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PubMed code 15006407

Compile data set for download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50141580
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-8-ethyl-3-hydro...)
Show SMILES CCc1cc(cc2c(NCc3ccc(OC)c(Cl)c3)c(CO)cnc12)C#N
Show InChI InChI=1S/C21H20ClN3O2/c1-3-15-6-14(9-23)7-17-20(15)25-11-16(12-26)21(17)24-10-13-4-5-19(27-2)18(22)8-13/h4-8,11,26H,3,10,12H2,1-2H3,(H,24,25)
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n/an/a 0.0500n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 from human platelets


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50141584
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-8-ethyl-quinoli...)
Show SMILES CCc1cc(cc2c(NCc3ccc(OC)c(Cl)c3)ccnc12)C#N
Show InChI InChI=1S/C20H18ClN3O/c1-3-15-8-14(11-22)9-16-18(6-7-23-20(15)16)24-12-13-4-5-19(25-2)17(21)10-13/h4-10H,3,12H2,1-2H3,(H,23,24)
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n/an/a 0.400n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 from human platelets


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50141588
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-3-hydroxymethyl...)
Show SMILES COc1ccc(CNc2c(CO)cnc3ccc(cc23)C#N)cc1Cl
Show InChI InChI=1S/C19H16ClN3O2/c1-25-18-5-3-13(7-16(18)20)9-23-19-14(11-24)10-22-17-4-2-12(8-21)6-15(17)19/h2-7,10,24H,9,11H2,1H3,(H,22,23)
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n/an/a 0.480n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 from human platelets


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50141586
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-6-cyano-8-ethyl...)
Show SMILES CCc1cc(cc2c(NCc3ccc(OC)c(Cl)c3)c(cnc12)C(=O)NCc1ccccn1)C#N
Show InChI InChI=1S/C27H24ClN5O2/c1-3-19-10-18(13-29)11-21-25(19)32-16-22(27(34)33-15-20-6-4-5-9-30-20)26(21)31-14-17-7-8-24(35-2)23(28)12-17/h4-12,16H,3,14-15H2,1-2H3,(H,31,32)(H,33,34)
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n/an/a 0.550n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 from human platelets


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50141583
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-6-cyano-8-ethyl...)
Show SMILES CCOC(=O)c1cnc2c(CC)cc(cc2c1NCc1ccc(OC)c(Cl)c1)C#N
Show InChI InChI=1S/C23H22ClN3O3/c1-4-16-8-15(11-25)9-17-21(16)27-13-18(23(28)30-5-2)22(17)26-12-14-6-7-20(29-3)19(24)10-14/h6-10,13H,4-5,12H2,1-3H3,(H,26,27)
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n/an/a 0.600n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 from human platelets


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50141587
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-6-cyano-quinoli...)
Show SMILES COc1ccc(CNc2c(cnc3ccc(cc23)C#N)C(=O)NCc2ccccn2)cc1Cl
Show InChI InChI=1S/C25H20ClN5O2/c1-33-23-8-6-17(11-21(23)26)13-30-24-19-10-16(12-27)5-7-22(19)29-15-20(24)25(32)31-14-18-4-2-3-9-28-18/h2-11,15H,13-14H2,1H3,(H,29,30)(H,31,32)
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n/an/a 1.30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 from human platelets


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50141582
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-quinoline-6-car...)
Show SMILES COc1ccc(CNc2ccnc3ccc(cc23)C#N)cc1Cl
Show InChI InChI=1S/C18H14ClN3O/c1-23-18-5-3-13(9-15(18)19)11-22-17-6-7-21-16-4-2-12(10-20)8-14(16)17/h2-9H,11H2,1H3,(H,21,22)
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n/an/a 1.40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 from human platelets


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14390
PNG
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
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n/an/a 1.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 from human platelets


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50141579
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-6-cyano-quinoli...)
Show SMILES CCOC(=O)c1cnc2ccc(cc2c1NCc1ccc(OC)c(Cl)c1)C#N
Show InChI InChI=1S/C21H18ClN3O3/c1-3-28-21(26)16-12-24-18-6-4-13(10-23)8-15(18)20(16)25-11-14-5-7-19(27-2)17(22)9-14/h4-9,12H,3,11H2,1-2H3,(H,24,25)
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 from human platelets


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50141585
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-6-trifluorometh...)
Show SMILES CCOC(=O)c1cnc2ccc(cc2c1NCc1ccc(OC)c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C21H18ClF3N2O3/c1-3-30-20(28)15-11-26-17-6-5-13(21(23,24)25)9-14(17)19(15)27-10-12-4-7-18(29-2)16(22)8-12/h4-9,11H,3,10H2,1-2H3,(H,26,27)
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n/an/a 73n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 from human platelets


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50141581
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-7-trifluorometh...)
Show SMILES CCOC(=O)c1cnc2cc(ccc2c1NCc1ccc(OC)c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C21H18ClF3N2O3/c1-3-30-20(28)15-11-26-17-9-13(21(23,24)25)5-6-14(17)19(15)27-10-12-4-7-18(29-2)16(22)8-12/h4-9,11H,3,10H2,1-2H3,(H,26,27)
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n/an/a 160n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 from human platelets


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50141581
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-7-trifluorometh...)
Show SMILES CCOC(=O)c1cnc2cc(ccc2c1NCc1ccc(OC)c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C21H18ClF3N2O3/c1-3-30-20(28)15-11-26-17-9-13(21(23,24)25)5-6-14(17)19(15)27-10-12-4-7-18(29-2)16(22)8-12/h4-9,11H,3,10H2,1-2H3,(H,26,27)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 6


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50141581
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-7-trifluorometh...)
Show SMILES CCOC(=O)c1cnc2cc(ccc2c1NCc1ccc(OC)c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C21H18ClF3N2O3/c1-3-30-20(28)15-11-26-17-9-13(21(23,24)25)5-6-14(17)19(15)27-10-12-4-7-18(29-2)16(22)8-12/h4-9,11H,3,10H2,1-2H3,(H,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of compound against phosphodiesterase 3 was tested


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Bos taurus-BOVINE)
BDBM50141581
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-7-trifluorometh...)
Show SMILES CCOC(=O)c1cnc2cc(ccc2c1NCc1ccc(OC)c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C21H18ClF3N2O3/c1-3-30-20(28)15-11-26-17-9-13(21(23,24)25)5-6-14(17)19(15)27-10-12-4-7-18(29-2)16(22)8-12/h4-9,11H,3,10H2,1-2H3,(H,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 1 of bovine heart


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50141581
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-7-trifluorometh...)
Show SMILES CCOC(=O)c1cnc2cc(ccc2c1NCc1ccc(OC)c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C21H18ClF3N2O3/c1-3-30-20(28)15-11-26-17-9-13(21(23,24)25)5-6-14(17)19(15)27-10-12-4-7-18(29-2)16(22)8-12/h4-9,11H,3,10H2,1-2H3,(H,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 2


Bioorg Med Chem Lett 14: 1577-80 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.090
BindingDB Entry DOI: 10.7270/Q2G1607Q
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%