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PubMed code 1534584

Compile data set for download or QSAR
Found 59 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate-NMDA


(RAT)		BDBM50005072
PNG
(5,7-Dichloro-4-(3-p-tolyl-ureido)-1,2,3,4-tetrahyd...)
Show SMILES Cc1ccc(NC(=O)N[C@H]2C[C@@H](Nc3cc(Cl)cc(Cl)c23)C(O)=O)cc1
Show InChI InChI=1S/C18H17Cl2N3O3/c1-9-2-4-11(5-3-9)21-18(26)23-14-8-15(17(24)25)22-13-7-10(19)6-12(20)16(13)14/h2-7,14-15,22H,8H2,1H3,(H,24,25)(H2,21,23,26)/t14-,15+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005044
PNG
((2R,4S)-5,7-Dichloro-4-(2-oxo-3-phenyl-imidazolidi...)
Show SMILES OC(=O)[C@H]1C[C@H](N2CCN(C2=O)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C19H17Cl2N3O3/c20-11-8-13(21)17-14(9-11)22-15(18(25)26)10-16(17)24-7-6-23(19(24)27)12-4-2-1-3-5-12/h1-5,8-9,15-16,22H,6-7,10H2,(H,25,26)/t15-,16+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005055
PNG
(7-Chloro-5-iodo-4-(3-phenyl-ureido)-1,2,3,4-tetrah...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Nc2ccccc2)c2c(I)cc(Cl)cc2N1
Show InChI InChI=1S/C17H15ClIN3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005086
PNG
(5,7-Dichloro-4-(3-o-tolyl-ureido)-1,2,3,4-tetrahyd...)
Show SMILES Cc1ccccc1NC(=O)N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C18H17Cl2N3O3/c1-9-4-2-3-5-12(9)22-18(26)23-14-8-15(17(24)25)21-13-7-10(19)6-11(20)16(13)14/h2-7,14-15,21H,8H2,1H3,(H,24,25)(H2,22,23,26)/t14-,15+/m0/s1
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n/an/a 7.30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005075
PNG
((2R,4S)-5,7-Dichloro-4-(3-phenyl-ureido)-1,2,3,4-t...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Nc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1
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n/an/a 7.40n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005047
PNG
(7-Chloro-5-iodo-4-phenylacetylamino-1,2,3,4-tetrah...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccccc2)c2c(I)cc(Cl)cc2N1
Show InChI InChI=1S/C18H16ClIN2O3/c19-11-7-12(20)17-13(8-11)21-15(18(24)25)9-14(17)22-16(23)6-10-4-2-1-3-5-10/h1-5,7-8,14-15,21H,6,9H2,(H,22,23)(H,24,25)/t14-,15+/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)		BDBM50005053
PNG
((-) 5,7-Dichloro-4-phenylacetylamino-1,2,3,4-tetra...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-11-7-12(20)17-13(8-11)21-15(18(24)25)9-14(17)22-16(23)6-10-4-2-1-3-5-10/h1-5,7-8,14-15,21H,6,9H2,(H,22,23)(H,24,25)/t14-,15+/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005081
PNG
(5,7-Dichloro-4-(3-naphthalen-1-yl-ureido)-1,2,3,4-...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Nc2cccc3ccccc23)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C21H17Cl2N3O3/c22-12-8-14(23)19-16(9-12)24-18(20(27)28)10-17(19)26-21(29)25-15-7-3-5-11-4-1-2-6-13(11)15/h1-9,17-18,24H,10H2,(H,27,28)(H2,25,26,29)/t17-,18+/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to N-methyl-D-aspartate glutamate receptor from rat cortical membranes

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005053
PNG
((-) 5,7-Dichloro-4-phenylacetylamino-1,2,3,4-tetra...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-11-7-12(20)17-13(8-11)21-15(18(24)25)9-14(17)22-16(23)6-10-4-2-1-3-5-10/h1-5,7-8,14-15,21H,6,9H2,(H,22,23)(H,24,25)/t14-,15+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005080
PNG
(4-[2-(4-Amino-phenyl)-acetylamino]-5,7-dichloro-1,...)
Show SMILES Nc1ccc(CC(=O)N[C@H]2C[C@@H](Nc3cc(Cl)cc(Cl)c23)C(O)=O)cc1
Show InChI InChI=1S/C18H17Cl2N3O3/c19-10-6-12(20)17-13(7-10)22-15(18(25)26)8-14(17)23-16(24)5-9-1-3-11(21)4-2-9/h1-4,6-7,14-15,22H,5,8,21H2,(H,23,24)(H,25,26)/t14-,15+/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005038
PNG
(5,7-Dichloro-4-(3-m-tolyl-ureido)-1,2,3,4-tetrahyd...)
Show SMILES Cc1cccc(NC(=O)N[C@H]2C[C@@H](Nc3cc(Cl)cc(Cl)c23)C(O)=O)c1
Show InChI InChI=1S/C18H17Cl2N3O3/c1-9-3-2-4-11(5-9)21-18(26)23-14-8-15(17(24)25)22-13-7-10(19)6-12(20)16(13)14/h2-7,14-15,22H,8H2,1H3,(H,24,25)(H2,21,23,26)/t14-,15+/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005054
PNG
(5,7-Dichloro-4-(3,3-diphenyl-ureido)-1,2,3,4-tetra...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)N(c2ccccc2)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C23H19Cl2N3O3/c24-14-11-17(25)21-18(12-14)26-20(22(29)30)13-19(21)27-23(31)28(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-12,19-20,26H,13H2,(H,27,31)(H,29,30)/t19-,20+/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005087
PNG
(5,7-Dichloro-4-[(9H-fluorene-9-carbonyl)-amino]-1,...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)C2c3ccccc3-c3ccccc23)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C24H18Cl2N2O3/c25-12-9-17(26)22-18(10-12)27-20(24(30)31)11-19(22)28-23(29)21-15-7-3-1-5-13(15)14-6-2-4-8-16(14)21/h1-10,19-21,27H,11H2,(H,28,29)(H,30,31)/t19-,20+/m0/s1
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n/an/a 25n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005039
PNG
(5,7-Dichloro-4-(1-oxo-1,3-dihydro-isoindol-2-yl)-1...)
Show SMILES OC(=O)[C@H]1C[C@H](N2Cc3ccccc3C2=O)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H14Cl2N2O3/c19-10-5-12(20)16-13(6-10)21-14(18(24)25)7-15(16)22-8-9-3-1-2-4-11(9)17(22)23/h1-6,14-15,21H,7-8H2,(H,24,25)/t14-,15+/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005074
PNG
(5,7-Dichloro-4-(3-cyclohexyl-ureido)-1,2,3,4-tetra...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)NC2CCCCC2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H21Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h6-7,10,13-14,21H,1-5,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005064
PNG
(4-(3-Benzyl-ureido)-5,7-dichloro-1,2,3,4-tetrahydr...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)NCc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H17Cl2N3O3/c19-11-6-12(20)16-13(7-11)22-15(17(24)25)8-14(16)23-18(26)21-9-10-4-2-1-3-5-10/h1-7,14-15,22H,8-9H2,(H,24,25)(H2,21,23,26)/t14-,15+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005035
PNG
((2R,4R)-5,7-Dichloro-4-phenylcarbamoylmethyl-1,2,3...)
Show SMILES OC(=O)[C@H]1C[C@H](CC(=O)Nc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-11-8-13(20)17-10(6-15(18(24)25)22-14(17)9-11)7-16(23)21-12-4-2-1-3-5-12/h1-5,8-10,15,22H,6-7H2,(H,21,23)(H,24,25)/t10-,15-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005067
PNG
(5,7-Dichloro-4-[2-(4-hydroxy-phenyl)-acetylamino]-...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccc(O)cc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H16Cl2N2O4/c19-10-6-12(20)17-13(7-10)21-15(18(25)26)8-14(17)22-16(24)5-9-1-3-11(23)4-2-9/h1-4,6-7,14-15,21,23H,5,8H2,(H,22,24)(H,25,26)/t14-,15+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005069
PNG
(5,7-Dichloro-4-(2-thiophen-3-yl-acetylamino)-1,2,3...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccsc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C16H14Cl2N2O3S/c17-9-4-10(18)15-11(5-9)19-13(16(22)23)6-12(15)20-14(21)3-8-1-2-24-7-8/h1-2,4-5,7,12-13,19H,3,6H2,(H,20,21)(H,22,23)/t12-,13+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005084
PNG
(5,7-Dichloro-4-(2-thiophen-2-yl-acetylamino)-1,2,3...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2cccs2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C16H14Cl2N2O3S/c17-8-4-10(18)15-11(5-8)19-13(16(22)23)7-12(15)20-14(21)6-9-2-1-3-24-9/h1-5,12-13,19H,6-7H2,(H,20,21)(H,22,23)/t12-,13+/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005036
PNG
(5,7-Dichloro-4-(2-p-tolyl-acetylamino)-1,2,3,4-tet...)
Show SMILES Cc1ccc(CC(=O)N[C@H]2C[C@@H](Nc3cc(Cl)cc(Cl)c23)C(O)=O)cc1
Show InChI InChI=1S/C19H18Cl2N2O3/c1-10-2-4-11(5-3-10)6-17(24)23-15-9-16(19(25)26)22-14-8-12(20)7-13(21)18(14)15/h2-5,7-8,15-16,22H,6,9H2,1H3,(H,23,24)(H,25,26)/t15-,16+/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005062
PNG
(5,7-Dichloro-4-[2-(4-methoxy-phenyl)-acetylamino]-...)
Show SMILES COc1ccc(CC(=O)N[C@H]2C[C@@H](Nc3cc(Cl)cc(Cl)c23)C(O)=O)cc1
Show InChI InChI=1S/C19H18Cl2N2O4/c1-27-12-4-2-10(3-5-12)6-17(24)23-15-9-16(19(25)26)22-14-8-11(20)7-13(21)18(14)15/h2-5,7-8,15-16,22H,6,9H2,1H3,(H,23,24)(H,25,26)/t15-,16+/m0/s1
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n/an/a 39n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005057
PNG
(5-Chloro-7-iodo-4-phenylacetylamino-1,2,3,4-tetrah...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccccc2)c2c(Cl)cc(I)cc2N1
Show InChI InChI=1S/C18H16ClIN2O3/c19-12-7-11(20)8-13-17(12)14(9-15(21-13)18(24)25)22-16(23)6-10-4-2-1-3-5-10/h1-5,7-8,14-15,21H,6,9H2,(H,22,23)(H,24,25)/t14-,15+/m0/s1
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n/an/a 42n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005059
PNG
(5,7-Dichloro-4-(3-methyl-3-phenyl-ureido)-1,2,3,4-...)
Show SMILES CN(C(=O)N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O)c1ccccc1
Show InChI InChI=1S/C18H17Cl2N3O3/c1-23(11-5-3-2-4-6-11)18(26)22-14-9-15(17(24)25)21-13-8-10(19)7-12(20)16(13)14/h2-8,14-15,21H,9H2,1H3,(H,22,26)(H,24,25)/t14-,15+/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005056
PNG
(5,7-Dichloro-4-(2-oxo-pyrrolidin-1-yl)-1,2,3,4-tet...)
Show SMILES OC(=O)[C@H]1C[C@H](N2CCCC2=O)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C14H14Cl2N2O3/c15-7-4-8(16)13-9(5-7)17-10(14(20)21)6-11(13)18-3-1-2-12(18)19/h4-5,10-11,17H,1-3,6H2,(H,20,21)/t10-,11+/m1/s1
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n/an/a 46n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005066
PNG
(5,7-Dichloro-4-[2-(4-chloro-phenyl)-acetylamino]-1...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccc(Cl)cc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H15Cl3N2O3/c19-10-3-1-9(2-4-10)5-16(24)23-14-8-15(18(25)26)22-13-7-11(20)6-12(21)17(13)14/h1-4,6-7,14-15,22H,5,8H2,(H,23,24)(H,25,26)/t14-,15+/m0/s1
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n/an/a 52n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005046
PNG
(5,7-Dichloro-4-diphenylacetylamino-1,2,3,4-tetrahy...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C24H20Cl2N2O3/c25-16-11-17(26)22-18(12-16)27-20(24(30)31)13-19(22)28-23(29)21(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-12,19-21,27H,13H2,(H,28,29)(H,30,31)/t19-,20+/m0/s1
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n/an/a 61n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005051
PNG
(5,7-Dimethyl-4-phenylacetylamino-1,2,3,4-tetrahydr...)
Show SMILES Cc1cc(C)c2[C@H](C[C@@H](Nc2c1)C(O)=O)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C20H22N2O3/c1-12-8-13(2)19-15(9-12)21-17(20(24)25)11-16(19)22-18(23)10-14-6-4-3-5-7-14/h3-9,16-17,21H,10-11H2,1-2H3,(H,22,23)(H,24,25)/t16-,17+/m0/s1
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n/an/a 67n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005043
PNG
(5,7-Dichloro-4-(3-oxo-3,4-dihydro-1H-isoquinolin-2...)
Show SMILES OC(=O)[C@H]1C[C@H](N2Cc3ccccc3CC2=O)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C19H16Cl2N2O3/c20-12-6-13(21)18-14(7-12)22-15(19(25)26)8-16(18)23-9-11-4-2-1-3-10(11)5-17(23)24/h1-4,6-7,15-16,22H,5,8-9H2,(H,25,26)/t15-,16+/m1/s1
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n/an/a 72n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005065
PNG
(5,7-Dichloro-4-(3-phenyl-propionylamino)-1,2,3,4-t...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)CCc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C19H18Cl2N2O3/c20-12-8-13(21)18-14(9-12)22-16(19(25)26)10-15(18)23-17(24)7-6-11-4-2-1-3-5-11/h1-5,8-9,15-16,22H,6-7,10H2,(H,23,24)(H,25,26)/t15-,16+/m0/s1
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n/an/a 76n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005078
PNG
(4-Benzyloxycarbonylamino-5,7-dichloro-1,2,3,4-tetr...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)OCc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H16Cl2N2O4/c19-11-6-12(20)16-13(7-11)21-15(17(23)24)8-14(16)22-18(25)26-9-10-4-2-1-3-5-10/h1-7,14-15,21H,8-9H2,(H,22,25)(H,23,24)/t14-,15+/m0/s1
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n/an/a 79n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005063
PNG
(5,7-Dichloro-4-(3-phenyl-thioureido)-1,2,3,4-tetra...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=S)Nc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H15Cl2N3O2S/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005049
PNG
(4-Benzoylamino-5,7-dichloro-1,2,3,4-tetrahydro-qui...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H14Cl2N2O3/c18-10-6-11(19)15-12(7-10)20-14(17(23)24)8-13(15)21-16(22)9-4-2-1-3-5-9/h1-7,13-14,20H,8H2,(H,21,22)(H,23,24)/t13-,14+/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005040
PNG
(5,7-Dichloro-4-(2-cyclohexyl-acetylamino)-1,2,3,4-...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)CC2CCCCC2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H22Cl2N2O3/c19-11-7-12(20)17-13(8-11)21-15(18(24)25)9-14(17)22-16(23)6-10-4-2-1-3-5-10/h7-8,10,14-15,21H,1-6,9H2,(H,22,23)(H,24,25)/t14-,15+/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005079
PNG
(5,7-Dichloro-4-[(furan-2-carbonyl)-amino]-1,2,3,4-...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)c2ccco2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C15H12Cl2N2O4/c16-7-4-8(17)13-9(5-7)18-11(15(21)22)6-10(13)19-14(20)12-2-1-3-23-12/h1-5,10-11,18H,6H2,(H,19,20)(H,21,22)/t10-,11+/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005058
PNG
(5,7-Dichloro-4-(cyclohexanecarbonyl-amino)-1,2,3,4...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)C2CCCCC2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H20Cl2N2O3/c18-10-6-11(19)15-12(7-10)20-14(17(23)24)8-13(15)21-16(22)9-4-2-1-3-5-9/h6-7,9,13-14,20H,1-5,8H2,(H,21,22)(H,23,24)/t13-,14+/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005045
PNG
(5,7-Dichloro-4-(4-phenyl-butyrylamino)-1,2,3,4-tet...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)CCCc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C20H20Cl2N2O3/c21-13-9-14(22)19-15(10-13)23-17(20(26)27)11-16(19)24-18(25)8-4-7-12-5-2-1-3-6-12/h1-3,5-6,9-10,16-17,23H,4,7-8,11H2,(H,24,25)(H,26,27)/t16-,17+/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005048
PNG
(5,7-Dichloro-4-[(2,3-dihydro-indole-1-carbonyl)-am...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)N2CCc3ccccc23)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C19H17Cl2N3O3/c20-11-7-12(21)17-13(8-11)22-15(18(25)26)9-14(17)23-19(27)24-6-5-10-3-1-2-4-16(10)24/h1-4,7-8,14-15,22H,5-6,9H2,(H,23,27)(H,25,26)/t14-,15+/m0/s1
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n/an/a 220n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005077
PNG
(4-Butyrylamino-5,7-dichloro-1,2,3,4-tetrahydro-qui...)
Show SMILES CCCC(=O)N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C14H16Cl2N2O3/c1-2-3-12(19)18-10-6-11(14(20)21)17-9-5-7(15)4-8(16)13(9)10/h4-5,10-11,17H,2-3,6H2,1H3,(H,18,19)(H,20,21)/t10-,11+/m0/s1
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n/an/a 370n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005037
PNG
(5,7-Dichloro-4-(phenylcarbamoylmethyl-amino)-1,2,3...)
Show SMILES OC(=O)[C@H]1C[C@H](NCC(=O)Nc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H17Cl2N3O3/c19-10-6-12(20)17-13(8-15(18(25)26)23-14(17)7-10)21-9-16(24)22-11-4-2-1-3-5-11/h1-7,13,15,21,23H,8-9H2,(H,22,24)(H,25,26)/t13-,15+/m0/s1
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n/an/a 420n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005061
PNG
(5,7-Dichloro-4-(2-oxo-1,4-dihydro-2H-quinazolin-3-...)
Show SMILES OC(=O)[C@H]1C[C@H](N2Cc3ccccc3NC2=O)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H15Cl2N3O3/c19-10-5-11(20)16-13(6-10)21-14(17(24)25)7-15(16)23-8-9-3-1-2-4-12(9)22-18(23)26/h1-6,14-15,21H,7-8H2,(H,22,26)(H,24,25)/t14-,15+/m1/s1
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n/an/a 510n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005089
PNG
(4-anilino(imino-N-cyano)methylamino-5,7-dichloro-(...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(Nc2ccccc2)=NC#N)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H15Cl2N5O2/c19-10-6-12(20)16-13(7-10)24-15(17(26)27)8-14(16)25-18(22-9-21)23-11-4-2-1-3-5-11/h1-7,14-15,24H,8H2,(H,26,27)(H2,22,23,25)/t14-,15+/m0/s1
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n/an/a 580n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005071
PNG
(5,7-Dichloro-4-[(pyridine-4-carbonyl)-amino]-1,2,3...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)c2ccncc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C16H13Cl2N3O3/c17-9-5-10(18)14-11(6-9)20-13(16(23)24)7-12(14)21-15(22)8-1-3-19-4-2-8/h1-6,12-13,20H,7H2,(H,21,22)(H,23,24)/t12-,13+/m0/s1
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n/an/a 630n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005052
PNG
(4-Acetylamino-5,7-dichloro-1,2,3,4-tetrahydro-quin...)
Show SMILES CC(=O)N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C12H12Cl2N2O3/c1-5(17)15-9-4-10(12(18)19)16-8-3-6(13)2-7(14)11(8)9/h2-3,9-10,16H,4H2,1H3,(H,15,17)(H,18,19)/t9-,10+/m0/s1
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n/an/a 900n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005070
PNG
(4-tert-Butoxycarbonylamino-5,7-dichloro-1,2,3,4-te...)
Show SMILES CC(C)(C)OC(=O)N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C15H18Cl2N2O4/c1-15(2,3)23-14(22)19-10-6-11(13(20)21)18-9-5-7(16)4-8(17)12(9)10/h4-5,10-11,18H,6H2,1-3H3,(H,19,22)(H,20,21)/t10-,11+/m0/s1
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n/an/a 940n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50406625
PNG
(CHEMBL2115081)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C19H19Cl2N3O3/c20-11-7-12(21)17-14(8-11)23-16(19(26)27)9-15(17)24-18(25)13(22)6-10-4-2-1-3-5-10/h1-5,7-8,13,15-16,23H,6,9,22H2,(H,24,25)(H,26,27)/t13-,15-,16+/m0/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005083
PNG
(4-Benzylcarbamoyl-5,7-dichloro-1,2,3,4-tetrahydro-...)
Show SMILES OC(=O)[C@H]1C[C@H](C(=O)NCc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-11-6-13(20)16-12(8-15(18(24)25)22-14(16)7-11)17(23)21-9-10-4-2-1-3-5-10/h1-7,12,15,22H,8-9H2,(H,21,23)(H,24,25)/t12-,15+/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005050
PNG
(5,7-Dichloro-4-(1,3-dioxo-1,3-dihydro-isoindol-2-y...)
Show SMILES OC(=O)[C@H]1C[C@H](N2C(=O)c3ccccc3C2=O)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H12Cl2N2O4/c19-8-5-11(20)15-12(6-8)21-13(18(25)26)7-14(15)22-16(23)9-3-1-2-4-10(9)17(22)24/h1-6,13-14,21H,7H2,(H,25,26)/t13-,14+/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005068
PNG
(4-Benzenesulfonylamino-5,7-dichloro-1,2,3,4-tetrah...)
Show SMILES OC(=O)[C@H]1C[C@H](NS(=O)(=O)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C16H14Cl2N2O4S/c17-9-6-11(18)15-12(7-9)19-14(16(21)22)8-13(15)20-25(23,24)10-4-2-1-3-5-10/h1-7,13-14,19-20H,8H2,(H,21,22)/t13-,14+/m0/s1
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n/an/a 5.20E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)		BDBM50005053
PNG
((-) 5,7-Dichloro-4-phenylacetylamino-1,2,3,4-tetra...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-11-7-12(20)17-13(8-11)21-15(18(24)25)9-14(17)22-16(23)6-10-4-2-1-3-5-10/h1-5,7-8,14-15,21H,6,9H2,(H,22,23)(H,24,25)/t14-,15+/m0/s1
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n/an/a 5.90E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005085
PNG
(5,7-Dichloro-1,2,3,4-tetrahydro-quinoline-2-carbox...)
Show SMILES OC(=O)[C@H]1CCc2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C10H9Cl2NO2/c11-5-3-7(12)6-1-2-8(10(14)15)13-9(6)4-5/h3-4,8,13H,1-2H2,(H,14,15)/t8-/m1/s1
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n/an/a 6.40E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50406626
PNG
(CHEMBL2115077)
Show SMILES N[C@H](Cc1ccccc1)C(=O)N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C19H19Cl2N3O3/c20-11-7-12(21)17-14(8-11)23-16(19(26)27)9-15(17)24-18(25)13(22)6-10-4-2-1-3-5-10/h1-5,7-8,13,15-16,23H,6,9,22H2,(H,24,25)(H,26,27)/t13-,15+,16-/m1/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005073
PNG
(4-Benzoylamino-5,7-dichloro-1,2,3,4-tetrahydro-qui...)
Show SMILES OC(=O)[C@H]1C[C@@H](NC(=O)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H14Cl2N2O3/c18-10-6-11(19)15-12(7-10)20-14(17(23)24)8-13(15)21-16(22)9-4-2-1-3-5-9/h1-7,13-14,20H,8H2,(H,21,22)(H,23,24)/t13-,14-/m1/s1
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n/an/a 8.30E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005088
PNG
(4-Benzylamino-5,7-dichloro-1,2,3,4-tetrahydro-quin...)
Show SMILES OC(=O)[C@H]1C[C@H](NCc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H16Cl2N2O2/c18-11-6-12(19)16-13(20-9-10-4-2-1-3-5-10)8-15(17(22)23)21-14(16)7-11/h1-7,13,15,20-21H,8-9H2,(H,22,23)/t13-,15+/m0/s1
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n/an/a 1.07E+4n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005076
PNG
(4-Amino-5,7-dichloro-1,2,3,4-tetrahydro-quinoline-...)
Show SMILES N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C10H10Cl2N2O2/c11-4-1-5(12)9-6(13)3-8(10(15)16)14-7(9)2-4/h1-2,6,8,14H,3,13H2,(H,15,16)/t6-,8+/m0/s1
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n/an/a 1.13E+4n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005041
PNG
(4-tert-Butoxycarbonylamino-5,7-dichloro-1,2,3,4-te...)
Show SMILES CC(C)(C)OC(=O)N[C@@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C15H18Cl2N2O4/c1-15(2,3)23-14(22)19-10-6-11(13(20)21)18-9-5-7(16)4-8(17)12(9)10/h4-5,10-11,18H,6H2,1-3H3,(H,19,22)(H,20,21)/t10-,11-/m1/s1
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n/an/a 1.14E+4n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50005082
PNG
(4-Amino-5,7-dichloro-1,2,3,4-tetrahydro-quinoline-...)
Show SMILES N[C@@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C10H10Cl2N2O2/c11-4-1-5(12)9-6(13)3-8(10(15)16)14-7(9)2-4/h1-2,6,8,14H,3,13H2,(H,15,16)/t6-,8-/m1/s1
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n/an/a 1.41E+4n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)		BDBM50406627
PNG
(CHEMBL2115479)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1C[C@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C19H19Cl2N3O3/c20-11-7-12(21)17-14(8-11)23-16(19(26)27)9-15(17)24-18(25)13(22)6-10-4-2-1-3-5-10/h1-5,7-8,13,15-16,23H,6,9,22H2,(H,24,25)(H,26,27)/t13-,15+,16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)		BDBM50229576
PNG
(CHEMBL3350319)
Show SMILES N[C@H](Cc1ccccc1)C(=O)N[C@@H]1C[C@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C19H19Cl2N3O3/c20-11-7-12(21)17-14(8-11)23-16(19(26)27)9-15(17)24-18(25)13(22)6-10-4-2-1-3-5-10/h1-5,7-8,13,15-16,23H,6,9,22H2,(H,24,25)(H,26,27)/t13-,15-,16+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.

J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%