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PubMed code 1388207

Compile data set for download or QSAR
Found 69 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002759
PNG
(5-(2-Benzenesulfonylamino-ethylsulfanyl)-5,11-dihy...)
Show SMILES OC(=O)c1ccc2SCc3ccccc3C(SCCNS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C23H21NO4S3/c25-23(26)16-10-11-21-20(14-16)22(19-9-5-4-6-17(19)15-30-21)29-13-12-24-31(27,28)18-7-2-1-3-8-18/h1-11,14,22,24H,12-13,15H2,(H,25,26)
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3.70n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002759
PNG
(5-(2-Benzenesulfonylamino-ethylsulfanyl)-5,11-dihy...)
Show SMILES OC(=O)c1ccc2SCc3ccccc3C(SCCNS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C23H21NO4S3/c25-23(26)16-10-11-21-20(14-16)22(19-9-5-4-6-17(19)15-30-21)29-13-12-24-31(27,28)18-7-2-1-3-8-18/h1-11,14,22,24H,12-13,15H2,(H,25,26)
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3.70n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002772
PNG
(11-[2-(2-Hydroxy-benzoylamino)-ethylsulfanyl]-6,11...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNC(=O)c3ccccc3O)c2c1
Show InChI InChI=1S/C24H21NO5S/c26-20-8-4-3-7-18(20)23(27)25-11-12-31-22-17-6-2-1-5-16(17)14-30-21-10-9-15(24(28)29)13-19(21)22/h1-10,13,22,26H,11-12,14H2,(H,25,27)(H,28,29)
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5.10n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002772
PNG
(11-[2-(2-Hydroxy-benzoylamino)-ethylsulfanyl]-6,11...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNC(=O)c3ccccc3O)c2c1
Show InChI InChI=1S/C24H21NO5S/c26-20-8-4-3-7-18(20)23(27)25-11-12-31-22-17-6-2-1-5-16(17)14-30-21-10-9-15(24(28)29)13-19(21)22/h1-10,13,22,26H,11-12,14H2,(H,25,27)(H,28,29)
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5.10n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002757
PNG
(11-[2-(Thiophene-2-sulfonylamino)-ethylsulfanyl]-6...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3cccs3)c2c1
Show InChI InChI=1S/C21H19NO5S3/c23-21(24)14-7-8-18-17(12-14)20(16-5-2-1-4-15(16)13-27-18)29-11-9-22-30(25,26)19-6-3-10-28-19/h1-8,10,12,20,22H,9,11,13H2,(H,23,24)
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5.70n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002757
PNG
(11-[2-(Thiophene-2-sulfonylamino)-ethylsulfanyl]-6...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3cccs3)c2c1
Show InChI InChI=1S/C21H19NO5S3/c23-21(24)14-7-8-18-17(12-14)20(16-5-2-1-4-15(16)13-27-18)29-11-9-22-30(25,26)19-6-3-10-28-19/h1-8,10,12,20,22H,9,11,13H2,(H,23,24)
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5.70n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002770
PNG
(11-[2-(3-Benzyl-thioureido)-ethylsulfanyl]-6,11-di...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNC(=S)NCc3ccccc3)c2c1
Show InChI InChI=1S/C25H24N2O3S2/c28-24(29)18-10-11-22-21(14-18)23(20-9-5-4-8-19(20)16-30-22)32-13-12-26-25(31)27-15-17-6-2-1-3-7-17/h1-11,14,23H,12-13,15-16H2,(H,28,29)(H2,26,27,31)
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6.10n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002770
PNG
(11-[2-(3-Benzyl-thioureido)-ethylsulfanyl]-6,11-di...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNC(=S)NCc3ccccc3)c2c1
Show InChI InChI=1S/C25H24N2O3S2/c28-24(29)18-10-11-22-21(14-18)23(20-9-5-4-8-19(20)16-30-22)32-13-12-26-25(31)27-15-17-6-2-1-3-7-17/h1-11,14,23H,12-13,15-16H2,(H,28,29)(H2,26,27,31)
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6.10n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002751
PNG
(11-[2-(2-Phenyl-ethenesulfonylamino)-ethylsulfanyl...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)\C=C\c3ccccc3)c2c1
Show InChI InChI=1S/C25H23NO5S2/c27-25(28)19-10-11-23-22(16-19)24(21-9-5-4-8-20(21)17-31-23)32-14-13-26-33(29,30)15-12-18-6-2-1-3-7-18/h1-12,15-16,24,26H,13-14,17H2,(H,27,28)/b15-12+
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6.5n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity at Thromboxane A2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets ...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002751
PNG
(11-[2-(2-Phenyl-ethenesulfonylamino)-ethylsulfanyl...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)\C=C\c3ccccc3)c2c1
Show InChI InChI=1S/C25H23NO5S2/c27-25(28)19-10-11-23-22(16-19)24(21-9-5-4-8-20(21)17-31-23)32-14-13-26-33(29,30)15-12-18-6-2-1-3-7-18/h1-12,15-16,24,26H,13-14,17H2,(H,27,28)/b15-12+
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6.5n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002758
PNG
(11-(2-Benzenesulfonylamino-ethylsulfanyl)-9-bromo-...)
Show SMILES OC(=O)c1ccc2OCc3ccc(Br)cc3C(SCCNS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C23H20BrNO5S2/c24-17-8-6-16-14-30-21-9-7-15(23(26)27)12-20(21)22(19(16)13-17)31-11-10-25-32(28,29)18-4-2-1-3-5-18/h1-9,12-13,22,25H,10-11,14H2,(H,26,27)
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6.80n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002758
PNG
(11-(2-Benzenesulfonylamino-ethylsulfanyl)-9-bromo-...)
Show SMILES OC(=O)c1ccc2OCc3ccc(Br)cc3C(SCCNS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C23H20BrNO5S2/c24-17-8-6-16-14-30-21-9-7-15(23(26)27)12-20(21)22(19(16)13-17)31-11-10-25-32(28,29)18-4-2-1-3-5-18/h1-9,12-13,22,25H,10-11,14H2,(H,26,27)
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6.80n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002777
PNG
(11-(2-Benzyloxycarbonylamino-ethylsulfanyl)-6,11-d...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNC(=O)OCc3ccccc3)c2c1
Show InChI InChI=1S/C25H23NO5S/c27-24(28)18-10-11-22-21(14-18)23(20-9-5-4-8-19(20)16-30-22)32-13-12-26-25(29)31-15-17-6-2-1-3-7-17/h1-11,14,23H,12-13,15-16H2,(H,26,29)(H,27,28)
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7.70n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002777
PNG
(11-(2-Benzyloxycarbonylamino-ethylsulfanyl)-6,11-d...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNC(=O)OCc3ccccc3)c2c1
Show InChI InChI=1S/C25H23NO5S/c27-24(28)18-10-11-22-21(14-18)23(20-9-5-4-8-19(20)16-30-22)32-13-12-26-25(29)31-15-17-6-2-1-3-7-17/h1-11,14,23H,12-13,15-16H2,(H,26,29)(H,27,28)
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7.70n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002760
PNG
(11-{2-[(3-Methyl-thiophene-2-carbonyl)-amino]-ethy...)
Show SMILES Cc1ccsc1C(=O)NCCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C23H21NO4S2/c1-14-8-10-29-20(14)22(25)24-9-11-30-21-17-5-3-2-4-16(17)13-28-19-7-6-15(23(26)27)12-18(19)21/h2-8,10,12,21H,9,11,13H2,1H3,(H,24,25)(H,26,27)
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10n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002760
PNG
(11-{2-[(3-Methyl-thiophene-2-carbonyl)-amino]-ethy...)
Show SMILES Cc1ccsc1C(=O)NCCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C23H21NO4S2/c1-14-8-10-29-20(14)22(25)24-9-11-30-21-17-5-3-2-4-16(17)13-28-19-7-6-15(23(26)27)12-18(19)21/h2-8,10,12,21H,9,11,13H2,1H3,(H,24,25)(H,26,27)
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10n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002763
PNG
(11-[2-(2-Methoxy-benzoylamino)-ethylsulfanyl]-6,11...)
Show SMILES COc1ccccc1C(=O)NCCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C25H23NO5S/c1-30-21-9-5-4-8-19(21)24(27)26-12-13-32-23-18-7-3-2-6-17(18)15-31-22-11-10-16(25(28)29)14-20(22)23/h2-11,14,23H,12-13,15H2,1H3,(H,26,27)(H,28,29)
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11n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002763
PNG
(11-[2-(2-Methoxy-benzoylamino)-ethylsulfanyl]-6,11...)
Show SMILES COc1ccccc1C(=O)NCCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C25H23NO5S/c1-30-21-9-5-4-8-19(21)24(27)26-12-13-32-23-18-7-3-2-6-17(18)15-31-22-11-10-16(25(28)29)14-20(22)23/h2-11,14,23H,12-13,15H2,1H3,(H,26,27)(H,28,29)
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11n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002764
PNG
(11-[2-(3-Nitro-benzenesulfonylamino)-ethylsulfanyl...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3cccc(c3)[N+]([O-])=O)c2c1
Show InChI InChI=1S/C23H20N2O7S2/c26-23(27)15-8-9-21-20(12-15)22(19-7-2-1-4-16(19)14-32-21)33-11-10-24-34(30,31)18-6-3-5-17(13-18)25(28)29/h1-9,12-13,22,24H,10-11,14H2,(H,26,27)
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14n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002752
PNG
(11-[2-(Naphthalene-2-sulfonylamino)-ethylsulfanyl]...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3ccc4ccccc4c3)c2c1
Show InChI InChI=1S/C27H23NO5S2/c29-27(30)20-10-12-25-24(16-20)26(23-8-4-3-7-21(23)17-33-25)34-14-13-28-35(31,32)22-11-9-18-5-1-2-6-19(18)15-22/h1-12,15-16,26,28H,13-14,17H2,(H,29,30)
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14n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002752
PNG
(11-[2-(Naphthalene-2-sulfonylamino)-ethylsulfanyl]...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3ccc4ccccc4c3)c2c1
Show InChI InChI=1S/C27H23NO5S2/c29-27(30)20-10-12-25-24(16-20)26(23-8-4-3-7-21(23)17-33-25)34-14-13-28-35(31,32)22-11-9-18-5-1-2-6-19(18)15-22/h1-12,15-16,26,28H,13-14,17H2,(H,29,30)
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14n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002764
PNG
(11-[2-(3-Nitro-benzenesulfonylamino)-ethylsulfanyl...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3cccc(c3)[N+]([O-])=O)c2c1
Show InChI InChI=1S/C23H20N2O7S2/c26-23(27)15-8-9-21-20(12-15)22(19-7-2-1-4-16(19)14-32-21)33-11-10-24-34(30,31)18-6-3-5-17(13-18)25(28)29/h1-9,12-13,22,24H,10-11,14H2,(H,26,27)
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14n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002776
PNG
(11-[2-(2-Nitro-benzenesulfonylamino)-ethylsulfanyl...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3ccccc3[N+]([O-])=O)c2c1
Show InChI InChI=1S/C23H20N2O7S2/c26-23(27)15-9-10-20-18(13-15)22(17-6-2-1-5-16(17)14-32-20)33-12-11-24-34(30,31)21-8-4-3-7-19(21)25(28)29/h1-10,13,22,24H,11-12,14H2,(H,26,27)
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15n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002776
PNG
(11-[2-(2-Nitro-benzenesulfonylamino)-ethylsulfanyl...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3ccccc3[N+]([O-])=O)c2c1
Show InChI InChI=1S/C23H20N2O7S2/c26-23(27)15-9-10-20-18(13-15)22(17-6-2-1-5-16(17)14-32-20)33-12-11-24-34(30,31)21-8-4-3-7-19(21)25(28)29/h1-10,13,22,24H,11-12,14H2,(H,26,27)
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15n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002769
PNG
(11-[2-(4-Methoxy-benzenesulfonylamino)-ethylsulfan...)
Show SMILES COc1ccc(cc1)S(=O)(=O)NCCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C24H23NO6S2/c1-30-18-7-9-19(10-8-18)33(28,29)25-12-13-32-23-20-5-3-2-4-17(20)15-31-22-11-6-16(24(26)27)14-21(22)23/h2-11,14,23,25H,12-13,15H2,1H3,(H,26,27)
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17n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002769
PNG
(11-[2-(4-Methoxy-benzenesulfonylamino)-ethylsulfan...)
Show SMILES COc1ccc(cc1)S(=O)(=O)NCCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C24H23NO6S2/c1-30-18-7-9-19(10-8-18)33(28,29)25-12-13-32-23-20-5-3-2-4-17(20)15-31-22-11-6-16(24(26)27)14-21(22)23/h2-11,14,23,25H,12-13,15H2,1H3,(H,26,27)
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17n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002774
PNG
(11-[2-(2,3,4-Trimethoxy-benzoylamino)-ethylsulfany...)
Show SMILES COc1ccc(C(=O)NCCSC2c3ccccc3COc3ccc(cc23)C(O)=O)c(OC)c1OC
Show InChI InChI=1S/C27H27NO7S/c1-32-22-11-9-19(23(33-2)24(22)34-3)26(29)28-12-13-36-25-18-7-5-4-6-17(18)15-35-21-10-8-16(27(30)31)14-20(21)25/h4-11,14,25H,12-13,15H2,1-3H3,(H,28,29)(H,30,31)
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18n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002774
PNG
(11-[2-(2,3,4-Trimethoxy-benzoylamino)-ethylsulfany...)
Show SMILES COc1ccc(C(=O)NCCSC2c3ccccc3COc3ccc(cc23)C(O)=O)c(OC)c1OC
Show InChI InChI=1S/C27H27NO7S/c1-32-22-11-9-19(23(33-2)24(22)34-3)26(29)28-12-13-36-25-18-7-5-4-6-17(18)15-35-21-10-8-16(27(30)31)14-20(21)25/h4-11,14,25H,12-13,15H2,1-3H3,(H,28,29)(H,30,31)
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18n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002771
PNG
(11-[2-(4-Trifluoromethyl-benzenesulfonylamino)-eth...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3ccc(cc3)C(F)(F)F)c2c1
Show InChI InChI=1S/C24H20F3NO5S2/c25-24(26,27)17-6-8-18(9-7-17)35(31,32)28-11-12-34-22-19-4-2-1-3-16(19)14-33-21-10-5-15(23(29)30)13-20(21)22/h1-10,13,22,28H,11-12,14H2,(H,29,30)
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20n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002771
PNG
(11-[2-(4-Trifluoromethyl-benzenesulfonylamino)-eth...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3ccc(cc3)C(F)(F)F)c2c1
Show InChI InChI=1S/C24H20F3NO5S2/c25-24(26,27)17-6-8-18(9-7-17)35(31,32)28-11-12-34-22-19-4-2-1-3-16(19)14-33-21-10-5-15(23(29)30)13-20(21)22/h1-10,13,22,28H,11-12,14H2,(H,29,30)
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20n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002756
PNG
(5-(2-Benzenesulfonylamino-ethylsulfanyl)-5H-dibenz...)
Show SMILES OC(=O)c1ccc2C=Cc3ccccc3C(SCCNS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C24H21NO4S2/c26-24(27)19-13-12-18-11-10-17-6-4-5-9-21(17)23(22(18)16-19)30-15-14-25-31(28,29)20-7-2-1-3-8-20/h1-13,16,23,25H,14-15H2,(H,26,27)
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25n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002756
PNG
(5-(2-Benzenesulfonylamino-ethylsulfanyl)-5H-dibenz...)
Show SMILES OC(=O)c1ccc2C=Cc3ccccc3C(SCCNS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C24H21NO4S2/c26-24(27)19-13-12-18-11-10-17-6-4-5-9-21(17)23(22(18)16-19)30-15-14-25-31(28,29)20-7-2-1-3-8-20/h1-13,16,23,25H,14-15H2,(H,26,27)
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25n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002773
PNG
(11-[2-(Toluene-4-sulfonylamino)-ethylsulfanyl]-6,1...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NCCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C24H23NO5S2/c1-16-6-9-19(10-7-16)32(28,29)25-12-13-31-23-20-5-3-2-4-18(20)15-30-22-11-8-17(24(26)27)14-21(22)23/h2-11,14,23,25H,12-13,15H2,1H3,(H,26,27)
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27n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002773
PNG
(11-[2-(Toluene-4-sulfonylamino)-ethylsulfanyl]-6,1...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NCCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C24H23NO5S2/c1-16-6-9-19(10-7-16)32(28,29)25-12-13-31-23-20-5-3-2-4-18(20)15-30-22-11-8-17(24(26)27)14-21(22)23/h2-11,14,23,25H,12-13,15H2,1H3,(H,26,27)
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27n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002775
PNG
(5-(2-Benzenesulfonylamino-ethylsulfanyl)-10,11-dih...)
Show SMILES OC(=O)c1ccc2CCc3ccccc3C(SCCNS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C24H23NO4S2/c26-24(27)19-13-12-18-11-10-17-6-4-5-9-21(17)23(22(18)16-19)30-15-14-25-31(28,29)20-7-2-1-3-8-20/h1-9,12-13,16,23,25H,10-11,14-15H2,(H,26,27)
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30n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002775
PNG
(5-(2-Benzenesulfonylamino-ethylsulfanyl)-10,11-dih...)
Show SMILES OC(=O)c1ccc2CCc3ccccc3C(SCCNS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C24H23NO4S2/c26-24(27)19-13-12-18-11-10-17-6-4-5-9-21(17)23(22(18)16-19)30-15-14-25-31(28,29)20-7-2-1-3-8-20/h1-9,12-13,16,23,25H,10-11,14-15H2,(H,26,27)
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30n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002750
PNG
(11-(2-Benzenesulfonylamino-ethylsulfanyl)-6,11-dih...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C23H21NO5S2/c25-23(26)16-10-11-21-20(14-16)22(19-9-5-4-6-17(19)15-29-21)30-13-12-24-31(27,28)18-7-2-1-3-8-18/h1-11,14,22,24H,12-13,15H2,(H,25,26)
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32n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002750
PNG
(11-(2-Benzenesulfonylamino-ethylsulfanyl)-6,11-dih...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C23H21NO5S2/c25-23(26)16-10-11-21-20(14-16)22(19-9-5-4-6-17(19)15-29-21)30-13-12-24-31(27,28)18-7-2-1-3-8-18/h1-11,14,22,24H,12-13,15H2,(H,25,26)
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32n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002755
PNG
(11-[2-(Benzenesulfonyl-methyl-amino)-ethylsulfanyl...)
Show SMILES CN(CCSC1c2ccccc2COc2ccc(cc12)C(O)=O)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H23NO5S2/c1-25(32(28,29)19-8-3-2-4-9-19)13-14-31-23-20-10-6-5-7-18(20)16-30-22-12-11-17(24(26)27)15-21(22)23/h2-12,15,23H,13-14,16H2,1H3,(H,26,27)
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33n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002755
PNG
(11-[2-(Benzenesulfonyl-methyl-amino)-ethylsulfanyl...)
Show SMILES CN(CCSC1c2ccccc2COc2ccc(cc12)C(O)=O)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H23NO5S2/c1-25(32(28,29)19-8-3-2-4-9-19)13-14-31-23-20-10-6-5-7-18(20)16-30-22-12-11-17(24(26)27)15-21(22)23/h2-12,15,23H,13-14,16H2,1H3,(H,26,27)
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33n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002766
PNG
(11-(2-Benzoylamino-ethylsulfanyl)-6,11-dihydro-dib...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNC(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C24H21NO4S/c26-23(16-6-2-1-3-7-16)25-12-13-30-22-19-9-5-4-8-18(19)15-29-21-11-10-17(24(27)28)14-20(21)22/h1-11,14,22H,12-13,15H2,(H,25,26)(H,27,28)
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44n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002766
PNG
(11-(2-Benzoylamino-ethylsulfanyl)-6,11-dihydro-dib...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNC(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C24H21NO4S/c26-23(16-6-2-1-3-7-16)25-12-13-30-22-19-9-5-4-8-18(19)15-29-21-11-10-17(24(27)28)14-20(21)22/h1-11,14,22H,12-13,15H2,(H,25,26)(H,27,28)
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44n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002754
PNG
(11-[2-(Pyridine-3-sulfonylamino)-ethylsulfanyl]-6,...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3cccnc3)c2c1
Show InChI InChI=1S/C22H20N2O5S2/c25-22(26)15-7-8-20-19(12-15)21(18-6-2-1-4-16(18)14-29-20)30-11-10-24-31(27,28)17-5-3-9-23-13-17/h1-9,12-13,21,24H,10-11,14H2,(H,25,26)
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47n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002754
PNG
(11-[2-(Pyridine-3-sulfonylamino)-ethylsulfanyl]-6,...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3cccnc3)c2c1
Show InChI InChI=1S/C22H20N2O5S2/c25-22(26)15-7-8-20-19(12-15)21(18-6-2-1-4-16(18)14-29-20)30-11-10-24-31(27,28)17-5-3-9-23-13-17/h1-9,12-13,21,24H,10-11,14H2,(H,25,26)
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47n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002761
PNG
(3-[(2-Benzenesulfonylamino-ethylsulfanyl)-phenyl-m...)
Show SMILES OC(=O)c1cccc(c1)C(SCCNS(=O)(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H21NO4S2/c24-22(25)19-11-7-10-18(16-19)21(17-8-3-1-4-9-17)28-15-14-23-29(26,27)20-12-5-2-6-13-20/h1-13,16,21,23H,14-15H2,(H,24,25)
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77n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002761
PNG
(3-[(2-Benzenesulfonylamino-ethylsulfanyl)-phenyl-m...)
Show SMILES OC(=O)c1cccc(c1)C(SCCNS(=O)(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H21NO4S2/c24-22(25)19-11-7-10-18(16-19)21(17-8-3-1-4-9-17)28-15-14-23-29(26,27)20-12-5-2-6-13-20/h1-13,16,21,23H,14-15H2,(H,24,25)
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77n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002768
PNG
(11-[2-(3,4,5-Trimethoxy-benzoylamino)-ethylsulfany...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)NCCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C27H27NO7S/c1-32-22-13-18(14-23(33-2)24(22)34-3)26(29)28-10-11-36-25-19-7-5-4-6-17(19)15-35-21-9-8-16(27(30)31)12-20(21)25/h4-9,12-14,25H,10-11,15H2,1-3H3,(H,28,29)(H,30,31)
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92n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity at TXA2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002768
PNG
(11-[2-(3,4,5-Trimethoxy-benzoylamino)-ethylsulfany...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)NCCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C27H27NO7S/c1-32-22-13-18(14-23(33-2)24(22)34-3)26(29)28-10-11-36-25-19-7-5-4-6-17(19)15-35-21-9-8-16(27(30)31)12-20(21)25/h4-9,12-14,25H,10-11,15H2,1-3H3,(H,28,29)(H,30,31)
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92n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002751
PNG
(11-[2-(2-Phenyl-ethenesulfonylamino)-ethylsulfanyl...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)\C=C\c3ccccc3)c2c1
Show InChI InChI=1S/C25H23NO5S2/c27-25(28)19-10-11-23-22(16-19)24(21-9-5-4-8-20(21)17-31-23)32-14-13-26-33(29,30)15-12-18-6-2-1-3-7-18/h1-12,15-16,24,26H,13-14,17H2,(H,27,28)/b15-12+
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250n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity at Thromboxane A2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002751
PNG
(11-[2-(2-Phenyl-ethenesulfonylamino)-ethylsulfanyl...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)\C=C\c3ccccc3)c2c1
Show InChI InChI=1S/C25H23NO5S2/c27-25(28)19-10-11-23-22(16-19)24(21-9-5-4-8-20(21)17-31-23)32-14-13-26-33(29,30)15-12-18-6-2-1-3-7-18/h1-12,15-16,24,26H,13-14,17H2,(H,27,28)/b15-12+
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250n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity at Thromboxane A2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002765
PNG
(BM 13177 | BM-13177 | CHEMBL8273 | Sulotroban | [4...)
Show SMILES OC(=O)COc1ccc(CCNS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C16H17NO5S/c18-16(19)12-22-14-8-6-13(7-9-14)10-11-17-23(20,21)15-4-2-1-3-5-15/h1-9,17H,10-12H2,(H,18,19)
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1.30E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity at Thromboxane A2 receptor by measuring its ability to displace [3H]-U-46,619 from guinea pig platelets ...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002765
PNG
(BM 13177 | BM-13177 | CHEMBL8273 | Sulotroban | [4...)
Show SMILES OC(=O)COc1ccc(CCNS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C16H17NO5S/c18-16(19)12-22-14-8-6-13(7-9-14)10-11-17-23(20,21)15-4-2-1-3-5-15/h1-9,17H,10-12H2,(H,18,19)
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1.30E+3n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the thromboxane A2 receptor assayed by binding to guinea pig platelets using [3H]-U-46,619 as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2)


(Homo sapiens (human))
BDBM50002762
PNG
(11-(2-Benzenesulfonylamino-ethylsulfanyl)-6,11-dih...)
Show SMILES OC(=O)c1ccc2C(SCCNS(=O)(=O)c3ccccc3)c3ccccc3COc2c1
Show InChI InChI=1S/C23H21NO5S2/c25-23(26)16-10-11-20-21(14-16)29-15-17-6-4-5-9-19(17)22(20)30-13-12-24-31(27,28)18-7-2-1-3-8-18/h1-11,14,22,24H,12-13,15H2,(H,25,26)
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n/an/a 370n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomes


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane-A synthase


(Rattus norvegicus)
BDBM50002762
PNG
(11-(2-Benzenesulfonylamino-ethylsulfanyl)-6,11-dih...)
Show SMILES OC(=O)c1ccc2C(SCCNS(=O)(=O)c3ccccc3)c3ccccc3COc2c1
Show InChI InChI=1S/C23H21NO5S2/c25-23(26)16-10-11-20-21(14-16)29-15-17-6-4-5-9-19(17)22(20)30-13-12-24-31(27,28)18-7-2-1-3-8-18/h1-11,14,22,24H,12-13,15H2,(H,25,26)
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n/an/a 370n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine platelets


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane-A synthase


(Rattus norvegicus)
BDBM50002767
PNG
(11-[2-(3-Phenyl-ureido)-ethylsulfanyl]-6,11-dihydr...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNC(=O)Nc3ccccc3)c2c1
Show InChI InChI=1S/C24H22N2O4S/c27-23(28)16-10-11-21-20(14-16)22(19-9-5-4-6-17(19)15-30-21)31-13-12-25-24(29)26-18-7-2-1-3-8-18/h1-11,14,22H,12-13,15H2,(H,27,28)(H2,25,26,29)
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n/an/a 830n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine platelets


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2)


(Homo sapiens (human))
BDBM50002767
PNG
(11-[2-(3-Phenyl-ureido)-ethylsulfanyl]-6,11-dihydr...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNC(=O)Nc3ccccc3)c2c1
Show InChI InChI=1S/C24H22N2O4S/c27-23(28)16-10-11-21-20(14-16)22(19-9-5-4-6-17(19)15-30-21)31-13-12-25-24(29)26-18-7-2-1-3-8-18/h1-11,14,22H,12-13,15H2,(H,27,28)(H2,25,26,29)
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n/an/a 830n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomes


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane-A synthase


(Rattus norvegicus)
BDBM50002753
PNG
(11-[2-(2,6-Dimethoxy-benzoylamino)-ethylsulfanyl]-...)
Show SMILES COc1cccc(OC)c1C(=O)NCCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C26H25NO6S/c1-31-21-8-5-9-22(32-2)23(21)25(28)27-12-13-34-24-18-7-4-3-6-17(18)15-33-20-11-10-16(26(29)30)14-19(20)24/h3-11,14,24H,12-13,15H2,1-2H3,(H,27,28)(H,29,30)
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n/an/a 850n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine platelets


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2)


(Homo sapiens (human))
BDBM50002753
PNG
(11-[2-(2,6-Dimethoxy-benzoylamino)-ethylsulfanyl]-...)
Show SMILES COc1cccc(OC)c1C(=O)NCCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C26H25NO6S/c1-31-21-8-5-9-22(32-2)23(21)25(28)27-12-13-34-24-18-7-4-3-6-17(18)15-33-20-11-10-16(26(29)30)14-19(20)24/h3-11,14,24H,12-13,15H2,1-2H3,(H,27,28)(H,29,30)
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n/an/a 850n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomes


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane-A synthase


(Rattus norvegicus)
BDBM50002754
PNG
(11-[2-(Pyridine-3-sulfonylamino)-ethylsulfanyl]-6,...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3cccnc3)c2c1
Show InChI InChI=1S/C22H20N2O5S2/c25-22(26)15-7-8-20-19(12-15)21(18-6-2-1-4-16(18)14-29-20)30-11-10-24-31(27,28)17-5-3-9-23-13-17/h1-9,12-13,21,24H,10-11,14H2,(H,25,26)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine platelets


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2)


(Homo sapiens (human))
BDBM50002754
PNG
(11-[2-(Pyridine-3-sulfonylamino)-ethylsulfanyl]-6,...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3cccnc3)c2c1
Show InChI InChI=1S/C22H20N2O5S2/c25-22(26)15-7-8-20-19(12-15)21(18-6-2-1-4-16(18)14-29-20)30-11-10-24-31(27,28)17-5-3-9-23-13-17/h1-9,12-13,21,24H,10-11,14H2,(H,25,26)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomes


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane-A synthase


(Rattus norvegicus)
BDBM50002755
PNG
(11-[2-(Benzenesulfonyl-methyl-amino)-ethylsulfanyl...)
Show SMILES CN(CCSC1c2ccccc2COc2ccc(cc12)C(O)=O)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H23NO5S2/c1-25(32(28,29)19-8-3-2-4-9-19)13-14-31-23-20-10-6-5-7-18(20)16-30-22-12-11-17(24(26)27)15-21(22)23/h2-12,15,23H,13-14,16H2,1H3,(H,26,27)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine platelets


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2)


(Homo sapiens (human))
BDBM50002755
PNG
(11-[2-(Benzenesulfonyl-methyl-amino)-ethylsulfanyl...)
Show SMILES CN(CCSC1c2ccccc2COc2ccc(cc12)C(O)=O)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H23NO5S2/c1-25(32(28,29)19-8-3-2-4-9-19)13-14-31-23-20-10-6-5-7-18(20)16-30-22-12-11-17(24(26)27)15-21(22)23/h2-12,15,23H,13-14,16H2,1H3,(H,26,27)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomes


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane-A synthase


(Rattus norvegicus)
BDBM50002750
PNG
(11-(2-Benzenesulfonylamino-ethylsulfanyl)-6,11-dih...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C23H21NO5S2/c25-23(26)16-10-11-21-20(14-16)22(19-9-5-4-6-17(19)15-29-21)30-13-12-24-31(27,28)18-7-2-1-3-8-18/h1-11,14,22,24H,12-13,15H2,(H,25,26)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine platelets


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane-A synthase


(Rattus norvegicus)
BDBM50002751
PNG
(11-[2-(2-Phenyl-ethenesulfonylamino)-ethylsulfanyl...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)\C=C\c3ccccc3)c2c1
Show InChI InChI=1S/C25H23NO5S2/c27-25(28)19-10-11-23-22(16-19)24(21-9-5-4-8-20(21)17-31-23)32-14-13-26-33(29,30)15-12-18-6-2-1-3-7-18/h1-12,15-16,24,26H,13-14,17H2,(H,27,28)/b15-12+
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n/an/a 3.70E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine platelets


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane-A synthase


(Rattus norvegicus)
BDBM50002751
PNG
(11-[2-(2-Phenyl-ethenesulfonylamino)-ethylsulfanyl...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)\C=C\c3ccccc3)c2c1
Show InChI InChI=1S/C25H23NO5S2/c27-25(28)19-10-11-23-22(16-19)24(21-9-5-4-8-20(21)17-31-23)32-14-13-26-33(29,30)15-12-18-6-2-1-3-7-18/h1-12,15-16,24,26H,13-14,17H2,(H,27,28)/b15-12+
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n/an/a 3.70E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against Thromboxane A2 synthase obtained from bovine platelet microsomes


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane-A synthase


(Rattus norvegicus)
BDBM50002751
PNG
(11-[2-(2-Phenyl-ethenesulfonylamino)-ethylsulfanyl...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)\C=C\c3ccccc3)c2c1
Show InChI InChI=1S/C25H23NO5S2/c27-25(28)19-10-11-23-22(16-19)24(21-9-5-4-8-20(21)17-31-23)32-14-13-26-33(29,30)15-12-18-6-2-1-3-7-18/h1-12,15-16,24,26H,13-14,17H2,(H,27,28)/b15-12+
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n/an/a 3.70E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine platelets


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane-A synthase


(Rattus norvegicus)
BDBM50002765
PNG
(BM 13177 | BM-13177 | CHEMBL8273 | Sulotroban | [4...)
Show SMILES OC(=O)COc1ccc(CCNS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C16H17NO5S/c18-16(19)12-22-14-8-6-13(7-9-14)10-11-17-23(20,21)15-4-2-1-3-5-15/h1-9,17H,10-12H2,(H,18,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against Thromboxane A2 synthase obtained from bovine platelet microsomes


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane-A synthase


(Rattus norvegicus)
BDBM50002765
PNG
(BM 13177 | BM-13177 | CHEMBL8273 | Sulotroban | [4...)
Show SMILES OC(=O)COc1ccc(CCNS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C16H17NO5S/c18-16(19)12-22-14-8-6-13(7-9-14)10-11-17-23(20,21)15-4-2-1-3-5-15/h1-9,17H,10-12H2,(H,18,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine platelets


Citation and Details
More data for this
Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2)


(Homo sapiens (human))
BDBM50002750
PNG
(11-(2-Benzenesulfonylamino-ethylsulfanyl)-6,11-dih...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCNS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C23H21NO5S2/c25-23(26)16-10-11-21-20(14-16)22(19-9-5-4-6-17(19)15-29-21)30-13-12-24-31(27,28)18-7-2-1-3-8-18/h1-11,14,22,24H,12-13,15H2,(H,25,26)
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n/an/a 2.40E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomes


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%