(H,42,49)/t29-,30-,31-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002560
PNG
(CHEMBL294814 | benzyl 2-[1-[3-carbamoyl-1-neopenty...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C35H42N4O7/c1-35(2,3)46-34(44)39-27(19-20-30(36)40)31(41)37-28(21-24-13-7-4-8-14-24)32(42)38-29(22-25-15-9-5-10-16-25)33(43)45-23-26-17-11-6-12-18-26/h4-18,27-29H,19-23H2,1-3H3,(H2,36,40)(H,37,41)(H,38,42)(H,39,44)/t27-,28+,29-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002575
PNG
(CHEMBL64166 | benzyl 2-[1-[3-carbamoyl-1-neopentyl...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C38H43N5O9/c1-38(2,3)52-37(50)42-29(17-18-33(39)46)34(47)40-30(20-26-21-43(23-44)32-12-8-7-11-28(26)32)35(48)41-31(19-24-13-15-27(45)16-14-24)36(49)51-22-25-9-5-4-6-10-25/h4-16,21,23,29-31,45H,17-20,22H2,1-3H3,(H2,39,46)(H,40,47)(H,41,48)(H,42,50)/t29-,30+,31-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002564
PNG
(Benzyloxycarbonyl-Gln-D-Trp(CHO)-Phe(methoxy-cyclo...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC1CCCCC1
Show InChI InChI=1S/C38H49N5O8/c1-38(2,3)51-37(49)42-29(18-19-33(39)45)34(46)40-30(21-27-22-43(24-44)32-17-11-10-16-28(27)32)35(47)41-31(20-25-12-6-4-7-13-25)36(48)50-23-26-14-8-5-9-15-26/h4,6-7,10-13,16-17,22,24,26,29-31H,5,8-9,14-15,18-21,23H2,1-3H3,(H2,39,45)(H,40,46)(H,41,47)(H,42,49)/t29-,30+,31-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002555
PNG
(CHEMBL293726 | benzyl 2-[2-(1-formyl-1H-3-indolyl)...)
Show SMILES CC(C)(C)OC(=O)NCC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C35H38N4O7/c1-35(2,3)46-34(44)36-20-31(41)37-28(19-26-21-39(23-40)30-17-11-10-16-27(26)30)32(42)38-29(18-24-12-6-4-7-13-24)33(43)45-22-25-14-8-5-9-15-25/h4-17,21,23,28-29H,18-20,22H2,1-3H3,(H,36,44)(H,37,41)(H,38,42)/t28-,29+/m1/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002570
PNG
(CHEMBL417390 | benzyl 2-benzoyl-1-[2-[3-carbamoyl-...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1[C@@H](CCC1C(=O)c1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C41H45N5O9/c1-41(2,3)55-40(53)44-30(18-21-35(42)48)37(50)43-31(22-28-23-45(25-47)32-17-11-10-16-29(28)32)38(51)46-33(36(49)27-14-8-5-9-15-27)19-20-34(46)39(52)54-24-26-12-6-4-7-13-26/h4-17,23,25,30-31,33-34H,18-22,24H2,1-3H3,(H2,42,48)(H,43,50)(H,44,53)/t30-,31+,33?,34-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002557
PNG
(Benzyloxycarbonyl-Gln-D-Trp(CHO)-Phe(ethoxyphenyl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCCc1ccccc1
Show InChI InChI=1S/C39H45N5O8/c1-39(2,3)52-38(50)43-30(18-19-34(40)46)35(47)41-31(23-28-24-44(25-45)33-17-11-10-16-29(28)33)36(48)42-32(22-27-14-8-5-9-15-27)37(49)51-21-20-26-12-6-4-7-13-26/h4-17,24-25,30-32H,18-23H2,1-3H3,(H2,40,46)(H,41,47)(H,42,48)(H,43,50)/t30-,31+,32-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002536
PNG
(CHEMBL292320 | benzyl 2-[1-[3-carbamoyl-1-neopenty...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C37H43N5O7/c1-37(2,3)49-36(47)42-29(18-19-32(38)43)33(44)40-30(21-26-22-39-28-17-11-10-16-27(26)28)34(45)41-31(20-24-12-6-4-7-13-24)35(46)48-23-25-14-8-5-9-15-25/h4-17,22,29-31,39H,18-21,23H2,1-3H3,(H2,38,43)(H,40,44)(H,41,45)(H,42,47)/t29-,30+,31-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002539
PNG
(CHEMBL405795 | D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-D-Trp...)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C66H74N14O10/c67-57(81)27-25-50(74-60(84)49-24-13-29-70-49)61(85)75-51(26-28-58(68)82)62(86)78-55(33-41-36-72-47-22-11-8-19-44(41)47)65(89)77-53(31-39-16-5-2-6-17-39)63(87)79-56(34-42-37-73-48-23-12-9-20-45(42)48)66(90)80-54(32-40-35-71-46-21-10-7-18-43(40)46)64(88)76-52(59(69)83)30-38-14-3-1-4-15-38/h1-12,14-23,35-37,49-56,70-73H,13,24-34H2,(H2,67,81)(H2,68,82)(H2,69,83)(H,74,84)(H,75,85)(H,76,88)(H,77,89)(H,78,86)(H,79,87)(H,80,90)/t49-,50+,51+,52+,53+,54-,55-,56-/m1/s1
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n/an/a 600n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002548
PNG
(CHEMBL304246 | benzyl 2-[1-[3-carbamoyl-1-neopenty...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C38H43N5O8/c1-38(2,3)51-37(49)42-29(18-19-33(39)45)34(46)40-30(21-27-22-43(24-44)32-17-11-10-16-28(27)32)35(47)41-31(20-25-12-6-4-7-13-25)36(48)50-23-26-14-8-5-9-15-26/h4-17,22,24,29-31H,18-21,23H2,1-3H3,(H2,39,45)(H,40,46)(H,41,47)(H,42,49)/t29-,30+,31+/m0/s1
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n/an/a 770n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002576
PNG
(CHEMBL303543 | benzyl 2-[1-[3-carbamoyl-1-neopenty...)
Show SMILES CSCC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C31H42N4O7S/c1-31(2,3)42-30(40)35-23(15-16-26(32)36)27(37)33-24(17-18-43-4)28(38)34-25(19-21-11-7-5-8-12-21)29(39)41-20-22-13-9-6-10-14-22/h5-14,23-25H,15-20H2,1-4H3,(H2,32,36)(H,33,37)(H,34,38)(H,35,40)/t23-,24+,25-/m0/s1
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n/an/a 790n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002532
PNG
(CHEMBL63059 | benzyl 2-[1-[3-carbamoyl-1-neopentyl...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C35H42N4O7/c1-35(2,3)46-34(44)39-27(19-20-30(36)40)31(41)37-28(21-24-13-7-4-8-14-24)32(42)38-29(22-25-15-9-5-10-16-25)33(43)45-23-26-17-11-6-12-18-26/h4-18,27-29H,19-23H2,1-3H3,(H2,36,40)(H,37,41)(H,38,42)(H,39,44)/t27-,28-,29-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002551
PNG
(CHEMBL59768 | benzyl 2-[1-[3-carbamoyl-1-neopentyl...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C32H44N4O7/c1-21(2)18-25(34-28(38)24(16-17-27(33)37)36-31(41)43-32(3,4)5)29(39)35-26(19-22-12-8-6-9-13-22)30(40)42-20-23-14-10-7-11-15-23/h6-15,21,24-26H,16-20H2,1-5H3,(H2,33,37)(H,34,38)(H,35,39)(H,36,41)/t24-,25+,26-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002556
PNG
(Benzyloxycarbonyl-Gln-D-Trp(CHO)-Phe(4-chloro-meth...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1
Show InChI InChI=1S/C38H42ClN5O8/c1-38(2,3)52-37(50)43-29(17-18-33(40)46)34(47)41-30(20-26-21-44(23-45)32-12-8-7-11-28(26)32)35(48)42-31(19-24-9-5-4-6-10-24)36(49)51-22-25-13-15-27(39)16-14-25/h4-16,21,23,29-31H,17-20,22H2,1-3H3,(H2,40,46)(H,41,47)(H,42,48)(H,43,50)/t29-,30+,31-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002530
PNG
(Benzyloxycarbonyl-Gln-D-Trp(CHO)-Phe(isopropyloxy)...)
Show SMILES CC(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C34H43N5O8/c1-21(2)46-32(44)27(17-22-11-7-6-8-12-22)37-31(43)26(18-23-19-39(20-40)28-14-10-9-13-24(23)28)36-30(42)25(15-16-29(35)41)38-33(45)47-34(3,4)5/h6-14,19-21,25-27H,15-18H2,1-5H3,(H2,35,41)(H,36,42)(H,37,43)(H,38,45)/t25-,26+,27-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002550
PNG
(Benzyloxycarbonyl-Phe-D-Trp-D-Trp-amine | CHEMBL62...)
Show SMILES NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C39H38N6O5/c40-36(46)33(20-27-22-41-31-17-9-7-15-29(27)31)43-38(48)35(21-28-23-42-32-18-10-8-16-30(28)32)44-37(47)34(19-25-11-3-1-4-12-25)45-39(49)50-24-26-13-5-2-6-14-26/h1-18,22-23,33-35,41-42H,19-21,24H2,(H2,40,46)(H,43,48)(H,44,47)(H,45,49)/t33-,34+,35-/m1/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002540
PNG
(Benzyloxycarbonyl-Gln-D-Trp(CHO)-Phe(methoxy) | CH...)
Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C32H39N5O8/c1-32(2,3)45-31(43)36-23(14-15-27(33)39)28(40)34-24(17-21-18-37(19-38)26-13-9-8-12-22(21)26)29(41)35-25(30(42)44-4)16-20-10-6-5-7-11-20/h5-13,18-19,23-25H,14-17H2,1-4H3,(H2,33,39)(H,34,40)(H,35,41)(H,36,43)/t23-,24+,25-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002531
PNG
(CHEMBL62349 | benzyl 3-(1H-3-indolyl)-2-[1-[2-(1H-...)
Show SMILES O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1
Show InChI InChI=1S/C46H43N5O6/c52-43(50-42(45(54)56-29-32-16-6-2-7-17-32)26-35-28-48-39-23-13-11-21-37(35)39)40(24-31-14-4-1-5-15-31)49-44(53)41(25-34-27-47-38-22-12-10-20-36(34)38)51-46(55)57-30-33-18-8-3-9-19-33/h1-23,27-28,40-42,47-48H,24-26,29-30H2,(H,49,53)(H,50,52)(H,51,55)/t40-,41+,42+/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002544
PNG
(CHEMBL294288 | benzyl 2-[1-[3-carbamoyl-1-neopenty...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C35H45N5O8/c1-22(2)17-28(33(45)47-20-23-11-7-6-8-12-23)38-32(44)27(18-24-19-40(21-41)29-14-10-9-13-25(24)29)37-31(43)26(15-16-30(36)42)39-34(46)48-35(3,4)5/h6-14,19,21-22,26-28H,15-18,20H2,1-5H3,(H2,36,42)(H,37,43)(H,38,44)(H,39,46)/t26-,27+,28-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002561
PNG
(CHEMBL64631 | benzyl 2-[1-[1-benzyloxycarbonyl-(5R...)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C30H37N5O8/c31-25(36)15-13-22(27(38)34-23(14-16-26(32)37)29(40)42-18-20-8-3-1-4-9-20)33-28(39)24-12-7-17-35(24)30(41)43-19-21-10-5-2-6-11-21/h1-6,8-11,22-24H,7,12-19H2,(H2,31,36)(H2,32,37)(H,33,39)(H,34,38)/t22-,23-,24+/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002547
PNG
(1N-[1-[1-carbamoyl-2-phenyl-(1S)-ethylcarbamoyl]-2...)
Show SMILES N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C31H32N6O3/c32-24(15-20-17-34-25-12-6-4-10-22(20)25)30(39)37-28(16-21-18-35-26-13-7-5-11-23(21)26)31(40)36-27(29(33)38)14-19-8-2-1-3-9-19/h1-13,17-18,24,27-28,34-35H,14-16,32H2,(H2,33,38)(H,36,40)(H,37,39)/t24-,27+,28-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002549
PNG
(CHEMBL64037 | tert-butyloxycarbonyl-D-Trp-D-Trp-Ph...)
Show SMILES CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H40N6O5/c1-36(2,3)47-35(46)42-31(19-24-21-39-28-16-10-8-14-26(24)28)34(45)41-30(18-23-20-38-27-15-9-7-13-25(23)27)33(44)40-29(32(37)43)17-22-11-5-4-6-12-22/h4-16,20-21,29-31,38-39H,17-19H2,1-3H3,(H2,37,43)(H,40,44)(H,41,45)(H,42,46)/t29-,30+,31+/m0/s1
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n/an/a 1.76E+4n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002558
PNG
(Benzyloxycarbonyl-D-Trp-Phe-D-Trp-OH | CHEMBL30266...)
Show SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C39H37N5O6/c45-36(43-35(38(47)48)21-28-23-41-32-18-10-8-16-30(28)32)33(19-25-11-3-1-4-12-25)42-37(46)34(20-27-22-40-31-17-9-7-15-29(27)31)44-39(49)50-24-26-13-5-2-6-14-26/h1-18,22-23,33-35,40-41H,19-21,24H2,(H,42,46)(H,43,45)(H,44,49)(H,47,48)/t33-,34+,35+/m0/s1
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n/an/a 2.38E+4n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002574
PNG
(CHEMBL263013 | tert-butyloxycarbonyl-Gln-D-Trp-Phe...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H38N6O6/c1-30(2,3)42-29(41)36-22(13-14-25(31)37)27(39)35-24(16-19-17-33-21-12-8-7-11-20(19)21)28(40)34-23(26(32)38)15-18-9-5-4-6-10-18/h4-12,17,22-24,33H,13-16H2,1-3H3,(H2,31,37)(H2,32,38)(H,34,40)(H,35,39)(H,36,41)/t22-,23-,24+/m0/s1
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n/an/a 3.87E+4n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002572
PNG
(2-[1-[1-amino-2-phenyl-(1S)-ethylcarboxamido]-2-(1...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C31H31N5O4/c32-24(14-19-8-2-1-3-9-19)29(37)35-27(15-20-17-33-25-12-6-4-10-22(20)25)30(38)36-28(31(39)40)16-21-18-34-26-13-7-5-11-23(21)26/h1-13,17-18,24,27-28,33-34H,14-16,32H2,(H,35,37)(H,36,38)(H,39,40)/t24-,27+,28+/m0/s1
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n/an/a 5.80E+4n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002567
PNG
(2-[1-[1-amino-2-(1H-3-indolyl)-(1R)-ethylcarboxami...)
Show SMILES N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C31H31N5O4/c32-24(15-20-17-33-25-12-6-4-10-22(20)25)29(37)35-27(14-19-8-2-1-3-9-19)30(38)36-28(31(39)40)16-21-18-34-26-13-7-5-11-23(21)26/h1-13,17-18,24,27-28,33-34H,14-16,32H2,(H,35,37)(H,36,38)(H,39,40)/t24-,27+,28-/m1/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002535
PNG
(2-[2-(1-methyl-1H-3-indolyl)-1-[2-oxo-(5S)-dihydro...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCC(=O)N1
Show InChI InChI=1S/C25H26N4O5/c30-22-11-10-19(27-22)23(31)28-20(13-16-14-26-18-9-5-4-8-17(16)18)24(32)29-21(25(33)34)12-15-6-2-1-3-7-15/h1-9,14,19-21,26H,10-13H2,(H,27,30)(H,28,31)(H,29,32)(H,33,34)/t19-,20+,21-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002565
PNG
(CHEMBL293200 | benzyl 2-[2-(1H-3-indolyl)-1-[2-(1H...)
Show SMILES CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C43H45N5O6/c1-43(2,3)54-42(52)48-37(24-31-26-45-35-21-13-11-19-33(31)35)40(50)46-36(23-30-25-44-34-20-12-10-18-32(30)34)39(49)47-38(22-28-14-6-4-7-15-28)41(51)53-27-29-16-8-5-9-17-29/h4-21,25-26,36-38,44-45H,22-24,27H2,1-3H3,(H,46,50)(H,47,49)(H,48,52)/t36-,37-,38+/m1/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002553
PNG
(Benzyloxycarbonyl-D-Pro-Gln-Gln-OH | CHEMBL293179)
Show SMILES NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C29H34N6O8/c30-24(36)12-10-21(26(38)34-23(28(40)41)14-18-15-32-20-9-5-4-8-19(18)20)33-27(39)22(11-13-25(31)37)35-29(42)43-16-17-6-2-1-3-7-17/h1-9,15,21-23,32H,10-14,16H2,(H2,30,36)(H2,31,37)(H,33,39)(H,34,38)(H,35,42)(H,40,41)/t21-,22-,23+/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002538
PNG
(CHEMBL294065 | tert-butyloxycarbonyl-Gln-D-Trp(CHO...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C31H37N5O8/c1-31(2,3)44-30(43)35-22(13-14-26(32)38)27(39)33-23(16-20-17-36(18-37)25-12-8-7-11-21(20)25)28(40)34-24(29(41)42)15-19-9-5-4-6-10-19/h4-12,17-18,22-24H,13-16H2,1-3H3,(H2,32,38)(H,33,39)(H,34,40)(H,35,43)(H,41,42)/t22-,23+,24-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002559
PNG
(CHEMBL304702 | tert-butyl 5-[3-carbamoyl-1-[1,3-di...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C20H34N6O7/c1-20(2,3)33-19(32)26-10-4-5-13(26)18(31)25-12(7-9-15(22)28)17(30)24-11(16(23)29)6-8-14(21)27/h11-13H,4-10H2,1-3H3,(H2,21,27)(H2,22,28)(H2,23,29)(H,24,30)(H,25,31)/t11-,12-,13+/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002554
PNG
(2-[3-carbamoyl-1-[2-oxo-(5S)-dihydro-1H-5-pyrrolyl...)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C21H25N5O6/c22-17(27)7-5-15(25-19(29)14-6-8-18(28)24-14)20(30)26-16(21(31)32)9-11-10-23-13-4-2-1-3-12(11)13/h1-4,10,14-16,23H,5-9H2,(H2,22,27)(H,24,28)(H,25,29)(H,26,30)(H,31,32)/t14-,15-,16+/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002534
PNG
(Benzyloxycarbonyl-D-Trp-Phe-D-Trp-amine | CHEMBL30...)
Show SMILES NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C39H38N6O5/c40-36(46)33(20-27-22-41-31-17-9-7-15-29(27)31)43-37(47)34(19-25-11-3-1-4-12-25)44-38(48)35(21-28-23-42-32-18-10-8-16-30(28)32)45-39(49)50-24-26-13-5-2-6-14-26/h1-18,22-23,33-35,41-42H,19-21,24H2,(H2,40,46)(H,43,47)(H,44,48)(H,45,49)/t33-,34+,35-/m1/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002569
PNG
(Benzyloxycarbonyl-Phe-D-Trp-D-Trp-OH | CHEMBL62634)
Show SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C39H37N5O6/c45-36(33(19-25-11-3-1-4-12-25)44-39(49)50-24-26-13-5-2-6-14-26)42-34(20-27-22-40-31-17-9-7-15-29(27)31)37(46)43-35(38(47)48)21-28-23-41-32-18-10-8-16-30(28)32/h1-18,22-23,33-35,40-41H,19-21,24H2,(H,42,45)(H,43,46)(H,44,49)(H,47,48)/t33-,34+,35+/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002566
PNG
(CHEMBL293445 | benzyl 3-(1H-3-indolyl)-2-[2-(1H-3-...)
Show SMILES O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1
Show InChI InChI=1S/C46H43N5O6/c52-43(40(24-31-14-4-1-5-15-31)51-46(55)57-30-33-18-8-3-9-19-33)49-41(25-34-27-47-38-22-12-10-20-36(34)38)44(53)50-42(45(54)56-29-32-16-6-2-7-17-32)26-35-28-48-39-23-13-11-21-37(35)39/h1-23,27-28,40-42,47-48H,24-26,29-30H2,(H,49,52)(H,50,53)(H,51,55)/t40-,41+,42+/m0/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002542
PNG
(CHEMBL64806 | tert-butyloxycarbonyl-Gln-D-Trp-Phe-...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C30H37N5O7/c1-30(2,3)42-29(41)35-22(13-14-25(31)36)26(37)33-23(16-19-17-32-21-12-8-7-11-20(19)21)27(38)34-24(28(39)40)15-18-9-5-4-6-10-18/h4-12,17,22-24,32H,13-16H2,1-3H3,(H2,31,36)(H,33,37)(H,34,38)(H,35,41)(H,39,40)/t22-,23+,24-/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002537
PNG
(Benzyloxycarbonyl-D-Pro-Gln-Gln-amine | CHEMBL2916...)
Show SMILES NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1S/C29H35N7O7/c30-24(37)12-10-21(27(40)35-23(26(32)39)14-18-15-33-20-9-5-4-8-19(18)20)34-28(41)22(11-13-25(31)38)36-29(42)43-16-17-6-2-1-3-7-17/h1-9,15,21-23,33H,10-14,16H2,(H2,30,37)(H2,31,38)(H2,32,39)(H,34,41)(H,35,40)(H,36,42)/t21-,22-,23+/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002546
PNG
(4-carbamoyl-2-[3-carbamoyl-1-[(5R)-dihydro-1H-5-py...)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1)C(O)=O
Show InChI InChI=1S/C15H25N5O6/c16-11(21)5-3-9(19-13(23)8-2-1-7-18-8)14(24)20-10(15(25)26)4-6-12(17)22/h8-10,18H,1-7H2,(H2,16,21)(H2,17,22)(H,19,23)(H,20,24)(H,25,26)/t8-,9+,10+/m1/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50002541
PNG
(CHEMBL64829 | tert-butyl 5-[1-[1-benzyloxycarbonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C27H39N5O8/c1-27(2,3)40-26(38)32-15-7-10-20(32)24(36)30-18(11-13-21(28)33)23(35)31-19(12-14-22(29)34)25(37)39-16-17-8-5-4-6-9-17/h4-6,8-9,18-20H,7,10-16H2,1-3H3,(H2,28,33)(H2,29,34)(H,30,36)(H,31,35)/t18-,19-,20+/m0/s1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%