Affinity Data by PubMed id=1527791

PubMed code 1527791

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50455629 (CHEMBL487720) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
British Bio-technology Limited Curated by ChEMBL					Assay Description Inhibitory activity against HMG-CoA reductase from rat liver microsomal preparation				J Med Chem 35: 3388-93 (1992) Article DOI: 10.1021/jm00096a015 BindingDB Entry DOI: 10.7270/Q2HD7W9V
British Bio-technology Limited Curated by ChEMBL					More data for this Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) (Homo sapiens (Human))	BDBM50455629 (CHEMBL487720) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
British Bio-technology Limited Curated by ChEMBL					Assay Description Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line				J Med Chem 35: 3388-93 (1992) Article DOI: 10.1021/jm00096a015 BindingDB Entry DOI: 10.7270/Q2HD7W9V
British Bio-technology Limited Curated by ChEMBL					More data for this Ligand-Target Pair
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50406129 (CHEMBL175236) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
British Bio-technology Limited Curated by ChEMBL					Assay Description Inhibitory activity against HMG-CoA reductase from rat liver microsomal preparation				J Med Chem 35: 3388-93 (1992) Article DOI: 10.1021/jm00096a015 BindingDB Entry DOI: 10.7270/Q2HD7W9V
British Bio-technology Limited Curated by ChEMBL					More data for this Ligand-Target Pair
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50004776 (CHEMBL323880 \| Sodium; 3,5-dihydroxy-7-[6-hydroxy-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
British Bio-technology Limited Curated by ChEMBL					Assay Description Inhibitory activity against HMG-CoA reductase from rat liver microsomal preparation				J Med Chem 35: 3388-93 (1992) Article DOI: 10.1021/jm00096a015 BindingDB Entry DOI: 10.7270/Q2HD7W9V
British Bio-technology Limited Curated by ChEMBL					More data for this Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) (Homo sapiens (Human))	BDBM50406129 (CHEMBL175236) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
British Bio-technology Limited Curated by ChEMBL					Assay Description Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line				J Med Chem 35: 3388-93 (1992) Article DOI: 10.1021/jm00096a015 BindingDB Entry DOI: 10.7270/Q2HD7W9V
British Bio-technology Limited Curated by ChEMBL					More data for this Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) (Homo sapiens (Human))	BDBM34168 (LOVASTATIN \| MLS000069585 \| SMR000058779 \| US91151...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
British Bio-technology Limited Curated by ChEMBL					Assay Description Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line				J Med Chem 35: 3388-93 (1992) Article DOI: 10.1021/jm00096a015 BindingDB Entry DOI: 10.7270/Q2HD7W9V
British Bio-technology Limited Curated by ChEMBL					More data for this Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) (Homo sapiens (Human))	BDBM50004775 (2-Methyl-butyric acid 3-hydroxy-8-[2-(4-hydroxy-6-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
British Bio-technology Limited Curated by ChEMBL					Assay Description Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line				J Med Chem 35: 3388-93 (1992) Article DOI: 10.1021/jm00096a015 BindingDB Entry DOI: 10.7270/Q2HD7W9V
British Bio-technology Limited Curated by ChEMBL					More data for this Ligand-Target Pair
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) (Homo sapiens (Human))	BDBM50004776 (CHEMBL323880 \| Sodium; 3,5-dihydroxy-7-[6-hydroxy-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
British Bio-technology Limited Curated by ChEMBL					Assay Description Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line				J Med Chem 35: 3388-93 (1992) Article DOI: 10.1021/jm00096a015 BindingDB Entry DOI: 10.7270/Q2HD7W9V
British Bio-technology Limited Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%