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PubMed code 14552778

Compile data set for download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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PubMed
0.309n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
Cataleptogenic effect against cloned human Dopamine receptor D2 in male Sprague-Dawley rats in a bar test


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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PubMed
0.310n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]-spiperone to cloned human Dopamine receptor D2 using apomorphine induced climbing test in male Swiss ...


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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0.708n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
Cataleptogenic effect against cloned human Dopamine receptor D3 in male Sprague-Dawley rats in a bar test


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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0.710n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]-7-OH-DPAT to cloned human Dopamine receptor D3 using apomorphine induced climbing test in male Swiss ...


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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0.890n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to cloned human Dopamine receptor D2 using apomorphine induced climbing test in male Swiss m...


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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0.891n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]-spiperone to cloned human Dopamine receptor D2 using apomorphine induced climbing test in male Swiss ...


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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4.60n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
Cataleptogenic effect against cloned human Dopamine receptor D3 in male Sprague-Dawley rats in a bar test


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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4.60n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]-7-OH-DPAT to cloned human Dopamine receptor D3 using apomorphine induced climbing test in male Swiss ...


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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10n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
Cataleptogenic effect against cloned human dopamine receptor D4 in male Sprague-Dawley rats in a bar test


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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10n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]-spiperone to cloned human dopamine receptor D4 using apomorphine induced climbing test in male Swiss ...


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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12n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]-spiperone to cloned human dopamine receptor D4 using apomorphine induced climbing test in male Swiss ...


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50185473
PNG
(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Show SMILES OC1(CC2CCC(C1)N2CCCC(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2
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12n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
Cataleptogenic effect against cloned human dopamine receptor D4 in male Sprague-Dawley rats in a bar test


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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54n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]-spiperone to cloned human dopamine receptor D4 using apomorphine induced climbing test in male Swiss ...


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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54n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]spiperone to cloned human dopamine receptor D4 using apomorphine induced climbing test in male Swiss m...


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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130n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]-spiperone to cloned human Dopamine receptor D2 using apomorphine induced climbing test in male Swiss ...


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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135n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
Cataleptogenic effect against cloned human Dopamine receptor D2 in male Sprague-Dawley rats in a bar test


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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240n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
Cataleptogenic effect against cloned human Dopamine receptor D3 in male Sprague-Dawley rats in a bar test


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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240n/an/an/an/an/an/an/an/a



Florida A & M University

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [3H]-7-OH-DPAT to cloned human Dopamine receptor D3 using apomorphine induced climbing test in male Swiss ...


Bioorg Med Chem Lett 13: 3779-82 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.015
BindingDB Entry DOI: 10.7270/Q2BK1BQH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%