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PubMed code 14684331

Compile data set for download or QSAR
Found 24 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM50094392
PNG
(2,3,4,5,6-Pentafluoro-N-(3-methyl-5-sulfamoyl-3H-[...)
Show SMILES Cn1nc(s\c1=N\C(=O)c1c(F)c(F)c(F)c(F)c1F)S(N)(=O)=O
Show InChI InChI=1S/C10H5F5N4O3S2/c1-19-9(23-10(18-19)24(16,21)22)17-8(20)2-3(11)5(13)7(15)6(14)4(2)12/h1H3,(H2,16,21,22)/b17-9+
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1.5n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase II


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM11635
PNG
(4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamid...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)c2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C15H17N3O5S2/c16-24(20,21)13-5-1-11(2-6-13)9-10-18-15(19)12-3-7-14(8-4-12)25(17,22)23/h1-8H,9-10H2,(H,18,19)(H2,16,20,21)(H2,17,22,23)
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5n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase II


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM10887
PNG
(Sulfamate 7 | Topiramate (TPM) | [(1R,2S,6S,9R)-4,...)
Show SMILES CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1
Show InChI InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
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5n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase II


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase IV


(Bos taurus (bovine))
BDBM50094392
PNG
(2,3,4,5,6-Pentafluoro-N-(3-methyl-5-sulfamoyl-3H-[...)
Show SMILES Cn1nc(s\c1=N\C(=O)c1c(F)c(F)c(F)c(F)c1F)S(N)(=O)=O
Show InChI InChI=1S/C10H5F5N4O3S2/c1-19-9(23-10(18-19)24(16,21)22)17-8(20)2-3(11)5(13)7(15)6(14)4(2)12/h1H3,(H2,16,21,22)/b17-9+
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8n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against bovine carbonic anhydrase IV


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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12n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase II


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase IV


(Bos taurus (bovine))
BDBM11635
PNG
(4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamid...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)c2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C15H17N3O5S2/c16-24(20,21)13-5-1-11(2-6-13)9-10-18-15(19)12-3-7-14(8-4-12)25(17,22)23/h1-8H,9-10H2,(H,18,19)(H2,16,20,21)(H2,17,22,23)
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13n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against bovine carbonic anhydrase IV


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM10881
PNG
(CHEMBL288100 | METHAZOLAMIDE | MZA3 | Methazolamid...)
Show SMILES CC(=O)N=c1sc(nn1C)S(N)(=O)=O
Show InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)
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14n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase II


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM50137674
PNG
(Benzene-1,4-disulfonic acid 1-amide 4-[(3-chloro-1...)
Show SMILES NS(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2[nH]cc(Cl)c12
Show InChI InChI=1S/C14H12ClN3O4S2/c15-11-8-17-12-2-1-3-13(14(11)12)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
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15n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase II


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (human))
BDBM11635
PNG
(4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamid...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)c2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C15H17N3O5S2/c16-24(20,21)13-5-1-11(2-6-13)9-10-18-15(19)12-3-7-14(8-4-12)25(17,22)23/h1-8H,9-10H2,(H,18,19)(H2,16,20,21)(H2,17,22,23)
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18n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase IX


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (human))
BDBM50137674
PNG
(Benzene-1,4-disulfonic acid 1-amide 4-[(3-chloro-1...)
Show SMILES NS(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2[nH]cc(Cl)c12
Show InChI InChI=1S/C14H12ClN3O4S2/c15-11-8-17-12-2-1-3-13(14(11)12)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
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24n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase IX


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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25n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase IX


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 9


(Homo sapiens (human))
BDBM10881
PNG
(CHEMBL288100 | METHAZOLAMIDE | MZA3 | Methazolamid...)
Show SMILES CC(=O)N=c1sc(nn1C)S(N)(=O)=O
Show InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)
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27n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase IX


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (human))
BDBM50094392
PNG
(2,3,4,5,6-Pentafluoro-N-(3-methyl-5-sulfamoyl-3H-[...)
Show SMILES Cn1nc(s\c1=N\C(=O)c1c(F)c(F)c(F)c(F)c1F)S(N)(=O)=O
Show InChI InChI=1S/C10H5F5N4O3S2/c1-19-9(23-10(18-19)24(16,21)22)17-8(20)2-3(11)5(13)7(15)6(14)4(2)12/h1H3,(H2,16,21,22)/b17-9+
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29n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase IX


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Homo sapiens (human))
BDBM50137674
PNG
(Benzene-1,4-disulfonic acid 1-amide 4-[(3-chloro-1...)
Show SMILES NS(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2[nH]cc(Cl)c12
Show InChI InChI=1S/C14H12ClN3O4S2/c15-11-8-17-12-2-1-3-13(14(11)12)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
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31n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase I


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic Anhydrase IV


(Bos taurus (bovine))
BDBM10881
PNG
(CHEMBL288100 | METHAZOLAMIDE | MZA3 | Methazolamid...)
Show SMILES CC(=O)N=c1sc(nn1C)S(N)(=O)=O
Show InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)
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36n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against bovine carbonic anhydrase IV


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Homo sapiens (human))
BDBM11635
PNG
(4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamid...)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)c2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C15H17N3O5S2/c16-24(20,21)13-5-1-11(2-6-13)9-10-18-15(19)12-3-7-14(8-4-12)25(17,22)23/h1-8H,9-10H2,(H,18,19)(H2,16,20,21)(H2,17,22,23)
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40n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase I


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Homo sapiens (human))
BDBM10881
PNG
(CHEMBL288100 | METHAZOLAMIDE | MZA3 | Methazolamid...)
Show SMILES CC(=O)N=c1sc(nn1C)S(N)(=O)=O
Show InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)
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50n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase I


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase IV


(Bos taurus (bovine))
BDBM10887
PNG
(Sulfamate 7 | Topiramate (TPM) | [(1R,2S,6S,9R)-4,...)
Show SMILES CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1
Show InChI InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
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54n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against bovine carbonic anhydrase IV


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (human))
BDBM10887
PNG
(Sulfamate 7 | Topiramate (TPM) | [(1R,2S,6S,9R)-4,...)
Show SMILES CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1
Show InChI InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
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58n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase IX


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic Anhydrase IV


(Bos taurus (bovine))
BDBM50137674
PNG
(Benzene-1,4-disulfonic acid 1-amide 4-[(3-chloro-1...)
Show SMILES NS(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2[nH]cc(Cl)c12
Show InChI InChI=1S/C14H12ClN3O4S2/c15-11-8-17-12-2-1-3-13(14(11)12)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
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65n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against bovine carbonic anhydrase IV


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic Anhydrase IV


(Bos taurus (bovine))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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70n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against bovine carbonic anhydrase IV


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
Carbonic anhydrase


(Homo sapiens (human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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250n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase I


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase


(Homo sapiens (human))
BDBM10887
PNG
(Sulfamate 7 | Topiramate (TPM) | [(1R,2S,6S,9R)-4,...)
Show SMILES CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1
Show InChI InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
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250n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase I


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase


(Homo sapiens (human))
BDBM50094392
PNG
(2,3,4,5,6-Pentafluoro-N-(3-methyl-5-sulfamoyl-3H-[...)
Show SMILES Cn1nc(s\c1=N\C(=O)c1c(F)c(F)c(F)c(F)c1F)S(N)(=O)=O
Show InChI InChI=1S/C10H5F5N4O3S2/c1-19-9(23-10(18-19)24(16,21)22)17-8(20)2-3(11)5(13)7(15)6(14)4(2)12/h1H3,(H2,16,21,22)/b17-9+
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270n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition against human carbonic anhydrase I


Bioorg Med Chem Lett 14: 217-23 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.062
BindingDB Entry DOI: 10.7270/Q2154HMF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%