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PubMed code 1447743

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-gated L-type calcium channel


(Rattus norvegicus-RAT)		BDBM50230150
PNG
(CHEMBL345052)
Show SMILES OC(COc1cccc2oc(cc12)C#N)CN1CCN(CC1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H29N3O3/c30-19-25-18-26-27(12-7-13-28(26)35-25)34-21-24(33)20-31-14-16-32(17-15-31)29(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,18,24,29,33H,14-17,20-21H2
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Article
PubMed
n/an/a>5.00E+6n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranes

J Med Chem 35: 4442-9 (1992)


Article DOI: 10.1021/jm00101a022
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus-RAT)		BDBM50230151
PNG
(CHEMBL136313)
Show SMILES OC(COc1ccnc2ccccc12)CN1CCN(CC1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H31N3O2/c33-25(22-34-28-15-16-30-27-14-8-7-13-26(27)28)21-31-17-19-32(20-18-31)29(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-16,25,29,33H,17-22H2
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n/an/a>5.00E+6n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranes

J Med Chem 35: 4442-9 (1992)


Article DOI: 10.1021/jm00101a022
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus-RAT)		BDBM50001689
PNG
(4-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropoxy...)
Show SMILES OC(COc1cccc2[nH]c(cc12)C#N)CN1CCN(CC1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H30N4O2/c30-19-24-18-26-27(31-24)12-7-13-28(26)35-21-25(34)20-32-14-16-33(17-15-32)29(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,18,25,29,31,34H,14-17,20-21H2
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PubMed
n/an/a 5.00E+6n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranes

J Med Chem 35: 4442-9 (1992)


Article DOI: 10.1021/jm00101a022
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%