Affinity Data by PubMed id=1433207

PubMed code 1433207

Found 22 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM21393 (7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...) Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibitory activity against 5-HT1A receptor in rats, using [3H]-8-OH-DPAT as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50003342 (6-Bromo-9-methoxy-3-propyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES CCCN1CCc2c(Br)ccc(OC)c2CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor in rats, using [3H]-8-OH-DPAT as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50003348 (6-Methoxy-3-propyl-2,3,4,5-tetrahydro-1H-benzo[d]a...) Show SMILES CCCN1CCc2cccc(OC)c2CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor in rats, using [3H]-8-OH-DPAT as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50003346 (3-Propyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol...) Show SMILES CCCN1CCc2cccc(O)c2CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor in rats, using [3H]-8-OH-DPAT as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50003345 (3-Cyclopropylmethyl-6-methoxy-2,3,4,5-tetrahydro-1...) Show SMILES COc1cccc2CCN(CC3CC3)CCc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor in rats, using [3H]-8-OH-DPAT as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50003347 (3-Ethyl-6-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]az...) Show SMILES CCN1CCc2cccc(OC)c2CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor in rats, using [3H]-8-OH-DPAT as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50003343 (3-Butyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol ...) Show SMILES CCCCN1CCc2cccc(O)c2CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor in rats, using [3H]-8-OH-DPAT as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50003340 (6-Methoxy-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]a...) Show SMILES COc1cccc2CCN(C)CCc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor in rats, using [3H]-8-OH-DPAT as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50003341 (3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol ...) Show SMILES CCN1CCc2cccc(O)c2CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor in rats, using [3H]-8-OH-DPAT as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50003342 (6-Bromo-9-methoxy-3-propyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES CCCN1CCc2c(Br)ccc(OC)c2CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against Dopamine receptor D2 in rats using [3H]-spiperone as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50003339 (3-Methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol...) Show SMILES CN1CCc2cccc(O)c2CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor in rats, using [3H]-8-OH-DPAT as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50003347 (3-Ethyl-6-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]az...) Show SMILES CCN1CCc2cccc(OC)c2CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against Dopamine receptor D2 in rats using [3H]-spiperone as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50003340 (6-Methoxy-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]a...) Show SMILES COc1cccc2CCN(C)CCc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against Dopamine receptor D2 in rats using [3H]-spiperone as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50003348 (6-Methoxy-3-propyl-2,3,4,5-tetrahydro-1H-benzo[d]a...) Show SMILES CCCN1CCc2cccc(OC)c2CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against Dopamine receptor D2 in rats using [3H]-spiperone as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50003344 (3-Propyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol...) Show SMILES CCCN1CCc2ccc(O)cc2CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor in rats, using [3H]-8-OH-DPAT as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM21393 (7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...) Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibitory activity against dopamine receptor in rats using [3H]-spiperone as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50003345 (3-Cyclopropylmethyl-6-methoxy-2,3,4,5-tetrahydro-1...) Show SMILES COc1cccc2CCN(CC3CC3)CCc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against Dopamine receptor D2 in rats using [3H]-spiperone as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50003344 (3-Propyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol...) Show SMILES CCCN1CCc2ccc(O)cc2CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against Dopamine receptor D2 in rats using [3H]-spiperone as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50003343 (3-Butyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol ...) Show SMILES CCCCN1CCc2cccc(O)c2CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against Dopamine receptor D2 in rats using [3H]-spiperone as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50003341 (3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol ...) Show SMILES CCN1CCc2cccc(O)c2CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against Dopamine receptor D2 in rats using [3H]-spiperone as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50003339 (3-Methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol...) Show SMILES CN1CCc2cccc(O)c2CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against Dopamine receptor D2 in rats using [3H]-spiperone as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50003346 (3-Propyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol...) Show SMILES CCCN1CCc2cccc(O)c2CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibitory activity against Dopamine receptor D2 in rats using [3H]-spiperone as radioligand				J Med Chem 35: 3984-90 (1992) Article DOI: 10.1021/jm00100a002 BindingDB Entry DOI: 10.7270/Q2QN65QF
University of Göteborg Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%