Affinity Data by PubMed id=1382133

PubMed code 1382133

Found 18 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glutamate-NMDA (RAT)	BDBM50001266 (5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...) Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM22778 (6,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione \| 6...) Show SMILES Clc1cc2[nH]c(=O)c(=O)[nH]c2cc1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002707 (7,8-Dichloro-5H-[1,2,4]triazolo[4,3-a]quinoxalin-4...) Show SMILES Clc1cc2[nH]c(=O)c3nncn3c2cc1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002696 (7,8-Dichloro-5H-imidazo[1,2-a]quinoxalin-4-one \| C...) Show SMILES Clc1cc2[nH]c(=O)c3nccn3c2cc1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002700 (1-Butyl-7,8-dichloro-5H-[1,2,4]triazolo[4,3-a]quin...) Show SMILES CCCCc1nnc2n1c1cc(Cl)c(Cl)cc1[nH]c2=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.48E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002710 (7,9-Dichloro-5H-[1,2,4]triazolo[4,3-a]quinoxalin-4...) Show SMILES Clc1cc(Cl)c2c(c1)[nH]c(=O)c1nncn21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.85E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002701 (7,8-Dichloro-1-propyl-5H-[1,2,4]triazolo[4,3-a]qui...) Show SMILES CCCc1nnc2n1c1cc(Cl)c(Cl)cc1[nH]c2=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.92E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002711 (7,8-Dichloro-1-ethyl-5H-[1,2,4]triazolo[4,3-a]quin...) Show SMILES CCc1nnc2n1c1cc(Cl)c(Cl)cc1[nH]c2=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.58E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002704 (7-Nitro-5H-[1,2,4]triazolo[4,3-a]quinoxalin-4-one ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7.35E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002695 (7,8-Dichloro-5H-1,2,3,5,9b-pentaaza-cyclopenta[a]n...) Show SMILES Clc1cc2[nH]c(=O)c3nnnn3c2cc1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002706 (7,8-Dichloro-1-phenyl-5H-[1,2,4]triazolo[4,3-a]qui...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002703 (7,8-Dichloro-1-methyl-5H-[1,2,4]triazolo[4,3-a]qui...) Show SMILES Cc1nnc2n1c1cc(Cl)c(Cl)cc1[nH]c2=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002709 (8,9-Dichloro-6H-pyrazolo[1,5-c]quinazolin-5-one \| ...) Show SMILES Clc1cc2[nH]c(=O)n3nccc3c2cc1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002705 (8-Chloro-6H-pyrazolo[1,5-c]quinazolin-5-one \| CHEM...) Show SMILES Clc1ccc2c3ccnn3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002708 (7-Nitro-5H-1,2,3,5,9b-pentaaza-cyclopenta[a]naphth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002702 (7,8-Dichloro-1-trifluoromethyl-5H-[1,2,4]triazolo[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002712 (8-Nitro-5H-1,2,3,5,9b-pentaaza-cyclopenta[a]naphth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-NMDA (RAT)	BDBM50002699 (7,8-Difluoro-5H-[1,2,4]triazolo[4,3-a]quinoxalin-4...) Show SMILES Fc1cc2[nH]c(=O)c3nncn3c2cc1F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]glycine from glycine site on the NMDA receptor.				J Med Chem 35: 3319-24 (1992) Article DOI: 10.1021/jm00096a002 BindingDB Entry DOI: 10.7270/Q2WM1F13
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%