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PubMed code 1560440

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor


(RAT)
BDBM10759
PNG
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Show SMILES CC(=O)OCC[N+](C)(C)C
Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
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n/an/a 12n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50005677
PNG
(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Show SMILES C[N+](C)(C)CC#CCN1CCCC1=O
Show InChI InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1
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n/an/a 13n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229526
PNG
(CHEMBL279356)
Show SMILES Cc1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H15N3O/c1-7-11-10(14-12-7)9-6-13-4-2-8(9)3-5-13/h8-9H,2-6H2,1H3
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n/an/a 14n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50004665
PNG
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Show SMILES O=C1CCCN1CC#CCN1CCCC1
Show InChI InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
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n/an/a 17n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229691
PNG
(CHEMBL23118)
Show SMILES Cc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C9H15N5/c1-7-10-12-14(11-7)9-6-13-4-2-8(9)3-5-13/h8-9H,2-6H2,1H3
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n/an/a 30n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229697
PNG
(CHEMBL23721)
Show SMILES Cn1ncc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-13-11-6-10(12-13)9-7-14-4-2-8(9)3-5-14/h6,8-9H,2-5,7H2,1H3
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n/an/a 48n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229618
PNG
(CHEMBL23335)
Show SMILES Cc1ncn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-8-11-7-14(12-8)10-6-13-4-2-9(10)3-5-13/h7,9-10H,2-6H2,1H3
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n/an/a 75n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM46858
PNG
(1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid...)
Show SMILES COC(=O)C1=CCCN(C)C1
Show InChI InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3
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n/an/a 115n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229688
PNG
(CHEMBL276975)
Show SMILES Cn1nnc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C9H15N5/c1-13-11-9(10-12-13)8-6-14-4-2-7(8)3-5-14/h7-8H,2-6H2,1H3
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n/an/a 140n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230645
PNG
(CHEMBL434772)
Show SMILES Cc1cnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-8-6-11-14(12-8)10-7-13-4-2-9(10)3-5-13/h6,9-10H,2-5,7H2,1H3
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n/an/a 170n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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n/an/a 213n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229667
PNG
(CHEMBL23563)
Show SMILES C1CN2CCC1C(C2)n1ncnn1
Show InChI InChI=1S/C8H13N5/c1-3-12-4-2-7(1)8(5-12)13-10-6-9-11-13/h6-8H,1-5H2
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n/an/a 240n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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n/an/a 322n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230639
PNG
(CHEMBL23172)
Show SMILES C1CN2CCC1C(C2)n1cncn1
Show InChI InChI=1S/C9H14N4/c1-3-12-4-2-8(1)9(5-12)13-7-10-6-11-13/h6-9H,1-5H2
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n/an/a 430n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230644
PNG
(CHEMBL429230)
Show SMILES Cn1nncc1C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-13-10(6-11-12-13)9-7-14-4-2-8(9)3-5-14/h6,8-9H,2-5,7H2,1H3
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n/an/a 930n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230645
PNG
(CHEMBL434772)
Show SMILES Cc1cnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-8-6-11-14(12-8)10-7-13-4-2-9(10)3-5-13/h6,9-10H,2-5,7H2,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229526
PNG
(CHEMBL279356)
Show SMILES Cc1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H15N3O/c1-7-11-10(14-12-7)9-6-13-4-2-8(9)3-5-13/h8-9H,2-6H2,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230642
PNG
(CHEMBL282490)
Show SMILES C1CN2CCC1C(C2)n1cnnn1
Show InChI InChI=1S/C8H13N5/c1-3-12-4-2-7(1)8(5-12)13-6-9-10-11-13/h6-8H,1-5H2
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n/an/a 2.30E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229691
PNG
(CHEMBL23118)
Show SMILES Cc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C9H15N5/c1-7-10-12-14(11-7)9-6-13-4-2-8(9)3-5-13/h8-9H,2-6H2,1H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]QNB as radioligand


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50004665
PNG
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Show SMILES O=C1CCCN1CC#CCN1CCCC1
Show InChI InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
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n/an/a 3.30E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230640
PNG
(CHEMBL22926)
Show SMILES Cn1cnc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-13-7-11-10(12-13)9-6-14-4-2-8(9)3-5-14/h7-9H,2-6H2,1H3
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n/an/a 3.40E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229697
PNG
(CHEMBL23721)
Show SMILES Cn1ncc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-13-11-6-10(12-13)9-7-14-4-2-8(9)3-5-14/h6,8-9H,2-5,7H2,1H3
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n/an/a 4.50E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229618
PNG
(CHEMBL23335)
Show SMILES Cc1ncn(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-8-11-7-14(12-8)10-6-13-4-2-9(10)3-5-13/h7,9-10H,2-6H2,1H3
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n/an/a 4.50E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230638
PNG
(CHEMBL278352)
Show SMILES Cn1cc(nn1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-13-7-10(11-12-13)9-6-14-4-2-8(9)3-5-14/h7-9H,2-6H2,1H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230641
PNG
(CHEMBL23222)
Show SMILES Cc1cn(nn1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-8-6-14(12-11-8)10-7-13-4-2-9(10)3-5-13/h6,9-10H,2-5,7H2,1H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229688
PNG
(CHEMBL276975)
Show SMILES Cn1nnc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C9H15N5/c1-13-11-9(10-12-13)8-6-14-4-2-7(8)3-5-14/h7-8H,2-6H2,1H3
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n/an/a 5.10E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230637
PNG
(CHEMBL23962)
Show SMILES Cn1nnnc1C1CN2CCC1CC2
Show InChI InChI=1S/C9H15N5/c1-13-9(10-11-12-13)8-6-14-4-2-7(8)3-5-14/h7-8H,2-6H2,1H3
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n/an/a 6.50E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230636
PNG
(CHEMBL23901)
Show SMILES Cc1cnnn1C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-8-6-11-12-14(8)10-7-13-4-2-9(10)3-5-13/h6,9-10H,2-5,7H2,1H3
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n/an/a 6.70E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229667
PNG
(CHEMBL23563)
Show SMILES C1CN2CCC1C(C2)n1ncnn1
Show InChI InChI=1S/C8H13N5/c1-3-12-4-2-7(1)8(5-12)13-10-6-9-11-13/h6-8H,1-5H2
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n/an/a 1.60E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230641
PNG
(CHEMBL23222)
Show SMILES Cc1cn(nn1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-8-6-14(12-11-8)10-7-13-4-2-9(10)3-5-13/h6,9-10H,2-5,7H2,1H3
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n/an/a 2.00E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50005677
PNG
(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Show SMILES C[N+](C)(C)CC#CCN1CCCC1=O
Show InChI InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1
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n/an/a 2.30E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]QNB as radioligand


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM10759
PNG
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Show SMILES CC(=O)OCC[N+](C)(C)C
Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
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n/an/a 2.40E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]QNB as radioligand


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM46858
PNG
(1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid...)
Show SMILES COC(=O)C1=CCCN(C)C1
Show InChI InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3
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n/an/a 2.54E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230639
PNG
(CHEMBL23172)
Show SMILES C1CN2CCC1C(C2)n1cncn1
Show InChI InChI=1S/C9H14N4/c1-3-12-4-2-8(1)9(5-12)13-7-10-6-11-13/h6-9H,1-5H2
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n/an/a 2.80E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]QNB as radioligand


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230644
PNG
(CHEMBL429230)
Show SMILES Cn1nncc1C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-13-10(6-11-12-13)9-7-14-4-2-8(9)3-5-14/h6,8-9H,2-5,7H2,1H3
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n/an/a 2.90E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230640
PNG
(CHEMBL22926)
Show SMILES Cn1cnc(n1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-13-7-11-10(12-13)9-6-14-4-2-8(9)3-5-14/h7-9H,2-6H2,1H3
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n/an/a 3.00E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230636
PNG
(CHEMBL23901)
Show SMILES Cc1cnnn1C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-8-6-11-12-14(8)10-7-13-4-2-9(10)3-5-13/h6,9-10H,2-5,7H2,1H3
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n/an/a 3.30E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]QNB as radioligand


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230643
PNG
(CHEMBL22925)
Show SMILES C1CN2CCC1C(C2)n1cnnc1
Show InChI InChI=1S/C9H14N4/c1-3-12-4-2-8(1)9(5-12)13-6-10-11-7-13/h6-9H,1-5H2
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n/an/a 4.00E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230638
PNG
(CHEMBL278352)
Show SMILES Cn1cc(nn1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H16N4/c1-13-7-10(11-12-13)9-6-14-4-2-8(9)3-5-14/h7-9H,2-6H2,1H3
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n/an/a 5.30E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230637
PNG
(CHEMBL23962)
Show SMILES Cn1nnnc1C1CN2CCC1CC2
Show InChI InChI=1S/C9H15N5/c1-13-9(10-11-12-13)8-6-14-4-2-7(8)3-5-14/h7-8H,2-6H2,1H3
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n/an/a 6.00E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230642
PNG
(CHEMBL282490)
Show SMILES C1CN2CCC1C(C2)n1cnnn1
Show InChI InChI=1S/C8H13N5/c1-3-12-4-2-7(1)8(5-12)13-6-9-10-11-13/h6-8H,1-5H2
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n/an/a 1.15E+5n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]QNB as radioligand


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50230643
PNG
(CHEMBL22925)
Show SMILES C1CN2CCC1C(C2)n1cnnc1
Show InChI InChI=1S/C9H14N4/c1-3-12-4-2-8(1)9(5-12)13-6-10-11-7-13/h6-9H,1-5H2
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n/an/a 1.65E+5n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%