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PubMed code 1447739

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003845
PNG
(6-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-2-...)
Show SMILES CO[C@]1(C)C[C@H](O)C[C@@H](CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)O1
Show InChI InChI=1S/C23H26N2O3S/c1-23(27-2)14-18(26)13-19(28-23)15-29-22-24-20(16-9-5-3-6-10-16)21(25-22)17-11-7-4-8-12-17/h3-12,18-19,26H,13-15H2,1-2H3,(H,24,25)/t18-,19+,23+/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003811
PNG
(2-(3-[1,3]Dioxan-2-yl-propylsulfanyl)-4,5-diphenyl...)
Show SMILES C(CSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)CC1OCCCO1
Show InChI InChI=1S/C22H24N2O2S/c1-3-9-17(10-4-1)20-21(18-11-5-2-6-12-18)24-22(23-20)27-16-7-13-19-25-14-8-15-26-19/h1-6,9-12,19H,7-8,13-16H2,(H,23,24)
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n/an/a 47n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50368461
PNG
(CHEMBL1794871)
Show SMILES Cc1cccc(c1)-c1nc(SC[C@H]2C[C@](C)(O)CC(=O)O2)[nH]c1-c1cccc(C)c1
Show InChI InChI=1S/C24H26N2O3S/c1-15-6-4-8-17(10-15)21-22(18-9-5-7-16(2)11-18)26-23(25-21)30-14-19-12-24(3,28)13-20(27)29-19/h4-11,19,28H,12-14H2,1-3H3,(H,25,26)/t19-,24+/m1/s1
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n/an/a 64n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003829
PNG
(2-(3,3-Diethoxy-propylsulfanyl)-4,5-diphenyl-1H-im...)
Show SMILES CCOC(CCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)OCC
Show InChI InChI=1S/C22H26N2O2S/c1-3-25-19(26-4-2)15-16-27-22-23-20(17-11-7-5-8-12-17)21(24-22)18-13-9-6-10-14-18/h5-14,19H,3-4,15-16H2,1-2H3,(H,23,24)
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n/an/a 69n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003846
PNG
(2-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-6-...)
Show SMILES CO[C@@H]1C[C@@](C)(O)C[C@H](CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)O1
Show InChI InChI=1S/C23H26N2O3S/c1-23(26)13-18(28-19(14-23)27-2)15-29-22-24-20(16-9-5-3-6-10-16)21(25-22)17-11-7-4-8-12-17/h3-12,18-19,26H,13-15H2,1-2H3,(H,24,25)/t18-,19+,23+/m1/s1
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n/an/a 82n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003813
PNG
(2-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-6-...)
Show SMILES CO[C@H]1C[C@H](O)C[C@@H](CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)O1
Show InChI InChI=1S/C22H24N2O3S/c1-26-19-13-17(25)12-18(27-19)14-28-22-23-20(15-8-4-2-5-9-15)21(24-22)16-10-6-3-7-11-16/h2-11,17-19,25H,12-14H2,1H3,(H,23,24)/t17-,18+,19-/m1/s1
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n/an/a 90n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003825
PNG
(2-Cyclohexylmethylsulfanyl-4,5-diphenyl-1H-imidazo...)
Show SMILES C(Sc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)C1CCCCC1
Show InChI InChI=1S/C22H24N2S/c1-4-10-17(11-5-1)16-25-22-23-20(18-12-6-2-7-13-18)21(24-22)19-14-8-3-9-15-19/h2-3,6-9,12-15,17H,1,4-5,10-11,16H2,(H,23,24)
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n/an/a 100n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003808
PNG
(6-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-4,...)
Show SMILES CC1(C)CC(CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)OC(=O)C1
Show InChI InChI=1S/C23H24N2O2S/c1-23(2)13-18(27-19(26)14-23)15-28-22-24-20(16-9-5-3-6-10-16)21(25-22)17-11-7-4-8-12-17/h3-12,18H,13-15H2,1-2H3,(H,24,25)
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Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003830
PNG
(6-[4,5-Bis-(3-chloro-phenyl)-1H-imidazol-2-ylsulfa...)
Show SMILES C[C@]1(O)CC(CSc2nc(c([nH]2)-c2cccc(Cl)c2)-c2cccc(Cl)c2)OC(=O)C1
Show InChI InChI=1S/C22H20Cl2N2O3S/c1-22(28)10-17(29-18(27)11-22)12-30-21-25-19(13-4-2-6-15(23)8-13)20(26-21)14-5-3-7-16(24)9-14/h2-9,17,28H,10-12H2,1H3,(H,25,26)/t17?,22-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003818
PNG
(6-[4,5-Bis-(2-chloro-phenyl)-1H-imidazol-2-ylsulfa...)
Show SMILES C[C@]1(O)CC(CSc2nc(c([nH]2)-c2ccccc2Cl)-c2ccccc2Cl)OC(=O)C1
Show InChI InChI=1S/C22H20Cl2N2O3S/c1-22(28)10-13(29-18(27)11-22)12-30-21-25-19(14-6-2-4-8-16(14)23)20(26-21)15-7-3-5-9-17(15)24/h2-9,13,28H,10-12H2,1H3,(H,25,26)/t13?,22-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003838
PNG
(6-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-4-...)
Show SMILES C[C@@]1(O)CC(CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)OC(=O)C1
Show InChI InChI=1S/C22H22N2O3S/c1-22(26)12-17(27-18(25)13-22)14-28-21-23-19(15-8-4-2-5-9-15)20(24-21)16-10-6-3-7-11-16/h2-11,17,26H,12-14H2,1H3,(H,23,24)/t17?,22-/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003839
PNG
(6-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-4-...)
Show SMILES C[C@@]1(O)CC(O)O[C@@H](CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)C1
Show InChI InChI=1S/C22H24N2O3S/c1-22(26)12-17(27-18(25)13-22)14-28-21-23-19(15-8-4-2-5-9-15)20(24-21)16-10-6-3-7-11-16/h2-11,17-18,25-26H,12-14H2,1H3,(H,23,24)/t17-,18?,22+/m1/s1
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n/an/a 160n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003842
PNG
(6-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-4-...)
Show SMILES C[C@]1(O)CC(CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)OC(=O)C1
Show InChI InChI=1S/C22H22N2O3S/c1-22(26)12-17(27-18(25)13-22)14-28-21-23-19(15-8-4-2-5-9-15)20(24-21)16-10-6-3-7-11-16/h2-11,17,26H,12-14H2,1H3,(H,23,24)/t17?,22-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50368458
PNG
(CHEMBL1794872)
Show SMILES Cc1ccc(cc1)-c1nc(SC[C@H]2C[C@@](C)(O)CC(=O)O2)[nH]c1-c1ccc(C)cc1
Show InChI InChI=1S/C24H26N2O3S/c1-15-4-8-17(9-5-15)21-22(18-10-6-16(2)7-11-18)26-23(25-21)30-14-19-12-24(3,28)13-20(27)29-19/h4-11,19,28H,12-14H2,1-3H3,(H,25,26)/t19-,24-/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003814
PNG
(2-([1,3]Dioxan-2-ylmethylsulfanyl)-4,5-diphenyl-1H...)
Show SMILES C(Sc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)C1OCCCO1
Show InChI InChI=1S/C20H20N2O2S/c1-3-8-15(9-4-1)18-19(16-10-5-2-6-11-16)22-20(21-18)25-14-17-23-12-7-13-24-17/h1-6,8-11,17H,7,12-14H2,(H,21,22)
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n/an/a 180n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003847
PNG
(6-[4,5-Bis-(4-chloro-phenyl)-1H-imidazol-2-ylsulfa...)
Show SMILES C[C@]1(O)CC(CSc2nc(c([nH]2)-c2ccc(Cl)cc2)-c2ccc(Cl)cc2)OC(=O)C1
Show InChI InChI=1S/C22H20Cl2N2O3S/c1-22(28)10-17(29-18(27)11-22)12-30-21-25-19(13-2-6-15(23)7-3-13)20(26-21)14-4-8-16(24)9-5-14/h2-9,17,28H,10-12H2,1H3,(H,25,26)/t17?,22-/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003834
PNG
(6-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-4-...)
Show SMILES CC1=CC(=O)OC(CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)C1
Show InChI InChI=1S/C22H20N2O2S/c1-15-12-18(26-19(25)13-15)14-27-22-23-20(16-8-4-2-5-9-16)21(24-22)17-10-6-3-7-11-17/h2-11,13,18H,12,14H2,1H3,(H,23,24)
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Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003836
PNG
(4,5-Diphenyl-2-(tetrahydro-pyran-2-ylmethylsulfany...)
Show SMILES C(Sc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)C1CCCCO1
Show InChI InChI=1S/C21H22N2OS/c1-3-9-16(10-4-1)19-20(17-11-5-2-6-12-17)23-21(22-19)25-15-18-13-7-8-14-24-18/h1-6,9-12,18H,7-8,13-15H2,(H,22,23)
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n/an/a 210n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50368459
PNG
(CHEMBL1794875)
Show SMILES CC(C)c1ccc(cc1)-c1nc(SC[C@H]2C[C@@](C)(O)CC(=O)O2)[nH]c1-c1ccc(cc1)C(C)C
Show InChI InChI=1S/C28H34N2O3S/c1-17(2)19-6-10-21(11-7-19)25-26(22-12-8-20(9-13-22)18(3)4)30-27(29-25)34-16-23-14-28(5,32)15-24(31)33-23/h6-13,17-18,23,32H,14-16H2,1-5H3,(H,29,30)/t23-,28-/m1/s1
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n/an/a 230n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003817
PNG
(6-[4,5-Bis-(4-chloro-phenyl)-1H-imidazol-2-ylsulfa...)
Show SMILES CC(C)(C)OC(=O)CC(C)(O)CC(O)CSc1nc(c([nH]1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H30Cl2N2O4S/c1-25(2,3)34-21(32)14-26(4,33)13-20(31)15-35-24-29-22(16-5-9-18(27)10-6-16)23(30-24)17-7-11-19(28)12-8-17/h5-12,20,31,33H,13-15H2,1-4H3,(H,29,30)
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n/an/a 250n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003820
PNG
(2-(2,2-Diethoxy-ethylsulfanyl)-4,5-diphenyl-1H-imi...)
Show SMILES CCOC(CSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)OCC
Show InChI InChI=1S/C21H24N2O2S/c1-3-24-18(25-4-2)15-26-21-22-19(16-11-7-5-8-12-16)20(23-21)17-13-9-6-10-14-17/h5-14,18H,3-4,15H2,1-2H3,(H,22,23)
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n/an/a 250n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003826
PNG
(2-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-6-...)
Show SMILES CO[C@H]1C[C@@](C)(O)C[C@H](CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)O1
Show InChI InChI=1S/C23H26N2O3S/c1-23(26)13-18(28-19(14-23)27-2)15-29-22-24-20(16-9-5-3-6-10-16)21(25-22)17-11-7-4-8-12-17/h3-12,18-19,26H,13-15H2,1-2H3,(H,24,25)/t18-,19-,23+/m1/s1
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n/an/a 280n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003806
PNG
(6-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-3,5-dihy...)
Show SMILES CCOC(=O)CC(C)(O)CC(O)CSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H28N2O4S/c1-3-30-20(28)15-24(2,29)14-19(27)16-31-23-25-21(17-10-6-4-7-11-17)22(26-23)18-12-8-5-9-13-18/h4-13,19,27,29H,3,14-16H2,1-2H3,(H,25,26)
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n/an/a 280n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003837
PNG
(6-(4,5-Di-p-tolyl-1H-imidazol-2-ylsulfanylmethyl)-...)
Show SMILES CC1=CC(=O)OC(CSc2nc(c([nH]2)-c2ccc(C)cc2)-c2ccc(C)cc2)C1
Show InChI InChI=1S/C24H24N2O2S/c1-15-4-8-18(9-5-15)22-23(19-10-6-16(2)7-11-19)26-24(25-22)29-14-20-12-17(3)13-21(27)28-20/h4-11,13,20H,12,14H2,1-3H3,(H,25,26)
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n/an/a 280n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003805
PNG
(2-Benzylsulfanyl-4,5-diphenyl-1H-imidazole | CHEMB...)
Show SMILES C(Sc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H18N2S/c1-4-10-17(11-5-1)16-25-22-23-20(18-12-6-2-7-13-18)21(24-22)19-14-8-3-9-15-19/h1-15H,16H2,(H,23,24)
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n/an/a 290n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003809
PNG
(6-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulf...)
Show SMILES COc1ccc(cc1)-c1nc(SCC2C[C@@](C)(O)CC(=O)O2)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C24H26N2O5S/c1-24(28)12-19(31-20(27)13-24)14-32-23-25-21(15-4-8-17(29-2)9-5-15)22(26-23)16-6-10-18(30-3)11-7-16/h4-11,19,28H,12-14H2,1-3H3,(H,25,26)/t19?,24-/m1/s1
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n/an/a 340n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003832
PNG
(5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-py...)
Show SMILES O=C1CCC(CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)N1
Show InChI InChI=1S/C20H19N3OS/c24-17-12-11-16(21-17)13-25-20-22-18(14-7-3-1-4-8-14)19(23-20)15-9-5-2-6-10-15/h1-10,16H,11-13H2,(H,21,24)(H,22,23)
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n/an/a 360n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003821
PNG
(6-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulf...)
Show SMILES COc1ccc(cc1)-c1nc(SCC2C[C@](C)(O)CC(=O)O2)[nH]c1-c1ccc(OC)cc1
Show InChI InChI=1S/C24H26N2O5S/c1-24(28)12-19(31-20(27)13-24)14-32-23-25-21(15-4-8-17(29-2)9-5-15)22(26-23)16-6-10-18(30-3)11-7-16/h4-11,19,28H,12-14H2,1-3H3,(H,25,26)/t19?,24-/m0/s1
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n/an/a 420n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003841
PNG
(6-[4,5-Bis-(3-chloro-phenyl)-1H-imidazol-2-ylsulfa...)
Show SMILES CC1=CC(=O)OC(CSc2nc(c([nH]2)-c2cccc(Cl)c2)-c2cccc(Cl)c2)C1
Show InChI InChI=1S/C22H18Cl2N2O2S/c1-13-8-18(28-19(27)9-13)12-29-22-25-20(14-4-2-6-16(23)10-14)21(26-22)15-5-3-7-17(24)11-15/h2-7,9-11,18H,8,12H2,1H3,(H,25,26)
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n/an/a 440n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003816
PNG
(2-([1,3]Dioxolan-2-ylmethylsulfanyl)-4,5-diphenyl-...)
Show SMILES C(Sc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)C1OCCO1
Show InChI InChI=1S/C19H18N2O2S/c1-3-7-14(8-4-1)17-18(15-9-5-2-6-10-15)21-19(20-17)24-13-16-22-11-12-23-16/h1-10,16H,11-13H2,(H,20,21)
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n/an/a 530n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003831
PNG
(4-(3-Chloro-phenyl)-5-phenyl-2-(tetrahydro-pyran-2...)
Show SMILES Clc1cccc(c1)-c1[nH]c(SCC2CCCCO2)nc1-c1ccccc1
Show InChI InChI=1S/C21H21ClN2OS/c22-17-10-6-9-16(13-17)20-19(15-7-2-1-3-8-15)23-21(24-20)26-14-18-11-4-5-12-25-18/h1-3,6-10,13,18H,4-5,11-12,14H2,(H,23,24)
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n/an/a 560n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003824
PNG
(6-[4,5-Bis-(3-methoxy-phenyl)-1H-imidazol-2-ylsulf...)
Show SMILES COc1cccc(c1)-c1nc(SCC2C[C@](C)(O)CC(=O)O2)[nH]c1-c1cccc(OC)c1
Show InChI InChI=1S/C24H26N2O5S/c1-24(28)12-19(31-20(27)13-24)14-32-23-25-21(15-6-4-8-17(10-15)29-2)22(26-23)16-7-5-9-18(11-16)30-3/h4-11,19,28H,12-14H2,1-3H3,(H,25,26)/t19?,24-/m0/s1
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n/an/a 570n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003822
PNG
(2-(2,2-Dimethoxy-ethylsulfanyl)-4,5-diphenyl-1H-im...)
Show SMILES COC(CSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)OC
Show InChI InChI=1S/C19H20N2O2S/c1-22-16(23-2)13-24-19-20-17(14-9-5-3-6-10-14)18(21-19)15-11-7-4-8-12-15/h3-12,16H,13H2,1-2H3,(H,20,21)
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n/an/a 580n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003828
PNG
(6-[4,5-Bis-(4-fluoro-phenyl)-1H-imidazol-2-ylsulfa...)
Show SMILES CC1=CC(=O)OC(CSc2nc(c([nH]2)-c2ccc(F)cc2)-c2ccc(F)cc2)C1
Show InChI InChI=1S/C22H18F2N2O2S/c1-13-10-18(28-19(27)11-13)12-29-22-25-20(14-2-6-16(23)7-3-14)21(26-22)15-4-8-17(24)9-5-15/h2-9,11,18H,10,12H2,1H3,(H,25,26)
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n/an/a 610n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003810
PNG
(6-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-pi...)
Show SMILES O=C1CCCC(CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)N1
Show InChI InChI=1S/C21H21N3OS/c25-18-13-7-12-17(22-18)14-26-21-23-19(15-8-3-1-4-9-15)20(24-21)16-10-5-2-6-11-16/h1-6,8-11,17H,7,12-14H2,(H,22,25)(H,23,24)
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n/an/a 610n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003833
PNG
(2-(2-[1,3]Dioxan-2-yl-ethylsulfanyl)-4,5-diphenyl-...)
Show SMILES C(CC1OCCCO1)Sc1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H22N2O2S/c1-3-8-16(9-4-1)19-20(17-10-5-2-6-11-17)23-21(22-19)26-15-12-18-24-13-7-14-25-18/h1-6,8-11,18H,7,12-15H2,(H,22,23)
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n/an/a 730n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003844
PNG
(6-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-te...)
Show SMILES O=C1CCCC(CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)O1
Show InChI InChI=1S/C21H20N2O2S/c24-18-13-7-12-17(25-18)14-26-21-22-19(15-8-3-1-4-9-15)20(23-21)16-10-5-2-6-11-16/h1-6,8-11,17H,7,12-14H2,(H,22,23)
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n/an/a 740n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003840
PNG
(2-Ethylsulfanyl-4,5-diphenyl-1H-imidazole | CHEMBL...)
Show SMILES CCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C17H16N2S/c1-2-20-17-18-15(13-9-5-3-6-10-13)16(19-17)14-11-7-4-8-12-14/h3-12H,2H2,1H3,(H,18,19)
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n/an/a 770n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003823
PNG
(6-[4,5-Bis-(4-fluoro-phenyl)-1H-imidazol-2-ylsulfa...)
Show SMILES C[C@]1(O)CC(CSc2nc(c([nH]2)-c2ccc(F)cc2)-c2ccc(F)cc2)OC(=O)C1
Show InChI InChI=1S/C22H20F2N2O3S/c1-22(28)10-17(29-18(27)11-22)12-30-21-25-19(13-2-6-15(23)7-3-13)20(26-21)14-4-8-16(24)9-5-14/h2-9,17,28H,10-12H2,1H3,(H,25,26)/t17?,22-/m0/s1
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n/an/a 790n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003843
PNG
(6-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-4-...)
Show SMILES OC1CC(CSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)OC(=O)C1
Show InChI InChI=1S/C21H20N2O3S/c24-16-11-17(26-18(25)12-16)13-27-21-22-19(14-7-3-1-4-8-14)20(23-21)15-9-5-2-6-10-15/h1-10,16-17,24H,11-13H2,(H,22,23)
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n/an/a 910n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50368460
PNG
(CHEMBL1794869)
Show SMILES C[C@@]1(O)C[C@H](CSc2nc(c([nH]2)-c2ccc(cc2)C(F)(F)F)-c2ccc(cc2)C(F)(F)F)OC(=O)C1
Show InChI InChI=1S/C24H20F6N2O3S/c1-22(34)10-17(35-18(33)11-22)12-36-21-31-19(13-2-6-15(7-3-13)23(25,26)27)20(32-21)14-4-8-16(9-5-14)24(28,29)30/h2-9,17,34H,10-12H2,1H3,(H,31,32)/t17-,22-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003827
PNG
(6-[4,5-Bis-(2-chloro-phenyl)-1H-imidazol-2-ylsulfa...)
Show SMILES CC1=CC(=O)OC(CSc2nc(c([nH]2)-c2ccccc2Cl)-c2ccccc2Cl)C1
Show InChI InChI=1S/C22H18Cl2N2O2S/c1-13-10-14(28-19(27)11-13)12-29-22-25-20(15-6-2-4-8-17(15)23)21(26-22)16-7-3-5-9-18(16)24/h2-9,11,14H,10,12H2,1H3,(H,25,26)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50368462
PNG
(CHEMBL1794870)
Show SMILES Cn1c(SC[C@H]2C[C@](C)(O)CC(=O)O2)nc(c1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H24N2O3S/c1-23(27)13-18(28-19(26)14-23)15-29-22-24-20(16-9-5-3-6-10-16)21(25(22)2)17-11-7-4-8-12-17/h3-12,18,27H,13-15H2,1-2H3/t18-,23+/m1/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%