Affinity Data by PubMed id=1433172

PubMed code 1433172

Found 18 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM30707 (2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamin...) Show SMILES COc1ccc2[nH]cc(CCN(C)C)c2c1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C) (Homo sapiens (human))	BDBM50003039 (2-(3,7,8,9-Tetrahydro-pyrano[3,2-e]indol-1-yl)-eth...) Show SMILES NCCc1c[nH]c2ccc3OCCCc3c12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1C receptor in pig choroid plexus using [3H]-mesulergine as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (human))	BDBM30707 (2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamin...) Show SMILES COc1ccc2[nH]cc(CCN(C)C)c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C) (Homo sapiens (human))	BDBM50003037 (2-(3-Methyl-3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...) Show SMILES Cn1cc(CCN)c2c3CCCOc3ccc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1C receptor in pig choroid plexus using [3H]-mesulergine as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C) (Homo sapiens (human))	BDBM50003038 (CHEMBL26427 \| Dimethyl-[2-(3-methyl-3,7,8,9-tetrah...) Show SMILES CN(C)CCc1cn(C)c2ccc3OCCCc3c12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1C receptor in pig choroid plexus using [3H]-mesulergine as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (human))	BDBM50003039 (2-(3,7,8,9-Tetrahydro-pyrano[3,2-e]indol-1-yl)-eth...) Show SMILES NCCc1c[nH]c2ccc3OCCCc3c12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C) (Homo sapiens (human))	BDBM50003036 (CHEMBL412876 \| Dimethyl-[2-(3,7,8,9-tetrahydro-pyr...) Show SMILES CN(C)CCc1c[nH]c2ccc3OCCCc3c12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1C receptor in pig choroid plexus using [3H]-mesulergine as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (human))	BDBM50003036 (CHEMBL412876 \| Dimethyl-[2-(3,7,8,9-tetrahydro-pyr...) Show SMILES CN(C)CCc1c[nH]c2ccc3OCCCc3c12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C) (Homo sapiens (human))	BDBM30707 (2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamin...) Show SMILES COc1ccc2[nH]cc(CCN(C)C)c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Binding affinity of the compound towards 5-hydroxytryptamine 1C receptor using [3H]-mesulergine as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM50003039 (2-(3,7,8,9-Tetrahydro-pyrano[3,2-e]indol-1-yl)-eth...) Show SMILES NCCc1c[nH]c2ccc3OCCCc3c12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (human))	BDBM50003040 (CHEMBL122860 \| Dimethyl-[2-(1,6,7,8-tetrahydro-pyr...) Show SMILES CN(C)CCc1c[nH]c2cc3CCCOc3cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM50003040 (CHEMBL122860 \| Dimethyl-[2-(1,6,7,8-tetrahydro-pyr...) Show SMILES CN(C)CCc1c[nH]c2cc3CCCOc3cc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM50003036 (CHEMBL412876 \| Dimethyl-[2-(3,7,8,9-tetrahydro-pyr...) Show SMILES CN(C)CCc1c[nH]c2ccc3OCCCc3c12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C) (Homo sapiens (human))	BDBM50003040 (CHEMBL122860 \| Dimethyl-[2-(1,6,7,8-tetrahydro-pyr...) Show SMILES CN(C)CCc1c[nH]c2cc3CCCOc3cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1C receptor in pig choroid plexus using [3H]-mesulergine as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (human))	BDBM50003037 (2-(3-Methyl-3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...) Show SMILES Cn1cc(CCN)c2c3CCCOc3ccc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM50003037 (2-(3-Methyl-3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...) Show SMILES Cn1cc(CCN)c2c3CCCOc3ccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM50003038 (CHEMBL26427 \| Dimethyl-[2-(3-methyl-3,7,8,9-tetrah...) Show SMILES CN(C)CCc1cn(C)c2ccc3OCCCc3c12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (human))	BDBM50003038 (CHEMBL26427 \| Dimethyl-[2-(3-methyl-3,7,8,9-tetrah...) Show SMILES CN(C)CCc1cn(C)c2ccc3OCCCc3c12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand				Citation and Details
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%