Affinity Data by PubMed id=1507199

PubMed code 1507199

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Muscarinic acetylcholine receptor M2 and M4 (Homo sapiens (Human))	BDBM50006243 (((2S,4R,5S)-4-Hydroxy-5-methyl-tetrahydro-furan-2-...) Show SMILES C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.45E+4	n/a	n/a	n/a	n/a	n/a
C.N.R.-Centro Studio Sostanze Organiche Naturali Curated by ChEMBL					Assay Description Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysis				J Med Chem 35: 3102-10 (1992) Article DOI: 10.1021/jm00095a003
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Cavia porcellus)	BDBM50229871 (CHEMBL316804) Show SMILES Show InChI	MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.91E+3	n/a	n/a	n/a	n/a	n/a
C.N.R.-Centro Studio Sostanze Organiche Naturali Curated by ChEMBL					Assay Description Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysis				J Med Chem 35: 3102-10 (1992) Article DOI: 10.1021/jm00095a003
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Cavia porcellus)	BDBM50006243 (((2S,4R,5S)-4-Hydroxy-5-methyl-tetrahydro-furan-2-...) Show SMILES C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O Show InChI	MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a
C.N.R.-Centro Studio Sostanze Organiche Naturali Curated by ChEMBL					Assay Description Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysis				J Med Chem 35: 3102-10 (1992) Article DOI: 10.1021/jm00095a003
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4 (Homo sapiens (Human))	BDBM50006243 (((2S,4R,5S)-4-Hydroxy-5-methyl-tetrahydro-furan-2-...) Show SMILES C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a
C.N.R.-Centro Studio Sostanze Organiche Naturali Curated by ChEMBL					Assay Description Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysis				J Med Chem 35: 3102-10 (1992) Article DOI: 10.1021/jm00095a003
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4 (Homo sapiens (Human))	BDBM50229871 (CHEMBL316804) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.14E+4	n/a	n/a	n/a	n/a	n/a
C.N.R.-Centro Studio Sostanze Organiche Naturali Curated by ChEMBL					Assay Description Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysis				J Med Chem 35: 3102-10 (1992) Article DOI: 10.1021/jm00095a003
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Cavia porcellus)	BDBM50006243 (((2S,4R,5S)-4-Hydroxy-5-methyl-tetrahydro-furan-2-...) Show SMILES C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O Show InChI	MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a
C.N.R.-Centro Studio Sostanze Organiche Naturali Curated by ChEMBL					Assay Description Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysis				J Med Chem 35: 3102-10 (1992) Article DOI: 10.1021/jm00095a003
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4 (Homo sapiens (Human))	BDBM50229871 (CHEMBL316804) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
C.N.R.-Centro Studio Sostanze Organiche Naturali Curated by ChEMBL					Assay Description Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysis				J Med Chem 35: 3102-10 (1992) Article DOI: 10.1021/jm00095a003
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Cavia porcellus)	BDBM50229871 (CHEMBL316804) Show SMILES Show InChI	MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.07E+4	n/a	n/a	n/a	n/a	n/a
C.N.R.-Centro Studio Sostanze Organiche Naturali Curated by ChEMBL					Assay Description Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysis				J Med Chem 35: 3102-10 (1992) Article DOI: 10.1021/jm00095a003
					More data for this Ligand-Target Pair

* indicates data uncertainty>20%