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PubMed code 15080982

Compile data set for download or QSAR
Found 122 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144159
PNG
(CHEMBL294800 | N-(1-Methoxy-6-m-tolyl-6H-benzo[c]c...)
Show SMILES COc1cccc2OC(c3cccc(C)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-14-6-4-7-15(12-14)22-18-13-16(23-28(3,24)25)10-11-17(18)21-19(26-2)8-5-9-20(21)27-22/h4-13,22-23H,1-3H3
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n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 70-92 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144153
PNG
(CHEMBL293452 | N-[6-(3,5-Dimethyl-phenyl)-1-methox...)
Show SMILES COc1cccc2OC(c3cc(C)cc(C)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C23H23NO4S/c1-14-10-15(2)12-16(11-14)23-19-13-17(24-29(4,25)26)8-9-18(19)22-20(27-3)6-5-7-21(22)28-23/h5-13,23-24H,1-4H3
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n/an/a 2n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144173
PNG
(CHEMBL65221 | N-(1-Difluoromethoxy-6-phenyl-6H-ben...)
Show SMILES CS(=O)(=O)Nc1ccc-2c(c1)C(Oc1cccc(OC(F)F)c-21)c1ccccc1
Show InChI InChI=1S/C21H17F2NO4S/c1-29(25,26)24-14-10-11-15-16(12-14)20(13-6-3-2-4-7-13)27-17-8-5-9-18(19(15)17)28-21(22)23/h2-12,20-21,24H,1H3
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n/an/a 2n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 9-12 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144181
PNG
(CHEMBL304877 | N-[6-(3,4-Dichloro-phenyl)-1-methox...)
Show SMILES COc1cccc2OC(c3ccc(Cl)c(Cl)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H17Cl2NO4S/c1-27-18-4-3-5-19-20(18)14-8-7-13(24-29(2,25)26)11-15(14)21(28-19)12-6-9-16(22)17(23)10-12/h3-11,21,24H,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 3-4 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144149
PNG
(CHEMBL65354 | N-[6-(3-Fluoro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3cccc(F)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18FNO4S/c1-26-18-7-4-8-19-20(18)16-10-9-15(23-28(2,24)25)12-17(16)21(27-19)13-5-3-6-14(22)11-13/h3-12,21,23H,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 3-4 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from human Progesterone receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144164
PNG
(CHEMBL65695 | N-[6-(3-Chloro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3cccc(Cl)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18ClNO4S/c1-26-18-7-4-8-19-20(18)16-10-9-15(23-28(2,24)25)12-17(16)21(27-19)13-5-3-6-14(22)11-13/h3-12,21,23H,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 3-3 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 10-12 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144177
PNG
(CHEMBL304482 | N-[1-Methoxy-6-(3-methoxy-phenyl)-6...)
Show SMILES COc1cccc(c1)C1Oc2cccc(OC)c2-c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C22H21NO5S/c1-26-16-7-4-6-14(12-16)22-18-13-15(23-29(3,24)25)10-11-17(18)21-19(27-2)8-5-9-20(21)28-22/h4-13,22-23H,1-3H3
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n/an/a 6n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144147
PNG
(CHEMBL65868 | N-(1-Methoxy-6-p-tolyl-6H-benzo[c]ch...)
Show SMILES COc1cccc2OC(c3ccc(C)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-14-7-9-15(10-8-14)22-18-13-16(23-28(3,24)25)11-12-17(18)21-19(26-2)5-4-6-20(21)27-22/h4-13,22-23H,1-3H3
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n/an/a 7n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 6-7 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144150
PNG
(CHEMBL293388 | N-(1-Methoxy-6-thiophen-2-yl-6H-ben...)
Show SMILES COc1cccc2OC(c3cccs3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C19H17NO4S2/c1-23-15-5-3-6-16-18(15)13-9-8-12(20-26(2,21)22)11-14(13)19(24-16)17-7-4-10-25-17/h3-11,19-20H,1-2H3
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n/an/a 7n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144160
PNG
(CHEMBL304019 | N-[6-(4-Chloro-phenyl)-1-methoxy-6H...)
Show SMILES COc1cccc2OC(c3ccc(Cl)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18ClNO4S/c1-26-18-4-3-5-19-20(18)16-11-10-15(23-28(2,24)25)12-17(16)21(27-19)13-6-8-14(22)9-7-13/h3-12,21,23H,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 9-12 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144183
PNG
(CHEMBL65498 | N-(1-Methoxy-6-thiophen-3-yl-6H-benz...)
Show SMILES COc1cccc2OC(c3ccsc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C19H17NO4S2/c1-23-16-4-3-5-17-18(16)14-7-6-13(20-26(2,21)22)10-15(14)19(24-17)12-8-9-25-11-12/h3-11,19-20H,1-2H3
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n/an/a 11n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 26-67 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144162
PNG
(CHEMBL65570 | Thiophene-2-sulfonic acid (1-methoxy...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NS(=O)(=O)c4cccs4)ccc3-c12
Show InChI InChI=1S/C24H19NO4S2/c1-28-20-9-5-10-21-23(20)18-13-12-17(25-31(26,27)22-11-6-14-30-22)15-19(18)24(29-21)16-7-3-2-4-8-16/h2-15,24-25H,1H3
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n/an/a 18n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 13-26 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144161
PNG
(CHEMBL65021 | N-(1-Methoxy-6-phenyl-6H-benzo[c]chr...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H19NO4S/c1-25-18-9-6-10-19-20(18)16-12-11-15(22-27(2,23)24)13-17(16)21(26-19)14-7-4-3-5-8-14/h3-13,21-22H,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 17-21 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144159
PNG
(CHEMBL294800 | N-(1-Methoxy-6-m-tolyl-6H-benzo[c]c...)
Show SMILES COc1cccc2OC(c3cccc(C)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-14-6-4-7-15(12-14)22-18-13-16(23-28(3,24)25)10-11-17(18)21-19(26-2)8-5-9-20(21)27-22/h4-13,22-23H,1-3H3
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n/an/a 21n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144185
PNG
(CHEMBL442744 | N-(1-Methoxy-6-pentyl-6H-benzo[c]ch...)
Show SMILES CCCCCC1Oc2cccc(OC)c2-c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C20H25NO4S/c1-4-5-6-8-17-16-13-14(21-26(3,22)23)11-12-15(16)20-18(24-2)9-7-10-19(20)25-17/h7,9-13,17,21H,4-6,8H2,1-3H3
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n/an/a 21n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144188
PNG
(CHEMBL417202 | N-[1-Methoxy-6-(3-methylamino-pheny...)
Show SMILES CNc1cccc(c1)C1Oc2cccc(OC)c2-c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C22H22N2O4S/c1-23-15-7-4-6-14(12-15)22-18-13-16(24-29(3,25)26)10-11-17(18)21-19(27-2)8-5-9-20(21)28-22/h4-13,22-24H,1-3H3
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n/an/a 23n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144169
PNG
(CHEMBL65657 | N-[6-(4-Fluoro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3ccc(F)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18FNO4S/c1-26-18-4-3-5-19-20(18)16-11-10-15(23-28(2,24)25)12-17(16)21(27-19)13-6-8-14(22)9-7-13/h3-12,21,23H,1-2H3
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n/an/a 29n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 23-33 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144151
PNG
(3-(8-Methanesulfonylamino-1-methoxy-6H-benzo[c]chr...)
Show SMILES CCOC(=O)c1cccc(c1)C1Oc2cccc(OC)c2-c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C24H23NO6S/c1-4-30-24(26)16-8-5-7-15(13-16)23-19-14-17(25-32(3,27)28)11-12-18(19)22-20(29-2)9-6-10-21(22)31-23/h5-14,23,25H,4H2,1-3H3
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n/an/a 31n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 28-34 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144146
PNG
(({3-methoxy-9-phenyl-8-oxatricyclo[8.4.0.0^{2,7}]t...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NS(=O)(=O)N(C)C)ccc3-c12
Show InChI InChI=1S/C22H22N2O4S/c1-24(2)29(25,26)23-16-12-13-17-18(14-16)22(15-8-5-4-6-9-15)28-20-11-7-10-19(27-3)21(17)20/h4-14,22-23H,1-3H3
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n/an/a 41n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144183
PNG
(CHEMBL65498 | N-(1-Methoxy-6-thiophen-3-yl-6H-benz...)
Show SMILES COc1cccc2OC(c3ccsc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C19H17NO4S2/c1-23-16-4-3-5-17-18(16)14-7-6-13(20-26(2,21)22)10-15(14)19(24-17)12-8-9-25-11-12/h3-11,19-20H,1-2H3
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n/an/a 43n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144178
PNG
(CHEMBL303071 | N-(6-Cyclohexyl-1-methoxy-6H-benzo[...)
Show SMILES COc1cccc2OC(C3CCCCC3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H25NO4S/c1-25-18-9-6-10-19-20(18)16-12-11-15(22-27(2,23)24)13-17(16)21(26-19)14-7-4-3-5-8-14/h6,9-14,21-22H,3-5,7-8H2,1-2H3
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n/an/a 47n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 43-50 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144176
PNG
(CHEMBL66582 | N-[1-Methoxy-6-(3-phenoxy-phenyl)-6H...)
Show SMILES COc1cccc2OC(c3cccc(Oc4ccccc4)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C27H23NO5S/c1-31-24-12-7-13-25-26(24)22-15-14-19(28-34(2,29)30)17-23(22)27(33-25)18-8-6-11-21(16-18)32-20-9-4-3-5-10-20/h3-17,27-28H,1-2H3
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n/an/a 48n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 44-53 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144173
PNG
(CHEMBL65221 | N-(1-Difluoromethoxy-6-phenyl-6H-ben...)
Show SMILES CS(=O)(=O)Nc1ccc-2c(c1)C(Oc1cccc(OC(F)F)c-21)c1ccccc1
Show InChI InChI=1S/C21H17F2NO4S/c1-29(25,26)24-14-10-11-15-16(12-14)20(13-6-3-2-4-7-13)27-17-8-5-9-18(19(15)17)28-21(22)23/h2-12,20-21,24H,1H3
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n/an/a 57n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144152
PNG
(4-(8-Methanesulfonylamino-1-methoxy-6H-benzo[c]chr...)
Show SMILES CCOC(=O)c1ccc(cc1)C1Oc2cccc(OC)c2-c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C24H23NO6S/c1-4-30-24(26)16-10-8-15(9-11-16)23-19-14-17(25-32(3,27)28)12-13-18(19)22-20(29-2)6-5-7-21(22)31-23/h5-14,23,25H,4H2,1-3H3
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n/an/a 61n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 133-161 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144170
PNG
(CHEMBL65444 | Ethanesulfonic acid (1-methoxy-6-phe...)
Show SMILES CCS(=O)(=O)Nc1ccc-2c(c1)C(Oc1cccc(OC)c-21)c1ccccc1
Show InChI InChI=1S/C22H21NO4S/c1-3-28(24,25)23-16-12-13-17-18(14-16)22(15-8-5-4-6-9-15)27-20-11-7-10-19(26-2)21(17)20/h4-14,22-23H,3H2,1-2H3
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n/an/a 62n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 3-4 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144182
PNG
(CHEMBL64095 | N-[1-Methoxy-6-(4-phenoxy-phenyl)-6H...)
Show SMILES COc1cccc2OC(c3ccc(Oc4ccccc4)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C27H23NO5S/c1-31-24-9-6-10-25-26(24)22-16-13-19(28-34(2,29)30)17-23(22)27(33-25)18-11-14-21(15-12-18)32-20-7-4-3-5-8-20/h3-17,27-28H,1-2H3
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n/an/a 63n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144150
PNG
(CHEMBL293388 | N-(1-Methoxy-6-thiophen-2-yl-6H-ben...)
Show SMILES COc1cccc2OC(c3cccs3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C19H17NO4S2/c1-23-15-5-3-6-16-18(15)13-9-8-12(20-26(2,21)22)11-14(13)19(24-16)17-7-4-10-25-17/h3-11,19-20H,1-2H3
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n/an/a 66n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144175
PNG
(CHEMBL416869 | N-(1-Methoxy-6-phenyl-6H-benzo[c]ch...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NC(C)=O)ccc3-c12
Show InChI InChI=1S/C22H19NO3/c1-14(24)23-16-11-12-17-18(13-16)22(15-7-4-3-5-8-15)26-20-10-6-9-19(25-2)21(17)20/h3-13,22H,1-2H3,(H,23,24)
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n/an/a 69n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144149
PNG
(CHEMBL65354 | N-[6-(3-Fluoro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3cccc(F)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18FNO4S/c1-26-18-7-4-8-19-20(18)16-10-9-15(23-28(2,24)25)12-17(16)21(27-19)13-5-3-6-14(22)11-13/h3-12,21,23H,1-2H3
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n/an/a 76n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 3-4 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144153
PNG
(CHEMBL293452 | N-[6-(3,5-Dimethyl-phenyl)-1-methox...)
Show SMILES COc1cccc2OC(c3cc(C)cc(C)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C23H23NO4S/c1-14-10-15(2)12-16(11-14)23-19-13-17(24-29(4,25)26)8-9-18(19)22-20(27-3)6-5-7-21(22)28-23/h5-13,23-24H,1-4H3
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n/an/a 78n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144155
PNG
(CHEMBL66598 | N-(1-Ethoxy-6-phenyl-6H-benzo[c]chro...)
Show SMILES CCOc1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-3-26-19-10-7-11-20-21(19)17-13-12-16(23-28(2,24)25)14-18(17)22(27-20)15-8-5-4-6-9-15/h4-14,22-23H,3H2,1-2H3
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n/an/a 81n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 70-92 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144161
PNG
(CHEMBL65021 | N-(1-Methoxy-6-phenyl-6H-benzo[c]chr...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H19NO4S/c1-25-18-9-6-10-19-20(18)16-12-11-15(22-27(2,23)24)13-17(16)21(26-19)14-7-4-3-5-8-14/h3-13,21-22H,1-2H3
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n/an/a 87n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 89n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]mibolerone from human Androgen receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144162
PNG
(CHEMBL65570 | Thiophene-2-sulfonic acid (1-methoxy...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NS(=O)(=O)c4cccs4)ccc3-c12
Show InChI InChI=1S/C24H19NO4S2/c1-28-20-9-5-10-21-23(20)18-13-12-17(25-31(26,27)22-11-6-14-30-22)15-19(18)24(29-21)16-7-3-2-4-8-16/h2-15,24-25H,1H3
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n/an/a 93n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144175
PNG
(CHEMBL416869 | N-(1-Methoxy-6-phenyl-6H-benzo[c]ch...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NC(C)=O)ccc3-c12
Show InChI InChI=1S/C22H19NO3/c1-14(24)23-16-11-12-17-18(13-16)22(15-7-4-3-5-8-15)26-20-10-6-9-19(25-2)21(17)20/h3-13,22H,1-2H3,(H,23,24)
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n/an/a 117n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 106-131 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144146
PNG
(({3-methoxy-9-phenyl-8-oxatricyclo[8.4.0.0^{2,7}]t...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NS(=O)(=O)N(C)C)ccc3-c12
Show InChI InChI=1S/C22H22N2O4S/c1-24(2)29(25,26)23-16-12-13-17-18(14-16)22(15-8-5-4-6-9-15)28-20-11-7-10-19(27-3)21(17)20/h4-14,22-23H,1-3H3
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n/an/a 121n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144177
PNG
(CHEMBL304482 | N-[1-Methoxy-6-(3-methoxy-phenyl)-6...)
Show SMILES COc1cccc(c1)C1Oc2cccc(OC)c2-c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C22H21NO5S/c1-26-16-7-4-6-14(12-16)22-18-13-15(23-29(3,24)25)10-11-17(18)21-19(27-2)8-5-9-20(21)28-22/h4-13,22-23H,1-3H3
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n/an/a 122n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144157
PNG
(CHEMBL304258 | N-(1-Methoxy-6-phenyl-6H-benzo[c]ch...)
Show SMILES CCC(=O)Nc1ccc-2c(c1)C(Oc1cccc(OC)c-21)c1ccccc1
Show InChI InChI=1S/C23H21NO3/c1-3-21(25)24-16-12-13-17-18(14-16)23(15-8-5-4-6-9-15)27-20-11-7-10-19(26-2)22(17)20/h4-14,23H,3H2,1-2H3,(H,24,25)
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n/an/a 124n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144160
PNG
(CHEMBL304019 | N-[6-(4-Chloro-phenyl)-1-methoxy-6H...)
Show SMILES COc1cccc2OC(c3ccc(Cl)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18ClNO4S/c1-26-18-4-3-5-19-20(18)16-11-10-15(23-28(2,24)25)12-17(16)21(27-19)13-6-8-14(22)9-7-13/h3-12,21,23H,1-2H3
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n/an/a 129n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144179
PNG
(CHEMBL65469 | N-(1-Methoxy-6-phenyl-6H-benzo[c]chr...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NS(=O)(=O)c4ccccc4)ccc3-c12
Show InChI InChI=1S/C26H21NO4S/c1-30-23-13-8-14-24-25(23)21-16-15-19(27-32(28,29)20-11-6-3-7-12-20)17-22(21)26(31-24)18-9-4-2-5-10-18/h2-17,26-27H,1H3
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n/an/a 137n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144179
PNG
(CHEMBL65469 | N-(1-Methoxy-6-phenyl-6H-benzo[c]chr...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NS(=O)(=O)c4ccccc4)ccc3-c12
Show InChI InChI=1S/C26H21NO4S/c1-30-23-13-8-14-24-25(23)21-16-15-19(27-32(28,29)20-11-6-3-7-12-20)17-22(21)26(31-24)18-9-4-2-5-10-18/h2-17,26-27H,1H3
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n/an/a 146n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 61-63 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144164
PNG
(CHEMBL65695 | N-[6-(3-Chloro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3cccc(Cl)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18ClNO4S/c1-26-18-7-4-8-19-20(18)16-10-9-15(23-28(2,24)25)12-17(16)21(27-19)13-5-3-6-14(22)11-13/h3-12,21,23H,1-2H3
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n/an/a 147n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144157
PNG
(CHEMBL304258 | N-(1-Methoxy-6-phenyl-6H-benzo[c]ch...)
Show SMILES CCC(=O)Nc1ccc-2c(c1)C(Oc1cccc(OC)c-21)c1ccccc1
Show InChI InChI=1S/C23H21NO3/c1-3-21(25)24-16-12-13-17-18(14-16)23(15-8-5-4-6-9-15)27-20-11-7-10-19(26-2)22(17)20/h4-14,23H,3H2,1-2H3,(H,24,25)
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n/an/a 160n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 159-161 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50144173
PNG
(CHEMBL65221 | N-(1-Difluoromethoxy-6-phenyl-6H-ben...)
Show SMILES CS(=O)(=O)Nc1ccc-2c(c1)C(Oc1cccc(OC(F)F)c-21)c1ccccc1
Show InChI InChI=1S/C21H17F2NO4S/c1-29(25,26)24-14-10-11-15-16(12-14)20(13-6-3-2-4-7-13)27-17-8-5-9-18(19(15)17)28-21(22)23/h2-12,20-21,24H,1H3
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n/an/a 162n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]aldosterone from human Mineralocorticoid receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144166
PNG
(CHEMBL63239 | N-(1-Hydroxymethyl-6-phenyl-6H-benzo...)
Show SMILES CS(=O)(=O)Nc1ccc-2c(c1)C(Oc1cccc(CO)c-21)c1ccccc1
Show InChI InChI=1S/C21H19NO4S/c1-27(24,25)22-16-10-11-17-18(12-16)21(14-6-3-2-4-7-14)26-19-9-5-8-15(13-23)20(17)19/h2-12,21-23H,13H2,1H3
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n/an/a 180n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 150-220 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144188
PNG
(CHEMBL417202 | N-[1-Methoxy-6-(3-methylamino-pheny...)
Show SMILES CNc1cccc(c1)C1Oc2cccc(OC)c2-c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C22H22N2O4S/c1-23-15-7-4-6-14(12-15)22-18-13-16(24-29(3,25)26)10-11-17(18)21-19(27-2)8-5-9-20(21)28-22/h4-13,22-24H,1-3H3
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n/an/a 180n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144172
PNG
(CHEMBL65074 | N-(1-Methoxy-6-phenyl-6H-benzo[c]chr...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(ccc3-c12)N(C)S(C)(=O)=O
Show InChI InChI=1S/C22H21NO4S/c1-23(28(3,24)25)16-12-13-17-18(14-16)22(15-8-5-4-6-9-15)27-20-11-7-10-19(26-2)21(17)20/h4-14,22H,1-3H3
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n/an/a 210n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144153
PNG
(CHEMBL293452 | N-[6-(3,5-Dimethyl-phenyl)-1-methox...)
Show SMILES COc1cccc2OC(c3cc(C)cc(C)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C23H23NO4S/c1-14-10-15(2)12-16(11-14)23-19-13-17(24-29(4,25)26)8-9-18(19)22-20(27-3)6-5-7-21(22)28-23/h5-13,23-24H,1-4H3
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n/an/a 210n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from human Progesterone receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144186
PNG
(CHEMBL65497 | N-[6-(3-Hydroxy-phenyl)-1-methoxy-6H...)
Show SMILES COc1cccc2OC(c3cccc(O)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H19NO5S/c1-26-18-7-4-8-19-20(18)16-10-9-14(22-28(2,24)25)12-17(16)21(27-19)13-5-3-6-15(23)11-13/h3-12,21-23H,1-2H3
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n/an/a 216n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 215-217 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144159
PNG
(CHEMBL294800 | N-(1-Methoxy-6-m-tolyl-6H-benzo[c]c...)
Show SMILES COc1cccc2OC(c3cccc(C)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-14-6-4-7-15(12-14)22-18-13-16(23-28(3,24)25)10-11-17(18)21-19(26-2)8-5-9-20(21)27-22/h4-13,22-23H,1-3H3
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n/an/a 236n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from human Progesterone receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144170
PNG
(CHEMBL65444 | Ethanesulfonic acid (1-methoxy-6-phe...)
Show SMILES CCS(=O)(=O)Nc1ccc-2c(c1)C(Oc1cccc(OC)c-21)c1ccccc1
Show InChI InChI=1S/C22H21NO4S/c1-3-28(24,25)23-16-12-13-17-18(14-16)22(15-8-5-4-6-9-15)27-20-11-7-10-19(26-2)21(17)20/h4-14,22-23H,3H2,1-2H3
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n/an/a 251n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144148
PNG
(CHEMBL302147 | N-(1-Methoxy-6-phenyl-6H-benzo[c]ch...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NC(=O)c4ccccc4)ccc3-c12
Show InChI InChI=1S/C27H21NO3/c1-30-23-13-8-14-24-25(23)21-16-15-20(28-27(29)19-11-6-3-7-12-19)17-22(21)26(31-24)18-9-4-2-5-10-18/h2-17,26H,1H3,(H,28,29)
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n/an/a 289n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144151
PNG
(3-(8-Methanesulfonylamino-1-methoxy-6H-benzo[c]chr...)
Show SMILES CCOC(=O)c1cccc(c1)C1Oc2cccc(OC)c2-c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C24H23NO6S/c1-4-30-24(26)16-8-5-7-15(13-16)23-19-14-17(25-32(3,27)28)11-12-18(19)22-20(29-2)9-6-10-21(22)31-23/h5-14,23,25H,4H2,1-3H3
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n/an/a 296n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144155
PNG
(CHEMBL66598 | N-(1-Ethoxy-6-phenyl-6H-benzo[c]chro...)
Show SMILES CCOc1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-3-26-19-10-7-11-20-21(19)17-13-12-16(23-28(2,24)25)14-18(17)22(27-20)15-8-5-4-6-9-15/h4-14,22-23H,3H2,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50144159
PNG
(CHEMBL294800 | N-(1-Methoxy-6-m-tolyl-6H-benzo[c]c...)
Show SMILES COc1cccc2OC(c3cccc(C)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-14-6-4-7-15(12-14)22-18-13-16(23-28(3,24)25)10-11-17(18)21-19(26-2)8-5-9-20(21)27-22/h4-13,22-23H,1-3H3
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n/an/a 333n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]aldosterone from human Mineralocorticoid receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144173
PNG
(CHEMBL65221 | N-(1-Difluoromethoxy-6-phenyl-6H-ben...)
Show SMILES CS(=O)(=O)Nc1ccc-2c(c1)C(Oc1cccc(OC(F)F)c-21)c1ccccc1
Show InChI InChI=1S/C21H17F2NO4S/c1-29(25,26)24-14-10-11-15-16(12-14)20(13-6-3-2-4-7-13)27-17-8-5-9-18(19(15)17)28-21(22)23/h2-12,20-21,24H,1H3
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n/an/a 367n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from human Progesterone receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144181
PNG
(CHEMBL304877 | N-[6-(3,4-Dichloro-phenyl)-1-methox...)
Show SMILES COc1cccc2OC(c3ccc(Cl)c(Cl)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H17Cl2NO4S/c1-27-18-4-3-5-19-20(18)14-8-7-13(24-29(2,25)26)11-15(14)21(28-19)12-6-9-16(22)17(23)10-12/h3-11,21,24H,1-2H3
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n/an/a 378n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144168
PNG
(CHEMBL65381 | Ethyl-(1-methoxy-6-phenyl-6H-benzo[c...)
Show SMILES CCNc1ccc-2c(c1)C(Oc1cccc(OC)c-21)c1ccccc1
Show InChI InChI=1S/C22H21NO2/c1-3-23-16-12-13-17-18(14-16)22(15-8-5-4-6-9-15)25-20-11-7-10-19(24-2)21(17)20/h4-14,22-23H,3H2,1-2H3
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n/an/a 382n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 6-8 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144152
PNG
(4-(8-Methanesulfonylamino-1-methoxy-6H-benzo[c]chr...)
Show SMILES CCOC(=O)c1ccc(cc1)C1Oc2cccc(OC)c2-c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C24H23NO6S/c1-4-30-24(26)16-10-8-15(9-11-16)23-19-14-17(25-32(3,27)28)12-13-18(19)22-20(29-2)6-5-7-21(22)31-23/h5-14,23,25H,4H2,1-3H3
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n/an/a 388n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144184
PNG
(Benzyl-(1-methoxy-6-phenyl-6H-benzo[c]chromen-8-yl...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NCc4ccccc4)ccc3-c12
Show InChI InChI=1S/C27H23NO2/c1-29-24-13-8-14-25-26(24)22-16-15-21(28-18-19-9-4-2-5-10-19)17-23(22)27(30-25)20-11-6-3-7-12-20/h2-17,27-28H,18H2,1H3
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n/an/a 402n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 39-94 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144148
PNG
(CHEMBL302147 | N-(1-Methoxy-6-phenyl-6H-benzo[c]ch...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NC(=O)c4ccccc4)ccc3-c12
Show InChI InChI=1S/C27H21NO3/c1-30-23-13-8-14-24-25(23)21-16-15-20(28-27(29)19-11-6-3-7-12-19)17-22(21)26(31-24)18-9-4-2-5-10-18/h2-17,26H,1H3,(H,28,29)
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n/an/a 404n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 294-554 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144158
PNG
(CHEMBL63768 | N-(7-Bromo-1-methoxy-6-phenyl-6H-ben...)
Show SMILES COc1cccc2OC(c3ccccc3)c3c(Br)c(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18BrNO4S/c1-26-16-9-6-10-17-18(16)14-11-12-15(23-28(2,24)25)20(22)19(14)21(27-17)13-7-4-3-5-8-13/h3-12,21,23H,1-2H3
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n/an/a 430n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144176
PNG
(CHEMBL66582 | N-[1-Methoxy-6-(3-phenoxy-phenyl)-6H...)
Show SMILES COc1cccc2OC(c3cccc(Oc4ccccc4)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C27H23NO5S/c1-31-24-12-7-13-25-26(24)22-15-14-19(28-34(2,29)30)17-23(22)27(33-25)18-8-6-11-21(16-18)32-20-9-4-3-5-10-20/h3-17,27-28H,1-2H3
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n/an/a 434n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144150
PNG
(CHEMBL293388 | N-(1-Methoxy-6-thiophen-2-yl-6H-ben...)
Show SMILES COc1cccc2OC(c3cccs3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C19H17NO4S2/c1-23-15-5-3-6-16-18(15)13-9-8-12(20-26(2,21)22)11-14(13)19(24-16)17-7-4-10-25-17/h3-11,19-20H,1-2H3
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n/an/a 450n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from human Progesterone receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50144158
PNG
(CHEMBL63768 | N-(7-Bromo-1-methoxy-6-phenyl-6H-ben...)
Show SMILES COc1cccc2OC(c3ccccc3)c3c(Br)c(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18BrNO4S/c1-26-16-9-6-10-17-18(16)14-11-12-15(23-28(2,24)25)20(22)19(14)21(27-17)13-7-4-3-5-8-13/h3-12,21,23H,1-2H3
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n/an/a 454n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]aldosterone from human Mineralocorticoid receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144171
PNG
(CHEMBL291610 | N-(1-Methoxy-6-pyridin-3-yl-6H-benz...)
Show SMILES COc1cccc2OC(c3cccnc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C20H18N2O4S/c1-25-17-6-3-7-18-19(17)15-9-8-14(22-27(2,23)24)11-16(15)20(26-18)13-5-4-10-21-12-13/h3-12,20,22H,1-2H3
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n/an/a 460n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 366-578 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144149
PNG
(CHEMBL65354 | N-[6-(3-Fluoro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3cccc(F)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18FNO4S/c1-26-18-7-4-8-19-20(18)16-10-9-15(23-28(2,24)25)12-17(16)21(27-19)13-5-3-6-14(22)11-13/h3-12,21,23H,1-2H3
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n/an/a 476n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from human Progesterone receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144164
PNG
(CHEMBL65695 | N-[6-(3-Chloro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3cccc(Cl)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18ClNO4S/c1-26-18-7-4-8-19-20(18)16-10-9-15(23-28(2,24)25)12-17(16)21(27-19)13-5-3-6-14(22)11-13/h3-12,21,23H,1-2H3
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n/an/a 498n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from human Progesterone receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144158
PNG
(CHEMBL63768 | N-(7-Bromo-1-methoxy-6-phenyl-6H-ben...)
Show SMILES COc1cccc2OC(c3ccccc3)c3c(Br)c(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18BrNO4S/c1-26-16-9-6-10-17-18(16)14-11-12-15(23-28(2,24)25)20(22)19(14)21(27-17)13-7-4-3-5-8-13/h3-12,21,23H,1-2H3
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n/an/a 519n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 2-2 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144154
PNG
(CHEMBL292970 | N-[6-(4-Ethoxy-benzyl)-1-methoxy-6H...)
Show SMILES CCOc1ccc(CC2Oc3cccc(OC)c3-c3ccc(NS(C)(=O)=O)cc23)cc1
Show InChI InChI=1S/C24H25NO5S/c1-4-29-18-11-8-16(9-12-18)14-23-20-15-17(25-31(3,26)27)10-13-19(20)24-21(28-2)6-5-7-22(24)30-23/h5-13,15,23,25H,4,14H2,1-3H3
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n/an/a 548n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 536-560 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144168
PNG
(CHEMBL65381 | Ethyl-(1-methoxy-6-phenyl-6H-benzo[c...)
Show SMILES CCNc1ccc-2c(c1)C(Oc1cccc(OC)c-21)c1ccccc1
Show InChI InChI=1S/C22H21NO2/c1-3-23-16-12-13-17-18(14-16)22(15-8-5-4-6-9-15)25-20-11-7-10-19(24-2)21(17)20/h4-14,22-23H,3H2,1-2H3
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n/an/a 564n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 379-840 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144178
PNG
(CHEMBL303071 | N-(6-Cyclohexyl-1-methoxy-6H-benzo[...)
Show SMILES COc1cccc2OC(C3CCCCC3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H25NO4S/c1-25-18-9-6-10-19-20(18)16-12-11-15(22-27(2,23)24)13-17(16)21(26-19)14-7-4-3-5-8-14/h6,9-14,21-22H,3-5,7-8H2,1-2H3
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n/an/a 630n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50144147
PNG
(CHEMBL65868 | N-(1-Methoxy-6-p-tolyl-6H-benzo[c]ch...)
Show SMILES COc1cccc2OC(c3ccc(C)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-14-7-9-15(10-8-14)22-18-13-16(23-28(3,24)25)11-12-17(18)21-19(26-2)5-4-6-20(21)27-22/h4-13,22-23H,1-3H3
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n/an/a 651n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]aldosterone from human Mineralocorticoid receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144180
PNG
(CHEMBL303094 | N-(6-Phenyl-1-thiophen-2-yl-6H-benz...)
Show SMILES CS(=O)(=O)Nc1ccc-2c(c1)C(Oc1cccc(-c3cccs3)c-21)c1ccccc1
Show InChI InChI=1S/C24H19NO3S2/c1-30(26,27)25-17-12-13-18-20(15-17)24(16-7-3-2-4-8-16)28-21-10-5-9-19(23(18)21)22-11-6-14-29-22/h2-15,24-25H,1H3
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n/an/a 656n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 639-673 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144156
PNG
(CHEMBL63431 | N-[1-Methoxy-6-(2-methoxy-phenyl)-6H...)
Show SMILES COc1ccccc1C1Oc2cccc(OC)c2-c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C22H21NO5S/c1-26-18-8-5-4-7-16(18)22-17-13-14(23-29(3,24)25)11-12-15(17)21-19(27-2)9-6-10-20(21)28-22/h4-13,22-23H,1-3H3
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n/an/a 665n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 3-3 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144147
PNG
(CHEMBL65868 | N-(1-Methoxy-6-p-tolyl-6H-benzo[c]ch...)
Show SMILES COc1cccc2OC(c3ccc(C)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-14-7-9-15(10-8-14)22-18-13-16(23-28(3,24)25)11-12-17(18)21-19(26-2)5-4-6-20(21)27-22/h4-13,22-23H,1-3H3
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n/an/a 673n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from human Progesterone receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50144149
PNG
(CHEMBL65354 | N-[6-(3-Fluoro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3cccc(F)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18FNO4S/c1-26-18-7-4-8-19-20(18)16-10-9-15(23-28(2,24)25)12-17(16)21(27-19)13-5-3-6-14(22)11-13/h3-12,21,23H,1-2H3
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n/an/a 683n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]aldosterone from human Mineralocorticoid receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144156
PNG
(CHEMBL63431 | N-[1-Methoxy-6-(2-methoxy-phenyl)-6H...)
Show SMILES COc1ccccc1C1Oc2cccc(OC)c2-c2ccc(NS(C)(=O)=O)cc12
Show InChI InChI=1S/C22H21NO5S/c1-26-18-8-5-4-7-16(18)22-17-13-14(23-29(3,24)25)11-12-15(17)21-19(27-2)9-6-10-20(21)28-22/h4-13,22-23H,1-3H3
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n/an/a 812n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 681-974 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144182
PNG
(CHEMBL64095 | N-[1-Methoxy-6-(4-phenoxy-phenyl)-6H...)
Show SMILES COc1cccc2OC(c3ccc(Oc4ccccc4)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C27H23NO5S/c1-31-24-9-6-10-25-26(24)22-16-13-19(28-34(2,29)30)17-23(22)27(33-25)18-11-14-21(15-12-18)32-20-7-4-3-5-8-20/h3-17,27-28H,1-2H3
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n/an/a 847n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144167
PNG
(CHEMBL303813 | N-(1-Hydroxy-6-phenyl-6H-benzo[c]ch...)
Show SMILES CS(=O)(=O)Nc1ccc-2c(c1)C(Oc1cccc(O)c-21)c1ccccc1
Show InChI InChI=1S/C20H17NO4S/c1-26(23,24)21-14-10-11-15-16(12-14)20(13-6-3-2-4-7-13)25-18-9-5-8-17(22)19(15)18/h2-12,20-22H,1H3
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n/an/a 892n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 559-1423 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50144155
PNG
(CHEMBL66598 | N-(1-Ethoxy-6-phenyl-6H-benzo[c]chro...)
Show SMILES CCOc1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-3-26-19-10-7-11-20-21(19)17-13-12-16(23-28(2,24)25)14-18(17)22(27-20)15-8-5-4-6-9-15/h4-14,22-23H,3H2,1-2H3
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n/an/a 893n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]aldosterone from human Mineralocorticoid receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144184
PNG
(Benzyl-(1-methoxy-6-phenyl-6H-benzo[c]chromen-8-yl...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NCc4ccccc4)ccc3-c12
Show InChI InChI=1S/C27H23NO2/c1-29-24-13-8-14-25-26(24)22-16-15-21(28-18-19-9-4-2-5-10-19)17-23(22)27(30-25)20-11-6-3-7-12-20/h2-17,27-28H,18H2,1H3
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n/an/a 910n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 838-988 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144172
PNG
(CHEMBL65074 | N-(1-Methoxy-6-phenyl-6H-benzo[c]chr...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(ccc3-c12)N(C)S(C)(=O)=O
Show InChI InChI=1S/C22H21NO4S/c1-23(28(3,24)25)16-12-13-17-18(14-16)22(15-8-5-4-6-9-15)27-20-11-7-10-19(26-2)21(17)20/h4-14,22H,1-3H3
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n/an/a 1.05E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 159-161 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144169
PNG
(CHEMBL65657 | N-[6-(4-Fluoro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3ccc(F)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18FNO4S/c1-26-18-4-3-5-19-20(18)16-11-10-15(23-28(2,24)25)12-17(16)21(27-19)13-6-8-14(22)9-7-13/h3-12,21,23H,1-2H3
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n/an/a 1.16E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from human Progesterone receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144163
PNG
(8-Methanesulfonylamino-6-phenyl-6H-benzo[c]chromen...)
Show SMILES COC(=O)c1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H19NO5S/c1-27-22(24)17-9-6-10-19-20(17)16-12-11-15(23-29(2,25)26)13-18(16)21(28-19)14-7-4-3-5-8-14/h3-13,21,23H,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 1382-1049 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50144153
PNG
(CHEMBL293452 | N-[6-(3,5-Dimethyl-phenyl)-1-methox...)
Show SMILES COc1cccc2OC(c3cc(C)cc(C)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C23H23NO4S/c1-14-10-15(2)12-16(11-14)23-19-13-17(24-29(4,25)26)8-9-18(19)22-20(27-3)6-5-7-21(22)28-23/h5-13,23-24H,1-4H3
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n/an/a 1.22E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]aldosterone from human Mineralocorticoid receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144187
PNG
(CHEMBL302166 | N-(1-Methoxy-6-pyridin-2-yl-6H-benz...)
Show SMILES COc1cccc2OC(c3ccccn3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C20H18N2O4S/c1-25-17-7-5-8-18-19(17)14-10-9-13(22-27(2,23)24)12-15(14)20(26-18)16-6-3-4-11-21-16/h3-12,20,22H,1-2H3
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n/an/a 1.43E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 1428-1433 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144167
PNG
(CHEMBL303813 | N-(1-Hydroxy-6-phenyl-6H-benzo[c]ch...)
Show SMILES CS(=O)(=O)Nc1ccc-2c(c1)C(Oc1cccc(O)c-21)c1ccccc1
Show InChI InChI=1S/C20H17NO4S/c1-26(23,24)21-14-10-11-15-16(12-14)20(13-6-3-2-4-7-13)25-18-9-5-8-17(22)19(15)18/h2-12,20-22H,1H3
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n/an/a 1.81E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on functional cellular GR-antagonism (GRAF) in human Glucocorticoid receptor (GR) expressing cells


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144174
PNG
(1-Methoxy-6-phenyl-6H-benzo[c]chromene | CHEMBL634...)
Show SMILES COc1cccc2OC(c3ccccc3)c3ccccc3-c12
Show InChI InChI=1S/C20H16O2/c1-21-17-12-7-13-18-19(17)15-10-5-6-11-16(15)20(22-18)14-8-3-2-4-9-14/h2-13,20H,1H3
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n/an/a 1.91E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144165
PNG
(1-Methoxy-6-phenyl-6H-benzo[c]chromen-8-ylamine | ...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(N)ccc3-c12
Show InChI InChI=1S/C20H17NO2/c1-22-17-8-5-9-18-19(17)15-11-10-14(21)12-16(15)20(23-18)13-6-3-2-4-7-13/h2-12,20H,21H2,1H3
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n/an/a 1.94E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 1273-2947 nM


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144165
PNG
(1-Methoxy-6-phenyl-6H-benzo[c]chromen-8-ylamine | ...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(N)ccc3-c12
Show InChI InChI=1S/C20H17NO2/c1-22-17-8-5-9-18-19(17)15-11-10-14(21)12-16(15)20(23-18)13-6-3-2-4-7-13/h2-12,20H,21H2,1H3
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n/an/a 2.02E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50144164
PNG
(CHEMBL65695 | N-[6-(3-Chloro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3cccc(Cl)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18ClNO4S/c1-26-18-7-4-8-19-20(18)16-10-9-15(23-28(2,24)25)12-17(16)21(27-19)13-5-3-6-14(22)11-13/h3-12,21,23H,1-2H3
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n/an/a 2.15E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]aldosterone from human Mineralocorticoid receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50144150
PNG
(CHEMBL293388 | N-(1-Methoxy-6-thiophen-2-yl-6H-ben...)
Show SMILES COc1cccc2OC(c3cccs3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C19H17NO4S2/c1-23-15-5-3-6-16-18(15)13-9-8-12(20-26(2,21)22)11-14(13)19(24-16)17-7-4-10-25-17/h3-11,19-20H,1-2H3
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n/an/a 2.25E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]aldosterone from human Mineralocorticoid receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50144158
PNG
(CHEMBL63768 | N-(7-Bromo-1-methoxy-6-phenyl-6H-ben...)
Show SMILES COc1cccc2OC(c3ccccc3)c3c(Br)c(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18BrNO4S/c1-26-16-9-6-10-17-18(16)14-11-12-15(23-28(2,24)25)20(22)19(14)21(27-17)13-7-4-3-5-8-13/h3-12,21,23H,1-2H3
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n/an/a 2.28E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]estradiol from human estrogen receptor alpha


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50144169
PNG
(CHEMBL65657 | N-[6-(4-Fluoro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3ccc(F)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18FNO4S/c1-26-18-4-3-5-19-20(18)16-11-10-15(23-28(2,24)25)12-17(16)21(27-19)13-6-8-14(22)9-7-13/h3-12,21,23H,1-2H3
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n/an/a 2.48E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]aldosterone from human Mineralocorticoid receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144161
PNG
(CHEMBL65021 | N-(1-Methoxy-6-phenyl-6H-benzo[c]chr...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H19NO4S/c1-25-18-9-6-10-19-20(18)16-12-11-15(22-27(2,23)24)13-17(16)21(26-19)14-7-4-3-5-8-14/h3-13,21-22H,1-2H3
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n/an/a 3.36E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from human Progesterone receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]aldosterone from human Mineralocorticoid receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50144161
PNG
(CHEMBL65021 | N-(1-Methoxy-6-phenyl-6H-benzo[c]chr...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H19NO4S/c1-25-18-9-6-10-19-20(18)16-12-11-15(22-27(2,23)24)13-17(16)21(26-19)14-7-4-3-5-8-14/h3-13,21-22H,1-2H3
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n/an/a 6.53E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]mibolerone from human Androgen receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144155
PNG
(CHEMBL66598 | N-(1-Ethoxy-6-phenyl-6H-benzo[c]chro...)
Show SMILES CCOc1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-3-26-19-10-7-11-20-21(19)17-13-12-16(23-28(2,24)25)14-18(17)22(27-20)15-8-5-4-6-9-15/h4-14,22-23H,3H2,1-2H3
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n/an/a 6.90E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from human Progesterone receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50144173
PNG
(CHEMBL65221 | N-(1-Difluoromethoxy-6-phenyl-6H-ben...)
Show SMILES CS(=O)(=O)Nc1ccc-2c(c1)C(Oc1cccc(OC(F)F)c-21)c1ccccc1
Show InChI InChI=1S/C21H17F2NO4S/c1-29(25,26)24-14-10-11-15-16(12-14)20(13-6-3-2-4-7-13)27-17-8-5-9-18(19(15)17)28-21(22)23/h2-12,20-21,24H,1H3
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n/an/a 8.73E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]mibolerone from human Androgen receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50144147
PNG
(CHEMBL65868 | N-(1-Methoxy-6-p-tolyl-6H-benzo[c]ch...)
Show SMILES COc1cccc2OC(c3ccc(C)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-14-7-9-15(10-8-14)22-18-13-16(23-28(3,24)25)11-12-17(18)21-19(26-2)5-4-6-20(21)27-22/h4-13,22-23H,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]estradiol from human estrogen receptor alpha


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50144155
PNG
(CHEMBL66598 | N-(1-Ethoxy-6-phenyl-6H-benzo[c]chro...)
Show SMILES CCOc1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-3-26-19-10-7-11-20-21(19)17-13-12-16(23-28(2,24)25)14-18(17)22(27-20)15-8-5-4-6-9-15/h4-14,22-23H,3H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]estradiol from human estrogen receptor alpha


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50144164
PNG
(CHEMBL65695 | N-[6-(3-Chloro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3cccc(Cl)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18ClNO4S/c1-26-18-7-4-8-19-20(18)16-10-9-15(23-28(2,24)25)12-17(16)21(27-19)13-5-3-6-14(22)11-13/h3-12,21,23H,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]mibolerone from human Androgen receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50144149
PNG
(CHEMBL65354 | N-[6-(3-Fluoro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3cccc(F)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18FNO4S/c1-26-18-7-4-8-19-20(18)16-10-9-15(23-28(2,24)25)12-17(16)21(27-19)13-5-3-6-14(22)11-13/h3-12,21,23H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]mibolerone from human Androgen receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50144153
PNG
(CHEMBL293452 | N-[6-(3,5-Dimethyl-phenyl)-1-methox...)
Show SMILES COc1cccc2OC(c3cc(C)cc(C)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C23H23NO4S/c1-14-10-15(2)12-16(11-14)23-19-13-17(24-29(4,25)26)8-9-18(19)22-20(27-3)6-5-7-21(22)28-23/h5-13,23-24H,1-4H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]mibolerone from human Androgen receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50144147
PNG
(CHEMBL65868 | N-(1-Methoxy-6-p-tolyl-6H-benzo[c]ch...)
Show SMILES COc1cccc2OC(c3ccc(C)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-14-7-9-15(10-8-14)22-18-13-16(23-28(3,24)25)11-12-17(18)21-19(26-2)5-4-6-20(21)27-22/h4-13,22-23H,1-3H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]mibolerone from human Androgen receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50144155
PNG
(CHEMBL66598 | N-(1-Ethoxy-6-phenyl-6H-benzo[c]chro...)
Show SMILES CCOc1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-3-26-19-10-7-11-20-21(19)17-13-12-16(23-28(2,24)25)14-18(17)22(27-20)15-8-5-4-6-9-15/h4-14,22-23H,3H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]mibolerone from human Androgen receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50144169
PNG
(CHEMBL65657 | N-[6-(4-Fluoro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3ccc(F)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18FNO4S/c1-26-18-4-3-5-19-20(18)16-11-10-15(23-28(2,24)25)12-17(16)21(27-19)13-6-8-14(22)9-7-13/h3-12,21,23H,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]estradiol from human estrogen receptor alpha


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50144149
PNG
(CHEMBL65354 | N-[6-(3-Fluoro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3cccc(F)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18FNO4S/c1-26-18-7-4-8-19-20(18)16-10-9-15(23-28(2,24)25)12-17(16)21(27-19)13-5-3-6-14(22)11-13/h3-12,21,23H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]estradiol from human estrogen receptor alpha


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50144150
PNG
(CHEMBL293388 | N-(1-Methoxy-6-thiophen-2-yl-6H-ben...)
Show SMILES COc1cccc2OC(c3cccs3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C19H17NO4S2/c1-23-15-5-3-6-16-18(15)13-9-8-12(20-26(2,21)22)11-14(13)19(24-16)17-7-4-10-25-17/h3-11,19-20H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]mibolerone from human Androgen receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50144158
PNG
(CHEMBL63768 | N-(7-Bromo-1-methoxy-6-phenyl-6H-ben...)
Show SMILES COc1cccc2OC(c3ccccc3)c3c(Br)c(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18BrNO4S/c1-26-16-9-6-10-17-18(16)14-11-12-15(23-28(2,24)25)20(22)19(14)21(27-17)13-7-4-3-5-8-13/h3-12,21,23H,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from human Progesterone receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50144174
PNG
(1-Methoxy-6-phenyl-6H-benzo[c]chromene | CHEMBL634...)
Show SMILES COc1cccc2OC(c3ccccc3)c3ccccc3-c12
Show InChI InChI=1S/C20H16O2/c1-21-17-12-7-13-18-19(17)15-10-5-6-11-16(15)20(22-18)14-8-3-2-4-9-14/h2-13,20H,1H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR)


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50144173
PNG
(CHEMBL65221 | N-(1-Difluoromethoxy-6-phenyl-6H-ben...)
Show SMILES CS(=O)(=O)Nc1ccc-2c(c1)C(Oc1cccc(OC(F)F)c-21)c1ccccc1
Show InChI InChI=1S/C21H17F2NO4S/c1-29(25,26)24-14-10-11-15-16(12-14)20(13-6-3-2-4-7-13)27-17-8-5-9-18(19(15)17)28-21(22)23/h2-12,20-21,24H,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]estradiol from human estrogen receptor alpha


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50144164
PNG
(CHEMBL65695 | N-[6-(3-Chloro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3cccc(Cl)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18ClNO4S/c1-26-18-7-4-8-19-20(18)16-10-9-15(23-28(2,24)25)12-17(16)21(27-19)13-5-3-6-14(22)11-13/h3-12,21,23H,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]estradiol from human estrogen receptor alpha


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50144161
PNG
(CHEMBL65021 | N-(1-Methoxy-6-phenyl-6H-benzo[c]chr...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H19NO4S/c1-25-18-9-6-10-19-20(18)16-12-11-15(22-27(2,23)24)13-17(16)21(26-19)14-7-4-3-5-8-14/h3-13,21-22H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]estradiol from human estrogen receptor alpha


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50144159
PNG
(CHEMBL294800 | N-(1-Methoxy-6-m-tolyl-6H-benzo[c]c...)
Show SMILES COc1cccc2OC(c3cccc(C)c3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C22H21NO4S/c1-14-6-4-7-15(12-14)22-18-13-16(23-28(3,24)25)10-11-17(18)21-19(26-2)8-5-9-20(21)27-22/h4-13,22-23H,1-3H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]mibolerone from human Androgen receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50144150
PNG
(CHEMBL293388 | N-(1-Methoxy-6-thiophen-2-yl-6H-ben...)
Show SMILES COc1cccc2OC(c3cccs3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C19H17NO4S2/c1-23-15-5-3-6-16-18(15)13-9-8-12(20-26(2,21)22)11-14(13)19(24-16)17-7-4-10-25-17/h3-11,19-20H,1-2H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]estradiol from human estrogen receptor alpha


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50144169
PNG
(CHEMBL65657 | N-[6-(4-Fluoro-phenyl)-1-methoxy-6H-...)
Show SMILES COc1cccc2OC(c3ccc(F)cc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H18FNO4S/c1-26-18-4-3-5-19-20(18)16-11-10-15(23-28(2,24)25)12-17(16)21(27-19)13-6-8-14(22)9-7-13/h3-12,21,23H,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

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Article
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]mibolerone from human Androgen receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50144161
PNG
(CHEMBL65021 | N-(1-Methoxy-6-phenyl-6H-benzo[c]chr...)
Show SMILES COc1cccc2OC(c3ccccc3)c3cc(NS(C)(=O)=O)ccc3-c12
Show InChI InChI=1S/C21H19NO4S/c1-25-18-9-6-10-19-20(18)16-12-11-15(22-27(2,23)24)13-17(16)21(26-19)14-7-4-3-5-8-14/h3-13,21-22H,1-2H3
PDB
MMDB

KEGG

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PubMed
n/an/a 2.29E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]aldosterone from human Mineralocorticoid receptor


Bioorg Med Chem Lett 14: 2079-82 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.048
BindingDB Entry DOI: 10.7270/Q21V5FHJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%