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PubMed code 1567835

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50059860
PNG
(((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-...)
Show SMILES CC(CC\C=C(/C)CCC=C(C)C)CC(=O)P(O)(O)=O
Show InChI InChI=1S/C15H27O4P/c1-12(2)7-5-8-13(3)9-6-10-14(4)11-15(16)20(17,18)19/h7,9,14H,5-6,8,10-11H2,1-4H3,(H2,17,18,19)/b13-9+
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PubMed
4.70n/an/an/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Assay using farnesyl-ras-CVLS as the protein acceptor substrate.


Citation and Details
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50059860
PNG
(((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-...)
Show SMILES CC(CC\C=C(/C)CCC=C(C)C)CC(=O)P(O)(O)=O
Show InChI InChI=1S/C15H27O4P/c1-12(2)7-5-8-13(3)9-6-10-14(4)11-15(16)20(17,18)19/h7,9,14H,5-6,8,10-11H2,1-4H3,(H2,17,18,19)/b13-9+
PDB
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PC cid
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PubMed
5.20n/an/an/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
FPTase activity was assayed in the biosynthetically forward direction at 30C.


Citation and Details
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50059865
PNG
(4,8,12-trimethyl-(3E,7E)-3,7,11-tridecatrienylhydr...)
Show SMILES CC(CC\C=C(/C)CCC=C(C)C)CC=CP(O)(=O)CP(O)(O)=O
Show InChI InChI=1S/C17H32O5P2/c1-15(2)8-5-9-16(3)10-6-11-17(4)12-7-13-23(18,19)14-24(20,21)22/h7-8,10,13,17H,5-6,9,11-12,14H2,1-4H3,(H,18,19)(H2,20,21,22)/b13-7?,16-10+
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PubMed
830n/an/an/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
FPTase activity was assayed in the biosynthetically forward direction at 30C.


Citation and Details
More data for this
Ligand-Target Pair
Farnesyl diphosphate synthase


(Homo sapiens (Human))
BDBM50059865
PNG
(4,8,12-trimethyl-(3E,7E)-3,7,11-tridecatrienylhydr...)
Show SMILES CC(CC\C=C(/C)CCC=C(C)C)CC=CP(O)(=O)CP(O)(O)=O
Show InChI InChI=1S/C17H32O5P2/c1-15(2)8-5-9-16(3)10-6-11-17(4)12-7-13-23(18,19)14-24(20,21)22/h7-8,10,13,17H,5-6,9,11-12,14H2,1-4H3,(H,18,19)(H2,20,21,22)/b13-7?,16-10+
PDB
MMDB

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PubMed
1.30E+3n/an/an/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Assay using farnesyl-ras-CVLS as the protein acceptor substrate.


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%