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PubMed code 1469687

Compile data set for download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421981
PNG
(CHEMBL607877)
Show SMILES CC(C)N=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C13H19N7O4/c1-5(2)18-19-13-16-10(14)7-11(17-13)20(4-15-7)12-9(23)8(22)6(3-21)24-12/h4-6,8-9,12,21-23H,3H2,1-2H3,(H2,14,16,17)/t6-,8-,9-,12?/m1/s1
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n/an/an/an/a 1.20E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421983
PNG
(CHEMBL608966)
Show SMILES Nc1nc(N=NCCCC2CCCCC2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C19H29N7O4/c20-16-13-17(26(10-21-13)18-15(29)14(28)12(9-27)30-18)24-19(23-16)25-22-8-4-7-11-5-2-1-3-6-11/h10-12,14-15,18,27-29H,1-9H2,(H2,20,23,24)/t12-,14-,15-,18?/m1/s1
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n/an/an/an/a 6.61E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421987
PNG
(CHEMBL611919)
Show SMILES CCC(CC)N=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C15H23N7O4/c1-3-7(4-2)20-21-15-18-12(16)9-13(19-15)22(6-17-9)14-11(25)10(24)8(5-23)26-14/h6-8,10-11,14,23-25H,3-5H2,1-2H3,(H2,16,18,19)/t8-,10-,11-,14?/m1/s1
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n/an/an/an/a 8.91E+3n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50364045
PNG
(CHEMBL1950554)
Show SMILES Nc1nc(N=NCC2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H25N7O4/c18-14-11-15(22-17(21-14)23-20-6-9-4-2-1-3-5-9)24(8-19-11)16-13(27)12(26)10(7-25)28-16/h8-10,12-13,16,25-27H,1-7H2,(H2,18,21,22)/t10-,12-,13-,16-/m1/s1
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n/an/an/an/a 3.55E+3n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421973
PNG
(CHEMBL610727)
Show SMILES CC(C)(C)CN=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C15H23N7O4/c1-15(2,3)5-18-21-14-19-11(16)8-12(20-14)22(6-17-8)13-10(25)9(24)7(4-23)26-13/h6-7,9-10,13,23-25H,4-5H2,1-3H3,(H2,16,19,20)/t7-,9-,10-,13?/m1/s1
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n/an/an/an/a 2.51E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421976
PNG
(CHEMBL607796)
Show SMILES Nc1nc(N=NCC2=CCCCC2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H23N7O4/c18-14-11-15(22-17(21-14)23-20-6-9-4-2-1-3-5-9)24(8-19-11)16-13(27)12(26)10(7-25)28-16/h4,8,10,12-13,16,25-27H,1-3,5-7H2,(H2,18,21,22)/t10-,12-,13-,16?/m1/s1
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n/an/an/an/a 1.74E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421980
PNG
(CHEMBL2113592)
Show SMILES CC(C)CCN=Nc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C15H23N7O4/c1-7(2)3-4-18-21-15-19-12(16)9-13(20-15)22(6-17-9)14-11(25)10(24)8(5-23)26-14/h6-8,10-11,14,23-25H,3-5H2,1-2H3,(H2,16,19,20)/t8-,10-,11-,14-/m1/s1
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n/an/an/an/a 2.09E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421984
PNG
(CHEMBL607599)
Show SMILES CC(C)CN=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C14H21N7O4/c1-6(2)3-17-20-14-18-11(15)8-12(19-14)21(5-16-8)13-10(24)9(23)7(4-22)25-13/h5-7,9-10,13,22-24H,3-4H2,1-2H3,(H2,15,18,19)/t7-,9-,10-,13?/m1/s1
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n/an/an/an/a 1.26E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421972
PNG
(CHEMBL611921)
Show SMILES CCCC(C)N=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C15H23N7O4/c1-3-4-7(2)20-21-15-18-12(16)9-13(19-15)22(6-17-9)14-11(25)10(24)8(5-23)26-14/h6-8,10-11,14,23-25H,3-5H2,1-2H3,(H2,16,18,19)/t7?,8-,10-,11-,14?/m1/s1
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n/an/an/an/a 1.66E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421977
PNG
(CHEMBL609231)
Show SMILES CCCN=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C13H19N7O4/c1-2-3-16-19-13-17-10(14)7-11(18-13)20(5-15-7)12-9(23)8(22)6(4-21)24-12/h5-6,8-9,12,21-23H,2-4H2,1H3,(H2,14,17,18)/t6-,8-,9-,12?/m1/s1
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n/an/an/an/a 1.35E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421985
PNG
(CHEMBL611916)
Show SMILES CCCCCN=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C15H23N7O4/c1-2-3-4-5-18-21-15-19-12(16)9-13(20-15)22(7-17-9)14-11(25)10(24)8(6-23)26-14/h7-8,10-11,14,23-25H,2-6H2,1H3,(H2,16,19,20)/t8-,10-,11-,14?/m1/s1
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n/an/an/an/a 2.51E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421975
PNG
(CHEMBL611607)
Show SMILES Nc1nc(N=NCC2CCC=CC2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H23N7O4/c18-14-11-15(22-17(21-14)23-20-6-9-4-2-1-3-5-9)24(8-19-11)16-13(27)12(26)10(7-25)28-16/h1-2,8-10,12-13,16,25-27H,3-7H2,(H2,18,21,22)/t9?,10-,12-,13-,16?/m1/s1
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n/an/an/an/a 7.24E+3n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50009509
PNG
((CGS 22,492) 2-[6-Amino-2-(2-cyclohexyl-ethylamino...)
Show SMILES Nc1nc(NCCC2CCCCC2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H28N6O4/c19-15-12-16(23-18(22-15)20-7-6-10-4-2-1-3-5-10)24(9-21-12)17-14(27)13(26)11(8-25)28-17/h9-11,13-14,17,25-27H,1-8H2,(H3,19,20,22,23)/t11-,13-,14-,17?/m1/s1
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n/an/an/an/a 1.23E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50009535
PNG
((CGS 22,989) 2-[6-Amino-2-(2-cyclohex-1-enyl-ethyl...)
Show SMILES Nc1nc(NCCC2=CCCCC2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H26N6O4/c19-15-12-16(23-18(22-15)20-7-6-10-4-2-1-3-5-10)24(9-21-12)17-14(27)13(26)11(8-25)28-17/h4,9,11,13-14,17,25-27H,1-3,5-8H2,(H3,19,20,22,23)/t11-,13-,14-,17?/m1/s1
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n/an/an/an/a 2.29E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421986
PNG
(CHEMBL610443)
Show SMILES Nc1nc(N=NCC2=CC3CCC2C3)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H23N7O4/c19-15-12-16(25(7-20-12)17-14(28)13(27)11(6-26)29-17)23-18(22-15)24-21-5-10-4-8-1-2-9(10)3-8/h4,7-9,11,13-14,17,26-28H,1-3,5-6H2,(H2,19,22,23)/t8?,9?,11-,13-,14-,17?/m1/s1
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n/an/an/an/a 2.04E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50368478
PNG
(CHEMBL610444)
Show SMILES NNc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C10H15N7O4/c11-7-4-8(15-10(14-7)16-12)17(2-13-4)9-6(20)5(19)3(1-18)21-9/h2-3,5-6,9,18-20H,1,12H2,(H3,11,14,15,16)/t3-,5-,6-,9?/m1/s1
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n/an/an/an/a 2.00E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421971
PNG
(CHEMBL611917)
Show SMILES CC1(C)C2CC1C(CN=Nc1nc(N)c3ncn(C4O[C@H](CO)[C@@H](O)[C@H]4O)c3n1)=CC2
Show InChI InChI=1S/C20H27N7O4/c1-20(2)10-4-3-9(11(20)5-10)6-23-26-19-24-16(21)13-17(25-19)27(8-22-13)18-15(30)14(29)12(7-28)31-18/h3,8,10-12,14-15,18,28-30H,4-7H2,1-2H3,(H2,21,24,25)/t10?,11?,12-,14-,15-,18?/m1/s1
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n/an/an/an/a 2.57E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421974
PNG
(CHEMBL607873)
Show SMILES CCN=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C12H17N7O4/c1-2-15-18-12-16-9(13)6-10(17-12)19(4-14-6)11-8(22)7(21)5(3-20)23-11/h4-5,7-8,11,20-22H,2-3H2,1H3,(H2,13,16,17)/t5-,7-,8-,11?/m1/s1
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n/an/an/an/a 3.63E+3n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421978
PNG
(CHEMBL611314)
Show SMILES CCC(CC)CN=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C16H25N7O4/c1-3-8(4-2)5-19-22-16-20-13(17)10-14(21-16)23(7-18-10)15-12(26)11(25)9(6-24)27-15/h7-9,11-12,15,24-26H,3-6H2,1-2H3,(H2,17,20,21)/t9-,11-,12-,15?/m1/s1
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n/an/an/an/a 1.10E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421979
PNG
(CHEMBL607585)
Show SMILES CCCCN=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C14H21N7O4/c1-2-3-4-17-20-14-18-11(15)8-12(19-14)21(6-16-8)13-10(24)9(23)7(5-22)25-13/h6-7,9-10,13,22-24H,2-5H2,1H3,(H2,15,18,19)/t7-,9-,10-,13?/m1/s1
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n/an/an/an/a 1.15E+4n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
Adenosine A1 receptor


(GUINEA PIG)
BDBM50421982
PNG
(CHEMBL608663)
Show SMILES Nc1nc(N=NCCC2CCCCC2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H27N7O4/c19-15-12-16(25(9-20-12)17-14(28)13(27)11(8-26)29-17)23-18(22-15)24-21-7-6-10-4-2-1-3-5-10/h9-11,13-14,17,26-28H,1-8H2,(H2,19,22,23)/t11-,13-,14-,17?/m1/s1
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n/an/an/an/a 9.77E+3n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro prolonging of the stimulus-QRS interval in guinea pig heart.


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%