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PubMed code 1433215

Compile data set for download or QSAR
Found 88 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003524
PNG
(CHEMBL3216197 | CHEMBL544141 | [4-(2,2-Diphenyl-pr...)
Show SMILES Cl.Cl.CC(C(=O)N1CCN(CC1)C(C#N)c1cccnc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H26N4O/c1-26(22-10-4-2-5-11-22,23-12-6-3-7-13-23)25(31)30-17-15-29(16-18-30)24(19-27)21-9-8-14-28-20-21/h2-14,20,24H,15-18H2,1H3
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n/an/a 1.90n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003499
PNG
(CHEMBL338940 | [4-(3-Hydroxy-3,3-diphenyl-propiony...)
Show SMILES OC(CC(=O)N1CCN(CC1)C(C#N)c1ccncc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H26N4O2/c27-20-24(21-11-13-28-14-12-21)29-15-17-30(18-16-29)25(31)19-26(32,22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-14,24,32H,15-19H2
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n/an/a 2.70n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003525
PNG
(CHEMBL133742 | [4-(2,3-Diphenyl-acryloyl)-piperazi...)
Show SMILES O=C(N1CCN(CC1)C(C#N)c1cccnc1)C(=C\c1ccccc1)\c1ccccc1
Show InChI InChI=1S/C26H24N4O/c27-19-25(23-12-7-13-28-20-23)29-14-16-30(17-15-29)26(31)24(22-10-5-2-6-11-22)18-21-8-3-1-4-9-21/h1-13,18,20,25H,14-17H2/b24-18+
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n/an/a 7.5n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003506
PNG
(CHEMBL322184 | CHEMBL545771 | {4-[2-(Benzhydryl-am...)
Show SMILES O=C(CNC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H27N5O/c27-18-24(23-12-7-13-28-19-23)30-14-16-31(17-15-30)25(32)20-29-26(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,19,24,26,29H,14-17,20H2
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n/an/a 9.10n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003473
PNG
(CHEMBL317193 | [4-(3,3-Diphenyl-acryloyl)-piperazi...)
Show SMILES O=C(C=C(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H24N4O/c27-19-25(23-12-7-13-28-20-23)29-14-16-30(17-15-29)26(31)18-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18,20,25H,14-17H2
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n/an/a 10n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003522
PNG
((4-Diphenylacetyl-piperazin-1-yl)-pyridin-3-yl-ace...)
Show SMILES O=C(C(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C25H24N4O/c26-18-23(22-12-7-13-27-19-22)28-14-16-29(17-15-28)25(30)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-13,19,23-24H,14-17H2
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n/an/a 10n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003514
PNG
(CHEMBL3216401 | CHEMBL545075 | [4-(2-Benzyl-3-phen...)
Show SMILES Cl.Cl.O=C(C(Cc1ccccc1)Cc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H28N4O/c28-20-26(24-12-7-13-29-21-24)30-14-16-31(17-15-30)27(32)25(18-22-8-3-1-4-9-22)19-23-10-5-2-6-11-23/h1-13,21,25-26H,14-19H2
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n/an/a 11n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003503
PNG
(1-(3,3-Diphenyl-propionyl)-4-(pyridin-3-ylamino)-p...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCC(CC1)(Nc1cccnc1)C#N
Show InChI InChI=1S/C26H26N4O/c27-20-26(29-23-12-7-15-28-19-23)13-16-30(17-14-26)25(31)18-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-12,15,19,24,29H,13-14,16-18H2
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n/an/a 15n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003490
PNG
(CHEMBL101245 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H26N4O/c27-19-25(23-12-7-13-28-20-23)29-14-16-30(17-15-29)26(31)18-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,20,24-25H,14-18H2
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n/an/a 20n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003536
PNG
((1-Diphenylacetyl-piperidin-4-yl)-pyridin-3-yl-ace...)
Show SMILES O=C(C(c1ccccc1)c1ccccc1)N1CCC(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H25N3O/c27-18-24(23-12-7-15-28-19-23)20-13-16-29(17-14-20)26(30)25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-12,15,19-20,24-25H,13-14,16-17H2
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n/an/a 21n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003494
PNG
(CHEMBL336612 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cncs1
Show InChI InChI=1S/C24H24N4OS/c25-16-22(23-17-26-18-30-23)27-11-13-28(14-12-27)24(29)15-21(19-7-3-1-4-8-19)20-9-5-2-6-10-20/h1-10,17-18,21-22H,11-15H2
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n/an/a 21n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003510
PNG
(CHEMBL103753 | [4-(3-Hydroxy-3,3-diphenyl-propiony...)
Show SMILES OC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H26N4O2/c27-19-24(21-8-7-13-28-20-21)29-14-16-30(17-15-29)25(31)18-26(32,22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1-13,20,24,32H,14-18H2
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n/an/a 21n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003519
PNG
(CHEMBL3216182 | CHEMBL543897 | [4-(2-Phenyl-propio...)
Show SMILES Cl.Cl.CC(C(=O)N1CCN(CC1)C(C#N)c1cccnc1)c1ccccc1
Show InChI InChI=1S/C20H22N4O/c1-16(17-6-3-2-4-7-17)20(25)24-12-10-23(11-13-24)19(14-21)18-8-5-9-22-15-18/h2-9,15-16,19H,10-13H2,1H3
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n/an/a 21n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003548
PNG
(CHEMBL335853 | [4-(2,2-Diphenyl-thioacetyl)-pipera...)
Show SMILES S=C(C(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C25H24N4S/c26-18-23(22-12-7-13-27-19-22)28-14-16-29(17-15-28)25(30)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-13,19,23-24H,14-17H2
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n/an/a 23n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003544
PNG
(CHEMBL132852 | {4-[2-(Benzyl-phenyl-amino)-acetyl]...)
Show SMILES O=C(CN(Cc1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H27N5O/c27-18-25(23-10-7-13-28-19-23)29-14-16-30(17-15-29)26(32)21-31(24-11-5-2-6-12-24)20-22-8-3-1-4-9-22/h1-13,19,25H,14-17,20-21H2
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n/an/a 24n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003497
PNG
(CHEMBL134123 | {1-[2-(Benzhydryl-amino)-acetyl]-pi...)
Show SMILES O=C(CNC(c1ccccc1)c1ccccc1)N1CCC(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H28N4O/c28-18-25(24-12-7-15-29-19-24)21-13-16-31(17-14-21)26(32)20-30-27(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-12,15,19,21,25,27,30H,13-14,16-17,20H2
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n/an/a 24n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003485
PNG
(CHEMBL134143 | [1-(3,3-Diphenyl-propionyl)-piperid...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCC(CC1)=C(C#N)c1cccnc1
Show InChI InChI=1S/C27H25N3O/c28-19-26(24-12-7-15-29-20-24)23-13-16-30(17-14-23)27(31)18-25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-12,15,20,25H,13-14,16-18H2
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n/an/a 26n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003527
PNG
(4-(Cyano-pyridin-3-yl-methyl)-piperazine-1-carboxy...)
Show SMILES Cl.Cl.O=C(OCC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H26N4O2/c27-18-25(23-12-7-13-28-19-23)29-14-16-30(17-15-29)26(31)32-20-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,19,24-25H,14-17,20H2
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n/an/a 26n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003523
PNG
(CHEMBL544607 | [4-(2-Dibenzylamino-acetyl)-piperaz...)
Show SMILES O=C(CN(Cc1ccccc1)Cc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H29N5O/c28-18-26(25-12-7-13-29-19-25)31-14-16-32(17-15-31)27(33)22-30(20-23-8-3-1-4-9-23)21-24-10-5-2-6-11-24/h1-13,19,26H,14-17,20-22H2
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n/an/a 32n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003552
PNG
(CHEMBL555567 | {4-[2-(Benzhydryl-amino)-ethyl]-pip...)
Show SMILES N#CC(N1CCN(CCNC(c2ccccc2)c2ccccc2)CC1)c1ccncc1
Show InChI InChI=1S/C26H29N5/c27-21-25(22-11-13-28-14-12-22)31-19-17-30(18-20-31)16-15-29-26(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-14,25-26,29H,15-20H2
MMDB

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n/an/a 36n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003484
PNG
(CHEMBL336816 | N-{2-[4-(Cyano-pyridin-3-yl-methyl)...)
Show SMILES O=C(NCCN1CCN(CC1)C(C#N)c1cccnc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H29N5O/c28-20-25(24-12-7-13-29-21-24)32-18-16-31(17-19-32)15-14-30-27(33)26(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,21,25-26H,14-19H2,(H,30,33)
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n/an/a 36n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003543
PNG
(CHEMBL554463 | {4-[2-(1-Phenyl-ethylamino)-acetyl]...)
Show SMILES CC(NCC(=O)N1CCN(CC1)C(C#N)c1cccnc1)c1ccccc1
Show InChI InChI=1S/C21H25N5O/c1-17(18-6-3-2-4-7-18)24-16-21(27)26-12-10-25(11-13-26)20(14-22)19-8-5-9-23-15-19/h2-9,15,17,20,24H,10-13,16H2,1H3
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n/an/a 36n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003474
PNG
(CHEMBL545773 | {4-[2-(1,2-Diphenyl-ethylamino)-ace...)
Show SMILES O=C(CNC(Cc1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H29N5O/c28-19-26(24-12-7-13-29-20-24)31-14-16-32(17-15-31)27(33)21-30-25(23-10-5-2-6-11-23)18-22-8-3-1-4-9-22/h1-13,20,25-26,30H,14-18,21H2
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n/an/a 50n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003558
PNG
(CHEMBL3216867 | CHEMBL555357 | [4-(3,3-Diphenyl-pr...)
Show SMILES Cl.Cl.O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1ccncc1
Show InChI InChI=1S/C26H26N4O/c27-20-25(23-11-13-28-14-12-23)29-15-17-30(18-16-29)26(31)19-24(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-14,24-25H,15-19H2
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n/an/a 51n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003489
PNG
(CHEMBL103801 | {4-[3-(Benzhydryl-amino)-propionyl]...)
Show SMILES O=C(CCNC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H29N5O/c28-20-25(24-12-7-14-29-21-24)31-16-18-32(19-17-31)26(33)13-15-30-27(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-12,14,21,25,27,30H,13,15-19H2
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n/an/a 53n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003556
PNG
(CHEMBL133457 | {4-[3-(Benzhydryl-amino)-propionyl]...)
Show SMILES O=C(CCNC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1ccncc1
Show InChI InChI=1S/C27H29N5O/c28-21-25(22-11-14-29-15-12-22)31-17-19-32(20-18-31)26(33)13-16-30-27(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-12,14-15,25,27,30H,13,16-20H2
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n/an/a 55n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003528
PNG
(CHEMBL545072 | {4-[2-(Benzhydryl-methyl-amino)-ace...)
Show SMILES CN(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H29N5O/c1-30(27(22-9-4-2-5-10-22)23-11-6-3-7-12-23)21-26(33)32-17-15-31(16-18-32)25(19-28)24-13-8-14-29-20-24/h2-14,20,25,27H,15-18,21H2,1H3
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n/an/a 60n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003513
PNG
(CHEMBL423524 | [4-(2-Naphthalen-1-yl-acetyl)-piper...)
Show SMILES O=C(Cc1cccc2ccccc12)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C23H22N4O/c24-16-22(20-8-4-10-25-17-20)26-11-13-27(14-12-26)23(28)15-19-7-3-6-18-5-1-2-9-21(18)19/h1-10,17,22H,11-15H2
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n/an/a 76n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003520
PNG
(CHEMBL552805 | {4-[2-(3,3-Diphenyl-propylamino)-ac...)
Show SMILES O=C(CNCCC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C28H31N5O/c29-20-27(25-12-7-14-30-21-25)32-16-18-33(19-17-32)28(34)22-31-15-13-26(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-12,14,21,26-27,31H,13,15-19,22H2
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n/an/a 86n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003501
PNG
(3,3-Diphenyl-1-[4-(pyridin-3-ylamino)-piperidin-1-...)
Show SMILES Cl.Cl.O=C(CC(c1ccccc1)c1ccccc1)N1CCC(CC1)Nc1cccnc1
Show InChI InChI=1S/C25H27N3O/c29-25(28-16-13-22(14-17-28)27-23-12-7-15-26-19-23)18-24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-12,15,19,22,24,27H,13-14,16-18H2
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n/an/a 87n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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n/an/a 91n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003537
PNG
(CHEMBL134094 | [4-(2-Phenylamino-acetyl)-piperazin...)
Show SMILES O=C(CNc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C19H21N5O/c20-13-18(16-5-4-8-21-14-16)23-9-11-24(12-10-23)19(25)15-22-17-6-2-1-3-7-17/h1-8,14,18,22H,9-12,15H2
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n/an/a 130n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003493
PNG
(1-[2-(Benzhydryl-amino)-acetyl]-4-(pyridin-3-ylami...)
Show SMILES O=C(CNC(c1ccccc1)c1ccccc1)N1CCC(CC1)(Nc1cccnc1)C#N
Show InChI InChI=1S/C26H27N5O/c27-20-26(30-23-12-7-15-28-18-23)13-16-31(17-14-26)24(32)19-29-25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-12,15,18,25,29-30H,13-14,16-17,19H2
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n/an/a 200n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003475
PNG
(CHEMBL543420 | {4-[2-(2,2-Diphenyl-ethylamino)-ace...)
Show SMILES O=C(CNCC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H29N5O/c28-18-26(24-12-7-13-29-19-24)31-14-16-32(17-15-31)27(33)21-30-20-25(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,19,25-26,30H,14-17,20-21H2
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n/an/a 220n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003516
PNG
(CHEMBL335044 | [4-(2,3-Diphenyl-propionyl)-piperaz...)
Show SMILES O=C(C(Cc1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H26N4O/c27-19-25(23-12-7-13-28-20-23)29-14-16-30(17-15-29)26(31)24(22-10-5-2-6-11-22)18-21-8-3-1-4-9-21/h1-13,20,24-25H,14-18H2
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n/an/a 230n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003551
PNG
(2-(4-Diphenylacetyl-piperazin-1-yl)-2-pyridin-3-yl...)
Show SMILES CC(C#N)(N1CCN(CC1)C(=O)C(c1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C26H26N4O/c1-26(20-27,23-13-8-14-28-19-23)30-17-15-29(16-18-30)25(31)24(21-9-4-2-5-10-21)22-11-6-3-7-12-22/h2-14,19,24H,15-18H2,1H3
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n/an/a 240n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003504
PNG
(CHEMBL3217094 | CHEMBL544368 | [4-(2-Benzylamino-a...)
Show SMILES Cl.Cl.O=C(CNCc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C20H23N5O/c21-13-19(18-7-4-8-22-15-18)24-9-11-25(12-10-24)20(26)16-23-14-17-5-2-1-3-6-17/h1-8,15,19,23H,9-12,14,16H2
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n/an/a 240n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003511
PNG
((4-{2-[Methyl-(1-phenyl-ethyl)-amino]-acetyl}-pipe...)
Show SMILES CC(N(C)CC(=O)N1CCN(CC1)C(C#N)c1cccnc1)c1ccccc1
Show InChI InChI=1S/C22H27N5O/c1-18(19-7-4-3-5-8-19)25(2)17-22(28)27-13-11-26(12-14-27)21(15-23)20-9-6-10-24-16-20/h3-10,16,18,21H,11-14,17H2,1-2H3
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n/an/a 240n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003526
PNG
(2-[4-(Cyano-pyridin-3-yl-methyl)-piperazin-1-yl]-N...)
Show SMILES O=C(CN1CCN(CC1)C(C#N)c1cccnc1)NCCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H31N5O/c29-20-27(25-12-7-14-30-21-25)33-18-16-32(17-19-33)22-28(34)31-15-13-26(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-12,14,21,26-27H,13,15-19,22H2,(H,31,34)
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n/an/a 240n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003509
PNG
(CHEMBL335556 | [4-(4-Phenyl-butyryl)-piperazin-1-y...)
Show SMILES O=C(CCCc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C21H24N4O/c22-16-20(19-9-5-11-23-17-19)24-12-14-25(15-13-24)21(26)10-4-8-18-6-2-1-3-7-18/h1-3,5-7,9,11,17,20H,4,8,10,12-15H2
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n/an/a 260n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003486
PNG
(4-(Cyano-pyridin-3-yl-methyl)-piperazine-1-carboxy...)
Show SMILES O=C(NC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C25H25N5O/c26-18-23(22-12-7-13-27-19-22)29-14-16-30(17-15-29)25(31)28-24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-13,19,23-24H,14-17H2,(H,28,31)
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n/an/a 360n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003481
PNG
(CHEMBL3215746 | CHEMBL554052 | Pyridin-3-yl-{4-[3-...)
Show SMILES Cl.Cl.COc1cc(CCC(=O)N2CCN(CC2)C(C#N)c2cccnc2)cc(OC)c1OC
Show InChI InChI=1S/C23H28N4O4/c1-29-20-13-17(14-21(30-2)23(20)31-3)6-7-22(28)27-11-9-26(10-12-27)19(15-24)18-5-4-8-25-16-18/h4-5,8,13-14,16,19H,6-7,9-12H2,1-3H3
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n/an/a 400n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003557
PNG
(CHEMBL559013 | [4-(2-1H-Indol-3-yl-acetyl)-piperaz...)
Show SMILES O=C(Cc1c[nH]c2ccccc12)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C21H21N5O/c22-13-20(16-4-3-7-23-14-16)25-8-10-26(11-9-25)21(27)12-17-15-24-19-6-2-1-5-18(17)19/h1-7,14-15,20,24H,8-12H2
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n/an/a 450n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003496
PNG
(CHEMBL133425 | Pyridin-3-yl-{4-[2-(3,4,5-trimethox...)
Show SMILES COc1cc(CC(=O)N2CCN(CC2)C(C#N)c2cccnc2)cc(OC)c1OC
Show InChI InChI=1S/C22H26N4O4/c1-28-19-11-16(12-20(29-2)22(19)30-3)13-21(27)26-9-7-25(8-10-26)18(14-23)17-5-4-6-24-15-17/h4-6,11-12,15,18H,7-10,13H2,1-3H3
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n/an/a 460n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003517
PNG
(CHEMBL3215980 | CHEMBL543663 | [4-(3-Phenyl-propio...)
Show SMILES Cl.Cl.O=C(CCc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C20H22N4O/c21-15-19(18-7-4-10-22-16-18)23-11-13-24(14-12-23)20(25)9-8-17-5-2-1-3-6-17/h1-7,10,16,19H,8-9,11-14H2
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n/an/a 520n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003488
PNG
(3,3-Diphenyl-1-(4-pyridin-3-ylmethyl-piperazin-1-y...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C25H27N3O/c29-25(28-16-14-27(15-17-28)20-21-8-7-13-26-19-21)18-24(22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1-13,19,24H,14-18,20H2
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n/an/a 520n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50368448
PNG
(CHEMBL1203313)
Show SMILES O=C(CNCCCc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C22H27N5O/c23-16-21(20-9-5-11-24-17-20)26-12-14-27(15-13-26)22(28)18-25-10-4-8-19-6-2-1-3-7-19/h1-3,5-7,9,11,17,21,25H,4,8,10,12-15,18H2
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n/an/a 530n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003542
PNG
(CHEMBL542731 | [4-(3,3-Diphenyl-propyl)-piperazin-...)
Show SMILES N#CC(N1CCN(CCC(c2ccccc2)c2ccccc2)CC1)c1cccnc1
Show InChI InChI=1S/C26H28N4/c27-20-26(24-12-7-14-28-21-24)30-18-16-29(17-19-30)15-13-25(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-12,14,21,25-26H,13,15-19H2
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n/an/a 630n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003530
PNG
(CHEMBL340989 | N-{2-[4-(Cyano-pyridin-4-yl-methyl)...)
Show SMILES O=C(CNC(=O)C(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1ccncc1
Show InChI InChI=1S/C27H27N5O2/c28-19-24(21-11-13-29-14-12-21)31-15-17-32(18-16-31)25(33)20-30-27(34)26(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-14,24,26H,15-18,20H2,(H,30,34)
MMDB

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n/an/a 680n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003505
PNG
(CHEMBL132636 | [4-(2-Naphthalen-2-yl-acetyl)-piper...)
Show SMILES O=C(Cc1ccc2ccccc2c1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C23H22N4O/c24-16-22(21-6-3-9-25-17-21)26-10-12-27(13-11-26)23(28)15-18-7-8-19-4-1-2-5-20(19)14-18/h1-9,14,17,22H,10-13,15H2
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n/an/a 720n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003483
PNG
((4-Octanoyl-piperazin-1-yl)-pyridin-3-yl-acetonitr...)
Show SMILES CCCCCCCC(=O)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C19H28N4O/c1-2-3-4-5-6-9-19(24)23-13-11-22(12-14-23)18(15-20)17-8-7-10-21-16-17/h7-8,10,16,18H,2-6,9,11-14H2,1H3
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n/an/a 920n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003480
PNG
(2,2-Diphenyl-1-[4-(1-pyridin-3-yl-ethyl)-piperazin...)
Show SMILES CC(N1CCN(CC1)C(=O)C(c1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C25H27N3O/c1-20(23-13-8-14-26-19-23)27-15-17-28(18-16-27)25(29)24(21-9-4-2-5-10-21)22-11-6-3-7-12-22/h2-14,19-20,24H,15-18H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003479
PNG
(CHEMBL543662 | [4-(Pyridine-3-carbothioyl)-piperaz...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCN(CC1)C(=S)c1cccnc1
Show InChI InChI=1S/C20H23N3O4S/c1-25-16-11-15(12-17(26-2)18(16)27-3)19(24)22-7-9-23(10-8-22)20(28)14-5-4-6-21-13-14/h4-6,11-13H,7-10H2,1-3H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003534
PNG
(CHEMBL3215728 | CHEMBL545770 | Pyridin-3-yl-[4-(3,...)
Show SMILES Cl.Cl.COc1cc(cc(OC)c1OC)C(=O)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C21H24N4O4/c1-27-18-11-16(12-19(28-2)20(18)29-3)21(26)25-9-7-24(8-10-25)17(13-22)15-5-4-6-23-14-15/h4-6,11-12,14,17H,7-10H2,1-3H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003538
PNG
(1-[4-(1-Oxy-pyridine-4-carbonyl)-piperazin-1-yl]-3...)
Show SMILES [O-][n+]1ccc(cc1)C(=O)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H25N3O3/c29-24(19-23(20-7-3-1-4-8-20)21-9-5-2-6-10-21)26-15-17-27(18-16-26)25(30)22-11-13-28(31)14-12-22/h1-14,23H,15-19H2
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n/an/a 1.90E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003545
PNG
(3,3-Diphenyl-1-[4-(pyridine-4-carbonyl)-piperazin-...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(=O)c1ccncc1
Show InChI InChI=1S/C25H25N3O2/c29-24(19-23(20-7-3-1-4-8-20)21-9-5-2-6-10-21)27-15-17-28(18-16-27)25(30)22-11-13-26-14-12-22/h1-14,23H,15-19H2
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n/an/a 1.90E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003529
PNG
((4-{2-[Methyl-(3-phenyl-propyl)-amino]-acetyl}-pip...)
Show SMILES Cl.Cl.CN(CCCc1ccccc1)CC(=O)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C23H29N5O/c1-26(12-6-9-20-7-3-2-4-8-20)19-23(29)28-15-13-27(14-16-28)22(17-24)21-10-5-11-25-18-21/h2-5,7-8,10-11,18,22H,6,9,12-16,19H2,1H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003476
PNG
(3-(4-Diphenylacetyl-piperazin-1-yl)-2-pyridin-3-yl...)
Show SMILES O=C(C(c1ccccc1)c1ccccc1)N1CCN(CC(C#N)c2cccnc2)CC1
Show InChI InChI=1S/C26H26N4O/c27-18-24(23-12-7-13-28-19-23)20-29-14-16-30(17-15-29)26(31)25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,19,24-25H,14-17,20H2
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n/an/a 2.30E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003549
PNG
(CHEMBL423891 | [4-(3-Phenyl-acryloyl)-piperazin-1-...)
Show SMILES O=C(\C=C\c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C20H20N4O/c21-15-19(18-7-4-10-22-16-18)23-11-13-24(14-12-23)20(25)9-8-17-5-2-1-3-6-17/h1-10,16,19H,11-14H2/b9-8+
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n/an/a 2.50E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003515
PNG
(2,2-Diphenyl-1-(4-pyridin-3-ylmethyl-piperazin-1-y...)
Show SMILES O=C(C(c1ccccc1)c1ccccc1)N1CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C24H25N3O/c28-24(23(21-9-3-1-4-10-21)22-11-5-2-6-12-22)27-16-14-26(15-17-27)19-20-8-7-13-25-18-20/h1-13,18,23H,14-17,19H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003492
PNG
(3,3-Diphenyl-propionic acid 1-(cyano-pyridin-3-yl-...)
Show SMILES Cl.Cl.O=C(CC(c1ccccc1)c1ccccc1)OC1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H27N3O2/c28-19-26(23-12-7-15-29-20-23)30-16-13-24(14-17-30)32-27(31)18-25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-12,15,20,24-26H,13-14,16-18H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003535
PNG
(CHEMBL134877 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES Cn1ccc(c1)C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H28N4O/c1-28-13-12-23(20-28)25(19-27)29-14-16-30(17-15-29)26(31)18-24(21-8-4-2-5-9-21)22-10-6-3-7-11-22/h2-13,20,24-25H,14-18H2,1H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003512
PNG
(CHEMBL133964 | [4-(2,4-Diphenyl-butyryl)-piperazin...)
Show SMILES O=C(C(CCc1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H28N4O/c28-20-26(24-12-7-15-29-21-24)30-16-18-31(19-17-30)27(32)25(23-10-5-2-6-11-23)14-13-22-8-3-1-4-9-22/h1-12,15,21,25-26H,13-14,16-19H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003546
PNG
((4-Pentanoyl-piperazin-1-yl)-pyridin-3-yl-acetonit...)
Show SMILES CCCCC(=O)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C16H22N4O/c1-2-3-6-16(21)20-10-8-19(9-11-20)15(12-17)14-5-4-7-18-13-14/h4-5,7,13,15H,2-3,6,8-11H2,1H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003554
PNG
(CHEMBL540829 | {4-[2-(Naphthalen-1-ylamino)-acetyl...)
Show SMILES O=C(CNc1cccc2ccccc12)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C23H23N5O/c24-15-22(19-7-4-10-25-16-19)27-11-13-28(14-12-27)23(29)17-26-21-9-3-6-18-5-1-2-8-20(18)21/h1-10,16,22,26H,11-14,17H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003495
PNG
((4-Phenylacetyl-piperazin-1-yl)-pyridin-3-yl-aceto...)
Show SMILES O=C(Cc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C19H20N4O/c20-14-18(17-7-4-8-21-15-17)22-9-11-23(12-10-22)19(24)13-16-5-2-1-3-6-16/h1-8,15,18H,9-13H2
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n/an/a 2.70E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003532
PNG
(CHEMBL554398 | {4-[2-(Methyl-phenyl-amino)-acetyl]...)
Show SMILES CN(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1)c1ccccc1
Show InChI InChI=1S/C20H23N5O/c1-23(18-7-3-2-4-8-18)16-20(26)25-12-10-24(11-13-25)19(14-21)17-6-5-9-22-15-17/h2-9,15,19H,10-13,16H2,1H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003478
PNG
((4-Benzoyl-piperazin-1-yl)-pyridin-3-yl-acetonitri...)
Show SMILES Cl.Cl.O=C(N1CCN(CC1)C(C#N)c1cccnc1)c1ccccc1
Show InChI InChI=1S/C18H18N4O/c19-13-17(16-7-4-8-20-14-16)21-9-11-22(12-10-21)18(23)15-5-2-1-3-6-15/h1-8,14,17H,9-12H2
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n/an/a 4.80E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003500
PNG
(CHEMBL134025 | [4-(2,2-Dimethyl-propionyl)-piperaz...)
Show SMILES CC(C)(C)C(=O)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C16H22N4O/c1-16(2,3)15(21)20-9-7-19(8-10-20)14(11-17)13-5-4-6-18-12-13/h4-6,12,14H,7-10H2,1-3H3
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n/an/a 5.20E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003540
PNG
(CHEMBL541330 | [4-(Pyridine-3-carbonyl)-piperazin-...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCN(CC1)C(=O)c1cccnc1
Show InChI InChI=1S/C20H23N3O5/c1-26-16-11-15(12-17(27-2)18(16)28-3)20(25)23-9-7-22(8-10-23)19(24)14-5-4-6-21-13-14/h4-6,11-13H,7-10H2,1-3H3
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n/an/a 5.20E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003541
PNG
(CHEMBL553093 | N-{2-[4-(Cyano-pyridin-3-yl-methyl)...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)NCCN1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C28H31N5O/c29-21-27(25-12-7-13-30-22-25)33-18-16-32(17-19-33)15-14-31-28(34)20-26(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-13,22,26-27H,14-20H2,(H,31,34)
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n/an/a 5.50E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003550
PNG
(CHEMBL134965 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES Cn1cc(C(C#N)N2CCN(CC2)C(=O)CC(c2ccccc2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C30H30N4O/c1-32-22-27(25-14-8-9-15-28(25)32)29(21-31)33-16-18-34(19-17-33)30(35)20-26(23-10-4-2-5-11-23)24-12-6-3-7-13-24/h2-15,22,26,29H,16-20H2,1H3
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n/an/a 5.70E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003498
PNG
(3-{Cyano-[4-(3,3-diphenyl-propionyl)-piperazin-1-y...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccc(c1)C#N
Show InChI InChI=1S/C28H26N4O/c29-20-22-8-7-13-25(18-22)27(21-30)31-14-16-32(17-15-31)28(33)19-26(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-13,18,26-27H,14-17,19H2
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n/an/a 7.40E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003508
PNG
(CHEMBL133555 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES FC(F)(F)c1cccc(c1)C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H26F3N3O/c29-28(30,31)24-13-7-12-23(18-24)26(20-32)33-14-16-34(17-15-33)27(35)19-25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18,25-26H,14-17,19H2
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n/an/a 9.00E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003521
PNG
(CHEMBL6244 | [4-(3,4,5-Trimethoxy-benzoyl)-piperaz...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCN(CC1)C(=O)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C24H30N2O8/c1-29-17-11-15(12-18(30-2)21(17)33-5)23(27)25-7-9-26(10-8-25)24(28)16-13-19(31-3)22(34-6)20(14-16)32-4/h11-14H,7-10H2,1-6H3
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n/an/a 9.40E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003487
PNG
(3,3-Diphenyl-1-[4-(pyridine-4-sulfonyl)-piperazin-...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)S(=O)(=O)c1ccncc1
Show InChI InChI=1S/C24H25N3O3S/c28-24(19-23(20-7-3-1-4-8-20)21-9-5-2-6-10-21)26-15-17-27(18-16-26)31(29,30)22-11-13-25-14-12-22/h1-14,23H,15-19H2
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n/an/a 1.10E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003482
PNG
(CHEMBL132246 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES [O-][N+](=O)c1cccc(c1)C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H26N4O3/c28-20-26(23-12-7-13-24(18-23)31(33)34)29-14-16-30(17-15-29)27(32)19-25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18,25-26H,14-17,19H2
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n/an/a 1.10E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003507
PNG
((4-Pyridin-3-ylmethyl-piperazin-1-yl)-(3,4,5-trime...)
Show SMILES Cl.Cl.COc1cc(cc(OC)c1OC)C(=O)N1CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C20H25N3O4/c1-25-17-11-16(12-18(26-2)19(17)27-3)20(24)23-9-7-22(8-10-23)14-15-5-4-6-21-13-15/h4-6,11-13H,7-10,14H2,1-3H3
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n/an/a 1.70E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003547
PNG
((3-Chloro-phenyl)-[4-(3,3-diphenyl-propionyl)-pipe...)
Show SMILES Clc1cccc(c1)C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H26ClN3O/c28-24-13-7-12-23(18-24)26(20-29)30-14-16-31(17-15-30)27(32)19-25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18,25-26H,14-17,19H2
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n/an/a 2.10E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003491
PNG
(2,2-Diphenyl-1-[4-(pyridine-3-carbonyl)-piperazin-...)
Show SMILES O=C(C(c1ccccc1)c1ccccc1)N1CCN(CC1)C(=O)c1cccnc1
Show InChI InChI=1S/C24H23N3O2/c28-23(21-12-7-13-25-18-21)26-14-16-27(17-15-26)24(29)22(19-8-3-1-4-9-19)20-10-5-2-6-11-20/h1-13,18,22H,14-17H2
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n/an/a 2.30E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003531
PNG
(CHEMBL132821 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES Cn1cccc1C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H28N4O/c1-28-14-8-13-24(28)25(20-27)29-15-17-30(18-16-29)26(31)19-23(21-9-4-2-5-10-21)22-11-6-3-7-12-22/h2-14,23,25H,15-19H2,1H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003502
PNG
(CHEMBL3215754 | CHEMBL545304 | [4-(Naphthalene-2-c...)
Show SMILES Cl.Cl.O=C(N1CCN(CC1)C(C#N)c1cccnc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C22H20N4O/c23-15-21(20-6-3-9-24-16-20)25-10-12-26(13-11-25)22(27)19-8-7-17-4-1-2-5-18(17)14-19/h1-9,14,16,21H,10-13H2
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n/an/a 2.50E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003518
PNG
(1-(4-Oxy-4-pyridin-3-ylmethyl-piperazin-1-yl)-2,2-...)
Show SMILES [O-][N+]1(Cc2cccnc2)CCN(CC1)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25N3O2/c28-24(23(21-9-3-1-4-10-21)22-11-5-2-6-12-22)26-14-16-27(29,17-15-26)19-20-8-7-13-25-18-20/h1-13,18,23H,14-17,19H2
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n/an/a 4.40E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003553
PNG
(CHEMBL544606 | Pyridin-2-yl-[4-(3,4,5-trimethoxy-b...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCN(CC1)C(C#N)c1ccccn1
Show InChI InChI=1S/C21H24N4O4/c1-27-18-12-15(13-19(28-2)20(18)29-3)21(26)25-10-8-24(9-11-25)17(14-22)16-6-4-5-7-23-16/h4-7,12-13,17H,8-11H2,1-3H3
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n/an/a 4.40E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003472
PNG
(1-[4-(3,4,5-Trimethoxy-benzoyl)-piperazin-1-yl]-3-...)
Show SMILES COc1cc(CCC(=O)N2CCN(CC2)C(=O)c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC
Show InChI InChI=1S/C26H34N2O8/c1-31-19-13-17(14-20(32-2)24(19)35-5)7-8-23(29)27-9-11-28(12-10-27)26(30)18-15-21(33-3)25(36-6)22(16-18)34-4/h13-16H,7-12H2,1-6H3
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n/an/a 7.30E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003555
PNG
((4-Hexadecanoyl-piperazin-1-yl)-pyridin-3-yl-aceto...)
Show SMILES CCCCCCCCCCCCCCCC(=O)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H44N4O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17-27(32)31-21-19-30(20-22-31)26(23-28)25-16-15-18-29-24-25/h15-16,18,24,26H,2-14,17,19-22H2,1H3
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n/an/a>2.00E+5n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003539
PNG
(2-(4-Diphenylacetyl-piperazin-1-yl)-2-pyridin-3-yl...)
Show SMILES NC(=O)C(N1CCN(CC1)C(=O)C(c1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C25H26N4O2/c26-24(30)23(21-12-7-13-27-18-21)28-14-16-29(17-15-28)25(31)22(19-8-3-1-4-9-19)20-10-5-2-6-11-20/h1-13,18,22-23H,14-17H2,(H2,26,30)
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n/an/a 2.00E+5n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)		BDBM50003533
PNG
((4-Dimethylamino-phenyl)-[4-(3,3-diphenyl-propiony...)
Show SMILES CN(C)c1ccc(cc1)C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H32N4O/c1-31(2)26-15-13-25(14-16-26)28(22-30)32-17-19-33(20-18-32)29(34)21-27(23-9-5-3-6-10-23)24-11-7-4-8-12-24/h3-16,27-28H,17-21H2,1-2H3
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n/an/a 2.10E+5n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.

J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%