Found 7 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)
(Homo sapiens (Human)) | BDBM50003237
 (2,2-Dimethyl-butyric acid 2-(1-hydroxy-ethyl)-8-[2...)Show SMILES CCC(C)(C)C(=O)O[C@H]1[C@H]([C@H](C)O)[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)C12 Show InChI InChI=1S/C27H42O6/c1-7-27(5,6)26(31)33-25-23(17(4)28)16(3)12-18-9-8-15(2)21(24(18)25)11-10-20-13-19(29)14-22(30)32-20/h8-9,12,15-17,19-21,23-25,28-29H,7,10-11,13-14H2,1-6H3/t15-,16-,17?,19+,20?,21-,23-,24?,25-/m0/s1 | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description The compound was tested in vitro for inhibitory activity against HMG-CoA reductase |
J Med Chem 35: 3813-21 (1992)
Article DOI: 10.1021/jm00099a009 BindingDB Entry DOI: 10.7270/Q27M06VP |
More data for this Ligand-Target Pair | |
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)
(Homo sapiens (Human)) | BDBM50003236
 (2,2-Dimethyl-butyric acid 2-hydroxymethyl-8-[2-(4-...)Show SMILES CCC(C)(C)C(=O)O[C@H]1[C@H](CO)[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)C12 Show InChI InChI=1S/C26H40O6/c1-6-26(4,5)25(30)32-24-21(14-27)16(3)11-17-8-7-15(2)20(23(17)24)10-9-19-12-18(28)13-22(29)31-19/h7-8,11,15-16,18-21,23-24,27-28H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19?,20-,21+,23?,24-/m0/s1 | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description The compound was tested in vitro for inhibitory activity against HMG-CoA reductase |
J Med Chem 35: 3813-21 (1992)
Article DOI: 10.1021/jm00099a009 BindingDB Entry DOI: 10.7270/Q27M06VP |
More data for this Ligand-Target Pair | |
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)
(Homo sapiens (Human)) | BDBM50003240
 (2,2-Dimethyl-butyric acid 8-[2-(4-hydroxy-6-oxo-te...)Show SMILES CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)C12 Show InChI InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19?,20-,21-,23?/m0/s1 | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description The compound was tested in vitro for inhibitory activity against HMG-CoA reductase |
J Med Chem 35: 3813-21 (1992)
Article DOI: 10.1021/jm00099a009 BindingDB Entry DOI: 10.7270/Q27M06VP |
More data for this Ligand-Target Pair | |
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)
(Homo sapiens (Human)) | BDBM50003239
 (2,2-Dimethyl-butyric acid 2-hydroxy-8-[2-(4-hydrox...)Show SMILES CCC(C)(C)C(=O)O[C@H]1[C@@H](O)[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)C12 Show InChI InChI=1S/C25H38O6/c1-6-25(4,5)24(29)31-23-21-16(11-15(3)22(23)28)8-7-14(2)19(21)10-9-18-12-17(26)13-20(27)30-18/h7-8,11,14-15,17-19,21-23,26,28H,6,9-10,12-13H2,1-5H3/t14-,15-,17+,18?,19-,21?,22-,23+/m0/s1 | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description The compound was tested in vitro for inhibitory activity against HMG-CoA reductase |
J Med Chem 35: 3813-21 (1992)
Article DOI: 10.1021/jm00099a009 BindingDB Entry DOI: 10.7270/Q27M06VP |
More data for this Ligand-Target Pair | |
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)
(Homo sapiens (Human)) | BDBM50003235
 (2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrah...)Show SMILES CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)C12 Show InChI InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19?,20-,21-,23?/m0/s1 | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description The compound was tested in vitro for inhibitory activity against HMG-CoA reductase |
J Med Chem 35: 3813-21 (1992)
Article DOI: 10.1021/jm00099a009 BindingDB Entry DOI: 10.7270/Q27M06VP |
More data for this Ligand-Target Pair | |
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)
(Homo sapiens (Human)) | BDBM50003241
 (2,2-Dimethyl-butyric acid 8-[2-(4-hydroxy-6-oxo-te...)Show SMILES CCC(C)(C)C(=O)O[C@H]1[C@H]([C@@H](O)c2ccccc2)[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)C12 Show InChI InChI=1S/C32H44O6/c1-6-32(4,5)31(36)38-30-27(29(35)21-10-8-7-9-11-21)20(3)16-22-13-12-19(2)25(28(22)30)15-14-24-17-23(33)18-26(34)37-24/h7-13,16,19-20,23-25,27-30,33,35H,6,14-15,17-18H2,1-5H3/t19-,20-,23+,24?,25-,27-,28?,29?,30-/m0/s1 | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description The compound was tested in vitro for inhibitory activity against HMG-CoA reductase |
J Med Chem 35: 3813-21 (1992)
Article DOI: 10.1021/jm00099a009 BindingDB Entry DOI: 10.7270/Q27M06VP |
More data for this Ligand-Target Pair | |
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)
(Homo sapiens (Human)) | BDBM50011036
 ((S)-((1S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxo-...)Show SMILES CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 Show InChI InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1 | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description The compound was tested in vitro for inhibitory activity against HMG-CoA reductase |
J Med Chem 35: 3813-21 (1992)
Article DOI: 10.1021/jm00099a009 BindingDB Entry DOI: 10.7270/Q27M06VP |
More data for this Ligand-Target Pair | |