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PubMed code 15482916

Compile data set for download or QSAR
Found 64 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155213
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-isoquinolin-8-yl-u...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1cccc2ccncc12
Show InChI InChI=1S/C17H16N4OS/c22-16(21-17-19-10-15(23-17)12-4-1-5-12)20-14-6-2-3-11-7-8-18-9-13(11)14/h2-3,6-10,12H,1,4-5H2,(H2,19,20,21,22)
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n/an/a 5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155231
PNG
(2-(1H-Benzoimidazol-5-yl)-N-(5-cyclobutyl-thiazol-...)
Show SMILES O=C(Cc1ccc2nc[nH]c2c1)Nc1ncc(s1)C1CCC1
Show InChI InChI=1S/C16H16N4OS/c21-15(7-10-4-5-12-13(6-10)19-9-18-12)20-16-17-8-14(22-16)11-2-1-3-11/h4-6,8-9,11H,1-3,7H2,(H,18,19)(H,17,20,21)
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n/an/a 7n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155209
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-isoquinolin-5-yl-u...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1cccc2cnccc12
Show InChI InChI=1S/C17H16N4OS/c22-16(21-17-19-10-15(23-17)11-3-1-4-11)20-14-6-2-5-12-9-18-8-7-13(12)14/h2,5-11H,1,3-4H2,(H2,19,20,21,22)
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n/an/a 8n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155236
PNG
(CHEMBL363954 | N-(5-Cyclobutyl-thiazol-2-yl)-2-qui...)
Show SMILES O=C(Cc1ccc2ncccc2c1)Nc1ncc(s1)C1CCC1
Show InChI InChI=1S/C18H17N3OS/c22-17(21-18-20-11-16(23-18)13-3-1-4-13)10-12-6-7-15-14(9-12)5-2-8-19-15/h2,5-9,11,13H,1,3-4,10H2,(H,20,21,22)
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n/an/a 10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155235
PNG
(CHEMBL186470 | N-(5-Cyclobutyl-thiazol-2-yl)-2-(2-...)
Show SMILES Cc1nc2ccc(CC(=O)Nc3ncc(s3)C3CCC3)cc2s1
Show InChI InChI=1S/C17H17N3OS2/c1-10-19-13-6-5-11(7-14(13)22-10)8-16(21)20-17-18-9-15(23-17)12-3-2-4-12/h5-7,9,12H,2-4,8H2,1H3,(H,18,20,21)
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n/an/a 12n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155207
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-quinolin-5-yl-urea...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1cccc2ncccc12
Show InChI InChI=1S/C17H16N4OS/c22-16(21-17-19-10-15(23-17)11-4-1-5-11)20-14-8-2-7-13-12(14)6-3-9-18-13/h2-3,6-11H,1,4-5H2,(H2,19,20,21,22)
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n/an/a 13n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155237
PNG
(CHEMBL184404 | N-(5-Cyclobutyl-thiazol-2-yl)-2-iso...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1ncc(s1)C1CCC1
Show InChI InChI=1S/C18H17N3OS/c22-17(21-18-20-11-16(23-18)12-3-1-4-12)9-13-5-2-6-14-10-19-8-7-15(13)14/h2,5-8,10-12H,1,3-4,9H2,(H,20,21,22)
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n/an/a 13n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155230
PNG
(CHEMBL187903 | N-(5-Cyclobutyl-thiazol-2-yl)-2-(5,...)
Show SMILES Cc1cc2ncn(CC(=O)Nc3ncc(s3)C3CCC3)c2cc1C
Show InChI InChI=1S/C18H20N4OS/c1-11-6-14-15(7-12(11)2)22(10-20-14)9-17(23)21-18-19-8-16(24-18)13-4-3-5-13/h6-8,10,13H,3-5,9H2,1-2H3,(H,19,21,23)
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n/an/a 13n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155235
PNG
(CHEMBL186470 | N-(5-Cyclobutyl-thiazol-2-yl)-2-(2-...)
Show SMILES Cc1nc2ccc(CC(=O)Nc3ncc(s3)C3CCC3)cc2s1
Show InChI InChI=1S/C17H17N3OS2/c1-10-19-13-6-5-11(7-14(13)22-10)8-16(21)20-17-18-9-15(23-17)12-3-2-4-12/h5-7,9,12H,2-4,8H2,1H3,(H,18,20,21)
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n/an/a 16n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155214
PNG
(CHEMBL186240 | N-(5-Cyclobutyl-thiazol-2-yl)-2-(1H...)
Show SMILES O=C(Cc1c[nH]c2ccccc12)Nc1ncc(s1)C1CCC1
Show InChI InChI=1S/C17H17N3OS/c21-16(8-12-9-18-14-7-2-1-6-13(12)14)20-17-19-10-15(22-17)11-4-3-5-11/h1-2,6-7,9-11,18H,3-5,8H2,(H,19,20,21)
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n/an/a 16n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155225
PNG
(CHEMBL365855 | N-(5-Cyclobutyl-thiazol-2-yl)-2-phe...)
Show SMILES O=C(Cc1ccccc1)Nc1ncc(s1)C1CCC1
Show InChI InChI=1S/C15H16N2OS/c18-14(9-11-5-2-1-3-6-11)17-15-16-10-13(19-15)12-7-4-8-12/h1-3,5-6,10,12H,4,7-9H2,(H,16,17,18)
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n/an/a 25n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155230
PNG
(CHEMBL187903 | N-(5-Cyclobutyl-thiazol-2-yl)-2-(5,...)
Show SMILES Cc1cc2ncn(CC(=O)Nc3ncc(s3)C3CCC3)c2cc1C
Show InChI InChI=1S/C18H20N4OS/c1-11-6-14-15(7-12(11)2)22(10-20-14)9-17(23)21-18-19-8-16(24-18)13-4-3-5-13/h6-8,10,13H,3-5,9H2,1-2H3,(H,19,21,23)
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n/an/a 26n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155236
PNG
(CHEMBL363954 | N-(5-Cyclobutyl-thiazol-2-yl)-2-qui...)
Show SMILES O=C(Cc1ccc2ncccc2c1)Nc1ncc(s1)C1CCC1
Show InChI InChI=1S/C18H17N3OS/c22-17(21-18-20-11-16(23-18)13-3-1-4-13)10-12-6-7-15-14(9-12)5-2-8-19-15/h2,5-9,11,13H,1,3-4,10H2,(H,20,21,22)
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n/an/a 26n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155231
PNG
(2-(1H-Benzoimidazol-5-yl)-N-(5-cyclobutyl-thiazol-...)
Show SMILES O=C(Cc1ccc2nc[nH]c2c1)Nc1ncc(s1)C1CCC1
Show InChI InChI=1S/C16H16N4OS/c21-15(7-10-4-5-12-13(6-10)19-9-18-12)20-16-17-8-14(22-16)11-2-1-3-11/h4-6,8-9,11H,1-3,7H2,(H,18,19)(H,17,20,21)
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n/an/a 33n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155214
PNG
(CHEMBL186240 | N-(5-Cyclobutyl-thiazol-2-yl)-2-(1H...)
Show SMILES O=C(Cc1c[nH]c2ccccc12)Nc1ncc(s1)C1CCC1
Show InChI InChI=1S/C17H17N3OS/c21-16(8-12-9-18-14-7-2-1-6-13(12)14)20-17-19-10-15(22-17)11-4-3-5-11/h1-2,6-7,9-11,18H,3-5,8H2,(H,19,20,21)
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n/an/a 40n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155232
PNG
(1-(3H-Benzotriazol-4-yl)-3-(5-cyclobutyl-thiazol-2...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1cccc2nn[nH]c12
Show InChI InChI=1S/C14H14N6OS/c21-13(16-9-5-2-6-10-12(9)19-20-18-10)17-14-15-7-11(22-14)8-3-1-4-8/h2,5-8H,1,3-4H2,(H,18,19,20)(H2,15,16,17,21)
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n/an/a 41n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155207
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-quinolin-5-yl-urea...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1cccc2ncccc12
Show InChI InChI=1S/C17H16N4OS/c22-16(21-17-19-10-15(23-17)11-4-1-5-11)20-14-8-2-7-13-12(14)6-3-9-18-13/h2-3,6-11H,1,4-5H2,(H2,19,20,21,22)
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n/an/a 43n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155221
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-quinolin-6-yl-urea...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1ccc2ncccc2c1
Show InChI InChI=1S/C17H16N4OS/c22-16(21-17-19-10-15(23-17)11-3-1-4-11)20-13-6-7-14-12(9-13)5-2-8-18-14/h2,5-11H,1,3-4H2,(H2,19,20,21,22)
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n/an/a 44n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155222
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-isoquinolin-6-yl-u...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C17H16N4OS/c22-16(21-17-19-10-15(23-17)11-2-1-3-11)20-14-5-4-13-9-18-7-6-12(13)8-14/h4-11H,1-3H2,(H2,19,20,21,22)
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n/an/a 44n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155220
PNG
(CHEMBL364338 | N-(5-Cyclobutyl-thiazol-2-yl)-2-ind...)
Show SMILES O=C(Cn1ccc2ccccc12)Nc1ncc(s1)C1CCC1
Show InChI InChI=1S/C17H17N3OS/c21-16(11-20-9-8-12-4-1-2-7-14(12)20)19-17-18-10-15(22-17)13-5-3-6-13/h1-2,4,7-10,13H,3,5-6,11H2,(H,18,19,21)
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n/an/a 48n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155213
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-isoquinolin-8-yl-u...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1cccc2ccncc12
Show InChI InChI=1S/C17H16N4OS/c22-16(21-17-19-10-15(23-17)12-4-1-5-12)20-14-6-2-3-11-7-8-18-9-13(11)14/h2-3,6-10,12H,1,4-5H2,(H2,19,20,21,22)
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n/an/a 55n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155206
PNG
(CHEMBL186511 | N-(5-Cyclopentyl-thiazol-2-yl)-2-ph...)
Show SMILES O=C(Cc1ccccc1)Nc1ncc(s1)C1CCCC1
Show InChI InChI=1S/C16H18N2OS/c19-15(10-12-6-2-1-3-7-12)18-16-17-11-14(20-16)13-8-4-5-9-13/h1-3,6-7,11,13H,4-5,8-10H2,(H,17,18,19)
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n/an/a 64n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155210
PNG
(CHEMBL426972 | N-(5-Isopropyl-thiazol-2-yl)-2-phen...)
Show SMILES CC(C)c1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C14H16N2OS/c1-10(2)12-9-15-14(18-12)16-13(17)8-11-6-4-3-5-7-11/h3-7,9-10H,8H2,1-2H3,(H,15,16,17)
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n/an/a 64n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155237
PNG
(CHEMBL184404 | N-(5-Cyclobutyl-thiazol-2-yl)-2-iso...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1ncc(s1)C1CCC1
Show InChI InChI=1S/C18H17N3OS/c22-17(21-18-20-11-16(23-18)12-3-1-4-12)9-13-5-2-6-14-10-19-8-7-15(13)14/h2,5-8,10-12H,1,3-4,9H2,(H,20,21,22)
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n/an/a 70n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155225
PNG
(CHEMBL365855 | N-(5-Cyclobutyl-thiazol-2-yl)-2-phe...)
Show SMILES O=C(Cc1ccccc1)Nc1ncc(s1)C1CCC1
Show InChI InChI=1S/C15H16N2OS/c18-14(9-11-5-2-1-3-6-11)17-15-16-10-13(19-15)12-7-4-8-12/h1-3,5-6,10,12H,4,7-9H2,(H,16,17,18)
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n/an/a 74n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155216
PNG
(CHEMBL185734 | N-(5-Methylsulfanyl-thiazol-2-yl)-2...)
Show SMILES CSc1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C12H12N2OS2/c1-16-11-8-13-12(17-11)14-10(15)7-9-5-3-2-4-6-9/h2-6,8H,7H2,1H3,(H,13,14,15)
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n/an/a 91n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155209
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-isoquinolin-5-yl-u...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1cccc2cnccc12
Show InChI InChI=1S/C17H16N4OS/c22-16(21-17-19-10-15(23-17)11-3-1-4-11)20-14-6-2-5-12-9-18-8-7-13(12)14/h2,5-11H,1,3-4H2,(H2,19,20,21,22)
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n/an/a 96n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155210
PNG
(CHEMBL426972 | N-(5-Isopropyl-thiazol-2-yl)-2-phen...)
Show SMILES CC(C)c1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C14H16N2OS/c1-10(2)12-9-15-14(18-12)16-13(17)8-11-6-4-3-5-7-11/h3-7,9-10H,8H2,1-2H3,(H,15,16,17)
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n/an/a 98n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155220
PNG
(CHEMBL364338 | N-(5-Cyclobutyl-thiazol-2-yl)-2-ind...)
Show SMILES O=C(Cn1ccc2ccccc12)Nc1ncc(s1)C1CCC1
Show InChI InChI=1S/C17H17N3OS/c21-16(11-20-9-8-12-4-1-2-7-14(12)20)19-17-18-10-15(22-17)13-5-3-6-13/h1-2,4,7-10,13H,3,5-6,11H2,(H,18,19,21)
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n/an/a 100n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155234
PNG
(1-(5-Isopropyl-thiazol-2-yl)-3-phenyl-urea | CHEMB...)
Show SMILES CC(C)c1cnc(NC(=O)Nc2ccccc2)s1
Show InChI InChI=1S/C13H15N3OS/c1-9(2)11-8-14-13(18-11)16-12(17)15-10-6-4-3-5-7-10/h3-9H,1-2H3,(H2,14,15,16,17)
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n/an/a 102n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155216
PNG
(CHEMBL185734 | N-(5-Methylsulfanyl-thiazol-2-yl)-2...)
Show SMILES CSc1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C12H12N2OS2/c1-16-11-8-13-12(17-11)14-10(15)7-9-5-3-2-4-6-9/h2-6,8H,7H2,1H3,(H,13,14,15)
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n/an/a 105n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155232
PNG
(1-(3H-Benzotriazol-4-yl)-3-(5-cyclobutyl-thiazol-2...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1cccc2nn[nH]c12
Show InChI InChI=1S/C14H14N6OS/c21-13(16-9-5-2-6-10-12(9)19-20-18-10)17-14-15-7-11(22-14)8-3-1-4-8/h2,5-8H,1,3-4H2,(H,18,19,20)(H2,15,16,17,21)
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n/an/a 106n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155206
PNG
(CHEMBL186511 | N-(5-Cyclopentyl-thiazol-2-yl)-2-ph...)
Show SMILES O=C(Cc1ccccc1)Nc1ncc(s1)C1CCCC1
Show InChI InChI=1S/C16H18N2OS/c19-15(10-12-6-2-1-3-7-12)18-16-17-11-14(20-16)13-8-4-5-9-13/h1-3,6-7,11,13H,4-5,8-10H2,(H,17,18,19)
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n/an/a 155n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155222
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-isoquinolin-6-yl-u...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1ccc2cnccc2c1
Show InChI InChI=1S/C17H16N4OS/c22-16(21-17-19-10-15(23-17)11-2-1-3-11)20-14-5-4-13-9-18-7-6-12(13)8-14/h4-11H,1-3H2,(H2,19,20,21,22)
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n/an/a 167n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155221
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-quinolin-6-yl-urea...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1ccc2ncccc2c1
Show InChI InChI=1S/C17H16N4OS/c22-16(21-17-19-10-15(23-17)11-3-1-4-11)20-13-6-7-14-12(9-13)5-2-8-18-14/h2,5-11H,1,3-4H2,(H2,19,20,21,22)
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n/an/a 167n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155211
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-phenyl-urea | CHEM...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1ccccc1
Show InChI InChI=1S/C14H15N3OS/c18-13(16-11-7-2-1-3-8-11)17-14-15-9-12(19-14)10-5-4-6-10/h1-3,7-10H,4-6H2,(H2,15,16,17,18)
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n/an/a 183n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155223
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-(1H-indazol-7-yl)-...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1cccc2c[nH]nc12
Show InChI InChI=1S/C15H15N5OS/c21-14(18-11-6-2-5-10-7-17-20-13(10)11)19-15-16-8-12(22-15)9-3-1-4-9/h2,5-9H,1,3-4H2,(H,17,20)(H2,16,18,19,21)
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n/an/a 190n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155234
PNG
(1-(5-Isopropyl-thiazol-2-yl)-3-phenyl-urea | CHEMB...)
Show SMILES CC(C)c1cnc(NC(=O)Nc2ccccc2)s1
Show InChI InChI=1S/C13H15N3OS/c1-9(2)11-8-14-13(18-11)16-12(17)15-10-6-4-3-5-7-10/h3-9H,1-2H3,(H2,14,15,16,17)
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n/an/a 265n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155211
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-phenyl-urea | CHEM...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1ccccc1
Show InChI InChI=1S/C14H15N3OS/c18-13(16-11-7-2-1-3-8-11)17-14-15-9-12(19-14)10-5-4-6-10/h1-3,7-10H,4-6H2,(H2,15,16,17,18)
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n/an/a 290n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155212
PNG
(CHEMBL363711 | N-(5-Isopropyl-thiazol-2-yl)-isobut...)
Show SMILES CC(C)C(=O)Nc1ncc(s1)C(C)C
Show InChI InChI=1S/C10H16N2OS/c1-6(2)8-5-11-10(14-8)12-9(13)7(3)4/h5-7H,1-4H3,(H,11,12,13)
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n/an/a 318n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155212
PNG
(CHEMBL363711 | N-(5-Isopropyl-thiazol-2-yl)-isobut...)
Show SMILES CC(C)C(=O)Nc1ncc(s1)C(C)C
Show InChI InChI=1S/C10H16N2OS/c1-6(2)8-5-11-10(14-8)12-9(13)7(3)4/h5-7H,1-4H3,(H,11,12,13)
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n/an/a 321n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155228
PNG
(CHEMBL186846 | N-(5-Cyclohexyl-thiazol-2-yl)-2-phe...)
Show SMILES O=C(Cc1ccccc1)Nc1ncc(s1)C1CCCCC1
Show InChI InChI=1S/C17H20N2OS/c20-16(11-13-7-3-1-4-8-13)19-17-18-12-15(21-17)14-9-5-2-6-10-14/h1,3-4,7-8,12,14H,2,5-6,9-11H2,(H,18,19,20)
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n/an/a 390n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155226
PNG
(CHEMBL185498 | N-(5-Ethyl-thiazol-2-yl)-2-phenyl-a...)
Show SMILES CCc1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C13H14N2OS/c1-2-11-9-14-13(17-11)15-12(16)8-10-6-4-3-5-7-10/h3-7,9H,2,8H2,1H3,(H,14,15,16)
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n/an/a 412n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155227
PNG
(CHEMBL186201 | N-(5-Bromo-thiazol-2-yl)-2-phenyl-a...)
Show SMILES Brc1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C11H9BrN2OS/c12-9-7-13-11(16-9)14-10(15)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H,13,14,15)
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n/an/a 480n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155226
PNG
(CHEMBL185498 | N-(5-Ethyl-thiazol-2-yl)-2-phenyl-a...)
Show SMILES CCc1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C13H14N2OS/c1-2-11-9-14-13(17-11)15-12(16)8-10-6-4-3-5-7-10/h3-7,9H,2,8H2,1H3,(H,14,15,16)
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n/an/a 621n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155223
PNG
(1-(5-Cyclobutyl-thiazol-2-yl)-3-(1H-indazol-7-yl)-...)
Show SMILES O=C(Nc1ncc(s1)C1CCC1)Nc1cccc2c[nH]nc12
Show InChI InChI=1S/C15H15N5OS/c21-14(18-11-6-2-5-10-7-17-20-13(10)11)19-15-16-8-12(22-15)9-3-1-4-9/h2,5-9H,1,3-4H2,(H,17,20)(H2,16,18,19,21)
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n/an/a 650n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155227
PNG
(CHEMBL186201 | N-(5-Bromo-thiazol-2-yl)-2-phenyl-a...)
Show SMILES Brc1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C11H9BrN2OS/c12-9-7-13-11(16-9)14-10(15)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H,13,14,15)
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n/an/a 900n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155208
PNG
((5-Isopropyl-thiazol-2-yl)-carbamic acid phenyl es...)
Show SMILES CC(C)c1cnc(NC(=O)Oc2ccccc2)s1
Show InChI InChI=1S/C13H14N2O2S/c1-9(2)11-8-14-12(18-11)15-13(16)17-10-6-4-3-5-7-10/h3-9H,1-2H3,(H,14,15,16)
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n/an/a 980n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155228
PNG
(CHEMBL186846 | N-(5-Cyclohexyl-thiazol-2-yl)-2-phe...)
Show SMILES O=C(Cc1ccccc1)Nc1ncc(s1)C1CCCCC1
Show InChI InChI=1S/C17H20N2OS/c20-16(11-13-7-3-1-4-8-13)19-17-18-12-15(21-17)14-9-5-2-6-10-14/h1,3-4,7-8,12,14H,2,5-6,9-11H2,(H,18,19,20)
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n/an/a 997n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155233
PNG
(CHEMBL188172 | N-(5-Isopropyl-thiazol-2-yl)-benzam...)
Show SMILES CC(C)c1cnc(NC(=O)c2ccccc2)s1
Show InChI InChI=1S/C13H14N2OS/c1-9(2)11-8-14-13(17-11)15-12(16)10-6-4-3-5-7-10/h3-9H,1-2H3,(H,14,15,16)
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n/an/a 1.02E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155233
PNG
(CHEMBL188172 | N-(5-Isopropyl-thiazol-2-yl)-benzam...)
Show SMILES CC(C)c1cnc(NC(=O)c2ccccc2)s1
Show InChI InChI=1S/C13H14N2OS/c1-9(2)11-8-14-13(17-11)15-12(16)10-6-4-3-5-7-10/h3-9H,1-2H3,(H,14,15,16)
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n/an/a 1.15E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155217
PNG
(2-Phenyl-N-(5-phenyl-thiazol-2-yl)-acetamide | CHE...)
Show SMILES O=C(Cc1ccccc1)Nc1ncc(s1)-c1ccccc1
Show InChI InChI=1S/C17H14N2OS/c20-16(11-13-7-3-1-4-8-13)19-17-18-12-15(21-17)14-9-5-2-6-10-14/h1-10,12H,11H2,(H,18,19,20)
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n/an/a 1.57E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155208
PNG
((5-Isopropyl-thiazol-2-yl)-carbamic acid phenyl es...)
Show SMILES CC(C)c1cnc(NC(=O)Oc2ccccc2)s1
Show InChI InChI=1S/C13H14N2O2S/c1-9(2)11-8-14-12(18-11)15-13(16)17-10-6-4-3-5-7-10/h3-9H,1-2H3,(H,14,15,16)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155217
PNG
(2-Phenyl-N-(5-phenyl-thiazol-2-yl)-acetamide | CHE...)
Show SMILES O=C(Cc1ccccc1)Nc1ncc(s1)-c1ccccc1
Show InChI InChI=1S/C17H14N2OS/c20-16(11-13-7-3-1-4-8-13)19-17-18-12-15(21-17)14-9-5-2-6-10-14/h1-10,12H,11H2,(H,18,19,20)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155215
PNG
(CHEMBL186932 | N-(5-Pentyl-thiazol-2-yl)-2-phenyl-...)
Show SMILES CCCCCc1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C16H20N2OS/c1-2-3-5-10-14-12-17-16(20-14)18-15(19)11-13-8-6-4-7-9-13/h4,6-9,12H,2-3,5,10-11H2,1H3,(H,17,18,19)
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n/an/a 3.27E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155218
PNG
(CHEMBL363252 | N-(5-Dimethylamino-thiazol-2-yl)-2-...)
Show SMILES CN(C)c1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C13H15N3OS/c1-16(2)12-9-14-13(18-12)15-11(17)8-10-6-4-3-5-7-10/h3-7,9H,8H2,1-2H3,(H,14,15,17)
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n/an/a 3.99E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155215
PNG
(CHEMBL186932 | N-(5-Pentyl-thiazol-2-yl)-2-phenyl-...)
Show SMILES CCCCCc1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C16H20N2OS/c1-2-3-5-10-14-12-17-16(20-14)18-15(19)11-13-8-6-4-7-9-13/h4,6-9,12H,2-3,5,10-11H2,1H3,(H,17,18,19)
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n/an/a 4.12E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155219
PNG
(CHEMBL434917 | N-(5-Isopropyl-thiazol-2-yl)-2-oxo-...)
Show SMILES CC(C)c1cnc(NC(=O)C(=O)c2ccccc2)s1
Show InChI InChI=1S/C14H14N2O2S/c1-9(2)11-8-15-14(19-11)16-13(18)12(17)10-6-4-3-5-7-10/h3-9H,1-2H3,(H,15,16,18)
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n/an/a 4.58E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155224
PNG
(CHEMBL362369 | N-(5-Acetyl-thiazol-2-yl)-2-phenyl-...)
Show SMILES CC(=O)c1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C13H12N2O2S/c1-9(16)11-8-14-13(18-11)15-12(17)7-10-5-3-2-4-6-10/h2-6,8H,7H2,1H3,(H,14,15,17)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155218
PNG
(CHEMBL363252 | N-(5-Dimethylamino-thiazol-2-yl)-2-...)
Show SMILES CN(C)c1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C13H15N3OS/c1-16(2)12-9-14-13(18-12)15-11(17)8-10-6-4-3-5-7-10/h3-7,9H,8H2,1-2H3,(H,14,15,17)
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n/an/a 4.81E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155229
PNG
(CHEMBL186847 | N-(5-Cyclopent-1-enyl-thiazol-2-yl)...)
Show SMILES O=C(Cc1ccccc1)Nc1ncc(s1)C1=CCCC1
Show InChI InChI=1S/C16H16N2OS/c19-15(10-12-6-2-1-3-7-12)18-16-17-11-14(20-16)13-8-4-5-9-13/h1-3,6-8,11H,4-5,9-10H2,(H,17,18,19)
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n/an/a 6.51E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155229
PNG
(CHEMBL186847 | N-(5-Cyclopent-1-enyl-thiazol-2-yl)...)
Show SMILES O=C(Cc1ccccc1)Nc1ncc(s1)C1=CCCC1
Show InChI InChI=1S/C16H16N2OS/c19-15(10-12-6-2-1-3-7-12)18-16-17-11-14(20-16)13-8-4-5-9-13/h1-3,6-8,11H,4-5,9-10H2,(H,17,18,19)
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n/an/a 6.53E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM50155224
PNG
(CHEMBL362369 | N-(5-Acetyl-thiazol-2-yl)-2-phenyl-...)
Show SMILES CC(=O)c1cnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C13H12N2O2S/c1-9(16)11-8-14-13(18-11)15-12(17)7-10-5-3-2-4-6-10/h2-6,8H,7H2,1H3,(H,14,15,17)
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n/an/a 7.67E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50155219
PNG
(CHEMBL434917 | N-(5-Isopropyl-thiazol-2-yl)-2-oxo-...)
Show SMILES CC(C)c1cnc(NC(=O)C(=O)c2ccccc2)s1
Show InChI InChI=1S/C14H14N2O2S/c1-9(2)11-8-15-14(19-11)16-13(18)12(17)10-6-4-3-5-7-10/h3-9H,1-2H3,(H,15,16,18)
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n/an/a 9.77E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay


Bioorg Med Chem Lett 14: 5521-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.006
BindingDB Entry DOI: 10.7270/Q2D50MFB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%