Affinity Data by PubMed id=1433214

PubMed code 1433214

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Folylpoly-gamma-glutamate synthetase (Homo sapiens (Human))	BDBM50002472 (5-Amino-2-{4-[(2-amino-5-chloro-4-oxo-3,4-dihydro-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)				J Med Chem 35: 4078-85 (1992) Article DOI: 10.1021/jm00100a013 BindingDB Entry DOI: 10.7270/Q26M35S6
Medical University of South Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Folylpoly-gamma-glutamate synthetase (Homo sapiens (Human))	BDBM50003467 (5-Amino-2-{4-[(2-amino-4-oxo-5-trifluoromethyl-3,4...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)				J Med Chem 35: 4078-85 (1992) Article DOI: 10.1021/jm00100a013 BindingDB Entry DOI: 10.7270/Q26M35S6
Medical University of South Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Folylpoly-gamma-glutamate synthetase (Homo sapiens (Human))	BDBM50003471 (5-Amino-2-{4-[(2-amino-4-oxo-5-trifluoromethyl-3,4...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)				J Med Chem 35: 4078-85 (1992) Article DOI: 10.1021/jm00100a013 BindingDB Entry DOI: 10.7270/Q26M35S6
Medical University of South Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Folylpoly-gamma-glutamate synthetase (Homo sapiens (Human))	BDBM50003470 (5-Amino-2-{4-[(5-fluoro-2-methyl-4-oxo-3,4-dihydro...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)				J Med Chem 35: 4078-85 (1992) Article DOI: 10.1021/jm00100a013 BindingDB Entry DOI: 10.7270/Q26M35S6
Medical University of South Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Folylpoly-gamma-glutamate synthetase (Homo sapiens (Human))	BDBM50003468 (5-Amino-2-{4-[(2-amino-5-chloro-4-oxo-3,4-dihydro-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)				J Med Chem 35: 4078-85 (1992) Article DOI: 10.1021/jm00100a013 BindingDB Entry DOI: 10.7270/Q26M35S6
Medical University of South Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Folylpoly-gamma-glutamate synthetase (Homo sapiens (Human))	BDBM50003469 (5-Amino-2-{4-[(2-amino-5-fluoro-4-oxo-3,4-dihydro-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)				J Med Chem 35: 4078-85 (1992) Article DOI: 10.1021/jm00100a013 BindingDB Entry DOI: 10.7270/Q26M35S6
Medical University of South Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Folylpoly-gamma-glutamate synthetase (Homo sapiens (Human))	BDBM50002473 (5-Amino-2-{4-[(2-amino-4-oxo-3,4-dihydro-pteridin-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)				J Med Chem 35: 4078-85 (1992) Article DOI: 10.1021/jm00100a013 BindingDB Entry DOI: 10.7270/Q26M35S6
Medical University of South Carolina Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%